Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
IL4R	3566	SILYBIN B	CHEMBL592675	agonist	TdgClinicalTrial, TTD
IL4R	3566	CINTREDEKIN BESUDOTOX	CHEMBL2108583		TdgClinicalTrial, ChemblInteractions
IL4R	3566	DUPILUMAB	CHEMBL2108675	antagonist	ChemblInteractions

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
IL4R	rs1805010	AA	pitrakinra	efficacy	yes	Subjects with the AA genotype have a reduced frequency of asthma exacerbations compared to those with the AG + GG genotypes.	Genotype AA is associated with increased response to pitrakinra in people with Asthma as compared to genotypes AG + GG.	22541248	981477286
IL4R	rs1029489	GG	pitrakinra	efficacy	yes	Subjects with the GG genotype have a reduced frequency of asthma exacerbations compared to those with the AA + AG genotypes. There is also a significant dose-response relationship for this phenotype in subjects with the GG genotype.	Genotype GG is associated with increased response to pitrakinra in people with Asthma as compared to genotypes AA + AG.	22541248	981477306
IL4R	rs3024530	AA	pitrakinra	efficacy	yes	Subjects with the AA genotype have a reduced frequency of asthma exacerbations compared to those with the AG + GG genotypes.	Genotype AA is associated with increased response to pitrakinra in people with Asthma as compared to genotypes AG + GG.	22541248	981477278
IL4R	rs1110470	AA	pitrakinra	efficacy	yes	Subjects with the AA genotype have a reduced frequency of asthma exacerbations compared to those with the AG + GG genotypes.	Genotype AA is associated with increased response to pitrakinra in people with Asthma as compared to genotypes AG + GG.	22541248	981477269
IL4R	rs2239347	AA	pitrakinra	efficacy	yes	Subjects with the AA genotype have a reduced frequency of asthma exacerbations compared to those with the AC + CC genotypes.	Genotype AA is associated with increased response to pitrakinra in people with Asthma as compared to genotypes AC + CC.	22541248	981477298
IL4R	rs8832	GG	pitrakinra	efficacy	yes	Subjects with the GG genotype have a reduced frequency of asthma exacerbations and nocturnal awakenings compared to those with the AA + AG genotypes. There is a significant dose-response relationship for both of these phenotypes in subjects with the GG genotype.	Genotype GG is associated with increased response to pitrakinra in people with Asthma as compared to genotypes AA + AG.	22541248	981477242
IL4R	rs1805015	C	Hepatitis vaccines	efficacy	yes	The C allele was associated with a protective immune response, that is, a lower chance of being a non-responder to hepatitis B vaccine. Hepatitis B vaccine at 0, 1 and 6 months standard schedule. Non-responders (n=24) were those who had insufficient anti-hepatitis B antibody levels (< 10 mIU/ml) after a 2nd round of revaccination. Responders (n=46) had anti-hepatitis B antibody levels >= 100 mIU/ml after the first standard 3-dose immunization. Significant in multivariable logistic regression analysis.	Allele C is associated with increased response to Hepatitis vaccines as compared to allele T.	21111021	1446905079