PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SIRT3	1	HSPD1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Law IK (2009), Yang Y (2011), Yang Y (2011), Huttlin EL (2017)	4
CDK2	0	HSPE1	0	affinity chromatography technology	Neganova I (2011)	1
SLC25A41	0	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ISG15	0	HSP90AB1	2	affinity chromatography technology	Zhao C (2005)	1
ALDH2	2	SIRT3	1	pull down, enzymatic study	Harris PS (2017), Harris PS (2017)	2
HSPD1	0	CASP3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Samali A (1999), Samali A (1999), Xanthoudakis S (1999)	3
DCAF5	1	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	STUB1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Connell P (2001), Connell P (2001), Windheim M (2008), Zhang M (2005)	4
ALDH2	2	HSPD1	0	two hybrid, biochemical	Lee KH (2002), Lee KH (2002)	2
MRPL4	1	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ALDH2	2	HSPE1	0	two hybrid	Lee KH (2002)	1
ALDH2	2	APP	1	pull down	Olah J (2011)	1
CDK2	0	CASP3	0	affinity chromatography technology	Neganova I (2011)	1
QTRT1	4	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ASB9	0	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Debrincat MA (2007), Debrincat MA (2007)	2
BRCA1	7	HSPD1	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
HSPD1	0	HSPE1	0	affinity chromatography technology, biochemical, two hybrid, biochemical, pull down, biochemical	Samali A (1999), Lee KH (2002), Lee KH (2002), Havugimana PC (2012), Suzuki T (2004), Wan C (2015)	6
APP	1	TUBG1	2	pull down	Virok DP (2011)	1
SIRT4	0	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MRPL4	1	MRPL37	0	affinity chromatography technology	Huttlin EL (2015)	1
CLU	1	HSPD1	0	affinity chromatography technology, affinity chromatography technology, pull down	Chaiwatanasirikul KA (2011), Chaiwatanasirikul KA (2011), Chaiwatanasirikul KA (2011)	3
LRRC28	1	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ERG	1	HSPD1	0	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
THBS3	3	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK2	0	ATP5F1	0	affinity chromatography technology	Neganova I (2011)	1
APP	1	STUB1	4	affinity chromatography technology, affinity chromatography technology	Kumar P (2007), Kumar P (2007)	2
UBC	7	DCAF5	1	affinity chromatography technology	Matsumoto M (2005)	1
HSPD1	0	LZTS2	4	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
QTRT1	4	APP	1	affinity chromatography technology	Huttlin EL (2017)	1
SIRT4	0	SIRT3	1	affinity chromatography technology	Ahuja N (2007)	1
CFTR	5	HSP90AB1	2	affinity chromatography technology	Wang X (2006)	1
HSPD1	0	APP	1	affinity chromatography technology, pull down	Kumar P (2007), Olah J (2011)	2
TUBG1	2	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Hein MY (2015)	2
BRCA1	7	HDAC1	4	pull down	Yarden RI (1999)	1
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
CASP3	0	HSPE1	0	affinity chromatography technology	Samali A (1999)	1
CDK2	0	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Varjosalo M (2013)	2
ALK	8	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Crockett DK (2004), Crockett DK (2004)	2
OXNAD1	1	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CASP3	0	APP	1	imaging technique	Chen TC (2014)	1
PLG	3	HSPD1	0	pull down, far western blotting	Dudani AK (2007), Dudani AK (2007)	2
BRCA1	7	TUBG1	2	imaging technique, affinity chromatography technology, pull down, biochemical, imaging technique, affinity chromatography technology, enzymatic study, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down	Hsu LC (2001), Hsu LC (2001), Hsu LC (2001), Hsu LC (1998), Hsu LC (1998), Hsu LC (1998), Starita LM (2004), Brodie KM (2012), Tarapore P (2012), Tarapore P (2012), Tarapore P (2012), Matsuzawa A (2014)	12
CFTR	5	HSPE1	0	affinity chromatography technology	Pankow S (2015)	1
STUB1	4	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Kumar P (2007), Kumar P (2007)	2
UBC	7	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
HSP90AB1	2	HSPE1	0	biochemical	Wan C (2015)	1
UBC	7	MRPL37	0	pull down	Nathan JA (2013)	1
UBC	7	DHFR	0	affinity chromatography technology	Matsumoto M (2005)	1
UBC	7	FBXO7	1	affinity chromatography technology	Matsumoto M (2005)	1
DHFR	0	HSPD1	0	pull down, biochemical	Mayhew M (1996), Mayhew M (1996)	2
UBC	7	HSP90AB1	2	affinity chromatography technology	Bish RA (2007)	1
CDK2	0	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Hein MY (2015)	2
ERG	1	STUB1	4	pull down	Wang S (2016)	1
MRPL37	0	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXO17	1	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	ALDH2	2	affinity chromatography technology	Bennett EJ (2010)	1
STUB1	4	CFTR	5	enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Younger JM (2004), Summers DW (2009), Ren HY (2011), Meacham GC (2001), Schmidt BZ (2009), Alberti S (2004)	6
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
ISG15	0	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Zhao C (2005), Zhao C (2005)	2
CUL3	17	MRPL4	1	affinity chromatography technology	Bennett EJ (2010)	1
TAZ	1	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TUBG1	2	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Hein MY (2015)	2
ERG	1	CUL3	17	affinity chromatography technology	Gan W (2015)	1
CUL3	17	MRPL37	0	affinity chromatography technology	Bennett EJ (2010)	1
FBXO7	1	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Teixeira FR (2016)	2
CUL3	17	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Oshikawa K (2003), Bennett EJ (2010)	2
CDK2	0	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Ruffner H (1999), Ruffner H (1999), Ruffner H (1999), Wang H (1997), Chen Y (1996)	5
APP	1	CLU	1	pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology	Hammad SM (1997), Ghiso J (1993), Chen P (2013), Chen P (2013)	4
ETFBKMT	4	HSPD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cloutier P (2013), Huttlin EL (2015), Huttlin EL (2017)	3
CFTR	5	ISG15	0	affinity chromatography technology	Pankow S (2015)	1
ATP5F1	0	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSP90AB1	2	STUB1	4	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HDAC1	4	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Johnson CA (2002), Hein MY (2015)	2
CDK2	0	TUBG1	2	biochemical	Nishimura T (2005)	1
ERG	1	APP	1	pull down	Olah J (2011)	1
CUL3	17	HSP90AB1	2	affinity chromatography technology	Bennett EJ (2010)	1
CFTR	5	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Pankow S (2015)	2
UBC	7	CLU	1	pull down	Zoubeidi A (2010)	1
TTC39B	1	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSPD1	0	HSP90AB1	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
BRCA1	7	HSP90AB1	2	affinity chromatography technology	Ertych N (2016)	1