PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MMP3	2	MMP10	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LRP1	25	A2M	8	x-ray crystallography	Dolmer K (2000)	1
CDC37	0	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
CSNK2A1	15	PDCD4	2	enzymatic study	Zhang M (2011)	1
IFIT3	1	IFIT5	0	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Pichlmair A (2011)	2
PCMT1	1	PRDX2	1	biochemical	Wan C (2015)	1
APOE	1	HTRA1	3	two hybrid	Soler-Lopez M (2011)	1
APOE	1	ST13	2	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
APOE	1	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	APOE	1	two hybrid	Soler-Lopez M (2011)	1
LRP8	4	ALB	1	affinity chromatography technology	Hein MY (2015)	1
A2M	8	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	MAPT	1	biochemical	Takashima A (1998)	1
CDC37	0	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
APOE	1	RHEB	2	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	CDC37	0	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
RNF32	0	APOE	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	RHEB	2	two hybrid	Soler-Lopez M (2011)	1
ELAVL1	0	CSNK2A1	15	affinity chromatography technology	Abdelmohsen K (2009)	1
MAST1	9	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
MANSC1	4	LRP2	13	affinity chromatography technology	Huttlin EL (2017)	1
ALB	1	APOE	1	affinity chromatography technology	Zhou M (2004)	1
PSEN1	11	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
APOE	1	ACTG1	5	two hybrid	Soler-Lopez M (2011)	1
VDAC3	1	APOE	1	affinity chromatography technology	Huttlin EL (2017)	1
IFIT3	1	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	PSEN1	11	two hybrid	Soler-Lopez M (2011)	1
VDAC1	2	VDAC3	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Malty RH (2017)	2
APOE	1	ARFGAP1	3	two hybrid	Wang J (2011)	1
MAST1	9	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	FARSA	6	two hybrid	Soler-Lopez M (2011)	1
APOE	1	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
APOE	1	EPN2	4	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
APOE	1	LRP2	13	pull down	Kounnas MZ (1995)	1
NOS3	7	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
APOE	1	NOS3	7	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
APOE	1	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
APOE	1	NEFM	0	pull down	Fleming LM (1996)	1
A2M	8	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
APOE	1	FXYD7	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
CSNK2A1	15	MAPT	1	enzymatic study	Raftery M (2005)	1
ECSIT	3	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
APOE	1	PLTP	3	affinity chromatography technology	Siggins S (2003)	1
APOE	1	ZNF558	0	two hybrid	Soler-Lopez M (2011)	1
APOE	1	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
LOXL4	1	APOE	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
GCDH	2	NOS3	7	affinity chromatography technology, two hybrid	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
IFIT3	1	APOE	1	two hybrid	Soler-Lopez M (2011)	1
APOE	1	APOE	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	TYRO3	4	two hybrid	Soler-Lopez M (2011)	1
ELAVL1	0	PDCD4	2	affinity chromatography technology	Abdelmohsen K (2009)	1
HLA-DPA1	1	APOE	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LCAT	2	APOE	1	enzymatic study	Zhao Y (2005)	1
PSEN1	11	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
LOXL4	1	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
APOE	1	LRP8	4	pull down, pull down	Li X (2003), Kim DH (1996)	2
ECSIT	3	FARSA	6	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
A2M	8	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
APOE	1	TIMM29	0	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	CDC37	0	affinity chromatography technology, two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011), Soler-Lopez M (2011)	3
RNF32	0	FBXL12	1	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
APOE	1	LRP1	25	affinity chromatography technology	Beisiegel U (1989)	1
A2M	8	FARSA	6	two hybrid	Soler-Lopez M (2011)	1
IFIT5	0	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
MMP3	2	APOE	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APOE	1	FOXG1	26	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	FBXL12	1	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
APOE	1	RPL4	4	two hybrid	Soler-Lopez M (2011)	1
CSNK2A1	15	APOE	1	enzymatic study	Raftery M (2005)	1
APOE	1	IQSEC1	3	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	APOE	1	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	RHEB	2	two hybrid	Soler-Lopez M (2011)	1
APOE	1	ELAVL1	0	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	PDCD4	2	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	PSEN1	11	two hybrid, affinity chromatography technology, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011), Soler-Lopez M (2011)	3
MAST1	9	A2M	8	two hybrid	Soler-Lopez M (2011)	1
MAPT	1	APOE	1	pull down, unspecified method	Fleming LM (1996), Huang DY (1995)	2
A2M	8	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
APOE	1	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	CDC37	0	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	CYP2C18	2	two hybrid	Soler-Lopez M (2011)	1
APOE	1	PCMT1	1	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	CYP2C18	2	two hybrid	Soler-Lopez M (2011)	1
A2M	8	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
IFNA8	0	APOE	1	affinity chromatography technology	Huttlin EL (2017)	1
APOE	1	TYRO3	4	two hybrid	Soler-Lopez M (2011)	1
C9	2	APOE	1	affinity chromatography technology	Huttlin EL (2017)	1
APOE	1	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
MMRN1	2	APOE	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APOE	1	ANKH	6	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	ST13	2	affinity chromatography technology, two hybrid	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
A2M	8	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
VDAC1	2	ELAVL1	0	affinity chromatography technology	Malty RH (2017)	1
A2M	8	APOE	1	affinity chromatography technology, pull down, two hybrid	Krimbou L (1998), Krimbou L (1998), Soler-Lopez M (2011)	3
MAST1	9	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	LCAT	2	affinity chromatography technology, pull down	Krimbou L (2001), Krimbou L (2001)	2
CDC37	0	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
APOE	1	PDCD4	2	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
PSEN1	11	APOE	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	APOE	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
CDC37	0	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
VDAC1	2	APOE	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDC37	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
APOE	1	MID1IP1	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
A2M	8	RHEB	2	two hybrid	Soler-Lopez M (2011)	1
APOE	1	PLEKHA6	5	two hybrid	Soler-Lopez M (2011)	1
APOE	1	FARSA	6	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	PRAM1	4	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
PSEN1	11	ST13	2	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
MANSC1	4	APOE	1	affinity chromatography technology	Huttlin EL (2017)	1
MAST1	9	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
IFNA8	0	IFIT3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ALB	1	ST13	2	affinity chromatography technology	Zhou M (2004)	1
RNF32	0	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	IFIT3	1	two hybrid, pull down, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011), Soler-Lopez M (2011)	3
PSEN1	11	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
MMP10	0	APOE	1	affinity chromatography technology	Huttlin EL (2017)	1
NOS3	7	HTRA1	3	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
ELAVL1	0	ST13	2	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF32	0	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	APOE	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
ECSIT	3	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	MAST1	9	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
IFIT5	0	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
ZNF558	0	ALB	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF32	0	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
A2M	8	CYP2C18	2	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	ELAVL1	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
ELAVL1	0	IFIT5	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CDC37	0	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
APOE	1	CYP2C18	2	two hybrid	Soler-Lopez M (2011)	1