PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
IRF9	0	STAT2	2	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Horvath CM (1996), Horvath CM (1996), Martinez-Moczygemba M (1997), Martinez-Moczygemba M (1997), Li S (2011), Huttlin EL (2017)	6
IFNAR2	1	IRF9	0	affinity chromatography technology	Tang X (2007)	1
RACK1	2	STAT1	1	affinity chromatography technology, pull down, affinity chromatography technology	Usacheva A (2003), Usacheva A (2001), Usacheva A (2001)	3
IFNAR2	1	RACK1	2	pull down, two hybrid, pull down, affinity chromatography technology	Usacheva A (2001), Croze E (2000), Croze E (2000), Croze E (2000)	4
RACK1	2	JAK1	6	affinity chromatography technology, pull down, affinity chromatography technology	Usacheva A (2003), Usacheva A (2003), Renga B (2012)	3
IFNAR2	1	STAT2	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Li X (1997), Nguyen VP (2002), Nguyen VP (2002), Tang X (2007)	4
IFNAR2	1	IFNA2	0	pull down, biochemical	Piehler J (1999), Piehler J (1999)	2
RACK1	2	IFNAR1	4	pull down	Usacheva A (2003)	1
IFNAR2	1	GRAP2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRAP2	0	RACK1	2	pull down	Ellis JH (2000)	1
USP18	1	IFNAR2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Malakhova OA (2006), Malakhova OA (2006), Ganesan M (2016)	3
IFNAR2	1	JAK1	6	pull down, affinity chromatography technology, affinity chromatography technology	Usacheva A (2002), Malakhova OA (2006), Malakhova OA (2006)	3
IRF9	0	STAT1	1	two hybrid, pull down	Horvath CM (1996), Horvath CM (1996)	2
IFNAR2	1	CREBBP	29	affinity chromatography technology	Tang X (2007)	1
IFNAR2	1	STAT1	1	pull down, pull down	Li X (1997), Usacheva A (2001)	2
IFNAR2	1	PPP1R3B	3	two hybrid	Wang J (2011)	1
CREBBP	29	STAT2	2	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Bhattacharya S (1996), Bhattacharya S (1996), Bhattacharya S (1996), Bhattacharya S (1996), Huttlin EL (2017), Lindstroem I (2017)	6
CREBBP	29	STAT1	1	pull down, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Zhang JJ (1996), Zhang JJ (1996), Horvai AE (1997), Horvai AE (1997), Ma Z (2005), Vaelineva T (2005), Strassheim D (2009), Kraemer OH (2006), Kraemer OH (2006), Jansma AL (2014), Chen Y (2015)	11
JAK1	6	STAT1	1	affinity chromatography technology, affinity chromatography technology	Andl CD (2004), Chang YJ (2004)	2
CREBBP	29	IRF9	0	affinity chromatography technology	Tang X (2007)	1
STAT1	1	STAT2	2	biochemical, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (1996), Dumler I (1999), Dumler I (1999), Dumler I (1999), Fagerlund R (2002), Tang X (2007), Gupta S (1999), Liu B (1998), Huttlin EL (2017)	9
IFNAR1	4	IFNAR2	1	imaging technique, affinity chromatography technology	Wilmes S (2015), Zheng H (2013)	2
IFNAR2	1	IFNAR2	1	affinity chromatography technology	Tang X (2007)	1
IFNAR1	4	STAT2	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Li X (1997), Uddin S (1995), Yan H (1996), Fagerlie SR (2004)	4