PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BRCA1	7	AR	3	pull down, pull down, two hybrid	Park JJ (2000), Yeh S (2000), Yeh S (2000)	3
IFI16	1	CASP1	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Dutta D (2015), Dutta D (2015), Dutta D (2015)	3
TMEM173	0	IFI16	1	affinity chromatography technology, pull down, imaging technique	Unterholzner L (2010), Unterholzner L (2010), Dutta D (2015)	3
PYCARD	1	CASP1	1	affinity chromatography technology, imaging technique	Dutta D (2015), Dutta D (2015)	2
PYCARD	1	BRCA1	7	affinity chromatography technology, imaging technique, affinity chromatography technology	Dutta D (2015), Dutta D (2015), Dutta D (2015)	3
BRCA1	7	CASP1	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Dutta D (2015), Dutta D (2015), Dutta D (2015)	3
BRCA1	7	IFI16	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Aglipay JA (2003), Dutta D (2015), Dutta D (2015), Dutta D (2015)	4
IFI16	1	AR	3	affinity chromatography technology, pull down	Alimirah F (2006), Alimirah F (2006)	2
IFI16	1	PYCARD	1	imaging technique, affinity chromatography technology	Dutta D (2015), Dutta D (2015)	2