PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTPN11	20	JAK1	6	pull down, enzymatic study, affinity chromatography technology	Yin T (1997), Yin T (1997), Lehmann U (2003)	3
DUSP18	0	PTPN6	0	affinity chromatography technology	St-Denis N (2016)	1
INSR	9	JAK1	6	affinity chromatography technology	Le MN (2002)	1
INSR	9	VAV3	4	affinity chromatography technology	Zeng L (2000)	1
CSK	3	RASA1	3	pull down	Neet K (1995)	1
INSR	9	MPZL2	0	affinity chromatography technology	Yao Z (2017)	1
KHDRBS1	1	SYNCRIP	6	biochemical	Wan C (2015)	1
PTPN11	20	CAV1	0	affinity chromatography technology	Caselli A (2002)	1
HNRNPL	3	SNX2	4	affinity chromatography technology	Fei T (2017)	1
NTRK1	1	PTPRR	3	affinity chromatography technology, two hybrid	Emdal KB (2015), Yao Z (2017)	2
SNX4	0	INSR	9	affinity chromatography technology	Haft CR (1998)	1
INSR	9	HACD3	2	affinity chromatography technology	Boutchueng-Djidjou M (2015)	1
GRB2	2	KHDRBS1	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, unspecified method, affinity chromatography technology, two hybrid	Liu SK (1998), Oneyama C (2002), Shen Z (1999), Shen Z (1999), Bandyopadhyay S (2010), Asbach B (2012), Bisson N (2011), Wang J (2011)	8
NTRK1	1	IRS2	6	affinity chromatography technology	Emdal KB (2015)	1
SQSTM1	0	ENPP1	4	affinity chromatography technology	Behrends C (2010)	1
HNRNPL	3	JAK2	1	affinity chromatography technology	Fei T (2017)	1
PTPN1	2	GRB2	2	pull down, pull down, affinity chromatography technology	Goldstein BJ (2000), Liu F (1996), Li X (2016)	3
HNRNPL	3	SH2B1	7	affinity chromatography technology	Fei T (2017)	1
IRS2	6	JAK1	6	affinity chromatography technology	Johnston JA (1995)	1
PTPN6	0	PRKCD	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Yoshida K (2001), Yoshida K (2001), Yoshida K (2001), Yoshida K (2001)	4
GRB10	4	JAK2	1	affinity chromatography technology	Moutoussamy S (1998)	1
IRS1	7	SOCS3	0	affinity chromatography technology, affinity chromatography technology	Calegari VC (2005), Calegari VC (2005)	2
INSL5	0	INSR	9	affinity chromatography technology	Huttlin EL (2017)	1
DUSP19	0	MAPK1	1	affinity chromatography technology	Li X (2016)	1
PTPN11	20	SOCS3	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lehmann U (2003), Lehmann U (2003), Schmitz J (2000), Orr SJ (2007)	4
CAV1	0	MAPK1	1	affinity chromatography technology	Hua H (2003)	1
INSR	9	KRT31	0	two hybrid	Rolland T (2014)	1
SCGB1D1	1	INSR	9	affinity chromatography technology	Huttlin EL (2017)	1
ARRB2	5	HGS	5	affinity chromatography technology, affinity chromatography technology	Han SO (2012), Malik R (2010)	2
KRT31	0	PRKAA2	1	two hybrid	Rolland T (2014)	1
INSR	9	SH2B1	7	affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid	Kotani K (1998), Kotani K (1998), Nelms K (1999), Nelms K (1999), Nishi M (2005)	5
INSR	9	PTPN11	20	pull down, affinity chromatography technology, pull down	Maegawa H (1994), Kharitonenkov A (1995), Kharitonenkov A (1995)	3
SH2B2	1	SORBS1	2	affinity chromatography technology, affinity chromatography technology	Limpert AS (2007), Ahn MY (2004)	2
PLCG1	6	SYNCRIP	6	pull down	Fu C (1997)	1
JAK2	1	SOCS3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sasaki A (2000), Sasaki A (2000), Sasaki A (1999), Sasaki A (1999), Sasaki A (1999), Masuhara M (1997), Masuhara M (1997), Monni R (2001), Haan S (2009), Babon JJ (2012), Calegari VC (2005), Calegari VC (2005), Varghese LN (2014), Kershaw NJ (2014)	14
CSK	3	SHC1	0	pull down, affinity chromatography technology	Sato K (2002), Brehme M (2009)	2
SNX17	0	HRAS	2	pull down	Ghai R (2013)	1
TRIM25	5	MAPK1	1	affinity chromatography technology	Choudhury NR (2017)	1
STAT5A	4	JAK2	1	affinity chromatography technology, two hybrid, pull down, enzymatic study	Barahmand-Pour F (1998), Fujitani Y (1997), Fujitani Y (1997), Gouilleux F (1994)	4
INSR	9	AHSG	0	pull down	Srinivas PR (1993)	1
DOK1	2	PLCG1	6	pull down	van Dijk TB (2000)	1
IRS1	7	SH2B1	7	unspecified method	Liu BA (2012)	1
TRIM25	5	KHDRBS1	1	affinity chromatography technology	Choudhury NR (2017)	1
ACP1	4	INSR	9	affinity chromatography technology, affinity chromatography technology	Chiarugi P (1997), Chiarugi P (1997)	2
SNX2	4	HGS	5	biochemical	Wan C (2015)	1
PTPRR	3	MAPK3	4	pull down, pull down, affinity chromatography technology	Pulido R (1998), Zuniga A (1999), St-Denis N (2016)	3
INSL5	0	SQSTM1	0	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	PON2	0	two hybrid	Wang J (2011)	1
INSR	9	PRKCD	2	affinity chromatography technology, affinity chromatography technology	Braiman L (2001), Rosenzweig T (2002)	2
INSR	9	KHDRBS1	1	affinity chromatography technology	Sanchez-Margalet V (2001)	1
FRS2	0	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ong SH (1996), Wong A (2002), Meakin SO (1999), Kouhara H (1997), Mason JM (2004), Liu BA (2012), Lao DH (2006), Bisson N (2011), Zhou L (2015)	9
IRS2	6	GRB2	2	unspecified method, affinity chromatography technology	Liu BA (2012), Bisson N (2011)	2
CAV1	0	SMAD2	5	biochemical	Razani B (2001)	1
SQSTM1	0	PRKCD	2	affinity chromatography technology	Linares JF (2011)	1
INSR	9	INSRR	8	affinity chromatography technology	Jui HY (1996)	1
INSR	9	SOCS6	0	affinity chromatography technology	Mooney RA (2001)	1
INSR	9	STAT5B	3	affinity chromatography technology	Le MN (2002)	1
NTRK1	1	SNX2	4	affinity chromatography technology	Emdal KB (2015)	1
SNX27	5	NTRK1	1	affinity chromatography technology, affinity chromatography technology	Ghai R (2013), Emdal KB (2015)	2
INSR	9	DUSP18	0	affinity chromatography technology, two hybrid	Yao Z (2017), Yao Z (2017)	2
NTRK1	1	HNRNPL	3	affinity chromatography technology	Emdal KB (2015)	1
TRIM25	5	INSR	9	affinity chromatography technology	Choudhury NR (2017)	1
VAV1	2	INSR	9	pull down	Uddin S (1995)	1
FRS2	0	NTRK1	1	pull down, two hybrid	Meakin SO (1999), Meakin SO (1999)	2
JAK1	6	SOCS3	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Park ES (2000), Cohney SJ (1999), Cohney SJ (1999), Cohney SJ (1999)	4
NTRK1	1	SYNCRIP	6	affinity chromatography technology	Emdal KB (2015)	1
INSR	9	MARCH1	1	affinity chromatography technology, enzymatic study	Nagarajan A (2016), Nagarajan A (2016)	2
SHC1	0	DOK1	2	affinity chromatography technology, affinity chromatography technology, unspecified method	Dunant NM (2000), Dunant NM (2000), Liu BA (2012)	3
NTRK1	1	RASA1	3	affinity chromatography technology	Emdal KB (2015)	1
PTPN11	20	STAT5A	4	pull down, enzymatic study, affinity chromatography technology	Yu CL (2000), Yu CL (2000), Chughtai N (2002)	3
HGS	5	SNX1	2	pull down, affinity chromatography technology	Chin LS (2001), Popoff V (2009)	2
SH2B1	7	SH2B2	1	two hybrid, affinity chromatography technology	Nishi M (2005), Nishi M (2005)	2
CAV1	0	PLCG1	6	affinity chromatography technology	Boettcher JP (2010)	1
NTRK1	1	SNX1	2	affinity chromatography technology	Emdal KB (2015)	1
SNX1	2	INSR	9	affinity chromatography technology	Haft CR (1998)	1
NTRK1	1	PLCG1	6	pull down, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Ohmichi M (1991), Qian X (1998), Meakin SO (1999), Koch A (2000), Emdal KB (2015), Emdal KB (2015)	6
SNX6	1	SNX1	2	affinity chromatography technology, biochemical, two hybrid, biochemical, affinity chromatography technology	Parks WT (2001), Havugimana PC (2012), Wang J (2011), Wan C (2015), Huttlin EL (2017)	5
STAT5B	3	JAK2	1	affinity chromatography technology, two hybrid, enzymatic study	Barahmand-Pour F (1998), Fujitani Y (1997), Varghese LN (2014)	3
HRAS	2	INSR	9	enzymatic study	OBrien RM (1987)	1
PTPRR	3	MAPK1	1	pull down, pull down, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Pulido R (1998), Zuniga A (1999), Zuniga A (1999), Zuniga A (1999), Zuniga A (1999), Zuniga A (1999), Huttlin EL (2015), Chen TC (2014), St-Denis N (2016), Huttlin EL (2017)	10
VAV1	2	PTPN6	0	pull down	Kon-Kozlowski M (1996)	1
PLCG1	6	PTPN6	0	affinity chromatography technology, affinity chromatography technology	Matalon O (2016), Matalon O (2016)	2
PLCG1	6	GRB14	1	affinity chromatography technology	Browaeys-Poly E (2010)	1
PLCG1	6	RASA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jabado N (1998), Jabado N (1997), Jabado N (1997)	3
NTRK1	1	JAK1	6	affinity chromatography technology	Emdal KB (2015)	1
INSR	9	SHC1	0	two hybrid, pull down	Kasus-Jacobi A (2000), Wolf G (1995)	2
VAV1	2	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Song JS (1996), Lee IS (1997)	2
SH2B1	7	GRB2	2	affinity chromatography technology, pull down	Qian X (1998), Kotani K (1998)	2
NTRK1	1	KHDRBS1	1	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	SHC1	0	two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Qian X (1998), Borrello MG (1994), Nakamura T (2002), Meakin SO (1999), Koch A (2000), Emdal KB (2015), Emdal KB (2015)	7
INSR	9	TEAD1	2	two hybrid	Wang J (2011)	1
GRB2	2	SOCS1	1	pull down	De Sepulveda P (1999)	1
SHC1	0	STAT5B	3	affinity chromatography technology	Dinerstein-Cali H (2000)	1
INSR	9	KIF5A	2	affinity chromatography technology	Boutchueng-Djidjou M (2015)	1
INPPL1	6	SORBS1	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Vandenbroere I (2003), Vandenbroere I (2003), Vandenbroere I (2003)	3
NTRK1	1	HGS	5	affinity chromatography technology	Emdal KB (2015)	1
JAK2	1	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chauhan D (1995), Chauhan D (1995), Giorgetti-Peraldi S (1995), Brizzi MF (1996)	4
MAPK1	1	SHC1	0	affinity chromatography technology	Dinerstein-Cali H (2000)	1
INSR	9	JAK2	1	affinity chromatography technology, affinity chromatography technology	Maegawa H (1996), Le MN (2002)	2
HNRNPL	3	PRKAA2	1	affinity chromatography technology	Fei T (2017)	1
SH2B2	1	INSR	9	affinity chromatography technology, affinity chromatography technology, two hybrid	Onnockx S (2008), Onnockx S (2008), Ahn MY (2004)	3
SMAD2	5	INSR	9	two hybrid, affinity chromatography technology, pull down	ONeill TJ (1997), ONeill TJ (1997), ONeill TJ (1997)	3
INSR	9	GRB14	1	affinity chromatography technology	Bereziat V (2002)	1
TRIM25	5	SH2B2	1	affinity chromatography technology	Choudhury NR (2017)	1
NTRK1	1	SH2B1	7	two hybrid, affinity chromatography technology, two hybrid	Qian X (1998), Qian X (1998), Koch A (2000)	3
TRIM25	5	SNX27	5	affinity chromatography technology	Choudhury NR (2017)	1
FAM19A4	0	INSR	9	affinity chromatography technology	Huttlin EL (2017)	1
PTPN11	20	IRS1	7	pull down, affinity chromatography technology, unspecified method, pull down, enzymatic study	Kuhne MR (1993), Myers MG (1998), Liu BA (2012), Strack V (2002), Strack V (2002)	5
INSR	9	PRKAA1	2	affinity chromatography technology	Boutchueng-Djidjou M (2015)	1
GRB2	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Bennett AM (1994), Ward AC (1998), Yin T (1997), Tang J (1997), Tang H (1999), Hadari YR (1998), Zhang S (1999), Wong L (1996), Brehme M (2009), Craddock BL (1997), Bisson N (2011), Blagoev B (2003), Bisson N (2011), Tauchi T (1995), Huttlin EL (2017), Kapoor GS (2010), Kapoor GS (2010), Vogel W (1996), Vogel W (1996), Yu WM (2006)	21
VAV1	2	PLCG1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Bertagnolo V (1998), Bertagnolo V (1998), Braiman A (2006), Braiman A (2006), Braiman A (2006)	5
PTPRK	1	INSR	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SH2B2	1	INPPL1	6	affinity chromatography technology	Onnockx S (2008)	1
PTPN1	2	STAT5B	3	unspecified method	Espanel X (2002)	1
GRB2	2	PTPN6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Kon-Kozlowski M (1996), Saci A (2002)	3
SNX27	5	SCGB1D1	1	affinity chromatography technology	Huttlin EL (2017)	1
PTPN1	2	CAV1	0	affinity chromatography technology	Caselli A (2002)	1
RASA1	3	HRAS	2	pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Molloy DP (1995), Scheffzek K (1997), Giglione C (2001), Ji H (2016), Ji H (2016), Ji H (2016)	6
HNRNPL	3	RASA1	3	affinity chromatography technology	Fei T (2017)	1
INSR	9	SORBS1	2	affinity chromatography technology	Lin WH (2001)	1
JAK1	6	GRB2	2	affinity chromatography technology, pull down	Kim H (2001), Giorgetti-Peraldi S (1995)	2
INSR	9	PPM1A	1	affinity chromatography technology	Yao Z (2017)	1
SOCS1	1	IRS2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rui L (2002), Rui L (2002), McCormick SM (2016), McCormick SM (2016)	4
TRIM25	5	PTPN11	20	affinity chromatography technology	Choudhury NR (2017)	1
INSR	9	SSH1	1	affinity chromatography technology	Yao Z (2017)	1
PRKAA2	1	PRKAA1	2	affinity chromatography technology	Behrends C (2010)	1
KHDRBS1	1	VAV1	2	unspecified method	Asbach B (2012)	1
IRS2	6	PTPN11	20	affinity chromatography technology	Argetsinger LS (1996)	1
TRIM25	5	STAT5B	3	affinity chromatography technology	Choudhury NR (2017)	1
PTPN1	2	JAK2	1	affinity chromatography technology, enzymatic study	Myers MP (2001), Lund IK (2005)	2
PTPN11	20	JAK2	1	pull down, enzymatic study, enzymatic study, affinity chromatography technology	Yin T (1997), Yin T (1997), Tauchi T (1996), Maegawa H (1996)	4
JAK2	1	VAV1	2	affinity chromatography technology, enzymatic study, affinity chromatography technology	Shigematsu H (1997), Shigematsu H (1997), Matsuguchi T (1995)	3
INSR	9	FRS2	0	enzymatic study	Delahaye L (2000)	1
PON2	0	ENPP1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PTPN1	2	IRS1	7	pull down, affinity chromatography technology	Goldstein BJ (2000), Ravichandran LV (2001)	2
INSR	9	IRF7	2	two hybrid	Wang J (2011)	1
INSR	9	GRB2	2	affinity chromatography technology	Ishihara H (1997)	1
CLEC3A	2	INSR	9	affinity chromatography technology	Huttlin EL (2017)	1
SQSTM1	0	STAT5A	4	affinity chromatography technology	Watanabe Y (2011)	1
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
NTRK1	1	INPPL1	6	affinity chromatography technology	Emdal KB (2015)	1
ARRB2	5	MAPK3	4	affinity chromatography technology, imaging technique	Tohgo A (2003), Chen TC (2014)	2
IRS1	7	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Skolnik EY (1993), Skolnik EY (1993), Skolnik EY (1993), Morrison KB (2002), Giorgetti-Peraldi S (1995), Liu BA (2012), Bisson N (2011)	7
SHC1	0	PRKCD	2	affinity chromatography technology, pull down, affinity chromatography technology	Leitges M (2002), Leitges M (2002), Brehme M (2009)	3
IRS1	7	KHDRBS1	1	affinity chromatography technology, affinity chromatography technology	Sanchez-Margalet V (2001), Sung CK (1994)	2
NTRK1	1	HACD3	2	affinity chromatography technology	Emdal KB (2015)	1
MOK	0	INSR	9	affinity chromatography technology	Varjosalo M (2013)	1
NTRK1	1	STAT5B	3	affinity chromatography technology	Emdal KB (2015)	1
SHC1	0	JAK2	1	pull down, pull down	VanderKuur J (1995), Giordano V (1997)	2
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
INSR	9	PRKAA2	1	affinity chromatography technology	Boutchueng-Djidjou M (2015)	1
DNASE1L2	2	INSR	9	affinity chromatography technology	Huttlin EL (2017)	1
STAT5A	4	STAT5B	3	affinity chromatography technology	Huttlin EL (2017)	1
PTPN6	0	INSR	9	affinity chromatography technology	Uchida T (1994)	1
IRS2	6	SOCS3	0	affinity chromatography technology, affinity chromatography technology	Calegari VC (2005), Calegari VC (2005)	2
SH2B2	1	SHC1	0	pull down	Yokouchi M (1997)	1
HNRNPL	3	HACD3	2	affinity chromatography technology	Fei T (2017)	1
TMEM17	0	FRS2	0	bioid	Gupta GD (2015)	1
TRIM25	5	SQSTM1	0	affinity chromatography technology	Choudhury NR (2017)	1
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
MAPK1	1	INSR	9	affinity chromatography technology	Lin YL (2000)	1
KHDRBS1	1	RASA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Sanchez-Margalet V (2001), Sanchez-Margalet V (2001), Jabado N (1998), Jabado N (1998), Koch CA (1992), Marengere LE (1992), Gold MR (1993), Darby C (1994)	8
JAK1	6	SOCS1	1	affinity chromatography technology	Park ES (2000)	1
PTPRR	3	SNX6	1	bioid	St-Denis N (2016)	1
CAV1	0	CSK	3	two hybrid	Cao H (2002)	1
HNRNPL	3	MARCH1	1	affinity chromatography technology	Fei T (2017)	1
INSR	9	PTPRR	3	affinity chromatography technology, two hybrid	Yao Z (2017), Yao Z (2017)	2
PTPN6	0	STAT5B	3	affinity chromatography technology	Ram PA (1997)	1
HNRNPL	3	STAT5B	3	affinity chromatography technology	Fei T (2017)	1
INSR	9	IRS1	7	two hybrid, two hybrid, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Aguirre V (2002), Sawka-Verhelle D (1996), Strack V (2002), Wolf G (1995), Kwon H (2015), Kwon H (2015)	6
INSR	9	ARRB2	5	affinity chromatography technology	Luan B (2009)	1
PLCG1	6	KHDRBS1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Oneyama C (2002), Jabado N (1998), Shen Z (1999), Shen Z (1999), Jabado N (1997), Jabado N (1997)	6
VAV1	2	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Song JS (1996), Ye ZS (1994), Ye ZS (1994), Germani A (1999), Lee IS (1997)	5
MAPK1	1	STYX	1	affinity chromatography technology, protein complementation assay	Reiterer V (2017), Reiterer V (2017)	2
JAK2	1	PLCG1	6	affinity chromatography technology	Chang YJ (2004)	1
SHC1	0	VAV3	4	affinity chromatography technology	Zeng L (2000)	1
SQSTM1	0	CAV1	0	affinity chromatography technology, affinity chromatography technology	Liang X (2013), Luo X (2017)	2
CAV1	0	MAPK3	4	affinity chromatography technology	Hua H (2003)	1
SOCS1	1	VAV1	2	affinity chromatography technology, affinity chromatography technology	De Sepulveda P (1999), De Sepulveda P (2000)	2
JAK1	6	IRS1	7	enzymatic study, affinity chromatography technology	Gual P (1998), Johnston JA (1995)	2
HNRNPL	3	PON2	0	affinity chromatography technology	Fei T (2017)	1
NTRK1	1	INSR	9	affinity chromatography technology	Emdal KB (2015)	1
SYNCRIP	6	PTPN11	20	two hybrid	Harris CE (1999)	1
SNX6	1	SNX2	4	affinity chromatography technology, biochemical, two hybrid, biochemical, biochemical	Parks WT (2001), Havugimana PC (2012), Wang J (2011), Kristensen AR (2012), Wan C (2015)	5
SNX17	0	NTRK1	1	affinity chromatography technology	Ghai R (2013)	1
PPM1A	1	PRKAA1	2	enzymatic study	Voss M (2011)	1
SHC1	0	PLCG1	6	affinity chromatography technology	Fixman ED (1996)	1
TMEM17	0	SNX2	4	bioid	Gupta GD (2015)	1
SHC1	0	STAT5A	4	affinity chromatography technology	Dinerstein-Cali H (2000)	1
IRS1	7	IRS2	6	biochemical	Sun H (2003)	1
RASA1	3	DOK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Dunant NM (2000), Yamanashi Y (1997), Nemorin JG (2000), Liu BA (2012), Di Cristofano A (1998), Bhat A (1998), Wick MJ (2001), Kashige N (2000), Kashige N (2000), Kepley CL (2004)	10
INSR	9	IRS2	6	two hybrid	Sawka-Verhelle D (1996)	1
NTRK1	1	PTPN11	20	affinity chromatography technology	Emdal KB (2015)	1
INSR	9	DUSP19	0	two hybrid	Yao Z (2017)	1
JAK2	1	PTPN6	0	affinity chromatography technology, affinity chromatography technology	Jiao H (1996), Wu DW (2000)	2
FAM19A3	0	SNX27	5	affinity chromatography technology	Huttlin EL (2017)	1
JAK2	1	SH2B2	1	enzymatic study	Wakioka T (1999)	1
KRT31	0	HGS	5	two hybrid	Rolland T (2014)	1
INSR	9	STYX	1	two hybrid	Yao Z (2017)	1
JAK2	1	SOCS1	1	two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Yasukawa H (1999), Dif F (2001), Endo TA (1997), Endo TA (1997), Endo TA (1997), Yasukawa H (1999), Yasukawa H (1999), Pezet A (1999), Ungureanu D (2002), Masuhara M (1997), Ali S (2003), Monni R (2001), Monni R (2001), Piessevaux J (2008), Yu L (2009), Maruoka M (2017)	16
ARRB2	5	CSK	3	affinity chromatography technology	Lodeiro M (2009)	1
SQSTM1	0	NTRK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wooten MW (2001), Geetha T (2003), Jadhav T (2008), Wooten MW (2008), Wooten MW (2008), Zheng C (2015)	6
ATIC	6	JAK1	6	affinity chromatography technology	Ewing RM (2007)	1
JAK1	6	PLCG1	6	affinity chromatography technology	Chang YJ (2004)	1
PTPN11	20	STAT5B	3	pull down, enzymatic study	Yu CL (2000), Yu CL (2000)	2
TRIM25	5	GRB2	2	affinity chromatography technology	Choudhury NR (2017)	1
ARRB2	5	PPM1A	1	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
HNRNPL	3	INSR	9	affinity chromatography technology	Fei T (2017)	1
INSR	9	SOCS1	1	affinity chromatography technology	Mooney RA (2001)	1
STAT5A	4	MAPK1	1	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Pircher TJ (1999), Pircher TJ (1999), Dinerstein-Cali H (2000), Chen TC (2014)	4
INSR	9	SYNCRIP	6	enzymatic study	Hresko RC (2002)	1
DOK1	2	VAV1	2	unspecified method	Liu BA (2012)	1
SOCS3	0	RASA1	3	pull down, affinity chromatography technology	Cacalano NA (2001), Cacalano NA (2001)	2
CAV1	0	NTRK1	1	affinity chromatography technology	Bilderback TR (1999)	1
TMEM17	0	HGS	5	bioid	Gupta GD (2015)	1
SNX2	4	SNX4	0	affinity chromatography technology	Haft CR (1998)	1
PLCG1	6	IRS2	6	affinity chromatography technology, affinity chromatography technology, unspecified method	Sozzani P (1998), Sozzani P (1998), Liu BA (2012)	3
PPM1F	1	PRKAA2	1	affinity chromatography technology, affinity chromatography technology	Voss M (2011), Voss M (2011)	2
SHC1	0	INPPL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wisniewski D (1999), Wisniewski D (1999), Pesesse X (2001), Habib T (1998), Brehme M (2009), Brehme M (2009)	6
TRIM25	5	FRS2	0	affinity chromatography technology	Choudhury NR (2017)	1
INSR	9	DOK1	2	enzymatic study	Wick MJ (2001)	1
PTPN11	20	PTPN6	0	affinity chromatography technology	Li X (2016)	1
JAK1	6	STAT5B	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Fujitani Y (1997), Fujitani Y (1997), Fujitani Y (1997)	3
GRB10	4	INSR	9	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Langlais P (2000), Hansen H (1996), Hansen H (1996), Hansen H (1996), Liu F (1995), Liu F (1995), Liu F (1995), He W (1998), He W (1998), Frantz JD (1997), Mori K (2005)	11
GRB2	2	AHSG	0	two hybrid	Wang J (2008)	1
FRS2	0	SORBS1	2	two hybrid, pull down, affinity chromatography technology	Tomasovic A (2012), Tomasovic A (2012), Tomasovic A (2012)	3
INSR	9	ATIC	6	affinity chromatography technology	Boutchueng-Djidjou M (2015)	1
RASA1	3	SOCS1	1	affinity chromatography technology, affinity chromatography technology	Madonna S (2008), Madonna S (2008)	2
SQSTM1	0	MAPK1	1	affinity chromatography technology	Linares JF (2011)	1
HNRNPL	3	SYNCRIP	6	biochemical	Wan C (2015)	1
CSK	3	KHDRBS1	1	enzymatic study, affinity chromatography technology, biochemical	Taylor SJ (1994), Taylor SJ (1994), Taylor SJ (1994)	3
SNX2	4	INSR	9	affinity chromatography technology	Haft CR (1998)	1
TRIM25	5	TEAD1	2	affinity chromatography technology	Choudhury NR (2017)	1
IRS1	7	SOCS1	1	affinity chromatography technology, affinity chromatography technology	Rui L (2002), Li JY (2007)	2
TMEM17	0	INSR	9	bioid	Gupta GD (2015)	1
SH2B2	1	GRB2	2	affinity chromatography technology, pull down	Qian X (1998), Yokouchi M (1997)	2
INSR	9	SOCS3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Senn JJ (2003), Calegari VC (2005), Calegari VC (2005)	3
KHDRBS1	1	SORBS1	2	unspecified method	Asbach B (2012)	1
HNRNPL	3	PTPRR	3	affinity chromatography technology	Fei T (2017)	1
INSR	9	PLCG1	6	unspecified method	Liu BA (2012)	1
INSR	9	INPPL1	6	affinity chromatography technology, affinity chromatography technology	Vandenbroere I (2003), Onnockx S (2008)	2
PRKCD	2	IRS1	7	affinity chromatography technology, enzymatic study	Rosenzweig T (2002), del Rincon SV (2004)	2
SMAD2	5	HGS	5	affinity chromatography technology	Miura S (2000)	1
DNASE1L2	2	CSK	3	affinity chromatography technology	Huttlin EL (2015)	1
GRB2	2	RASA1	3	affinity chromatography technology	Lamprecht R (2002)	1
TRIM25	5	PON2	0	affinity chromatography technology	Choudhury NR (2017)	1
HGS	5	INSR	9	affinity chromatography technology	Hasseine LK (2007)	1
HNRNPL	3	GRB10	4	affinity chromatography technology	Fei T (2017)	1
JAK1	6	STAT5A	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Fujitani Y (1997), Fujitani Y (1997), Fujitani Y (1997), Fujitani Y (1997)	4
SMAD2	5	IRF7	2	pull down, affinity chromatography technology	Qing J (2004), Qing J (2004)	2
SNX6	1	SNX4	0	affinity chromatography technology	Parks WT (2001)	1
SNX1	2	SNX2	4	affinity chromatography technology, affinity chromatography technology	Haft CR (1998), Huttlin EL (2017)	2
SMAD2	5	KHDRBS1	1	two hybrid	Colland F (2004)	1
PLCG1	6	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pei Z (1997), Pei Z (1997), Nel AE (1995), Scholler JK (2000), Choi JH (2005), Choi JH (2005)	6
TRIM25	5	SSH1	1	affinity chromatography technology	Choudhury NR (2017)	1
GRB2	2	DOK1	2	affinity chromatography technology	Kepley CL (2004)	1
FAM19A3	0	INSR	9	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	PPM1F	1	affinity chromatography technology	Emdal KB (2015)	1
PPM1A	1	INPPL1	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UNC5CL	5	INSR	9	affinity chromatography technology	Huttlin EL (2017)	1
PON2	0	INSR	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRB10	4	IRS1	7	pull down, affinity chromatography technology	Hansen H (1996), Deng Y (2003)	2
JAK2	1	IRS1	7	enzymatic study, affinity chromatography technology	Gual P (1998), Kawazoe Y (2001)	2
INSR	9	STAT5A	4	affinity chromatography technology	Le MN (2002)	1
TMEM17	0	SQSTM1	0	bioid	Gupta GD (2015)	1
INSR	9	RASA1	3	affinity chromatography technology	Pronk GJ (1992)	1
PTPN6	0	JAK1	6	enzymatic study	Yetter A (1995)	1
PTPN1	2	NTRK1	1	unspecified method	Espanel X (2002)	1
PTPN1	2	INSR	9	affinity chromatography technology	Bereziat V (2002)	1
INSR	9	PPM1F	1	affinity chromatography technology	Yao Z (2017)	1
SNX27	5	INSR	9	affinity chromatography technology	Ghai R (2013)	1
FRS2	0	PTPN11	20	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, unspecified method, affinity chromatography technology	Delahaye L (2000), Delahaye L (2000), Kurokawa K (2001), Hadari YR (1998), Hadari YR (1998), Liu BA (2012), Zhou L (2015)	7
ARRB2	5	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Shenoy SK (2005), Luttrell LM (2001), Xiao K (2007), Chen TC (2014)	4
SNX6	1	INSR	9	affinity chromatography technology	Parks WT (2001)	1
GRB2	2	NTRK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Song C (2002), MacDonald JI (2000), Emdal KB (2015), Emdal KB (2015)	4
MAPK3	4	IRS1	7	enzymatic study	Luo M (2007)	1
NTRK1	1	SH2B2	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Qian X (1998), Qian X (1998), Emdal KB (2015)	3
GRB10	4	IRS2	6	affinity chromatography technology, affinity chromatography technology	Deng Y (2003), Warren KJ (2016)	2
TMEM17	0	CAV1	0	bioid	Gupta GD (2015)	1
INSR	9	GRB7	1	two hybrid, pull down	Kasus-Jacobi A (2000), Kasus-Jacobi A (2000)	2
GRB2	2	VAV3	4	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology	Blagoev B (2003), Zeng L (2000), Bandyopadhyay S (2010), Thalappilly S (2008), Bisson N (2011)	5
INSR	9	CAV1	0	affinity chromatography technology	Nystrom FH (1999)	1
INSR	9	ENPP1	4	affinity chromatography technology, pull down	Maddux BA (2000), Maddux BA (2000)	2
INSRR	8	STYX	1	two hybrid	Yao Z (2017)	1
NTRK1	1	MAPK1	1	affinity chromatography technology	Emdal KB (2015)	1
INSR	9	SQSTM1	0	enzymatic study, affinity chromatography technology	Sung CK (1998), Milan E (2015)	2
NTRK1	1	ATIC	6	affinity chromatography technology	Emdal KB (2015)	1
INPPL1	6	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
DUSP18	0	SNX4	0	bioid	St-Denis N (2016)	1
TMEM17	0	PTPN1	2	bioid	Gupta GD (2015)	1
MAPK3	4	INSR	9	affinity chromatography technology	Lin YL (2000)	1
GRB2	2	SYNCRIP	6	pull down	Fu C (1997)	1
HNRNPL	3	PLCG1	6	affinity chromatography technology	Fei T (2017)	1
SNX27	5	AHSG	0	affinity chromatography technology	Huttlin EL (2017)	1
INSR	9	INSR	9	pull down, enzymatic study	Frattali AL (1991), Frattali AL (1991)	2
TRIM25	5	SYNCRIP	6	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
PTPN6	0	CAV1	0	affinity chromatography technology	Caselli A (2002)	1
GRB2	2	HGS	5	affinity chromatography technology	Bisson N (2011)	1
SOCS1	1	PTPN11	20	affinity chromatography technology	Ali S (2003)	1
JAK2	1	SH2B1	7	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Rui L (1997), Rui L (1997), Rui L (1997), Xie S (2002), Li Z (2007), Nishi M (2005), Nishi M (2005)	7
TRIM25	5	INPPL1	6	affinity chromatography technology	Choudhury NR (2017)	1
NTRK1	1	PRKAA1	2	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	SORBS1	2	affinity chromatography technology	Limpert AS (2007)	1
PPM1F	1	PRKAA1	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Voss M (2011), Voss M (2011), Voss M (2011)	3
PTPN1	2	STAT5A	4	unspecified method	Espanel X (2002)	1
HNRNPL	3	ARRB2	5	affinity chromatography technology	Fei T (2017)	1
GRB2	2	CSK	3	affinity chromatography technology	Bisson N (2011)	1
CSK	3	INSR	9	two hybrid	Arbet-Engels C (1999)	1
SNX17	0	INSR	9	affinity chromatography technology	Ghai R (2013)	1