Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
CXCL10 3627 STAVUDINE CHEMBL991 NCI 11141242
CXCL10 3627 ELDELUMAB CHEMBL2109664 TdgClinicalTrial
CXCL10 3627 OXALIPLATIN CHEMBL414804 NCI 16101140
CXCL10 3627 TESTOSTERONE CHEMBL386630 NCI 9681518
CXCL10 3627 NI-0801 CHEMBL2109379 inhibitor ChemblInteractions
CXCL10 3627 ZIDOVUDINE CHEMBL129 NCI 11141242
CXCL10 3627 ANTIBIOTIC CHEMBL606111 NCI 10634213
CXCL10 3627 RITONAVIR CHEMBL163 NCI 11141242
CXCL10 3627 ATROPINE CHEMBL517712 NCI 15315164
CXCL10 3627 GONADOTROPIN, CHORIONIC CHEMBL1201509 NCI 15590984
CXCL10 3627 METHYLPREDNISOLONE CHEMBL650 NCI 17220550
CXCL10 3627 REGRAMOSTIM CHEMBL2107881 NCI 11591765
CXCL10 3627 ATORVASTATIN CHEMBL1487 NCI 10559511

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
CXCL10 rs56061981 CT + TT peginterferon alfa-2a efficacy yes PEG-interferon alfa (2a and b) was co-adminstered with ribavirin. Response was assessed by sustained virological response (SVR) percent by genotype. When assessed alone, the polymorphism was not significantly associated with SVR. However, in patients infected with hepatitis C- genotype I (N=266), who also carried the rs12979860 CT or TT genotypes, the CT+TT genotypes of rs56061981 became associated with increased rats of SVR when compared to patients with the CC genotype (CC+CT genotype 66.7% vs. CC genotype 33.0%, P = 0.004). Please note, alleles have been complemented to the + chromosomal strand. Genotypes CT + TT are associated with increased response to peginterferon alfa-2a or peginterferon alfa-2b in people with Hepatitis C, Chronic as compared to genotype CC. 26339796 1446904186