PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NOD1	3	NOD2	1	affinity chromatography technology, affinity chromatography technology	Travassos LH (2010), Travassos LH (2010)	2
ULK1	8	BECN1	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Bodemann BO (2011), Chauhan S (2015), Chauhan S (2016)	3
ATG16L1	1	ULK1	8	affinity chromatography technology	Gammoh N (2013)	1
IRGM	1	NOD2	1	affinity chromatography technology, affinity chromatography technology, pull down	Chauhan S (2015), Chauhan S (2015), Chauhan S (2015)	3
BECN1	2	AMBRA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Strappazzon F (2011), Xia P (2013), Xia P (2013), Xia P (2013), Luciani A (2010), Luciani A (2010), Di Bartolomeo S (2010), Gu W (2014), Gu W (2014), Antonioli M (2014)	11
IRGM	1	AMBRA1	7	affinity chromatography technology	Chauhan S (2015)	1
ATG16L1	1	NOD1	3	affinity chromatography technology, affinity chromatography technology, pull down	Travassos LH (2010), Travassos LH (2010), Ver Heul AM (2013)	3
IRGM	1	ULK1	8	affinity chromatography technology	Chauhan S (2015)	1
DDX58	3	IRGM	1	affinity chromatography technology	Chauhan S (2015)	1
IRGM	1	TLR3	2	affinity chromatography technology	Chauhan S (2015)	1
IRGM	1	IRGM	1	affinity chromatography technology	Chauhan S (2015)	1
ATG16L1	1	NOD2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Boada-Romero E (2013), Travassos LH (2010), Travassos LH (2010)	3
IRGM	1	ATG16L1	1	affinity chromatography technology, affinity chromatography technology	Chauhan S (2015), Chauhan S (2015)	2
ULK1	8	AMBRA1	7	enzymatic study, affinity chromatography technology, affinity chromatography technology	Di Bartolomeo S (2010), Nazio F (2013), Nazio F (2013)	3
IRGM	1	BECN1	2	affinity chromatography technology, affinity chromatography technology	Chauhan S (2015), Chauhan S (2015)	2
IRGM	1	NOD1	3	affinity chromatography technology	Chauhan S (2015)	1
BECN1	2	ATG14	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Luciani A (2010), Luciani A (2010), Matsunaga K (2009), Matsunaga K (2009), Matsunaga K (2009), Matsunaga K (2009), Matsunaga K (2009), Ma B (2014), Itakura E (2008), Itakura E (2008), Sun Q (2008), Sun Q (2008), Sun Q (2008), Sun Q (2008), Fogel AI (2013), Hein MY (2015), Chauhan S (2015), Wei Y (2015), Huttlin EL (2017), Stjepanovic G (2017), Liu X (2017), Liu X (2017)	24
IRGM	1	ATG14	1	affinity chromatography technology	Chauhan S (2015)	1