Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
APOA4 337 RITONAVIR CHEMBL163 PharmGKB

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
APOA4 rs1263177 CC + CT fenofibrate efficacy no No significant difference in the change in plasma triglyceride (TG) or high-density lipoprotein (HDL) levels between genotypes was seen, after three weeks of treatment with fenofibrate. Genotypes CC + CT are not associated with response to fenofibrate in people with Hypertriglyceridemia as compared to genotype TT. 19057464 982038004
APOA4 rs5090 CG fenofibrate efficacy no No significant difference in the change in plasma triglyceride (TG) or high-density lipoprotein (HDL) levels between genotypes was seen, after three weeks of treatment with fenofibrate. Genotype CG is not associated with response to fenofibrate in people with Hypertriglyceridemia as compared to genotype GG. 19057464 982038053
APOA4 rs5092 CC + CT fenofibrate efficacy no No significant difference in the change in plasma triglyceride (TG) or high-density lipoprotein (HDL) levels between genotypes was seen, after three weeks of treatment with fenofibrate. Please note alleles have been complemented to the plus chromosomal strand. Genotypes CC + CT are not associated with response to fenofibrate in people with Hypertriglyceridemia as compared to genotype TT. 19057464 982038045
APOA4 rs675 AA + AT fenofibrate efficacy no No significant difference in the change in plasma triglyceride (TG) or high-density lipoprotein (HDL) levels between genotypes was seen, after three weeks of treatment with fenofibrate. Genotypes AA + AT are not associated with response to fenofibrate in people with Hypertriglyceridemia as compared to genotype TT. 19057464 982038027
APOA4 rs5104 CC + CT fenofibrate efficacy no No significant difference in the change in plasma triglyceride (TG) or high-density lipoprotein (HDL) levels between genotypes was seen, after three weeks of treatment with fenofibrate. Please note alleles have been complemented to the plus chromosomal strand. Genotypes CC + CT are not associated with response to fenofibrate in people with Hypertriglyceridemia as compared to genotype TT. 19057464 982038036