Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
HTR6 3362 ARIPIPRAZOLE CHEMBL1112 antagonist DrugBank 17848919
HTR6 3362 MIANSERIN CHEMBL6437 antagonist, binder GuideToPharmacologyInteractions, DrugBank
HTR6 3362 PF-05212377 CHEMBL3545344 antagonist ChemblInteractions
HTR6 3362 CHEMBL392760 CHEMBL392760 agonist GuideToPharmacologyInteractions
HTR6 3362 SEROTONIN CHEMBL39 agonist GuideToPharmacologyInteractions
HTR6 3362 [3H]LSD CHEMBL463207 agonist GuideToPharmacologyInteractions
HTR6 3362 LISURIDE CHEMBL157138 agonist GuideToPharmacologyInteractions
HTR6 3362 AMITRIPTYLINE CHEMBL629 antagonist GuideToPharmacologyInteractions
HTR6 3362 METITEPINE CHEMBL93240 antagonist GuideToPharmacologyInteractions
HTR6 3362 SUMATRIPTAN CHEMBL128 antagonist GuideToPharmacologyInteractions
HTR6 3362 CHLORPROMAZINE CHEMBL71 antagonist GuideToPharmacologyInteractions
HTR6 3362 OLANZAPINE CHEMBL715 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, DrugBank 17848919
HTR6 3362 LOXAPINE CHEMBL831 antagonist, binder GuideToPharmacologyInteractions, DrugBank
HTR6 3362 CHEMBL571858 CHEMBL571858 agonist GuideToPharmacologyInteractions
HTR6 3362 BRL-15,572 CHEMBL534232 agonist GuideToPharmacologyInteractions
HTR6 3362 DONITRIPTAN CHEMBL1742428 agonist GuideToPharmacologyInteractions
HTR6 3362 CYPROHEPTADINE CHEMBL516 antagonist GuideToPharmacologyInteractions
HTR6 3362 MESULERGINE CHEMBL12314 antagonist GuideToPharmacologyInteractions
HTR6 3362 CHEMBL7318 CHEMBL7318 antagonist GuideToPharmacologyInteractions
HTR6 3362 CHEMBL46071 CHEMBL46071 antagonist GuideToPharmacologyInteractions
HTR6 3362 CHEMBL60264 CHEMBL60264 antagonist GuideToPharmacologyInteractions
HTR6 3362 CHEMBL329383 CHEMBL329383 antagonist GuideToPharmacologyInteractions
HTR6 3362 THIORIDAZINE CHEMBL479 antagonist GuideToPharmacologyInteractions
HTR6 3362 ZOTEPINE CHEMBL285802 antagonist GuideToPharmacologyInteractions
HTR6 3362 CLOZAPINE CHEMBL42 antagonist GuideToPharmacologyInteractions, DrugBank 17848919
HTR6 3362 SERTINDOLE CHEMBL12713 antagonist TdgClinicalTrial, TEND, DrugBank 19506838, 11888555
HTR6 3362 CERLAPIRDINE CHEMBL2103880 antagonist GuideToPharmacologyInteractions, ChemblInteractions
HTR6 3362 ASENAPINE (CHEMBL3187365) CHEMBL3187365 TdgClinicalTrial
HTR6 3362 5-METHOXYTRYPTAMINE CHEMBL8165 agonist GuideToPharmacologyInteractions
HTR6 3362 BROMOCRIPTINE CHEMBL493 agonist GuideToPharmacologyInteractions
HTR6 3362 ERGOTAMINE CHEMBL442 agonist GuideToPharmacologyInteractions
HTR6 3362 LYSERGIDE CHEMBL263881 agonist GuideToPharmacologyInteractions
HTR6 3362 XANOMELINE CHEMBL21536 agonist GuideToPharmacologyInteractions
HTR6 3362 CHEMBL362628 CHEMBL362628 agonist GuideToPharmacologyInteractions
HTR6 3362 GR-127935 CHEMBL15928 agonist GuideToPharmacologyInteractions
HTR6 3362 DULOXETINE CHEMBL1175 antagonist GuideToPharmacologyInteractions
HTR6 3362 METERGOLINE CHEMBL19215 antagonist GuideToPharmacologyInteractions
HTR6 3362 METHYSERGIDE CHEMBL1065 antagonist GuideToPharmacologyInteractions
HTR6 3362 RISPERIDONE CHEMBL85 antagonist GuideToPharmacologyInteractions
HTR6 3362 CHEMBL431298 CHEMBL431298 antagonist GuideToPharmacologyInteractions
HTR6 3362 EPINASTINE CHEMBL1106 antagonist GuideToPharmacologyInteractions
HTR6 3362 TIOSPIRONE CHEMBL35057 antagonist GuideToPharmacologyInteractions
HTR6 3362 VORTIOXETINE CHEMBL2104993 antagonist GuideToPharmacologyInteractions
HTR6 3362 N,N-DIMETHYLTRYPTAMINE CHEMBL12420 agonist GuideToPharmacologyInteractions, DrugBank 17239595, 270770, 278843, 10715164
HTR6 3362 IDALOPIRDINE CHEMBL3286580 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions
HTR6 3362 SB-742457 CHEMBL1083390 antagonist GuideToPharmacologyInteractions, ChemblInteractions, TTD
HTR6 3362 PROCAINAMIDE CHEMBL640 agonist GuideToPharmacologyInteractions
HTR6 3362 CHEMBL267615 CHEMBL267615 agonist GuideToPharmacologyInteractions
HTR6 3362 RU-24969 CHEMBL18785 agonist GuideToPharmacologyInteractions
HTR6 3362 Capeserod CHEMBL2027925 agonist GuideToPharmacologyInteractions
HTR6 3362 RITANSERIN CHEMBL267777 antagonist GuideToPharmacologyInteractions
HTR6 3362 FLUPERLAPINE CHEMBL63756 antagonist GuideToPharmacologyInteractions
HTR6 3362 FLUPHENAZINE CHEMBL726 antagonist GuideToPharmacologyInteractions
HTR6 3362 PERPHENAZINE CHEMBL567 antagonist GuideToPharmacologyInteractions
HTR6 3362 AMOXAPINE CHEMBL1113 antagonist GuideToPharmacologyInteractions, DrugBank 7908055
HTR6 3362 ILOPERIDONE CHEMBL14376 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, DrugBank 23272794

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
HTR6 rs1805054 CC antidepressants efficacy no Genotype CC is not associated with response to antidepressants in people with Depressive Disorder, Major as compared to genotypes CT + TT. 23733030 982028725
HTR6 rs1805054 T risperidone efficacy no Allele T is not associated with response to risperidone in people with Schizophrenia as compared to allele C. 28696411 1450928217
HTR6 rs1805054 C citalopram efficacy no This SNP was also not found to be associated with Major Depressive Disorder. Allele C is not associated with response to citalopram, fluoxetine or paroxetine in people with Depressive Disorder, Major as compared to allele T. 19590397 981750809