Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
APOC1 341 RITONAVIR CHEMBL163 PharmGKB
APOC1 341 SIMVASTATIN CHEMBL1064 PharmGKB

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
APOC1 rs4420638 G hmg coa reductase inhibitors efficacy yes as measured by lesser reductions in LDL-C. These individuals were also more likely to start out with higher LDL-C before treatment. Allele G is associated with decreased response to hmg coa reductase inhibitors in people with Cardiovascular Diseases or Hypercholesterolemia as compared to allele A. 27648687 1448263689