PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDC5L	2	PRKDC	12	affinity chromatography technology, biochemical, affinity chromatography technology	Ajuh P (2000), Ajuh P (2000), Lleres D (2010)	3
CDC5L	2	ILF3	5	affinity chromatography technology	Lleres D (2010)	1
HNRNPR	3	RAD50	3	biochemical	Havugimana PC (2012)	1
H2AFX	1	ILF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang X (2010), Huttlin EL (2015), Huttlin EL (2017)	3
MCM5	1	CDC5L	2	pull down, affinity chromatography technology	Ramachandran N (2004), Lleres D (2010)	2
HNRNPA1	1	ZFR	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Huttlin EL (2015), Huttlin EL (2017)	4
HNRNPA1	1	MOV10	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Huttlin EL (2015), Roy R (2014), Huttlin EL (2017)	4
HNRNPA1	1	ILF3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Roy R (2014), Hein MY (2015)	3
MCM5	1	H2AFX	1	affinity chromatography technology	Drissi R (2015)	1
MOV10	6	ZFR	3	affinity chromatography technology	Castello A (2012)	1
MCM5	1	HNRNPR	3	affinity chromatography technology	Drissi R (2015)	1
PRKDC	12	ILF2	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ting NS (1998), Ting NS (1998), Shi L (2007), Karmakar S (2010)	4
HNRNPA1	1	ILF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Roy R (2014), Hein MY (2015)	3
ILF2	3	MCM5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Karmakar S (2010), Karmakar S (2010), Karmakar S (2010), Drissi R (2015)	4
BIRC2	1	ILF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Graber TE (2010), Graber TE (2010), Graber TE (2010)	3
ILF3	5	MOV10	6	biochemical	Havugimana PC (2012)	1
HNRNPA1	1	HNRNPR	3	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Havugimana PC (2012), Huttlin EL (2015), Roy R (2014), Hein MY (2015), Huttlin EL (2017)	7
CDC5L	2	RAD50	3	affinity chromatography technology	Lleres D (2010)	1
BIRC2	1	ILF3	5	affinity chromatography technology, affinity chromatography technology	Graber TE (2010), Graber TE (2010)	2
MCM5	1	HNRNPA1	1	affinity chromatography technology	Drissi R (2015)	1
ILF2	3	RAD50	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Karmakar S (2010), Karmakar S (2010), Karmakar S (2010)	3
HNRNPR	3	ILF3	5	biochemical	Havugimana PC (2012)	1
ILF2	3	MOV10	6	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017)	3
ILF3	5	ILF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reichman TW (2002), Shi L (2007), Shamanna RA (2011), Havugimana PC (2012), Karmakar S (2010), Karmakar S (2010), Karmakar S (2010), Huttlin EL (2015), Huttlin EL (2017), Zhu X (2016), Zhu X (2016)	11
HNRNPR	3	ILF2	3	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017)	3
PRKDC	12	HNRNPA1	1	enzymatic study	Zhang S (2004)	1
PRKDC	12	H2AFX	1	enzymatic study, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study	Park EJ (2003), Mischo HE (2005), Heo K (2008), Heo K (2008), Li A (2010), Kim K (2012)	6
ILF2	3	ZFR	3	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
ILF3	5	RAD50	3	affinity chromatography technology, affinity chromatography technology	Karmakar S (2010), Karmakar S (2010)	2
CDC5L	2	HNRNPR	3	biochemical	Havugimana PC (2012)	1
H2AFX	1	HNRNPR	3	affinity chromatography technology, affinity chromatography technology	Du YC (2006), Yang X (2010)	2
HNRNPA1	1	RAD50	3	affinity chromatography technology	Close P (2012)	1
HNRNPA1	1	CDC5L	2	affinity chromatography technology, affinity chromatography technology	Close P (2012), Huttlin EL (2015)	2
ILF3	5	MCM5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Karmakar S (2010), Karmakar S (2010), Drissi R (2015)	3
HNRNPR	3	ZFR	3	affinity chromatography technology	Huttlin EL (2017)	1
PRKDC	12	ILF3	5	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ting NS (1998), Ting NS (1998), Shamanna RA (2011), Shamanna RA (2011)	4
H2AFX	1	HNRNPA1	1	affinity chromatography technology	Yang X (2010)	1
MCM5	1	RAD50	3	affinity chromatography technology, affinity chromatography technology	Karmakar S (2010), Karmakar S (2010)	2
CDC5L	2	ILF2	3	affinity chromatography technology, biochemical, affinity chromatography technology	Ajuh P (2000), Ajuh P (2000), Huttlin EL (2015)	3
H2AFX	1	RAD50	3	imaging technique, affinity chromatography technology	Paull TT (2000), Lukas C (2004)	2