PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	BAG1	1	genetic interference	Matsuzawa S (1998)	1
SNCA	0	HSPA4	3	affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology	Kalia LV (2011), Huang C (2006), Huang C (2006), Lindersson E (2004), Kawakami F (2011), Pemberton S (2011), Klucken J (2006)	7
STUB1	4	SNCA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Kalia LV (2011), Kalia LV (2011), Tetzlaff JE (2008)	3
ESR1	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tarallo R (2011), Cho J (2005), Cho J (2005)	3
HIF1A	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kong X (2006), Qian DZ (2006), Kong X (2006), Zhou J (2004), Zhou J (2004), van de Sluis B (2009), Luo W (2010), Luo W (2010), Luo W (2010), Bento CF (2010), Katschinski DM (2004), Sun H (2013)	12
BAG3	4	STUB1	4	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Hein MY (2015)	4
ESR1	0	STUB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Fan M (2005), Tateishi Y (2004), Tateishi Y (2004), Tateishi Y (2004), Berry NB (2008), Dhamad AE (2016)	6
TP53	0	STUB1	4	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Stankiewicz M (2010), Tripathi V (2007), Tripathi V (2007), Esser C (2005), Lim JH (2011), Wang J (2011), Burch L (2004), Landre V (2013), Horikawa I (2014), Horikawa I (2014), Horikawa I (2014), Fraser JA (2015), Narayan V (2015), Yue X (2016), Parrales A (2016), Parrales A (2016)	17
PRKN	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2002), Imai Y (2003), Zhu X (2017)	5
TP53	0	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Fraser JA (2010), Sun Y (2007), Wang J (2011), Horikawa I (2014), Horikawa I (2014), Kishor A (2013)	7
STUB1	4	HSPA4	3	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Dai Q (2005), Tateishi Y (2004), Tateishi Y (2004), Ko HS (2009), Qian SB (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Wang L (2011), Wang L (2011), Graf C (2010), Kundrat L (2010), Matsumoto K (2011), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Luo W (2010), Soss SE (2011), Zhou P (2003), Kalia LV (2011), Gao Y (2010), Gao Y (2010), Grelle G (2006), Rao SN (2010), Tetzlaff JE (2008), Kim SA (2005), Dai Q (2003), Zhang X (2011), Zhang X (2011), Muller P (2012), Jang KW (2011), Schuelke JP (2010), Jinwal UK (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Mao RF (2013), Lee JS (2013), Lee JS (2013)	42
BAG3	4	HSPA4	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doong H (2003), Doong H (2003), Gentilella A (2011), Gamerdinger M (2009), Gamerdinger M (2009), Ammirante M (2010), Chen Y (2013), Chen Y (2013)	8
ESR1	0	HSPA4	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Nair SC (1996), Tateishi Y (2004), Suzuki T (2011), Azuma K (2004), Azuma K (2004), Nalvarte I (2010), Dhamad AE (2016)	7
PRKN	1	SNCA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, genetic interference, affinity chromatography technology	Choi P (2001), Choi P (2001), Kawahara K (2008), Hampe C (2006), Nemes Z (2009), Oluwatosin-Chigbu Y (2003), Yang Y (2003), Norris KL (2015)	8
PRKN	1	TP53	0	pull down, enzymatic study	Jung YY (2017), Jung YY (2017)	2
TP53	0	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology	Liu G (2000), Duong V (2007), Saxena R (2016)	3
HIF1A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Chen D (2003), Ravi R (2000), Hansson LO (2002), An WG (1998), An WG (1998), Chowdhury AR (2017), Chowdhury AR (2017), Suzuki H (2001), Sanchez-Puig N (2005)	9
HSPA4	3	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Moore DJ (2008), Hampe C (2006), Tsai YC (2003), Morishima Y (2008), Kalia SK (2004), Kalia SK (2004), Imai Y (2003), Imai Y (2003)	8
ESR1	0	BAG1	1	pull down, affinity chromatography technology, affinity chromatography technology	Zeiner M (1995), Tateishi Y (2004), Berry NB (2008)	3
BAG1	1	BAG3	4	biochemical	Havugimana PC (2012)	1
HIF1A	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Luo W (2010), Luo W (2010), Luo W (2010), Luo W (2010)	4
BAG1	1	STUB1	4	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Demand J (2001), Tateishi Y (2004), Tsukahara F (2010), Arndt V (2005), Taipale M (2014), Taipale M (2014), Narayan V (2015)	7
BAG1	1	HSPA4	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Takayama S (1997), Kalia SK (2004), Gamerdinger M (2009), Gamerdinger M (2009), Lueders J (2000), Townsend PA (2003), Townsend PA (2003), Takahashi N (2001), Deeg S (2010), Song J (2001), Song J (2001)	11