Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
HSD11B1 3290 CHEMBL1161866 CHEMBL1161866 DrugBank 17139284, 17016423, 9141556, 8585102
HSD11B1 3290 PREDNISONE CHEMBL635 ligand DrugBank 20634231
HSD11B1 3290 CARBENOXOLONE CHEMBL499915 inhibitor DrugBank 11752352
HSD11B1 3290 CORTICOSTERONE CHEMBL110739 DrugBank 10592235
HSD11B1 3290 PHENYLARSINE OXIDE CHEMBL477683 inhibitor TdgClinicalTrial, DrugBank, TTD
HSD11B1 3290 CHEMBL218006 CHEMBL218006 DrugBank 10592235
HSD11B1 3290 CHEMBL2153191 CHEMBL2153191 inhibitor GuideToPharmacologyInteractions
HSD11B1 3290 CHEMBL427896 CHEMBL427896 DrugBank 10592235
HSD11B1 3290 CHEMBL453620 CHEMBL453620 DrugBank 10592235
HSD11B1 3290 CHEMBL392452 CHEMBL392452 DrugBank 10592235
HSD11B1 3290 CHEMBL495597 CHEMBL495597 DrugBank 10592235
HSD11B1 3290 CHEMBL460962 CHEMBL460962 DrugBank 10592235
HSD11B1 3290 CHEMBL2177609 CHEMBL2177609 inhibitor GuideToPharmacologyInteractions, TTD
HSD11B1 3290 CHEMBL1161862 CHEMBL1161862 DrugBank 17139284, 17016423
HSD11B1 3290 CHEMBL406572 CHEMBL406572 DrugBank 10592235
HSD11B1 3290 CHEMBL455907 CHEMBL455907 DrugBank 10592235
HSD11B1 3290 CHEMBL222670 CHEMBL222670 inhibitor GuideToPharmacologyInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
HSD11B1 rs846908 AA tacrolimus metabolism/PK yes In patients who are CYP3A5 expressers (CYP3A5 *1/*1 or *1/*3). This variant is in strong linkage disequilibrium with rs846910 and rs4844880, and the AA-AA-AA haplotype for these three SNPs is also associated with decreased dose-adjusted trough concentrations of tacrolimus as compared to all other haplotypes (p=0.0367). Genotype AA is associated with decreased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to genotypes AG + GG. 25587129 1444935858
HSD11B1 rs4844880 AA tacrolimus metabolism/PK yes In patients who are CYP3A5 expressers (CYP3A5 *1/*1 or *1/*3). This variant is in strong linkage disequilibrium with rs846910 and rs846908, and the AA-AA-AA haplotype for these three SNPs is also associated with decreased dose-adjusted trough concentrations of tacrolimus as compared to all other haplotypes (p=0.0367). Genotype AA is associated with decreased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to genotypes AT + TT. 25587129 1444935875
HSD11B1 rs846910 AA tacrolimus metabolism/PK yes In patients who are CYP3A5 expressers (CYP3A5 *1/*1 or *1/*3). This variant is in strong linkage disequilibrium with rs846908 and rs4844880, and the AA-AA-AA haplotype for these three SNPs is also associated with decreased dose-adjusted trough concentrations of tacrolimus as compared to all other haplotypes (p=0.0367). Genotype AA is associated with decreased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to genotypes AG + GG. 25587129 1444935867