PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ID1	0	BUD31	0	affinity chromatography technology	Hein MY (2015)	1
PSMD4	1	TCF3	7	affinity chromatography technology, two hybrid	Anand G (1997), Anand G (1997)	2
IKBKG	0	PPP2CA	7	affinity chromatography technology	Kray AE (2005)	1
ID1	0	MYOD1	0	two hybrid, two hybrid, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Garkavtsev I (2004), Langlands K (1997), Langlands K (1997), Finkel T (1993), Gupta K (1998), McLoughlin P (2002), Ling MT (2008), Philipot O (2010)	8
TCF3	7	MYF5	2	two hybrid, pull down	Langlands K (1997), Braun T (1990)	2
CDC20	1	ID1	0	affinity chromatography technology, affinity chromatography technology	Wang X (2008), Wang X (2008)	2
ID1	0	IKBKG	0	two hybrid	Ravasi T (2010)	1
ID1	0	POT1	2	affinity chromatography technology	Hein MY (2015)	1
USP15	4	TRAF6	0	enzymatic study	Bremm A (2010)	1
ID1	0	STXBP1	38	affinity chromatography technology	Hein MY (2015)	1
TCF4	26	TCF3	7	two hybrid, affinity chromatography technology	Ravasi T (2010), Huttlin EL (2017)	2
VHL	0	PPP2CA	7	affinity chromatography technology, affinity chromatography technology	Guo J (2016), Guo J (2016)	2
SMURF2	3	ID1	0	enzymatic study, affinity chromatography technology	Kong Y (2011), Kong Y (2011)	2
MYOD1	0	SUV39H1	0	pull down, affinity chromatography technology	Mal AK (2006), Mal AK (2006)	2
ID1	0	CHD1L	5	affinity chromatography technology	Hein MY (2015)	1
ID1	0	TXNL4A	0	affinity chromatography technology	Hein MY (2015)	1
ID1	0	B4GALT7	1	affinity chromatography technology	Hein MY (2015)	1
ID1	0	CAV1	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Zhang X (2007), Zhang X (2007), Zhang X (2007)	3
VHL	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Chen K (2016), Chen K (2016)	2
MYOD1	0	TCF3	7	pull down, two hybrid, pull down, two hybrid	Maleki SJ (1997), Langlands K (1997), Dear TN (1997), Dear TN (1997)	4
ELOC	0	SQSTM1	0	affinity chromatography technology	Chen K (2016)	1
SQSTM1	0	STXBP1	38	pull down	Pridgeon JW (2004)	1
PSMD5	0	PSMD4	1	biochemical, affinity chromatography technology	Shim SM (2012), Huttlin EL (2017)	2
ID1	0	GATA4	4	affinity chromatography technology, pull down	Ding B (2006), Ding B (2006)	2
DNMT3L	2	ID1	0	pull down	Pacaud R (2014)	1
ID1	0	PIAS1	4	affinity chromatography technology	Hein MY (2015)	1
APPL1	1	TRAF6	0	affinity chromatography technology	Cheng KK (2013)	1
USP15	4	SMURF2	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Eichhorn PJ (2012), Iyengar PV (2015), Iyengar PV (2015)	3
TCF4	26	TCF12	14	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
ID1	0	ERP44	1	affinity chromatography technology	Hein MY (2015)	1
VHL	0	ELOC	0	affinity chromatography technology, pull down, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ohh M (1999), Tsuchiya H (1996), Min JH (2002), Li Z (2002), Hacker KE (2008), Kim BY (2008), Baek JH (2007), Baek JH (2007), Kuznetsova AV (2003), Cockman ME (2000), Lisztwan J (1999), Stickle NH (2004), Lai Y (2011), Liu YV (2007), Norman JA (2006), Kinoshita K (2007), Cai Q (2010), Lai Y (2012), Miller F (2005), Mahrour N (2008), Mahrour N (2008), Russell RC (2011), He X (2011), McClellan AJ (2005), Bex C (2007), Pause A (1997), Pause A (1997), Stebbins CE (1999), Iliopoulos O (1998), Feldman DE (2003), Kibel A (1995), Kibel A (1995), Pause A (1999), Pause A (1999), Duan DR (1995), Kamura T (2004), Russell RC (2008), Russell RC (2008), Essers PB (2014), Gerez J (2015), Nguyen HC (2015), Lee SB (2016), Uchida T (2016), Zhang C (2016), Huttlin EL (2017), Sun W (2017), Sun W (2017)	48
ID1	0	NKX2-5	0	affinity chromatography technology	Ding B (2006)	1
ID1	0	PPP2CA	7	affinity chromatography technology	Zhang X (2007)	1
POT1	2	CCDC9	1	two hybrid	Lee OH (2011)	1
TRAF6	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanz L (2000), Sanz L (2000), Nakamura K (2010), Kim JY (2009), Seibenhener ML (2004), Feng Y (2005), Martin P (2006), Martin P (2006), Geetha T (2012), Geetha T (2012), Linares JF (2013), Linares JF (2011), Linares JF (2015), Schimmack G (2017), Tsai WT (2016)	15
ID1	0	VHL	0	affinity chromatography technology	Lee SB (2016)	1
APPL1	1	ID1	0	two hybrid	Grossmann A (2015)	1
PSMD4	1	SQSTM1	0	affinity chromatography technology	Seibenhener ML (2004)	1
FZR1	1	VHL	0	affinity chromatography technology, affinity chromatography technology	Liu W (2011), Liu W (2011)	2
ID1	0	COL12A1	4	affinity chromatography technology	Hein MY (2015)	1
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
TCF4	26	MYOD1	0	two hybrid	Goldfarb AN (1996)	1
GATA4	4	NKX2-5	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down	Garg V (2003), Durocher D (1997), Durocher D (1997), Zhu W (2000), Zhu W (2000), Kim TG (2004), Kim TG (2004)	7
ID1	0	TCF12	14	two hybrid, affinity chromatography technology	Langlands K (1997), Hein MY (2015)	2
ID1	0	CASK	18	two hybrid, pull down	Qi J (2005), Qi J (2005)	2
CDC20	1	PPP2CA	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Craney A (2016), Craney A (2016), Craney A (2016)	3
FZR1	1	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Stewart S (2005), Stewart S (2005), Wang Y (2007), Wang Y (2007), Tian W (2012), Hyun SY (2013), Hyun SY (2013)	7
CDC20	1	RASSF1	3	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chow C (2011), Chow C (2011), Wang X (2008), Song MS (2004)	4
SQSTM1	0	CAV1	0	affinity chromatography technology, affinity chromatography technology	Liang X (2013), Luo X (2017)	2
TCF12	14	TCF3	7	affinity chromatography technology	Yoon SJ (2011)	1
RASSF1	3	FZR1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ID1	0	PSMD4	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Hasskarl J (2008), Anand G (1997), Anand G (1997)	3
RASSF1	3	ID1	0	affinity chromatography technology	Wang X (2008)	1
SQSTM1	0	ID1	0	affinity chromatography technology	Li X (2017)	1
ID1	0	FZR1	1	affinity chromatography technology, affinity chromatography technology	Wang X (2008), Wang X (2008)	2
ID1	0	DPF2	3	affinity chromatography technology	Hein MY (2015)	1
COPB1	0	ID1	0	two hybrid	Wang J (2011)	1
ID1	0	SUV39H1	0	two hybrid	Weimann M (2013)	1
ID1	0	THOC6	0	affinity chromatography technology	Hein MY (2015)	1
TCF4	26	ID1	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Massari ME (1998), Langlands K (1997), Wang J (2011), Li X (2015), Huttlin EL (2017)	5
CAV1	0	PPP2CA	7	pull down, affinity chromatography technology	Li L (2003), Zhang X (2007)	2
ERP44	1	PIAS1	4	affinity chromatography technology	Hein MY (2015)	1
ID1	0	MYF5	2	two hybrid	Langlands K (1997)	1
ID1	0	ZC3H13	8	affinity chromatography technology	Hein MY (2015)	1
MYOD1	0	PSMD4	1	two hybrid, affinity chromatography technology	Anand G (1997), Anand G (1997)	2
ID1	0	MPP1	1	affinity chromatography technology	Hein MY (2015)	1
USP15	4	ZC3H13	8	biochemical	Havugimana PC (2012)	1
ID1	0	TCF3	7	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Langlands K (1997), Sun R (2009), Sun R (2009), Teachenor R (2012), Langlands K (1997), Hein MY (2015)	6
RASSF1	3	SUV39H1	0	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
IKBKG	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Martin P (2006), Zotti T (2014)	2
TRAF6	0	ID1	0	affinity chromatography technology	Li X (2017)	1
ID1	0	ELOC	0	affinity chromatography technology	Lee SB (2016)	1
ID1	0	CCDC9	1	affinity chromatography technology	Hein MY (2015)	1
ID1	0	PSMD5	0	affinity chromatography technology	Hein MY (2015)	1
ID1	0	USP15	4	affinity chromatography technology	Hein MY (2015)	1
ID1	0	MKNK1	0	affinity chromatography technology	Hein MY (2015)	1