Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
IFNGR2 3460 INTERFERON GAMA-1B CHEMBL1201564 agonist, binder TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 17618444, 11752352, 17239631

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
IFNGR2 rs8126756 CC Tumor necrosis factor alpha efficacy yes When comparing responders against non-responders. However, no association was seen when comparing the CT vs TT genotype or the CC+CT vs TT genotype. Additionally, no association was seen when comparing responders vs. partial responders for any genotype. Genotype CC is associated with decreased response to Tumor necrosis factor alpha (TNF-alpha) inhibitors in people with Crohn Disease as compared to genotype TT. 28139755 1448604122