PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBC	7	RLIM	1	affinity chromatography technology	Matsumoto M (2005)	1
PJA1	1	NSMCE4A	0	affinity chromatography technology	Huttlin EL (2017)	1
ASNA1	2	UBC	7	affinity chromatography technology	Baron Y (2014)	1
CFTR	5	PSMA6	1	affinity chromatography technology	Pankow S (2015)	1
CYLD	2	HSPA4	3	affinity chromatography technology	Elliott PR (2016)	1
NSMCE4A	0	DNAJB2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
DNAJB2	0	RFWD3	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CFTR	5	HSPA8	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meacham GC (1999), Younger JM (2004), Fuller W (2000), Rubenstein RC (2000), Matsumura Y (2011), Goldstein RF (2007), Goldstein RF (2007), Meacham GC (2001), Meacham GC (2001), Wang X (2006), Matsumura Y (2013), Zaman K (2006), Pankow S (2015)	13
MAP3K1	4	UBQLN1	1	enzymatic study	Charlaftis N (2014)	1
HSPA8	4	ASNA1	2	biochemical	Kristensen AR (2012)	1
UBQLN1	1	DNAJB2	0	pull down	Heir R (2006)	1
CSNK2A1	15	HSPA4	3	enzymatic study	Muller P (2012)	1
TRAF2	1	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Yang Y (2013), Elliott PR (2016), Wu GR (2017)	7
CYLD	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, pull down	Almeida S (2008), Bremm A (2010), Komander D (2009), Kwasna D (2018)	4
DNAJB2	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNAJB2	0	PJA1	1	affinity chromatography technology	Huttlin EL (2015)	1
ESRRB	1	DNAJB2	0	affinity chromatography technology	Li J (2013)	1
FBXO25	1	HSPA8	4	affinity chromatography technology	Teixeira FR (2010)	1
UBQLN1	1	ATXN3	2	pull down	Heir R (2006)	1
UBQLN1	1	PSMA6	1	affinity chromatography technology	Lim PJ (2009)	1
UBC	7	PJA1	1	affinity chromatography technology	Matsumoto M (2005)	1
ATXN3	2	HSPA8	4	affinity chromatography technology	Kristensen LV (2018)	1
DNAJB2	0	MORF4L1	1	affinity chromatography technology	Huttlin EL (2015)	1
CYLD	2	TARDBP	4	affinity chromatography technology	Elliott PR (2016)	1
UBC	7	PSMA6	1	affinity chromatography technology	Matsumoto M (2005)	1
DNAJB2	0	PSMA6	1	affinity chromatography technology	Westhoff B (2005)	1
SMAD4	9	DNAJB2	0	two hybrid	Colland F (2004)	1
CYLD	2	PSMA6	1	affinity chromatography technology	Elliott PR (2016)	1
DNAJB2	0	CTSA	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNAJB2	0	LACC1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNAJB2	0	TARDBP	4	affinity chromatography technology	Chen HJ (2016)	1
DNAJB2	0	ATP7B	7	affinity chromatography technology	Huttlin EL (2015)	1
CFTR	5	TARDBP	4	affinity chromatography technology	Pankow S (2015)	1
HDAC11	0	DNAJB2	0	affinity chromatography technology	Joshi P (2013)	1
ATXN3	2	UBB	4	affinity chromatography technology, affinity chromatography technology	Kristensen LV (2018), Kristensen LV (2018)	2
HSPA8	4	UBC	7	two hybrid	Stelzl U (2005)	1
UBC	7	TRO	1	affinity chromatography technology	Matsumoto M (2005)	1
DNAJB2	0	RNF115	1	affinity chromatography technology	Huttlin EL (2015)	1
ESRRB	1	HSPA8	4	affinity chromatography technology	Li J (2013)	1
TRAF2	1	MAP3K1	4	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Baud V (1999), Baud V (1999), Wu Y (2006), Charlaftis N (2014), Chen TC (2014)	5
PSMA6	1	TARDBP	4	biochemical	Havugimana PC (2012)	1
TARDBP	4	HSPA8	4	affinity chromatography technology	Freibaum BD (2010)	1
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
DNAJB2	0	ATP7A	0	affinity chromatography technology	Huttlin EL (2015)	1
TARDBP	4	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang YJ (2010), Freibaum BD (2010), Chen HJ (2016)	3
DNAJB2	0	KCTD3	2	affinity chromatography technology	Huttlin EL (2015)	1
CYLD	2	UBQLN1	1	affinity chromatography technology	Elliott PR (2016)	1
UBB	4	UBQLN1	1	two hybrid	Rolland T (2014)	1
CYLD	2	HSPA8	4	affinity chromatography technology	Elliott PR (2016)	1
HSPA4	3	DNAJB8	0	imaging technique	Nillegoda NB (2017)	1
DNAJB2	0	CYHR1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXO25	1	UBQLN1	1	enzymatic study	Teixeira FR (2013)	1
DNAJB2	0	ARFGEF2	9	affinity chromatography technology	Huttlin EL (2015)	1
DNAJB2	0	RLIM	1	affinity chromatography technology	Huttlin EL (2017)	1
RNF19B	0	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
FBXO25	1	DNAJB2	0	enzymatic study	Teixeira FR (2013)	1
HSPA4	3	HSPA8	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical	Hidalgo-de-Quintana J (2008), Havugimana PC (2012), Taipale M (2014), Taipale M (2014), Wan C (2015)	5
DNAJB8	0	DNAJB2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNAJB2	0	ASNA1	2	affinity chromatography technology	Huttlin EL (2015)	1
DNAJB2	0	ATXN3	2	affinity chromatography technology	Gao XC (2011)	1
HSPA8	4	DNAJB6	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
TARDBP	4	DNAJB6	3	affinity chromatography technology	Freibaum BD (2010)	1
CTSA	2	GLB1	3	affinity chromatography technology	Boldt K (2016)	1
HDAC11	0	DNAJB6	3	affinity chromatography technology	Joshi P (2013)	1
CFTR	5	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goldstein RF (2007), Goldstein RF (2007), Sun F (2008), Schmidt BZ (2009), Rosser MF (2008), Pankow S (2015)	6
CSNK2A1	15	DNAJB2	0	enzymatic study	Ottaviani D (2017)	1
RNF115	1	UBC	7	two hybrid, pull down, protein complementation assay, pull down	Amemiya Y (2008), Amemiya Y (2008), Amemiya Y (2008), Amemiya Y (2008)	4
RHO	3	HSPA4	3	affinity chromatography technology	Chapple JP (2003)	1
PJA1	1	ATXN3	2	enzymatic study	Loch CM (2012)	1
RHO	3	DNAJB2	0	imaging technique, affinity chromatography technology, affinity chromatography technology	Chapple JP (2003), Chapple JP (2003), Chapple JP (2003)	3
UBC	7	UBQLN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, two hybrid, pull down, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Matsumoto M (2005), Ko HS (2004), Ko HS (2004), Sokratous K (2012), Raasi S (2005), Raasi S (2005), Massey LK (2004), Ko HS (2004), Ko HS (2004), Rolland T (2014), Castaneda CA (2013), Nakayasu ES (2013), Nakayasu ES (2013), Kristariyanto YA (2015), Kristariyanto YA (2015), Kurlawala Z (2017)	16
ESRRB	1	DNAJB8	0	affinity chromatography technology	Li J (2013)	1
UBQLN1	1	TARDBP	4	two hybrid, pull down	Kim SH (2009), Kim SH (2009)	2
MAP3K1	4	DNAJB6	3	enzymatic study	Charlaftis N (2014)	1
UBC	7	RNF19B	0	affinity chromatography technology	Matsumoto M (2005)	1
DNAJB2	0	TRO	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATXN3	2	UBC	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, imaging technique, enzymatic study, pull down	Winborn BJ (2008), Mao Y (2005), Berke SJ (2005), Matsumoto M (2005), Bremm A (2010), Nicastro G (2010), Nicastro G (2010), Donaldson KM (2003), Chai Y (2004), Chai Y (2004), Nathan JA (2013), Seki T (2013), Yang H (2014), Yang H (2014), Blount JR (2014), Evers MM (2013), Weeks SD (2011), Donaldson KM (2003), Winborn BJ (2008), Faggiano S (2015), Wauer T (2015), Satoh T (2014), Satoh T (2014), Zhang X (2017), Toonen LJA (2017), Toonen LJA (2017), Kwasna D (2018)	27
CYLD	2	DNAJB2	0	affinity chromatography technology	Elliott PR (2016)	1
UBC	7	CSNK2A1	15	affinity chromatography technology	Matsumoto M (2005)	1
MORF4L1	1	HSPA4	3	affinity chromatography technology	Hayakawa T (2007)	1
DNAJB2	0	GLB1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNAJB2	0	UBC	7	affinity chromatography technology, pull down, two hybrid	Westhoff B (2005), Fenner BJ (2009), Westhoff B (2005)	3
CFTR	5	DNAJB6	3	affinity chromatography technology	Pankow S (2015)	1
DNAJB2	0	NEK4	5	affinity chromatography technology	Huttlin EL (2015)	1
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
DNAJB2	0	RNF19B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CYLD	2	BIRC2	1	affinity chromatography technology	Elliott PR (2016)	1
DNAJB2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CFTR	5	DNAJB2	0	affinity chromatography technology	Pankow S (2015)	1
DNAJB6	3	DNAJB2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	DNAJB6	3	affinity chromatography technology	Matsumoto M (2005)	1
ESRRB	1	DNAJB6	3	affinity chromatography technology	Li J (2013)	1
MAP3K1	4	ATXN3	2	enzymatic study	Charlaftis N (2014)	1
CYLD	2	DNAJB6	3	affinity chromatography technology	Elliott PR (2016)	1
DNAJB2	0	HSPA8	4	affinity chromatography technology	Westhoff B (2005)	1
DNAJB2	0	FAM83H	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAP3K1	4	DNAJB2	0	enzymatic study	Charlaftis N (2014)	1
DNAJB2	0	UBB	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNAJB2	0	HSPA4	3	affinity chromatography technology, imaging technique, pull down	Gao XC (2011), Nillegoda NB (2017), Gao XC (2012)	3