PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ERBB2	6	JAK2	1	affinity chromatography technology	Ren Z (2002)	1
PTPN11	20	JAK1	6	pull down, enzymatic study, affinity chromatography technology	Yin T (1997), Yin T (1997), Lehmann U (2003)	3
CDH1	4	TRIM25	5	bioid	Guo Z (2014)	1
HCK	5	ERBB3	3	unspecified method	Jones RB (2006)	1
IL6ST	0	PTPN6	0	affinity chromatography technology	Bartoe JL (2000)	1
STAT3	0	CDK9	3	affinity chromatography technology, affinity chromatography technology, pull down	Giraud S (2004), Giraud S (2004), Giraud S (2004)	3
ERBB2	6	PTPN11	20	affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, affinity chromatography technology	Schulze WX (2006), Crovello CS (1998), Jones RB (2006), Yao Z (2017), Vogel W (1996)	5
IL6ST	0	STAT3	0	affinity chromatography technology	Novotny-Diermayr V (2002)	1
TYK2	1	JAK1	6	affinity chromatography technology	Domanski P (1995)	1
CDH1	4	ERBB3	3	bioid	Guo Z (2014)	1
PTPN6	0	PRKCD	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Yoshida K (2001), Yoshida K (2001), Yoshida K (2001), Yoshida K (2001)	4
IL6ST	0	TYK2	1	affinity chromatography technology	Kim H (1997)	1
ERBB2	6	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Scaltriti M (2009), Graus-Porta D (1997), Le XF (2005), Chen TC (2014), Ritch PS (2005)	5
IL6ST	0	MAGEA11	1	two hybrid	Rolland T (2014)	1
PTPN11	20	SOCS3	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lehmann U (2003), Lehmann U (2003), Schmitz J (2000), Orr SJ (2007)	4
ERBB2	6	STAT3	0	affinity chromatography technology, unspecified method	Ren Z (2002), Jones RB (2006)	2
JAK2	1	SOCS3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sasaki A (2000), Sasaki A (2000), Sasaki A (1999), Sasaki A (1999), Sasaki A (1999), Masuhara M (1997), Masuhara M (1997), Monni R (2001), Haan S (2009), Babon JJ (2012), Calegari VC (2005), Calegari VC (2005), Varghese LN (2014), Kershaw NJ (2014)	14
SHC1	0	IL6ST	0	affinity chromatography technology, pull down	Giordano V (1997), Giordano V (1997)	2
JAK1	6	STAT3	0	pull down, affinity chromatography technology, affinity chromatography technology	Ueda T (2002), Spiekermann K (2001), Andl CD (2004)	3
GRB2	2	PIK3R1	6	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Saleem A (1995), Saleem A (1995), Wang J (1995), Wang J (1995), Wang J (1995), Bandyopadhyay S (2010), Takahashi Y (1999), Gelkop S (2001), Jain SK (1997), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Cerboni C (1998), Bisson N (2011), Bisson N (2011), Weinger JG (2008), Weinger JG (2008), Weinger JG (2008)	18
IL6ST	0	TLE1	6	two hybrid, affinity chromatography technology	Liu F (2002), Liu F (2002)	2
ERBB3	3	SHC1	0	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Crovello CS (1998), Jones RB (2006), Li J (2013), Hellyer NJ (2001)	5
LIFR	1	CNTFR	1	pull down, affinity chromatography technology, pull down	Man D (2003), Man D (2003), He W (2002)	3
PYCARD	1	IL6ST	0	affinity chromatography technology	Dowling JK (2014)	1
IL6R	1	STAT3	0	affinity chromatography technology	Zhang T (2000)	1
PTPN6	0	PIK3R1	6	two hybrid	Sathish JG (2001)	1
JAK1	6	SOCS3	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Park ES (2000), Cohney SJ (1999), Cohney SJ (1999), Cohney SJ (1999)	4
TRIM25	5	UBQLN1	1	affinity chromatography technology	Choudhury NR (2017)	1
PIK3R1	6	JAK2	1	pull down, genetic interference	Ren SY (2005), Shen JP (2017)	2
VAV1	2	PTPN6	0	pull down	Kon-Kozlowski M (1996)	1
JAK1	6	IL6ST	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Haan C (2001), Haan C (2001), Kim H (1997), Haan C (2002)	4
STAT3	0	PIK3R1	6	two hybrid	Grossmann A (2015)	1
TRIM25	5	TLE1	6	affinity chromatography technology	Choudhury NR (2017)	1
JAK2	1	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chauhan D (1995), Chauhan D (1995), Giorgetti-Peraldi S (1995), Brizzi MF (1996)	4
IL6ST	0	JAK2	1	affinity chromatography technology	Kim H (1997)	1
LIFR	1	OSM	0	affinity chromatography technology	Gearing DP (1992)	1
IL6ST	0	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Lehmann U (2003), Anhuf D (2000), Kim H (1997), Schmitz J (2000)	4
PIK3R1	6	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang S (1999), Takahashi Y (1999), Craddock BL (1997), Wu CJ (2000), Wu CJ (2001), Yu WM (2006)	6
AR	3	IL6ST	0	affinity chromatography technology	Xie S (2004)	1
GRB2	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Bennett AM (1994), Ward AC (1998), Yin T (1997), Tang J (1997), Tang H (1999), Hadari YR (1998), Zhang S (1999), Wong L (1996), Brehme M (2009), Craddock BL (1997), Bisson N (2011), Blagoev B (2003), Bisson N (2011), Tauchi T (1995), Huttlin EL (2017), Kapoor GS (2010), Kapoor GS (2010), Vogel W (1996), Vogel W (1996), Yu WM (2006)	21
LIFR	1	IL6ST	0	affinity chromatography technology, affinity chromatography technology	Timmermann A (2002), Mosley B (1996)	2
ERBB2	6	PTPN6	0	two hybrid, affinity chromatography technology	Yao Z (2017), Yao Z (2017)	2
GRB2	2	PTPN6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Kon-Kozlowski M (1996), Saci A (2002)	3
JAK1	6	GRB2	2	affinity chromatography technology, pull down	Kim H (2001), Giorgetti-Peraldi S (1995)	2
IL6ST	0	ERBB2	6	affinity chromatography technology, affinity chromatography technology	Grant SL (2002), Grant SL (2002)	2
TRIM25	5	STAT3	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	PTPN11	20	affinity chromatography technology	Choudhury NR (2017)	1
ERBB3	3	PTPN11	20	affinity chromatography technology, two hybrid	Crovello CS (1998), Yao Z (2017)	2
TRIM25	5	OSMR	1	affinity chromatography technology	Choudhury NR (2017)	1
PTPN11	20	JAK2	1	pull down, enzymatic study, enzymatic study, affinity chromatography technology	Yin T (1997), Yin T (1997), Tauchi T (1996), Maegawa H (1996)	4
JAK2	1	VAV1	2	affinity chromatography technology, enzymatic study, affinity chromatography technology	Shigematsu H (1997), Shigematsu H (1997), Matsuguchi T (1995)	3
CDK9	3	IL6ST	0	pull down	Falco GD (2002)	1
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
ERBB2	6	VAV1	2	unspecified method	Jones RB (2006)	1
SHC1	0	PRKCD	2	affinity chromatography technology, pull down, affinity chromatography technology	Leitges M (2002), Leitges M (2002), Brehme M (2009)	3
LIFR	1	PTPN6	0	affinity chromatography technology	Bartoe JL (2000)	1
HCK	5	IL6ST	0	affinity chromatography technology	Schaeffer M (2001)	1
JAK2	1	ERBB3	3	unspecified method	Jones RB (2006)	1
IL6ST	0	GRB2	2	pull down, affinity chromatography technology	Lee IS (1997), Lee IS (1997)	2
SHC1	0	JAK2	1	pull down, pull down	VanderKuur J (1995), Giordano V (1997)	2
ERBB2	6	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method	Schulze WX (2006), Bourguignon LY (2001), Olayioye MA (1998), Li X (2007), Li X (2007), Crovello CS (1998), Jones RB (2006)	7
OSMR	1	JAK1	6	affinity chromatography technology	Huttlin EL (2017)	1
VAV1	2	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Song JS (1996), Ye ZS (1994), Ye ZS (1994), Germani A (1999), Lee IS (1997)	5
OSM	0	IL6ST	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AR	3	STAT3	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Matsuda T (2001), Ueda T (2002), Yamamoto T (2003), Yamamoto T (2003)	4
TRIM25	5	LIFR	1	affinity chromatography technology	Choudhury NR (2017)	1
IL6ST	0	VAV1	2	pull down	Lee IS (1997)	1
STAT3	0	HCK	5	pull down	Schreiner SJ (2002)	1
SHC1	0	PIK3R1	6	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harrison-Findik D (1995), Ren SY (2005), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Lee DY (2010)	6
JAK2	1	STAT3	0	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Ram PA (1997), Manea A (2010), Andl CD (2004), Kamakura S (2004), He K (2013), Kucia-Tran JA (2016), M L (2016)	7
IL6ST	0	SGTB	2	two hybrid	Rolland T (2014)	1
IL6ST	0	PRKCD	2	affinity chromatography technology	Novotny-Diermayr V (2002)	1
AR	3	MAGEA11	1	imaging technique, two hybrid, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid	Bai S (2005), Bai S (2005), Bai S (2005), Bai S (2005), Bai S (2008), Liu Q (2011), Askew EB (2009), Askew EB (2009), Minges JT (2013), Corominas R (2014)	10
JAK2	1	PTPN6	0	affinity chromatography technology, affinity chromatography technology	Jiao H (1996), Wu DW (2000)	2
IL6ST	0	UBQLN1	1	two hybrid	Rolland T (2014)	1
ERBB3	3	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Crovello CS (1998), Li J (2013)	3
IL6ST	0	PIK3R1	6	affinity chromatography technology	Chung TD (2000)	1
CDH1	4	IL6ST	0	bioid	Guo Z (2014)	1
OSMR	1	OSM	0	pull down	Diveu C (2006)	1
TRIM25	5	GRB2	2	affinity chromatography technology	Choudhury NR (2017)	1
IL6R	1	IL6ST	0	affinity chromatography technology	Taga T (1989)	1
ERBB3	3	PTPN6	0	two hybrid	Yao Z (2017)	1
VAV1	2	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Bertagnolo V (1998), Bertagnolo V (1998), Bertagnolo V (1998), Shigematsu H (1997), Shigematsu H (1997), Shigematsu H (1997)	6
PTPN11	20	PTPN6	0	affinity chromatography technology	Li X (2016)	1
IL6ST	0	OSMR	1	affinity chromatography technology	Mosley B (1996)	1
IL6ST	0	CNTFR	1	pull down, affinity chromatography technology	Man D (2003), Man D (2003)	2
ERBB3	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hellyer NJ (2001), Lin J (1999), Crovello CS (1998), Graus-Porta D (1997), Jones RB (2006), Li J (2013), Servidei T (2008), Servidei T (2008), Ritch PS (2005), Tang X (2002)	10
CDH1	4	ERBB2	6	bioid	Guo Z (2014)	1
PRKCD	2	STAT3	0	affinity chromatography technology, enzymatic study	Jain N (1999), Jain N (1999)	2
OSMR	1	ERBB2	6	affinity chromatography technology, imaging technique	Grant SL (2002), Chen TC (2014)	2
TYK2	1	VAV1	2	affinity chromatography technology	Adam L (2000)	1
PTPN6	0	JAK1	6	enzymatic study	Yetter A (1995)	1
IL6ST	0	KCNIP3	1	two hybrid	Rolland T (2014)	1
ERBB2	6	JAK1	6	unspecified method	Jones RB (2006)	1
ERBB2	6	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid	Schulze WX (2006), Wong L (1999), Olayioye MA (1998), Crovello CS (1998), Jones RB (2006), Yao Z (2017)	6
TRIM25	5	IL6ST	0	affinity chromatography technology	Choudhury NR (2017)	1
IL6ST	0	ERBB3	3	affinity chromatography technology	Grant SL (2002)	1
ERBB3	3	VAV1	2	unspecified method	Jones RB (2006)	1
CDK9	3	AR	3	affinity chromatography technology, pull down	Lee DK (2001), Lee DK (2001)	2
ERBB2	6	PIK3R1	6	affinity chromatography technology, unspecified method	Crovello CS (1998), Jones RB (2006)	2
STAT3	0	PTPN11	20	affinity chromatography technology, affinity chromatography technology	Gunaje JJ (2001), M L (2016)	2
IL6ST	0	SOCS3	0	affinity chromatography technology, pull down, pull down, enzymatic study	Lehmann U (2003), Lehmann U (2003), Schmitz J (2000), Kershaw NJ (2014)	4
PTPN6	0	TYK2	1	affinity chromatography technology, enzymatic study	Yetter A (1995), Yetter A (1995)	2