Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
HSPA5 3309 FLUOROURACIL CHEMBL185 CIViC 23456958
HSPA5 3309 ASPIRIN CHEMBL25 binding DrugBank 11689471

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
HSPA5 rs430397 TT Platinum compounds efficacy yes Resistance was measured by comparing responders (patients with complete or partial response) with non-responders (stable or progressive disease). Please note that alleles have been complemented to the plus chromosomal strand. Genotype TT is associated with increased resistance to Platinum compounds in people with Carcinoma, Non-Small-Cell Lung as compared to genotype CC. 21940774 981475658