PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DND1	0	APOBEC1	0	pull down	Bhattacharya C (2008)	1
BAG4	2	APOBEC1	0	pull down, affinity chromatography technology, two hybrid	Lau PP (2003), Lau PP (2003), Lau PP (2003)	3
APOBEC1	0	KPNA2	0	two hybrid	Chester A (2003)	1
A1CF	1	APOBEC1	0	affinity chromatography technology, pull down, affinity chromatography technology	Blanc V (2001), Blanc V (2001), Mehta A (2000)	3
APOBEC1	0	APOBEC1	0	pull down	Oka K (1997)	1
SYNCRIP	6	A1CF	1	pull down, two hybrid, affinity chromatography technology, pull down	Lau PP (2001), Blanc V (2001), Blanc V (2001), Blanc V (2001)	4
DNAJB11	3	APOBEC1	0	pull down	Lau PP (2001)	1
APOBEC1	0	SYNCRIP	6	two hybrid, pull down	Lau PP (2001), Lau PP (2001)	2
APOBEC2	0	APOBEC1	0	far western blotting	Anant S (2001)	1