PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CTBP2	7	ZBTB18	9	two hybrid	Rolland T (2014)	1
RBFOX2	5	PRRC2A	10	affinity chromatography technology	Huttlin EL (2015)	1
NCOR2	12	ATXN1L	0	two hybrid, pull down, affinity chromatography technology	Mizutani A (2005), Mizutani A (2005), Mizutani A (2005)	3
ATXN1L	0	MBD6	5	two hybrid	Lim J (2006)	1
ATXN1L	0	PRRC2A	10	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
ATXN1L	0	MBD1	1	two hybrid	Lim J (2006)	1
ATXN1L	0	RBFOX2	5	two hybrid	Lim J (2006)	1
ATXN1	2	RAD54L2	5	two hybrid	Lim J (2006)	1
ATXN1	2	HSFX1	0	two hybrid	Lim J (2006)	1
ATXN1	2	RBPMS	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
ATXN1L	0	YY1AP1	0	two hybrid	Lim J (2006)	1
COIL	1	PICK1	2	two hybrid	Lim J (2006)	1
NTRK1	1	RBFOX2	5	affinity chromatography technology	Emdal KB (2015)	1
EPB41L2	2	GPATCH8	5	affinity chromatography technology	Huttlin EL (2017)	1
ATXN1	2	ZC3H7B	3	two hybrid	Lim J (2006)	1
ATXN1L	0	CBFA2T2	3	two hybrid	Lim J (2006)	1
ATXN1L	0	EPB41L2	2	two hybrid	Lim J (2006)	1
ATXN1L	0	ZSWIM8	8	two hybrid	Lim J (2006)	1
NTRK1	1	ACOT7	2	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	ACO2	4	affinity chromatography technology	Emdal KB (2015)	1
AP2M1	5	AP1G2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATXN1L	0	AP1G2	4	two hybrid	Lim J (2006)	1
ATXN1L	0	AP2M1	5	two hybrid	Lim J (2006)	1
ATXN1L	0	APBB1	3	two hybrid	Lim J (2006)	1
NTRK1	1	CTBP1	2	affinity chromatography technology	Emdal KB (2015)	1
CLASRP	1	ATXN1L	0	affinity chromatography technology	Huttlin EL (2017)	1
ATXN1L	0	CTBP2	7	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
AES	2	RBPMS	0	two hybrid	Rolland T (2014)	1
ATXN1L	0	THY1	0	two hybrid	Lim J (2006)	1
ATXN1L	0	TMEM25	0	two hybrid	Lim J (2006)	1
ATXN1L	0	PRRC2B	9	two hybrid	Lim J (2006)	1
ATXN1L	0	CHD6	6	two hybrid	Lim J (2006)	1
RBPMS	0	RBFOX2	5	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2015), Huttlin EL (2017)	3
ATXN1	2	APBB1	3	two hybrid	Lim J (2006)	1
ATXN1L	0	RBPMS	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
ATXN1L	0	SREBF1	5	two hybrid	Lim J (2006)	1
ATXN1	2	SUGP2	3	two hybrid	Lim J (2006)	1
ATXN1L	0	ALG13	9	two hybrid	Lim J (2006)	1
ATXN1L	0	PICK1	2	two hybrid	Lim J (2006)	1
NTRK1	1	HGS	5	affinity chromatography technology	Emdal KB (2015)	1
ZBTB18	9	ATXN1L	0	affinity chromatography technology	Huttlin EL (2017)	1
ATXN1L	0	MEOX2	2	two hybrid	Lim J (2006)	1
NCOR1	9	CBFA2T2	3	affinity chromatography technology	Amann JM (2005)	1
ATXN1L	0	ATXN1L	0	two hybrid	Mizutani A (2005)	1
ATXN1L	0	METTL17	1	two hybrid	Lim J (2006)	1
ATXN1	2	SREBF1	5	two hybrid	Lim J (2006)	1
CTBP2	7	CTBP1	2	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sewalt RG (1999), Wang J (2011), Corominas R (2014), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
ATXN1L	0	STAC2	3	two hybrid	Lim J (2006)	1
ATXN1	2	GMEB2	1	two hybrid	Lim J (2006)	1
ATXN1	2	NCOR1	9	two hybrid	Lim J (2006)	1
ATXN1L	0	ST6GALNAC6	1	two hybrid	Lim J (2006)	1
HGS	5	DAZAP2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ATXN1	2	YY1AP1	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
DAZAP2	1	RBPMS	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ATXN1L	0	SMARCC2	9	two hybrid	Lim J (2006)	1
ATXN1	2	PRRC2B	9	two hybrid	Lim J (2006)	1
ATXN1L	0	MATN2	6	two hybrid	Lim J (2006)	1
DAZAP2	1	CLASRP	1	two hybrid	Rolland T (2014)	1
RBFOX2	5	GPATCH8	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NCOR1	9	SMARCC2	9	biochemical	Underhill C (2000)	1
NCOR2	12	ATXN1	2	two hybrid	Mizutani A (2005)	1
ATXN1L	0	ADORA1	2	two hybrid	Lim J (2006)	1
NTRK1	1	CAMSAP2	4	affinity chromatography technology	Emdal KB (2015)	1
ATXN1	2	ST6GALNAC6	1	two hybrid	Lim J (2006)	1
DAZAP2	1	RBFOX2	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	4
ATXN1L	0	ACO2	4	two hybrid	Lim J (2006)	1
ATXN1L	0	ACOT7	2	two hybrid	Lim J (2006)	1
ATXN1L	0	ELP5	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
ATXN1L	0	EPB41L3	5	two hybrid	Lim J (2006)	1
NTRK1	1	FUS	0	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	FADS2	1	affinity chromatography technology	Emdal KB (2015)	1
ATXN1L	0	TRIP11	5	two hybrid	Lim J (2006)	1
DAB2	1	AP2M1	5	affinity chromatography technology	Mulkearns EE (2012)	1
ATXN1	2	ZSWIM8	8	two hybrid	Lim J (2006)	1
ATXN1	2	DAZAP2	1	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
ATXN1L	0	ANKHD1	0	two hybrid	Lim J (2006)	1
ATXN1L	0	HIVEP1	13	two hybrid	Lim J (2006)	1
ATXN1L	0	TMEM8B	1	two hybrid	Lim J (2006)	1
ATXN1L	0	GORASP2	1	two hybrid	Lim J (2006)	1
AES	2	HGS	5	biochemical	Kristensen AR (2012)	1
ATXN1	2	RBFOX2	5	two hybrid, affinity chromatography technology, two hybrid, two hybrid	Lim J (2006), Lim J (2006), Suter B (2013), Rolland T (2014)	4
ATXN1L	0	NIT1	1	two hybrid	Lim J (2006)	1
ATXN1L	0	SCAF11	8	two hybrid	Lim J (2006)	1
EPB41L3	5	GPATCH8	5	affinity chromatography technology	Hauri S (2013)	1
ATXN1	2	HIVEP1	13	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
NTRK1	1	ZSWIM8	8	affinity chromatography technology	Emdal KB (2015)	1
ATXN1L	0	FUS	0	two hybrid	Lim J (2006)	1
ATXN1L	0	H2AFY	1	two hybrid	Lim J (2006)	1
PRRC2A	10	GORASP2	1	two hybrid	Wang J (2011)	1
ATXN1	2	USP54	5	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
EPB41L3	5	EPB41L2	2	affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Huttlin EL (2017)	2
NCOR2	12	AP2M1	5	two hybrid	Albers M (2005)	1
NTRK1	1	PRRC2A	10	affinity chromatography technology	Emdal KB (2015)	1
ATXN1L	0	PHPT1	0	two hybrid	Lim J (2006)	1
ATXN1	2	SMARCC2	9	two hybrid	Lim J (2006)	1
ATXN1L	0	RRAGC	3	two hybrid	Lim J (2006)	1
ATXN1L	0	SUGP2	3	two hybrid	Lim J (2006)	1
ATXN1L	0	COIL	1	two hybrid	Lim J (2006)	1
ATXN1L	0	RAD54L2	5	two hybrid	Lim J (2006)	1
AES	2	GORASP2	1	two hybrid	Rolland T (2014)	1
ATXN1	2	METTL17	1	two hybrid	Lim J (2006)	1
ATXN1	2	ANKHD1	0	two hybrid	Lim J (2006)	1
ATXN1L	0	HGS	5	two hybrid	Lim J (2006)	1
CTBP1	2	NCOR2	12	affinity chromatography technology	Mendez LM (2008)	1
NTRK1	1	SMARCC2	9	affinity chromatography technology	Emdal KB (2015)	1
ATXN1L	0	DAB2	1	two hybrid	Lim J (2006)	1
ATXN1L	0	ATXN1	2	two hybrid, affinity chromatography technology, two hybrid	Mizutani A (2005), Mizutani A (2005), Lim J (2006)	3
ATXN1L	0	FADS2	1	two hybrid	Lim J (2006)	1
ATXN1L	0	DAZAP2	1	two hybrid	Lim J (2006)	1
ATXN1	2	CLASRP	1	two hybrid, affinity chromatography technology	Lim J (2006), Huttlin EL (2017)	2
ATXN1L	0	AFAP1L2	2	two hybrid	Lim J (2006)	1
ATXN1L	0	GPATCH8	5	two hybrid	Lim J (2006)	1
ATXN1L	0	GAS7	0	two hybrid	Lim J (2006)	1
ATXN1L	0	ZC3H7B	3	two hybrid	Lim J (2006)	1
ATXN1	2	PHPT1	0	two hybrid	Lim J (2006)	1
ATXN1L	0	CAMSAP2	4	two hybrid	Lim J (2006)	1
ATXN1	2	ELP5	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
ATXN1L	0	HSFX1	0	two hybrid	Lim J (2006)	1
ATXN1	2	GPATCH8	5	two hybrid	Lim J (2006)	1
ATXN1L	0	AES	2	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
NCOR2	12	NCOR1	9	biochemical, two hybrid	Li J (2000), Korutla L (2005)	2
ATXN1L	0	GMEB2	1	two hybrid	Lim J (2006)	1
ATXN1L	0	CTBP1	2	two hybrid	Lim J (2006)	1
ATXN1	2	ACOT7	2	two hybrid	Lim J (2006)	1
ATXN1	2	PRRC2A	10	two hybrid	Lim J (2006)	1
ATXN1	2	STAC2	3	two hybrid	Lim J (2006)	1
CTBP1	2	ZBTB18	9	two hybrid, affinity chromatography technology	Corominas R (2014), Huttlin EL (2017)	2
ATXN1	2	MATN2	6	two hybrid	Lim J (2006)	1
NTRK1	1	ATXN1L	0	affinity chromatography technology	Emdal KB (2015)	1
ATXN1	2	COIL	1	two hybrid, pull down, pull down, affinity chromatography technology, pull down, two hybrid	Hong S (2003), Hong S (2003), Hong S (2003), Hong S (2003), Hong S (2008), Lim J (2006)	6
RBPMS	0	RAD54L2	5	two hybrid	Yu H (2011)	1
ATXN1L	0	USP54	5	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
NCOR1	9	ATXN1L	0	two hybrid	Mizutani A (2005)	1
ATXN1L	0	NBR1	0	two hybrid	Lim J (2006)	1