PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Wang C (2003), Akakura S (2001), Peng Y (2001), Nagata Y (1999), Wang J (2011), Burch L (2004), Taipale M (2012), Fogeron ML (2013), Walerych D (2004)	9
BAG3	4	HSF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013), Chen Y (2013), Taipale M (2014), Taipale M (2014), Boldt K (2016)	6
EGFR	5	HSPA5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavictoire SJ (2003), Foerster S (2013), Li J (2013), Yao Z (2017)	4
PIK3C3	1	HSP90AA1	7	affinity chromatography technology	Yang Y (2013)	1
MAPT	1	PRKN	1	affinity chromatography technology, affinity chromatography technology	Moore DJ (2008), Petrucelli L (2004)	2
BAG3	4	STUB1	4	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Hein MY (2015)	4
HSPA5	0	STUB1	4	affinity chromatography technology	Hein MY (2015)	1
PRKN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2003), Taipale M (2012), Zanon A (2013)	3
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
EGFR	5	HSPA1A	0	protein complementation assay, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013)	5
TP53	0	STUB1	4	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Stankiewicz M (2010), Tripathi V (2007), Tripathi V (2007), Esser C (2005), Lim JH (2011), Wang J (2011), Burch L (2004), Landre V (2013), Horikawa I (2014), Horikawa I (2014), Horikawa I (2014), Fraser JA (2015), Narayan V (2015), Yue X (2016), Parrales A (2016), Parrales A (2016)	17
PRKN	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2002), Imai Y (2003), Zhu X (2017)	5
HSP90AA1	7	HSPA5	0	affinity chromatography technology	Gano JJ (2010)	1
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
TP53	0	HSPA5	0	affinity chromatography technology, affinity chromatography technology	Sun Y (2007), Fogeron ML (2013)	2
PIK3C3	1	HSPA1A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang Y (2013), Yang Y (2013), Yang Y (2013)	3
SLC6A4	3	STUB1	4	affinity chromatography technology	El-Kasaby A (2014)	1
HSP90AA1	7	HSF1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Hu Y (2003), Nair SC (1996), Guo Y (2001), Bento CF (2010), Wang X (2006), Rao R (2012), Fu Q (2008), Prince TL (2015), Prince TL (2015)	9
PRKN	1	HSPA5	0	affinity chromatography technology	Zanon A (2013)	1
PRKN	1	TP53	0	pull down, enzymatic study	Jung YY (2017), Jung YY (2017)	2
SLC6A4	3	HSPA1A	0	pull down, fluorescent resonance energy transfe, affinity chromatography technology	El-Kasaby A (2014), El-Kasaby A (2014), El-Kasaby A (2014)	3
PRKN	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
STUB1	4	HSF1	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, pull down	Kim SA (2005), Dai Q (2003), Shimamoto S (2013), Shimamoto S (2013), Kim SA (2005)	5
HSPA1A	0	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaur J (1996), Fogeron ML (2013), Horikawa I (2014), Matsumoto H (1994), Matsumoto H (1994)	5
HSPA5	0	HSPA1A	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Hein MY (2015)	3
PRKN	1	HSPA1A	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2002), Zanon A (2013)	4
PRKN	1	PIK3C3	1	affinity chromatography technology	Choubey V (2014)	1
PIK3C3	1	HSPA5	0	affinity chromatography technology	Yang Y (2013)	1
STUB1	4	HSPA1A	0	pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Imai Y (2002), Havugimana PC (2012), Jinwal UK (2012), Yang SW (2013), Choi JR (2016), Schoenbuehler B (2016)	8
MAPT	1	STUB1	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Dickey CA (2008), Hatakeyama S (2004), Hatakeyama S (2004), Hatakeyama S (2004), Petrucelli L (2004), Dolan PJ (2010), Dolan PJ (2010), Shimura H (2004), Shimura H (2004), Shimura H (2004), Dickey CA (2007), Sakagami Y (2013), Ozdemir AY (2013), Grelle G (2006), Grelle G (2006)	15
EGFR	5	MAPT	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
HSP90AA1	7	HSPA1A	0	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kanelakis KC (2002), Gano JJ (2010), Falsone SF (2005), Brychzy A (2003), Scholz GM (2001), Scholz GM (2001)	6
EGFR	5	STUB1	4	protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Wang T (2014), Wang T (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Chung C (2016), Chung C (2016)	8
MAPT	1	HSPA1A	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Jinwal UK (2012), Jinwal UK (2012), Jinwal UK (2012), Ozdemir AY (2013)	4
BAG3	4	HSP90AA1	7	affinity chromatography technology	Chen Y (2013)	1
BAG3	4	HSPA1A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doong H (2000), Antoku K (2001), Chen Y (2013), Hein MY (2015)	4
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
HSF1	1	HSPA1A	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Shi Y (1998), Shi Y (1998), Shi Y (1998), Zhou X (1998), Hu Y (2011)	5