Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
HTR2C 3358 MIRTAZAPINE CHEMBL654 antagonist GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank, TTD 11752352, 11271412, 9832994, 10762339, 16433010, 14615872
HTR2C 3358 TEGASEROD CHEMBL76370 antagonist DrugBank 15466450
HTR2C 3358 YOHIMBINE CHEMBL15245 antagonist DrugBank 8032658, 6136920
HTR2C 3358 CHEMBL609728 CHEMBL609728 DrugBank
HTR2C 3358 THIORIDAZINE HYDROCHLORIDE CHEMBL1200916 antagonist ChemblInteractions
HTR2C 3358 ESMIRTAZAPINE MALEATE CHEMBL2107339 antagonist ChemblInteractions
HTR2C 3358 EPLIVANSERIN FUMARATE CHEMBL2103845 binder TTD
HTR2C 3358 DOXEPIN CHEMBL1628227 TdgClinicalTrial
HTR2C 3358 ZIPRASIDONE CHEMBL708 antagonist GuideToPharmacologyInteractions, TEND
HTR2C 3358 TRAZODONE CHEMBL621 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions
HTR2C 3358 ZIPRASIDONE MESYLATE CHEMBL1200997 antagonist ChemblInteractions
HTR2C 3358 CARPHENAZINE MALEATE CHEMBL2358147 antagonist ChemblInteractions
HTR2C 3358 LOXAPINE SUCCINATE CHEMBL1201155 antagonist ChemblInteractions
HTR2C 3358 CHEMBL1600780 CHEMBL1600780 agonist GuideToPharmacologyInteractions
HTR2C 3358 CHEMBL134519 CHEMBL134519 agonist GuideToPharmacologyInteractions
HTR2C 3358 LYSERGIDE CHEMBL263881 agonist GuideToPharmacologyInteractions
HTR2C 3358 CHEMBL6616 CHEMBL6616 agonist GuideToPharmacologyInteractions
HTR2C 3358 TRYPTAMINE CHEMBL6640 agonist GuideToPharmacologyInteractions
HTR2C 3358 CHEMBL309760 CHEMBL309760 agonist GuideToPharmacologyInteractions
HTR2C 3358 CHEMBL407909 CHEMBL407909 agonist GuideToPharmacologyInteractions
HTR2C 3358 GR-127935 CHEMBL15928 agonist GuideToPharmacologyInteractions
HTR2C 3358 CHLOROPHENYLPIPERAZINE CHEMBL478 agonist GuideToPharmacologyInteractions
HTR2C 3358 CHLORPROMAZINE CHEMBL71 antagonist GuideToPharmacologyInteractions
HTR2C 3358 DULOXETINE CHEMBL1175 antagonist GuideToPharmacologyInteractions
HTR2C 3358 GLEMANSERIN CHEMBL18972 antagonist GuideToPharmacologyInteractions
HTR2C 3358 KETANSERIN CHEMBL51 antagonist GuideToPharmacologyInteractions
HTR2C 3358 MESORIDAZINE CHEMBL1088 antagonist GuideToPharmacologyInteractions
HTR2C 3358 RITANSERIN CHEMBL267777 antagonist GuideToPharmacologyInteractions
HTR2C 3358 SB-242084 CHEMBL14563 antagonist GuideToPharmacologyInteractions
HTR2C 3358 CHEMBL316069 CHEMBL316069 antagonist GuideToPharmacologyInteractions
HTR2C 3358 TRIFLUOPERAZINE CHEMBL422 antagonist GuideToPharmacologyInteractions
HTR2C 3358 QUETIAPINE FUMARATE CHEMBL1200911 antagonist ChemblInteractions
HTR2C 3358 ILOPERIDONE CHEMBL14376 PharmGKB
HTR2C 3358 FENFLURAMINE CHEMBL87493 agonist DrugBank 16973729, 10617681, 15869562, 12708517, 16249524
HTR2C 3358 ERGOTAMINE CHEMBL442 agonist GuideToPharmacologyInteractions, DrugBank 12525272
HTR2C 3358 ARIPIPRAZOLE CHEMBL1112 agonist, antagonist GuideToPharmacologyInteractions, DrugBank 17848919
HTR2C 3358 PALIPERIDONE CHEMBL1621 antagonist DrugBank 11132243
HTR2C 3358 LEVOMEPROMAZINE CHEMBL1764 antagonist DrugBank 15701205
HTR2C 3358 TRIMIPRAMINE MALEATE CHEMBL1200948 antagonist ChemblInteractions
HTR2C 3358 THIETHYLPERAZINE CHEMBL1378 TdgClinicalTrial, TEND
HTR2C 3358 METHIXENE HYDROCHLORIDE CHEMBL1200426 antagonist ChemblInteractions
HTR2C 3358 BIFEPRUNOX CHEMBL218166 TdgClinicalTrial
HTR2C 3358 METHYSERGIDE MALEATE CHEMBL1200938 antagonist ChemblInteractions
HTR2C 3358 NEFAZODONE HYDROCHLORIDE CHEMBL1200492 antagonist ChemblInteractions
HTR2C 3358 RENZAPRIDE CHEMBL159825 TdgClinicalTrial
HTR2C 3358 [3H]LSD CHEMBL463207 agonist GuideToPharmacologyInteractions
HTR2C 3358 5-MEO-DMT CHEMBL7257 agonist GuideToPharmacologyInteractions
HTR2C 3358 CHEMBL3186179 CHEMBL3186179 agonist GuideToPharmacologyInteractions
HTR2C 3358 QUIPAZINE CHEMBL18772 agonist GuideToPharmacologyInteractions
HTR2C 3358 CHEMBL1628670 CHEMBL1628670 agonist GuideToPharmacologyInteractions
HTR2C 3358 BRL-15,572 CHEMBL534232 agonist GuideToPharmacologyInteractions
HTR2C 3358 Capeserod CHEMBL2027925 agonist GuideToPharmacologyInteractions
HTR2C 3358 ACETIC ACID CHEMBL539 antagonist GuideToPharmacologyInteractions
HTR2C 3358 IDALOPIRDINE CHEMBL3286580 antagonist GuideToPharmacologyInteractions
HTR2C 3358 ROXINDOLE CHEMBL431367 antagonist GuideToPharmacologyInteractions
HTR2C 3358 CHEMBL473186 CHEMBL473186 antagonist GuideToPharmacologyInteractions
HTR2C 3358 CHEMBL14276 CHEMBL14276 antagonist GuideToPharmacologyInteractions
HTR2C 3358 MESULERGINE CHEMBL12314 antagonist GuideToPharmacologyInteractions
HTR2C 3358 METERGOLINE CHEMBL19215 antagonist GuideToPharmacologyInteractions
HTR2C 3358 METHYSERGIDE CHEMBL1065 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank, TTD 11752352, 12555241
HTR2C 3358 CABERGOLINE CHEMBL1201087 agonist GuideToPharmacologyInteractions, DrugBank 10641988, 18691132, 18992242, 20426763
HTR2C 3358 ROPINIROLE CHEMBL589 agonist DrugBank 18691132
HTR2C 3358 CLOZAPINE CHEMBL42 antagonist PharmGKB, TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank 15917433, 16182256
HTR2C 3358 PROMAZINE CHEMBL564 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
HTR2C 3358 LISURIDE CHEMBL157138 agonist GuideToPharmacologyInteractions, DrugBank 18691132, 9600588
HTR2C 3358 RISPERIDONE CHEMBL85 antagonist PharmGKB, GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 11132243, 7898773
HTR2C 3358 CHLORPROTHIXENE CHEMBL908 antagonist TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 17139284, 17016423
HTR2C 3358 METHYLENEDIOXYMETHAMPHETAMINE CHEMBL43048 agonist DrugBank 2871581, 7824160
HTR2C 3358 TEDATIOXETINE CHEMBL2104986 antagonist TdgClinicalTrial, ChemblInteractions
HTR2C 3358 NEFAZODONE CHEMBL623 antagonist TTD
HTR2C 3358 AMISULPRIDE CHEMBL243712 PharmGKB
HTR2C 3358 LORCASERIN HYDROCHLORIDE CHEMBL2095211 agonist ChemblInteractions
HTR2C 3358 ASENAPINE (CHEMBL3187365) CHEMBL3187365 TdgClinicalTrial
HTR2C 3358 ZIPRASIDONE HYDROCHLORIDE CHEMBL1712 antagonist ChemblInteractions
HTR2C 3358 5-METHOXYTRYPTAMINE CHEMBL8165 agonist GuideToPharmacologyInteractions
HTR2C 3358 CHEMBL133455 CHEMBL133455 agonist GuideToPharmacologyInteractions
HTR2C 3358 BROLAMFETAMINE CHEMBL6607 agonist GuideToPharmacologyInteractions
HTR2C 3358 MK-212 CHEMBL269521 agonist GuideToPharmacologyInteractions
HTR2C 3358 CHEMBL506999 CHEMBL506999 agonist GuideToPharmacologyInteractions
HTR2C 3358 OXYMETAZOLINE CHEMBL762 agonist GuideToPharmacologyInteractions
HTR2C 3358 QUINPIROLE CHEMBL240773 agonist GuideToPharmacologyInteractions
HTR2C 3358 CHEMBL76781 CHEMBL76781 agonist GuideToPharmacologyInteractions
HTR2C 3358 RU-24969 CHEMBL18785 agonist GuideToPharmacologyInteractions
HTR2C 3358 PERPHENAZINE CHEMBL567 antagonist GuideToPharmacologyInteractions
HTR2C 3358 RS-102,221 CHEMBL88402 antagonist GuideToPharmacologyInteractions
HTR2C 3358 CHEMBL65280 CHEMBL65280 antagonist GuideToPharmacologyInteractions
HTR2C 3358 VORTIOXETINE CHEMBL2104993 antagonist GuideToPharmacologyInteractions
HTR2C 3358 TIOSPIRONE CHEMBL35057 antagonist GuideToPharmacologyInteractions
HTR2C 3358 ZOTEPINE CHEMBL285802 antagonist GuideToPharmacologyInteractions
HTR2C 3358 OLANZAPINE PAMOATE CHEMBL1201741 antagonist ChemblInteractions
HTR2C 3358 LOXAPINE HYDROCHLORIDE CHEMBL1201060 antagonist ChemblInteractions
HTR2C 3358 OLANZAPINE CHEMBL715 antagonist PharmGKB, TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank 16952163, 16336943, 11752352, 10227113, 17624999, 16918396, 16983399
HTR2C 3358 AMOXAPINE CHEMBL1113 antagonist DrugBank 10821800
HTR2C 3358 APOMORPHINE CHEMBL53 agonist, antagonist GuideToPharmacologyInteractions, DrugBank 18691132
HTR2C 3358 PROPIOMAZINE CHEMBL1201210 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
HTR2C 3358 MINAPRINE CHEMBL278819 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423, 1361012, 2975224
HTR2C 3358 DEXFENFLURAMINE CHEMBL248702 agonist DrugBank 10353435, 11888565, 11489456, 12678838, 11198050
HTR2C 3358 THIORIDAZINE CHEMBL479 antagonist GuideToPharmacologyInteractions, ChemblInteractions
HTR2C 3358 TRAZODONE HYDROCHLORIDE CHEMBL1200798 antagonist ChemblInteractions
HTR2C 3358 VABICASERIN HYDROCHLORIDE CHEMBL2104991 agonist ChemblInteractions
HTR2C 3358 QUETIAPINE CHEMBL716 TdgClinicalTrial, TEND
HTR2C 3358 TRAMADOL CHEMBL1237044 TdgClinicalTrial, TEND
HTR2C 3358 CYCLOBENZAPRINE HYDROCHLORIDE CHEMBL1200636 antagonist ChemblInteractions
HTR2C 3358 TRIFLUOPERAZINE HYDROCHLORIDE CHEMBL1710 antagonist ChemblInteractions
HTR2C 3358 SEROTONIN CHEMBL39 agonist GuideToPharmacologyInteractions
HTR2C 3358 8-OH-DPAT CHEMBL56 agonist GuideToPharmacologyInteractions
HTR2C 3358 METHYLERGONOVINE CHEMBL1201356 agonist GuideToPharmacologyInteractions
HTR2C 3358 BROMOCRIPTINE CHEMBL493 agonist GuideToPharmacologyInteractions
HTR2C 3358 PERGOLIDE CHEMBL531 agonist GuideToPharmacologyInteractions
HTR2C 3358 CHEMBL20963 CHEMBL20963 agonist GuideToPharmacologyInteractions
HTR2C 3358 CYAMEMAZINE CHEMBL2104153 antagonist GuideToPharmacologyInteractions
HTR2C 3358 SARPOGRELATE CHEMBL52939 antagonist GuideToPharmacologyInteractions
HTR2C 3358 CHEMBL323356 CHEMBL323356 antagonist GuideToPharmacologyInteractions
HTR2C 3358 CHEMBL297784 CHEMBL297784 antagonist GuideToPharmacologyInteractions
HTR2C 3358 SB-224289 CHEMBL281350 antagonist GuideToPharmacologyInteractions
HTR2C 3358 SB-243213 CHEMBL14460 antagonist GuideToPharmacologyInteractions
HTR2C 3358 SPIPERONE CHEMBL267930 antagonist GuideToPharmacologyInteractions
HTR2C 3358 SPIRAMIDE CHEMBL79834 antagonist GuideToPharmacologyInteractions
HTR2C 3358 TERGURIDE CHEMBL73151 antagonist GuideToPharmacologyInteractions
HTR2C 3358 VOLINANSERIN CHEMBL74355 antagonist GuideToPharmacologyInteractions
HTR2C 3358 XANOMELINE CHEMBL21536 antagonist GuideToPharmacologyInteractions
HTR2C 3358 METITEPINE CHEMBL93240 antagonist GuideToPharmacologyInteractions
HTR2C 3358 LORCASERIN CHEMBL360328 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, DrugBank, TTD 16625817, 16259227
HTR2C 3358 DAPOXETINE CHEMBL2110900 DrugBank 17624269
HTR2C 3358 SERTINDOLE CHEMBL12713 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank 16925508, 11594443
HTR2C 3358 MIANSERIN CHEMBL6437 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank 11004734
HTR2C 3358 AGOMELATINE CHEMBL10878 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, DrugBank 15289999
HTR2C 3358 LOXAPINE CHEMBL831 antagonist GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 10991983
HTR2C 3358 DERAMCICLANE CHEMBL2104698 inverse agonist DrugBank 9551765
HTR2C 3358 CAPTODIAME CHEMBL2110809 antagonist DrugBank 23863923

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
HTR2C rs3813928 A risperidone efficacy yes HTR2C is on the X chromosome and this variant described as rs3813928 (c.-995G>A). Males with A genotype plus females with AA/AG genotype had 4.1% higher ATEC (ie. less response) than males with G genotype or females with GG genotype. Allele A is associated with decreased response to risperidone in children with Autistic Disorder as compared to genotype GG. 19997080 655387241
HTR2C rs3813929 TT risperidone efficacy no This was not significant in male or female patients. The HTR2C is x-linked and males have only one copy, the authors analyzed male and female samples separately. Genotype TT is not associated with increased response to risperidone in women with Schizophrenia as compared to genotypes CC + CT. 20415561 1448998855
HTR2C rs3813929 T botulinum toxin type a efficacy no No significant difference in allele frequency between responders and non-responders. Allele T is not associated with response to botulinum toxin type a in women with Migraine NOS as compared to allele C. 31014225 1451104973
HTR2C rs3813928 A risperidone efficacy no Allele A is not associated with response to risperidone in people with Schizophrenia as compared to allele G. 28696411 1450928254
HTR2C rs6318 C clozapine efficacy yes This gene is x-linked. Authors found those with one of more C alleles (Ser23/Ser23 CC and Ser23/Cys23 CG females and Ser23 C0 males) were more likely to be classified as clozapine responders than those without Ser23 alleles. Allele C is associated with increased response to clozapine in people with Schizophrenia as compared to allele G. 8742444 1448998711
HTR2C rs518147 CC risperidone efficacy yes This was not significant in male patients. The HTR2C is x-linked and males have only one copy, the authors analyzed male and female samples separately. Genotype CC is associated with increased response to risperidone in women with Schizophrenia as compared to genotypes CG + GG. 20415561 1448998827
HTR2C rs1023574 CC risperidone efficacy yes This was not significant in male patients. The HTR2C is x-linked and males have only one copy, the authors analyzed male and female samples separately. Genotype CC is associated with increased response to risperidone in women with Schizophrenia as compared to genotypes CG + GG. 20415561 1448998839
HTR2C rs9698290 TT risperidone efficacy yes This was not significant in male patients. The HTR2C is x-linked and males have only one copy, the authors analyzed male and female samples separately. Genotype TT is associated with increased response to risperidone in women with Schizophrenia as compared to genotypes CC + CT. 20415561 1448998848