PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
INSM1	1	CCND1	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Liu WD (2006), Liu WD (2006), Liu WD (2006), Liu WD (2006), Liu WD (2006)	5
INSM1	1	HDAC1	4	affinity chromatography technology	Liu WD (2006)	1
SORBS1	2	INSM1	1	two hybrid, pull down, affinity chromatography technology	Xie J (2002), Xie J (2002), Xie J (2002)	3
INSM1	1	HDAC3	5	affinity chromatography technology	Liu WD (2006)	1
TUBB3	3	INSM1	1	two hybrid	Stelzl U (2005)	1
CCND1	1	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Petre-Draviam CE (2005), Lin HM (2002), Fu M (2005), Fu M (2005), Batra S (2010)	5
HDAC1	4	CCND1	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Fu M (2005), Fu M (2005), Batra S (2010)	3