PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RNF31	3	UBE2D1	0	pull down, pull down	Nakamura M (2006), Kirisako T (2006)	2
BIRC2	1	MAP3K2	1	enzymatic study	Takeda AN (2014)	1
TRIM25	5	MAVS	1	affinity chromatography technology	Liu B (2017)	1
BIRC2	1	TSGA10	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TRAF6	0	BCL10	0	affinity chromatography technology	Bidere N (2006)	1
UBA1	1	UBE2L6	0	enzymatic study	Kumar S (1997)	1
EGLN3	0	GSPT1	3	affinity chromatography technology	Rodriguez J (2016)	1
TRIM25	5	JUP	7	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
FAM19A3	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
RHOA	0	RIPK4	0	two hybrid	Gebbink MF (1997)	1
RNF181	0	UBE2N	1	pull down	Pedersen SM (2015)	1
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
EGLN3	0	USP7	14	affinity chromatography technology	Rodriguez J (2016)	1
CD40LG	0	BIRC3	1	affinity chromatography technology	Salzmann S (2013)	1
CASP10	1	CASP2	1	enzymatic study	Srinivasula SM (1996)	1
FBXO7	1	GSK3B	1	enzymatic study, affinity chromatography technology, pull down	Teixeira FR (2016), Teixeira FR (2016), Teixeira FR (2016)	3
CASP3	0	CASP7	1	enzymatic study	Walsh JG (2008)	1
TNFSF14	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Kuai J (2003), Kuai J (2003)	2
TRAF3	1	DCAF7	4	affinity chromatography technology	van Zuylen WJ (2012)	1
SPINK7	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
SH3KBP1	1	RAF1	3	affinity chromatography technology	Sato S (2013)	1
CASP10	1	RIPK1	2	affinity chromatography technology	Chaudhary PM (2000)	1
TRIM25	5	RABGEF1	1	affinity chromatography technology	Choudhury NR (2017)	1
UBA1	1	UBE2B	3	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Wauer T (2015), Kumar B (2010), Huguenin-Dezot N (2016)	5
EGLN3	0	ADRM1	4	affinity chromatography technology	Rodriguez J (2016)	1
BIRC5	1	CASP3	0	pull down, enzymatic study, pull down	Tamm I (1998), Shin S (2001), Shin S (2001)	3
BIRC2	1	NFKB2	3	affinity chromatography technology	Goncharov T (2013)	1
TNFRSF1A	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Won M (2010), Zilberman-Rudenko J (2016), Moquin DM (2013)	3
TRIM25	5	MAP3K2	1	affinity chromatography technology	Choudhury NR (2017)	1
LTBR	0	RNF31	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNF	0	TNFAIP3	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skaug B (2011), Tokunaga F (2012), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	5
TNFRSF1A	3	TRAF3	1	pull down	Mosialos G (1995)	1
CASP8	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (2000), Oshima S (2009), Bertrand MJ (2008), Knox PG (2011), Kim S (2010), Cheung HH (2009), Tenev T (2011), Tenev T (2011), Mahul-Mellier AL (2011), Legarda-Addison D (2009), Biton S (2011), Bellail AC (2012), Bellail AC (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Puliyappadamba VT (2013), Wu P (2014), Wu P (2014), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Moquin DM (2013), Ranjan K (2016), Zinngrebe J (2016), Nakazawa S (2016), Zheng M (2016)	27
UBE2B	3	UBR4	15	affinity chromatography technology	Hong JH (2015)	1
UBR5	13	UBE2D3	1	pull down	Honda Y (2002)	1
TRIM25	5	PCSK9	3	affinity chromatography technology	Choudhury NR (2017)	1
UBA1	1	UBE2J1	1	pull down	Jin J (2007)	1
TOMM20	0	UBC	7	imaging technique	Michel MA (2017)	1
UBC	7	DHX9	3	affinity chromatography technology	Matsumoto M (2005)	1
RIPK1	2	BIRC2	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Xu M (2009), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Fu J (2016), Vu NT (2016), Vu NT (2016)	12
TLR3	2	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Cusson-Hermance N (2005), Zinngrebe J (2016)	2
TNFRSF1A	3	UBC	7	affinity chromatography technology	Nakazawa S (2016)	1
RNF31	3	TRAF2	1	affinity chromatography technology	Schaeffer V (2014)	1
TOLLIP	3	TRAF6	0	affinity chromatography technology	Lee JY (2009)	1
FBXO7	1	UBE2D1	0	pull down	Teixeira FR (2016)	1
EGLN3	0	UBR4	15	affinity chromatography technology	Rodriguez J (2016)	1
DIABLO	2	BIRC5	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down	Song Z (2003), Song Z (2003), McNeish IA (2005), Pavlyukov MS (2011), Pavlyukov MS (2011), Guvenc H (2013), Song Z (2004), Song Z (2004)	8
BIRC2	1	EAF2	1	two hybrid	Rolland T (2014)	1
UBE2D1	0	DZIP3	6	two hybrid, pull down	Markson G (2009), Kreft SG (2003)	2
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
UBXN7	3	USP9X	15	biochemical	Havugimana PC (2012)	1
NFKBIA	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2015)	1
XIAP	0	PGAM5	4	enzymatic study, pull down, affinity chromatography technology	Zhuang M (2013), Zhuang M (2013), Zhuang M (2013)	3
BIRC3	1	TRAF1	0	pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Roy N (1997), Li X (2002), Goncharov T (2013), Chen TC (2014), Greenfeld H (2015)	5
BIRC2	1	UBE2S	2	two hybrid, pull down	Dynek JN (2010), Phu L (2011)	2
E2F1	0	XIAP	0	affinity chromatography technology, affinity chromatography technology	Cartier J (2011), Cao Z (2014)	2
UBR5	13	UBE2L3	1	pull down, pull down	Honda Y (2002), Flack JE (2017)	2
IKBKG	0	NFKBIA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Stempin CC (2011), Pringle LM (2011), Wu CJ (2006), Higashimoto T (2008), Ducut Sigala JL (2004), Shibata Y (2011), Liu L (2002), Xiao G (2000), Chan H (2005), Funakoshi-Tago M (2005), Wu X (2007), Kato T (2008), Niu J (2011), Neumann M (2011), Keusekotten K (2013), Fu J (2013), Dan HC (2008), Criollo A (2010), Hein MY (2015), Baratchian M (2016)	20
GSK3B	1	BIRC2	1	affinity chromatography technology	Sun M (2009)	1
TRAF6	0	ULK1	8	affinity chromatography technology, affinity chromatography technology	Nazio F (2013), Nazio F (2013)	2
IKBKE	2	UBC	7	affinity chromatography technology, pull down, affinity chromatography technology	Rajsbaum R (2014), Paz S (2009), Bharaj P (2016)	3
BCL10	0	UBE2N	1	pull down	Zhou H (2004)	1
LRRN2	2	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
MAVS	1	BIRC3	1	affinity chromatography technology	Mao AP (2010)	1
UBE2N	1	BIRC3	1	two hybrid, pull down, two hybrid	van Wijk SJ (2009), Wu CJ (2006), Schimmack G (2017)	3
GFAP	0	IKBKG	0	two hybrid	Wang J (2011)	1
BIRC2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Goncharov T (2013), Schaeffer V (2014)	2
TRIM25	5	RNF31	3	affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology	Inn KS (2011), Inn KS (2011), Inn KS (2011), Choudhury NR (2017)	4
BIRC3	1	CASP7	1	pull down, affinity chromatography technology	Roy N (1997), Eckelman BP (2006)	2
UBXN1	0	MAVS	1	affinity chromatography technology, affinity chromatography technology	Wang P (2013), Wang P (2013)	2
IKBKE	2	TRAF3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ng MH (2011), Charoenthongtrakul S (2013), Peng Y (2014), Gu L (2017), Fang R (2017)	5
TNFRSF1A	3	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moquin DM (2013), Nakazawa S (2016), Elliott PR (2016)	3
HSP90B1	3	BIRC2	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Didelot C (2008), Didelot C (2008), Didelot C (2008), Didelot C (2008), Didelot C (2008)	5
RIPK1	2	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wright A (2007), Nagabhushana A (2011), ODonnell MA (2012), Wu GR (2017)	4
CD40	3	RNF31	3	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
TANK	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Li S (2011), Goncharov T (2013)	2
EGFR	5	VPS4B	3	affinity chromatography technology	Tong J (2014)	1
UBE2L3	1	NFKBIA	0	enzymatic study	Gonen H (1999)	1
UBC	7	TOLLIP	3	pull down, pull down, pull down, biochemical, pull down, pull down, pull down, pull down	Fenner BJ (2009), Nathan JA (2013), Mitra S (2013), Mitra S (2013), Shih SC (2003), Lu K (2014), Lu K (2014), Zhang X (2017)	8
ILF3	5	JUP	7	biochemical	Havugimana PC (2012)	1
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
MAP3K14	1	TRAF1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Luftig MA (2001), Zheng C (2010), Song HY (1997), Liao G (2004), Choudhary S (2013), Choudhary S (2013)	6
IKBKE	2	BIRC2	1	affinity chromatography technology, enzymatic study	Zhou AY (2013), Zhou AY (2013)	2
TNFSF14	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Kuai J (2003), Kuai J (2003)	2
IKBKE	2	TANK	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nomura F (2000), Nomura F (2000), Nomura F (2000), Gatot JS (2007), Renner F (2011), Shen RR (2012), Ryzhakov G (2007), So J (2015)	8
UBE2D1	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
XIAP	0	RIPK2	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Bertrand MJ (2011), Damgaard RB (2012), Krieg A (2009), Krieg A (2009), Krieg A (2009), Conde C (2012), Damgaard RB (2013), Damgaard RB (2013), Rolland T (2014)	9
OTUB1	0	MAVS	1	affinity chromatography technology	Li S (2010)	1
TRIM25	5	UBA1	1	affinity chromatography technology	Pauli EK (2014)	1
RIPK4	0	PRDX3	3	affinity chromatography technology	Rodriguez J (2016)	1
BIRC2	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hu S (2003), Dynek JN (2010), Dynek JN (2010), Xu M (2009), Phu L (2011), Oberoi TK (2012), Bertrand MJ (2011), Guicciardi ME (2014), Takeda AN (2014), Wauer T (2015), Vu NT (2016)	11
RIPK4	0	RAF1	3	affinity chromatography technology	Rodriguez J (2016)	1
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
EGLN3	0	MAGEA11	1	affinity chromatography technology	Aprelikova O (2009)	1
TRIM32	2	UBE2D1	0	affinity chromatography technology, pull down, pull down, pull down, pull down	Napolitano LM (2011), Zhang J (2012), Streich FC (2013), Albor A (2006), Mokhonova EI (2015)	5
TNFAIP3	3	TRAF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Song HY (1996), Song HY (1996), Heyninck K (1999), Greenfeld H (2015), Greenfeld H (2015)	5
CYLD	2	JUP	7	affinity chromatography technology	Elliott PR (2016)	1
TRAF2	1	RIPK3	2	affinity chromatography technology	Yu PW (1999)	1
BIRC3	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014)	4
EGLN3	0	RAC1	7	affinity chromatography technology	Rodriguez J (2016)	1
RIPK2	0	RIPK1	2	affinity chromatography technology	Damgaard RB (2012)	1
BIRC2	1	TUFT1	1	two hybrid	Yu H (2011)	1
CYLD	2	USP15	4	affinity chromatography technology	Elliott PR (2016)	1
CD27	1	TRAF1	0	affinity chromatography technology	Yamamoto H (1998)	1
BIRC2	1	GAP43	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D1	0	RNF181	0	two hybrid, pull down, pull down	van Wijk SJ (2009), Brophy TM (2008), Pedersen SM (2015)	3
BIRC2	1	CSE1L	1	affinity chromatography technology, enzymatic study	Monian P (2016), Monian P (2016)	2
EGFR	5	USP9X	15	affinity chromatography technology	Foerster S (2013)	1
GLMN	2	BIRC2	1	affinity chromatography technology, pull down	Suzuki S (2017), Suzuki S (2017)	2
RIPK4	0	UBA1	1	affinity chromatography technology	Rodriguez J (2016)	1
MAVS	1	RNF31	3	affinity chromatography technology	Khan M (2016)	1
USP15	4	TRAF6	0	enzymatic study	Bremm A (2010)	1
UBR5	13	UBE2B	3	pull down	Honda Y (2002)	1
ADRM1	4	UBC	7	x-ray crystallography, pull down, two hybrid, pull down, pull down, x-ray crystallography, pull down	Schreiner P (2008), Hennig J (2012), Husnjak K (2008), Sahtoe DD (2015), Chen X (2016), Chen X (2016), Zhang X (2017)	7
EGFR	5	HSP90B1	3	protein complementation assay, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Lavictoire SJ (2003), Yao Z (2017)	3
IKBKE	2	TRAF2	1	enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Shen RR (2012), Shen RR (2012), Shen RR (2012), Zhang W (2010), Zhou AY (2013), Zhou AY (2013), So J (2015), Fang R (2017)	8
BIRC2	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
EGFR	5	IKBKG	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
TANK	1	CD40	3	affinity chromatography technology	Qiao G (2007)	1
OTUB1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Li S (2010), Peng Y (2014)	2
UBXN1	0	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Wu-Baer F (2010), Fenner BJ (2009), Alexandru G (2008), LaLonde DP (2011), McNeill H (2004), Zhang X (2017)	6
TRAF1	0	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Greenfeld H (2015), Huttlin EL (2017)	3
CD27	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TANK	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, pull down	Wang W (2015), Wang W (2015), Wang W (2015)	3
RIPK2	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Hasegawa M (2008)	2
NOD2	1	TNFAIP3	3	affinity chromatography technology	Draber P (2015)	1
UBXN7	3	BIRC2	1	affinity chromatography technology	Alexandru G (2008)	1
EGFR	5	XIAP	0	affinity chromatography technology	Yao Z (2017)	1
UBE2V1	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
RAC1	7	BIRC2	1	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Oberoi TK (2012), Oberoi TK (2012), Marivin A (2013), Woolery AR (2014), Woolery AR (2014)	5
TRAF2	1	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Yang Y (2013), Elliott PR (2016), Wu GR (2017)	7
BIRC3	1	BIRC5	1	pull down	Dohi T (2004)	1
UBA1	1	UBE2D3	1	enzymatic study, pull down, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Song AX (2014), Huguenin-Dezot N (2016)	4
BIRC3	1	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, imaging technique	Deveraux QL (1998), Deveraux QL (1998), Eckelman BP (2006), Cheung HH (2006), Wang J (2011), McDonald ER (2004), Chen TC (2014)	7
CYLD	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, pull down	Almeida S (2008), Bremm A (2010), Komander D (2009), Kwasna D (2018)	4
UBA1	1	UBE2W	0	pull down, enzymatic study, enzymatic study	Jin J (2007), Wauer T (2015), Huguenin-Dezot N (2016)	3
DNAJB2	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TOLLIP	3	DIABLO	2	affinity chromatography technology	Li S (2011)	1
BIRC2	1	RIPK3	2	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
TMEM9B	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
RHOA	0	BIRC2	1	pull down	Marivin A (2013)	1
BIRC5	1	CASP9	6	affinity chromatography technology, imaging technique	OConnor DS (2000), Chen TC (2014)	2
BIRC2	1	IGF2BP1	2	affinity chromatography technology, affinity chromatography technology, unspecified method	Graber TE (2010), Graber TE (2010), Faye MD (2015)	3
BCL10	0	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Yoneda T (2000), Yoneda T (2000), Yoneda T (2000), Yui D (2001), Rolland T (2014)	5
TNFRSF12A	0	TRAF2	1	pull down	Wiley SR (2001)	1
UBE2D2	0	TRIM25	5	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Markson G (2009), Nakajima A (2007), Ronchi VP (2012), Sanchez JG (2016), Choudhury NR (2017)	5
BIRC5	1	USP9X	15	affinity chromatography technology	Vong QP (2005)	1
EGLN3	0	GLMN	2	affinity chromatography technology	Rodriguez J (2016)	1
CBLC	1	UBE2D2	0	pull down, pull down	Ryan PE (2010), Kim M (2004)	2
XIAP	0	CASP7	1	pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Tenev T (2005), Paulsen M (2008), Huang Y (2001), Huang Y (2001), Chai J (2001), Chai J (2001), Huang Y (2003), Huang Y (2003), Sun M (2009), Takahashi R (1998), Lee JS (2012), Lin YF (2013), Lin YF (2013), Hou Y (2017)	20
CBLC	1	EGFR	5	affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, x-ray crystallography	Kim M (1999), Keane MM (1999), Keane MM (1999), Takeshita K (2012), Takeshita K (2012), Takeshita K (2012)	6
EGLN3	0	MRE11	3	affinity chromatography technology	Rodriguez J (2016)	1
UBC	7	E2F1	0	affinity chromatography technology	Rizos H (2007)	1
DHX9	3	ILF3	5	biochemical, affinity chromatography technology	Havugimana PC (2012), Chu L (2012)	2
TRAF2	1	XIAP	0	affinity chromatography technology	Vince JE (2009)	1
TNF	0	CYLD	2	affinity chromatography technology, affinity chromatography technology	Draber P (2015), Schlicher L (2016)	2
TLR3	2	TRAF3	1	affinity chromatography technology	Li S (2011)	1
RABGEF1	1	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
IKBKG	0	TRAF3	1	affinity chromatography technology	Belgnaoui SM (2012)	1
EGFR	5	MAP3K14	1	affinity chromatography technology	Habib AA (2001)	1
USP15	4	UBE2S	2	enzymatic study	Bremm A (2010)	1
TRAF1	0	RNF31	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	6
TRAF2	1	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Li S (2011), Huttlin EL (2017)	3
BIRC3	1	DCAF7	4	affinity chromatography technology	Goncharov T (2013)	1
BIRC2	1	UBE2Q2	4	two hybrid	Dynek JN (2010)	1
PCSK9	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Xu W (2012), Xu W (2012), Xu W (2012), Xu W (2012), Xu W (2012)	5
TRAF6	0	XIAP	0	affinity chromatography technology, two hybrid, imaging technique	Sanna MG (2002), Woodsmith J (2012), Chen TC (2014)	3
EGLN3	0	CDC42	3	affinity chromatography technology	Rodriguez J (2016)	1
USP7	14	HTRA2	1	two hybrid	Lim J (2006)	1
TRAF3	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakhaei P (2009), Arnaud N (2011), Paz S (2011), Wang Y (2012), Saha SK (2006), Saha SK (2006), Ng MH (2011), Johnsen IB (2009), van Zuylen WJ (2012), Belgnaoui SM (2012), Chen X (2014), Wang P (2013), Wang P (2013), Minassian A (2015), Gu L (2017), Khan M (2016), Fang R (2017), Fang R (2017)	18
UBXN7	3	UBR5	13	affinity chromatography technology	Alexandru G (2008)	1
USP15	4	USP7	14	enzymatic study	Loch CM (2012)	1
EGLN3	0	BIRC3	1	affinity chromatography technology	Fu J (2016)	1
IKBKG	0	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Brummelkamp TR (2003), Trompouki E (2003), Chu L (2006), Shibata Y (2012), Wang J (2011), Zilberman-Rudenko J (2016), Zilberman-Rudenko J (2016)	11
VPS4B	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BIRC2	1	C19orf44	1	affinity chromatography technology	Huttlin EL (2017)	1
FAM19A3	0	TRAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
NFKBIA	0	RHOA	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBXN1	0	USP9X	15	biochemical	Havugimana PC (2012)	1
TOLLIP	3	BIRC2	1	affinity chromatography technology	Li S (2011)	1
XIAP	0	CASP10	1	two hybrid, affinity chromatography technology	Rolland T (2014), McDonald ER (2004)	2
TNFRSF1A	3	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
RNF181	0	UBC	7	enzymatic study	Pedersen SM (2015)	1
EGFR	5	MAP3K3	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
CYLD	2	UBE2S	2	enzymatic study	Bremm A (2010)	1
BIRC2	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
BIRC2	1	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
USP7	14	UBE2S	2	enzymatic study	Bremm A (2010)	1
TLR3	2	TOLLIP	3	affinity chromatography technology	Li S (2011)	1
UBE2D1	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
UBR5	13	GSPT1	3	affinity chromatography technology	Su H (2011)	1
CLEC11A	0	XIAP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNFRSF1A	3	CASP2	1	affinity chromatography technology	Duan H (1997)	1
USP7	14	TRAF6	0	pull down, affinity chromatography technology, enzymatic study	Zapata JM (2001), Daubeuf S (2009), Bremm A (2010)	3
TRAF1	0	HTRA2	1	affinity chromatography technology	Greenfeld H (2015)	1
TNF	0	NFKBIA	0	enzymatic study	Rodriguez MS (1995)	1
FSD1	3	UBE2D2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BIRC3	1	CASP3	0	pull down, affinity chromatography technology	Roy N (1997), Rajalingam K (2006)	2
UBC	7	RHOA	0	affinity chromatography technology	Huang G (2014)	1
IKBKG	0	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Zhao T (2007), Zhou AY (2013)	2
E2F1	0	BIRC3	1	affinity chromatography technology	Cartier J (2011)	1
ILF3	5	MAGEA11	1	two hybrid	Rual JF (2005)	1
TRIM25	5	FBXO7	1	affinity chromatography technology	Choudhury NR (2017)	1
UBC	7	UBR4	15	affinity chromatography technology, pull down, affinity chromatography technology	Matsumoto M (2005), Nathan JA (2013), Bish RA (2007)	3
CASP10	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
UBE2L6	0	CBLC	1	two hybrid	Markson G (2009)	1
TNFAIP3	3	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Song HY (1996), Song HY (1996), Fries KL (1999), Yamaguchi N (2013), Rolland T (2014)	5
TNFAIP3	3	BIRC3	1	affinity chromatography technology	Yamaguchi N (2013)	1
DHX9	3	USP7	14	biochemical	Wan C (2015)	1
BIRC3	1	USP7	14	affinity chromatography technology	Goncharov T (2013)	1
CASP8	1	XIAP	0	genetic interference, affinity chromatography technology, affinity chromatography technology	Guo Y (2002), Lee JS (2012), McDonald ER (2004)	3
TRAF6	0	IKBKE	2	affinity chromatography technology	Fang R (2017)	1
RAC1	7	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Oberoi TK (2012), Oberoi TK (2012), Woolery AR (2014), Woolery AR (2014), Fujita M (2015)	5
CASP8	1	CASP7	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
BIRC2	1	CASP3	0	pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology	Roy N (1997), Choi YE (2009), Choi YE (2009), Clem RJ (2001), Rajalingam K (2006)	5
CASP8	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
BIRC3	1	RIPK2	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Thome M (1998), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	6
TNFSF12	0	BIRC2	1	affinity chromatography technology	Goncharov T (2013)	1
TNF	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Yamaguchi N (2015)	2
CYLD	2	TRAF6	0	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Bremm A (2010), Wu J (2015), Wu J (2015)	4
UBE2V1	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
TOMM20	0	TRAF6	0	affinity chromatography technology	Murata H (2013)	1
LTBR	0	TRAF3	1	affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	VanArsdale TL (1997), Wu MY (1999), Marsters SA (1997), Sanjo H (2010), Sanjo H (2010), Mosialos G (1995), Li C (2003), Li C (2003), Force WR (1997), Force WR (1997), Huttlin EL (2015), Huttlin EL (2017)	12
EGFR	5	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soubeyran P (2002), Szymkiewicz I (2002), Schmidt MH (2004), Schmidt MH (2003), Ronning SB (2011), Ronning SB (2011), Yang S (2006), Schmidt MH (2003)	8
BIRC7	0	UBC	7	x-ray crystallography	Dou H (2012)	1
TANK	1	TRAF2	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, unspecified method	Bouwmeester T (2004), Rothe M (1996), Rothe M (1996), Nomura F (2000), Nomura F (2000), Pomerantz JL (1999), Behrends C (2010), Li S (2011), Li S (2011), Li C (2002), Shen RR (2012), Shen RR (2012), Wang J (2011), Huttlin EL (2017), Kim CM (2017)	15
BIRC2	1	PACS2	9	enzymatic study, affinity chromatography technology, pull down	Guicciardi ME (2014), Guicciardi ME (2014), Guicciardi ME (2014)	3
BIRC2	1	DHX9	3	affinity chromatography technology, affinity chromatography technology	Graber TE (2010), Graber TE (2010)	2
ADAMTS4	1	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
BIRC3	1	IKBKE	2	enzymatic study	Zhou AY (2013)	1
UBC	7	UBE2B	3	affinity chromatography technology, affinity chromatography technology	Bish RA (2007), Hong JH (2015)	2
TNF	0	CASP8	1	affinity chromatography technology	Fritsch J (2014)	1
BIRC3	1	CASP8	1	affinity chromatography technology, affinity chromatography technology	McDonald ER (2004), Zinngrebe J (2016)	2
CASP10	1	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011)	9
TRAF6	0	CASP8	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Bidere N (2006), Bidere N (2006), He L (2006), He L (2006), Zinngrebe J (2016)	5
TNFRSF1A	3	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Shu HB (1996), Vince JE (2009), Mahul-Mellier AL (2011), Won M (2010), Kolliputi N (2009), Park KJ (2002), Lee IT (2010), Kim WJ (2005), Zheng L (2006), Vince JE (2007), Jeon J (2014), Chen TC (2014), Lee CK (2015), Jeong M (2017)	16
BIRC2	1	GFAP	0	two hybrid	Rolland T (2014)	1
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
BIRC3	1	DZIP3	6	two hybrid	Woodsmith J (2012)	1
TRIM25	5	DHX9	3	affinity chromatography technology	Choudhury NR (2017)	1
DHX9	3	ILF2	3	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
AIMP2	0	TRAF2	1	affinity chromatography technology, two hybrid, two hybrid	Choi JW (2009), Choi JW (2009), Choi JW (2009)	3
TNF	0	CDC42	3	affinity chromatography technology	Kuai J (2004)	1
IKBKG	0	BCL10	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wu CJ (2008), Wu CJ (2008), Bhattacharyya S (2010), Stilo R (2004), Poyet JL (2001), Poyet JL (2001), Park Y (2013), Zhou H (2004), Yang YK (2016)	9
TNFSF12	0	TRAF2	1	affinity chromatography technology	Goncharov T (2013)	1
EGFR	5	RAF1	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
EGFR	5	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
MAVS	1	TRAF1	0	affinity chromatography technology	Minassian A (2015)	1
EGFR	5	TNFRSF1A	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
BIRC2	1	CSTF2T	4	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
UBC	7	UBA1	1	affinity chromatography technology, unspecified method, x-ray crystallography, biochemical, affinity chromatography technology, pull down	Nicassio F (2007), Zhao B (2012), Schaefer A (2014), Schaefer A (2014), Bish RA (2007), Zhang X (2017)	6
GSK3B	1	MAP3K2	1	affinity chromatography technology	Greenblatt MB (2016)	1
BIRC2	1	TRIM34	1	two hybrid	Woodsmith J (2012)	1
RIPK1	2	BIRC3	1	affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Wu CJ (2006)	8
TNF	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006), Tokunaga F (2012), Verhelst K (2012), Draber P (2015), Pescatore A (2016)	6
UBXN7	3	UBR4	15	affinity chromatography technology	Alexandru G (2008)	1
BIRC3	1	RIPK4	0	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
UBR5	13	UBC	7	pull down, x-ray crystallography, pull down	Kozlov G (2007), Kozlov G (2007), Zhang X (2017)	3
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
XIAP	0	RIPK4	0	pull down, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011)	2
TNFAIP3	3	UBE2N	1	pull down	Wertz IE (2004)	1
TNF	0	UBE2N	1	genetic interference, affinity chromatography technology	Deng L (2000), Fritsch J (2014)	2
BIRC2	1	USP15	4	affinity chromatography technology	Goncharov T (2013)	1
HTRA2	1	XIAP	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, unspecified method, pull down	Hegde R (2003), Verhagen AM (2002), Hao Y (2004), Sekine K (2005), Vucic D (2002), van Loo G (2002), Seong YM (2004), Seong YM (2004), Martins LM (2002), Martins LM (2002), Suzuki Y (2001), Suzuki Y (2001), Hegde R (2002), Plun-Favreau H (2007), Singh N (2014), Singh N (2014), Singh N (2014)	17
PACS2	9	TRAF2	1	pull down	Guicciardi ME (2014)	1
UBE2S	2	IGF2BP1	2	affinity chromatography technology	Hu L (2017)	1
UBE2D1	0	TRIM25	5	two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Gack MU (2007), Wang Y (2014), Ronchi VP (2012), Wang S (2016)	5
BIRC3	1	WDR1	3	affinity chromatography technology	Goncharov T (2013)	1
TNFRSF1A	3	TNF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Bouwmeester T (2004), Micheau O (2003), Legler DF (2003), Kuai J (2004), Skaug B (2011), Tokunaga F (2012), Klingseisen L (2012), Thoma B (1990), Keusekotten K (2013), Crowe PD (1994), Liu LS (1998), Higuchi M (1992), Chaturvedi MM (1994), Schaeffer V (2014), Fritsch J (2014), Chainy GB (1996), Huttlin EL (2015), Chen TC (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Huttlin EL (2017), Nielsen FS (2004), Ameloot P (2001)	24
TRIM25	5	ILF3	5	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
EGLN3	0	UBR5	13	affinity chromatography technology	Rodriguez J (2016)	1
TRAF3	1	RIPK2	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Cai X (2013), Cai X (2013), Cai X (2013), Cai X (2013)	4
BIRC2	1	TSG101	1	two hybrid	Dynek JN (2010)	1
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
CASP8	1	CASP9	6	enzymatic study, genetic interference, enzymatic study	Guo Y (2002), Guo Y (2002), Srinivasula SM (1996)	3
UBA1	1	UBE2Q2	4	enzymatic study, enzymatic study	Wauer T (2015), Huguenin-Dezot N (2016)	2
UBXN1	0	CSE1L	1	biochemical	Havugimana PC (2012)	1
UBE2D3	1	DZIP3	6	two hybrid	Markson G (2009)	1
AIMP2	0	UBA1	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
MAP3K14	1	UBC	7	affinity chromatography technology	Sanjo H (2010)	1
CDC42	3	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
RHOA	0	CASP8	1	biochemical	Gajate C (2005)	1
RAF1	3	BIRC7	0	affinity chromatography technology, affinity chromatography technology	Oberoi-Khanuja TK (2012), Oberoi-Khanuja TK (2012)	2
XIAP	0	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
IKBKE	2	NFKBIA	0	enzymatic study	Zhang W (2010)	1
BIRC7	0	HTRA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vucic D (2002), Huttlin EL (2015), Huttlin EL (2017)	3
TRAF6	0	NOD2	1	affinity chromatography technology	Park S (2013)	1
BIRC2	1	USP7	14	affinity chromatography technology	Goncharov T (2013)	1
XIAP	0	BIRC5	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Arora V (2007), Dohi T (2004), Dohi T (2004), Pavlyukov MS (2011)	4
FBXO7	1	UBR5	13	affinity chromatography technology	Teixeira FR (2016)	1
BIRC2	1	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Deveraux QL (1998), Deveraux QL (1998), Eckelman BP (2006), Cheung HH (2006), Kulathila R (2009), Kulathila R (2009), Vucic D (2000), Rolland T (2014), McDonald ER (2004), Chen TC (2014), Vu NT (2016), Vu NT (2016)	12
BIRC2	1	AIMP2	0	affinity chromatography technology	Choi JW (2009)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
BIRC2	1	MXD1	2	enzymatic study, affinity chromatography technology, affinity chromatography technology	Xu L (2007), Xu L (2007), Xu L (2007)	3
OTUB1	0	UBE2N	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Nakada S (2010), Nakada S (2010), Sato Y (2012), Sato Y (2012), Sato Y (2012), Wiener R (2012), Herhaus L (2013), Herhaus L (2015), Scholz CC (2016), Boldt K (2016), Weber E (2017)	12
TNFRSF1A	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1996), Vince JE (2009), Vince JE (2007), Wang YB (2015)	4
TLR3	2	CASP8	1	affinity chromatography technology	Zinngrebe J (2016)	1
BIRC2	1	USP9X	15	affinity chromatography technology	Goncharov T (2013)	1
EGFR	5	ADRM1	4	protein complementation assay	Deribe YL (2009)	1
BIRC3	1	UBE2V1	0	pull down, pull down	Bertrand MJ (2008), Wu CJ (2006)	2
EGLN3	0	BIRC2	1	affinity chromatography technology	Fu J (2016)	1
NFKBIA	0	UBE2D1	0	two hybrid, enzymatic study	Desterro JM (1997), Kroll M (1997)	2
BIRC3	1	UBE2D2	0	x-ray crystallography, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Mace PD (2008), Mace PD (2008), Dynek JN (2010), Feltham R (2011), Dou H (2012), Li X (2002), Schumacher FR (2013), Choi JS (2014), Wu CJ (2006), Fang S (2001), Hu S (2003), Suzuki S (2017)	12
MAVS	1	BIRC2	1	affinity chromatography technology	Mao AP (2010)	1
BIRC2	1	WDYHV1	0	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
TRIM25	5	DCAF7	4	affinity chromatography technology	Choudhury NR (2017)	1
UBE2D3	1	NFKBIA	0	enzymatic study, enzymatic study	Gonen H (1999), Wu K (2010)	2
TRAF2	1	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
BIRC2	1	UBE2L6	0	affinity chromatography technology	Hu S (2003)	1
CD40LG	0	CD40	3	affinity chromatography technology	Salzmann S (2013)	1
NOD2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Damgaard RB (2012), Damgaard RB (2013), Draber P (2015)	3
UBE2N	1	DZIP3	6	two hybrid	Markson G (2009)	1
RNF181	0	BCL10	0	enzymatic study	Pedersen SM (2015)	1
RNF31	3	UBE2D3	1	pull down, pull down, pull down	Inn KS (2011), Tokunaga F (2011), Kirisako T (2006)	3
XIAP	0	XAF1	1	two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Liston P (2001), Liston P (2001), Liston P (2001), Arora V (2007), Tse MK (2012), Ju JH (2013), Ju JH (2013)	7
CYLD	2	ILF3	5	affinity chromatography technology	Elliott PR (2016)	1
CD27	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Yamamoto H (1998), Akiba H (1998), Gravestein LA (1998), Huttlin EL (2015), Huttlin EL (2017)	5
BIRC2	1	ILF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Graber TE (2010), Graber TE (2010), Graber TE (2010)	3
TRAF2	1	FBXO7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuiken HJ (2012), Chen CM (2014), Huttlin EL (2017)	3
UBE2D1	0	XIAP	0	two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Markson G (2009), Hu S (2003), Dynek JN (2010), Morizane Y (2005), Janzer A (2012), Liu WH (2007), Takeda AN (2014), Markson G (2009), Hao Y (2004), Hanson AJ (2012)	10
BIRC2	1	PPM1K	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
EGLN3	0	UBXN1	0	affinity chromatography technology	Rodriguez J (2016)	1
MAP3K3	3	RIPK1	2	affinity chromatography technology	Yang J (2001)	1
IKBKE	2	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Saitoh T (2005)	2
UBA1	1	UBE2L3	1	enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Ronchi VP (2012), Jin J (2007), Liu Z (2014), Nuber U (1996), Huang DT (2009), Kang D (2002), Wauer T (2015), Huguenin-Dezot N (2016)	9
UBE2N	1	RIPK1	2	enzymatic study	Bohgaki M (2008)	1
GPR107	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
TSG101	1	NFKB2	3	affinity chromatography technology	Schlundt A (2009)	1
AIMP2	0	TRAF6	0	affinity chromatography technology	Kim DG (2016)	1
TRIM32	2	UBC	7	enzymatic study, pull down	Streich FC (2013), Zhang X (2017)	2
TNF	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Fritsch J (2014), Yamaguchi N (2015)	7
TNFRSF12A	0	TRAF1	0	pull down	Wiley SR (2001)	1
TRAF3	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013)	2
LPIN3	3	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K14	1	TRAF2	1	pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Luftig MA (2001), Luftig MA (2001), Malinin NL (1997), Malinin NL (1997), Malinin NL (1997), Sanjo H (2010), Kanno Y (2010), Zheng C (2010), Song HY (1997), Liao G (2004), Choudhary S (2013), Lee S (2014), Rolland T (2014)	13
NOD2	1	UBC	7	x-ray crystallography	Ver Heul AM (2013)	1
RNF31	3	RIPK1	2	affinity chromatography technology	Draber P (2015)	1
EGLN3	0	USP9X	15	affinity chromatography technology	Rodriguez J (2016)	1
UBE2S	2	UBE2D3	1	affinity chromatography technology	Kuang P (2016)	1
UBC	7	RABGEF1	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down	Mattera R (2004), La Rosa P (2011), Kalesnikoff J (2007), Penengo L (2006), Sokratous K (2012), Rolland T (2014), Mattera R (2006), Zhang X (2017), Kristariyanto YA (2017)	9
RHOA	0	CASP10	1	biochemical	Gajate C (2005)	1
CD40	3	TRAF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Hostager BS (2010), Hostager BS (2010)	3
UBE2D3	1	TRIM25	5	two hybrid, pull down, pull down, affinity chromatography technology	Markson G (2009), Ronchi VP (2012), Choudhury NR (2017), Choudhury NR (2017)	4
TRIM25	5	RAF1	3	affinity chromatography technology	Choudhury NR (2017)	1
TRAF2	1	ZFAND6	0	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Chang EJ (2011), Chang EJ (2011), Chang EJ (2011), Huttlin EL (2017)	5
BIRC3	1	TANK	1	affinity chromatography technology	Goncharov T (2013)	1
BIRC3	1	UBE2D3	1	affinity chromatography technology, two hybrid, pull down, pull down	Hu S (2003), Dynek JN (2010), Darding M (2011), Hu S (2003)	4
UBE2L3	1	UBE2B	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
NOD2	1	BIRC3	1	affinity chromatography technology	Damgaard RB (2012)	1
UBC	7	MRE11	3	affinity chromatography technology	Matsumoto M (2005)	1
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
TOLLIP	3	RAC1	7	affinity chromatography technology, affinity chromatography technology	Visvikis O (2011), Visvikis O (2011)	2
BIRC2	1	UBE2D2	0	two hybrid, pull down, pull down, pull down	Dynek JN (2010), Li X (2002), Feltham R (2011), Choi YE (2009)	4
USP7	14	TRAF2	1	pull down	Zapata JM (2001)	1
FBXO7	1	TOMM20	0	enzymatic study, affinity chromatography technology	Teixeira FR (2016), Teixeira FR (2016)	2
MAVS	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2010), Li S (2011), Li S (2011), Wang L (2012), Wang L (2012), Zhou Z (2014)	6
BIRC2	1	E2F1	0	affinity chromatography technology, affinity chromatography technology	Cartier J (2011), Cartier J (2011)	2
BIRC3	1	XAF1	1	affinity chromatography technology	Arora V (2007)	1
HTRA2	1	BIRC3	1	pull down, affinity chromatography technology	Hegde R (2003), Suzuki Y (2001)	2
CD40	3	DIABLO	2	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
BIRC7	0	BIRC2	1	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Dynek JN (2010), Oberoi-Khanuja TK (2012), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	5
RNF31	3	UBC	7	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Wauer T (2013), Fujita H (2014), Schaeffer V (2014), Tokunaga F (2011), Kirisako T (2006), Haas TL (2009), Emmerich CH (2013), Sakamoto H (2015), Lechtenberg BC (2016), Lechtenberg BC (2016), Stieglitz B (2012), Zhang X (2017), Kliza K (2017), Liu J (2017)	14
DNASE2B	2	BIRC2	1	affinity chromatography technology	Huttlin EL (2015)	1
UBE2N	1	UBA1	1	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Huen MS (2008), Wu PY (2003), Wauer T (2015), Boldt K (2016)	4
ENDOG	2	BIRC2	1	affinity chromatography technology	Seo TW (2014)	1
BIRC2	1	UBA1	1	affinity chromatography technology	Goncharov T (2013)	1
XIAP	0	RIPK3	2	pull down	Bertrand MJ (2011)	1
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
EGLN3	0	RHOA	0	affinity chromatography technology	Rodriguez J (2016)	1
TNFSF14	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Kuai J (2003), Kuai J (2003)	2
CYLD	2	CSE1L	1	affinity chromatography technology	Elliott PR (2016)	1
TRIM25	5	TNFRSF1A	3	affinity chromatography technology	Choudhury NR (2017)	1
TNF	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legler DF (2003), Haas TL (2009), Ea CK (2006), Ramakrishnan P (2011), Skaug B (2011), Darding M (2011), Tokunaga F (2012), Klingseisen L (2012), Schaeffer V (2014), Fritsch J (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	14
TLR3	2	BIRC2	1	affinity chromatography technology	Zinngrebe J (2016)	1
BIRC2	1	RNF181	0	two hybrid	Woodsmith J (2012)	1
UBE2V1	0	UBC	7	pull down	McKenna S (2003)	1
BIRC3	1	RIPK3	2	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
IKBKG	0	TRAF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	3
PRDX3	3	XIAP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
CD40	3	HTRA2	1	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
FBXO7	1	DHX9	3	affinity chromatography technology	Teixeira FR (2016)	1
JUP	7	WDYHV1	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
UBE2B	3	UBXN7	3	biochemical	Havugimana PC (2012)	1
TRIM25	5	UBE2L3	1	affinity chromatography technology	Choudhury NR (2017)	1
TNFSF14	0	DIABLO	2	affinity chromatography technology	Kuai J (2003)	1
BIRC7	0	CASP7	1	pull down	Kasof GM (2001)	1
DNASE2B	2	TRAF2	1	affinity chromatography technology	Huttlin EL (2015)	1
TRIM25	5	WDR1	3	affinity chromatography technology	Choudhury NR (2017)	1
UBE2D3	1	RNF181	0	two hybrid, pull down	van Wijk SJ (2009), Pedersen SM (2015)	2
CASP3	0	TRAF1	0	imaging technique	Chen TC (2014)	1
MAVS	1	IKBKE	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paz S (2009), Li S (2011), Paz S (2011), Paz S (2011), Fang R (2017)	5
RNF31	3	UBE2L3	1	pull down, pull down, pull down	Kirisako T (2006), Greenfeld H (2015), Liu J (2017)	3
CDC42	3	BIRC2	1	pull down, pull down, affinity chromatography technology, enzymatic study	Marivin A (2013), Marivin A (2013), Marivin A (2013), Murali A (2017)	4
RNF31	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012)	2
BIRC2	1	DCAF7	4	affinity chromatography technology	Goncharov T (2013)	1
UBA1	1	UBE2D2	0	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Choi JS (2014), Huang DT (2009), Kang D (2002), Kumar B (2010), Liu X (2017), Huguenin-Dezot N (2016)	8
DCAF12	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2N	1	XIAP	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
BIRC3	1	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Uren AG (1996), Roy N (1997), Yoneda T (2000), Yoneda T (2000), Li X (2002), Behrends C (2010), Samuel T (2006), Vince JE (2009), Darding M (2011), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Rothe M (1995), Varfolomeev E (2006), Choudhary S (2013), Goncharov T (2013), Wang J (2011), Harikumar KB (2014), Shen RR (2012), Chen TC (2014), Akhtar N (2016)	23
CBLC	1	UBC	7	enzymatic study	Kim M (2004)	1
BIRC2	1	XAF1	1	affinity chromatography technology	Arora V (2007)	1
UBE2D1	0	UBR5	13	biochemical	Havugimana PC (2012)	1
BIRC2	1	ILF3	5	affinity chromatography technology, affinity chromatography technology	Graber TE (2010), Graber TE (2010)	2
MAP3K14	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Mochida Y (2000), Song HY (1997), Li Q (2006), Chen TC (2014)	4
TNFRSF1A	3	BCL10	0	two hybrid	Costanzo A (1999)	1
TRIM25	5	UBR5	13	affinity chromatography technology	Choudhury NR (2017)	1
CASP8	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Feoktistova M (2012), McDonald ER (2004), Zinngrebe J (2016)	4
TNFRSF1A	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Zhang SQ (2000), Nakazawa S (2016)	2
TRAF1	0	TANK	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Rothe M (1996), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017), Kim CM (2017), Kim CM (2017)	6
DIABLO	2	BIRC3	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Verhagen AM (2000), Yang QH (2004), Hu S (2003), Burke SP (2010), Budhidarmo R (2014), Hu S (2003), Wo L (2016)	7
NFKBIA	0	NFKB2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
TLR3	2	BIRC3	1	affinity chromatography technology	Zinngrebe J (2016)	1
EGFR	5	UBE2S	2	affinity chromatography technology	Tong J (2014)	1
WDYHV1	0	HTRA2	1	affinity chromatography technology	Huttlin EL (2017)	1
GSK3B	1	UBE2D1	0	two hybrid	Vinayagam A (2011)	1
CASP10	1	TRAF1	0	enzymatic study	Leo E (2001)	1
TNFSF14	0	LTBR	0	affinity chromatography technology	Kuai J (2003)	1
UBE2D3	1	OTUB1	0	two hybrid, enzymatic study, pull down, affinity chromatography technology	Rolland T (2014), Li Y (2014), Li Y (2014), Scholz CC (2016)	4
TRIM32	2	UBE2D3	1	affinity chromatography technology, pull down, pull down, pull down	Napolitano LM (2011), Zhang J (2012), Streich FC (2013), Mokhonova EI (2015)	4
BIRC2	1	TRAF1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Shu HB (1996), Li X (2002), Li S (2011), Mace PD (2010), Rothe M (1995), Varfolomeev E (2006), Goncharov T (2013), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017)	11
USP7	14	UBE2D3	1	enzymatic study	Zhang ZM (2015)	1
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
EGLN3	0	CYLD	2	affinity chromatography technology	Rodriguez J (2016)	1
BIRC2	1	BCL10	0	affinity chromatography technology, affinity chromatography technology	Yoneda T (2000), Hu S (2006)	2
FBXO7	1	RNF181	0	affinity chromatography technology	Huttlin EL (2017)	1
NOD2	1	BIRC2	1	affinity chromatography technology	Damgaard RB (2012)	1
RNF31	3	UBE2D2	0	pull down, x-ray crystallography, pull down	Kirisako T (2006), Lechtenberg BC (2016), Lechtenberg BC (2016)	3
TRAF2	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Li S (2011), He L (2004), He L (2004), Pullen SS (1998)	4
715	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	BIRC2	1	affinity chromatography technology	Choudhury NR (2017)	1
EGFR	5	JUP	7	pull down, affinity chromatography technology, two hybrid, protein complementation assay	Hazan RB (1998), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014)	4
CYLD	2	PGAM5	4	affinity chromatography technology	Elliott PR (2016)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
RNF31	3	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Draber P (2015), Draber P (2015), Draber P (2015), Goto E (2017), Schlicher L (2016), Elliott PR (2016), Elliott PR (2016), Elliott PR (2016)	8
UBE2D2	0	FBXO7	1	enzymatic study, pull down	Cenciarelli C (1999), Teixeira FR (2016)	2
CASP3	0	CASP2	1	enzymatic study, enzymatic study	Paroni G (2001), Walsh JG (2008)	2
BIRC2	1	CASP2	1	pull down	Cheung HH (2006)	1
BIRC2	1	BOLA1	0	two hybrid	Rolland T (2014)	1
UBXN1	0	UBR4	15	affinity chromatography technology	Alexandru G (2008)	1
BIRC2	1	MAGEA11	1	two hybrid	Rual JF (2005)	1
TNFAIP3	3	NFKB2	3	affinity chromatography technology	Yamaguchi N (2013)	1
MAP3K14	1	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
RIPK1	2	EGLN3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fu J (2016), Fu J (2016), Rodriguez J (2016)	3
TOLLIP	3	WDYHV1	0	two hybrid	Rolland T (2014)	1
CASP7	1	CASP9	6	enzymatic study	Walsh JG (2008)	1
USP9X	15	UBC	7	unspecified method, pull down	Ernst A (2013), Kwasna D (2018)	2
ZFAND6	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
ADAMTS4	1	XIAP	0	affinity chromatography technology	Huttlin EL (2017)	1
TAS2R7	1	CCNYL1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BIRC3	1	USP15	4	affinity chromatography technology	Goncharov T (2013)	1
IKBKG	0	MAP3K2	1	pull down	Fenner BJ (2010)	1
RIPK2	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McCarthy JV (1998), LeBlanc PM (2008), Marinis JM (2011)	3
LTBR	0	TRAF1	0	pull down, affinity chromatography technology, affinity chromatography technology	Marsters SA (1997), Huttlin EL (2015), Huttlin EL (2017)	3
BIRC2	1	CASP7	1	pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Choi YE (2009), Choi YE (2009), Tenev T (2005), Eckelman BP (2006), Vucic D (2000)	6
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
NOD2	1	RIPK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ogura Y (2001), Tao M (2009), Abbott DW (2004), Abbott DW (2004), Tigno-Aranjuez JT (2010), Tigno-Aranjuez JT (2010), Damgaard RB (2012), Marinis JM (2011), Draber P (2015)	9
OTUB1	0	UBE2D2	0	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Nakada S (2010), Juang YC (2012), Ernst A (2013), Juang YC (2012), Huttlin EL (2015), Scholz CC (2016), Huttlin EL (2017)	8
BIRC2	1	JUP	7	two hybrid	Rual JF (2005)	1
BIRC3	1	UBR4	15	affinity chromatography technology	Goncharov T (2013)	1
LTBR	0	DIABLO	2	affinity chromatography technology, affinity chromatography technology	Kuai J (2003), Kuai J (2003)	2
NFKBIA	0	MAVS	1	affinity chromatography technology	Liu S (2015)	1
RIPK2	0	RNF31	3	affinity chromatography technology	Damgaard RB (2012)	1
BIRC2	1	WDR82	3	affinity chromatography technology	Goncharov T (2013)	1
BIRC3	1	RAF1	3	pull down	Dogan T (2008)	1
CASP8	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
MAP3K3	3	XIAP	0	pull down, enzymatic study	Takeda AN (2014), Takeda AN (2014)	2
EGLN3	0	PRDX3	3	affinity chromatography technology	Rodriguez J (2016)	1
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
BIRC7	0	UBE2D3	1	two hybrid	Dynek JN (2010)	1
RIPK2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Thome M (1998), Li S (2011)	2
LRRN2	2	TRAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
TSG101	1	TRIM25	5	biochemical	Wan C (2015)	1
BIRC2	1	BIRC2	1	enzymatic study, biochemical, enzymatic study, two hybrid, enzymatic study, enzymatic study, enzymatic study, pull down, x-ray crystallography, pull down, enzymatic study, two hybrid, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study	Li X (2002), Lopez J (2011), Yin Q (2009), Dynek JN (2010), Dynek JN (2010), Phu L (2011), Darding M (2011), Dueber EC (2011), Dueber EC (2011), Feltham R (2011), Feltham R (2011), Woodsmith J (2012), Takeda AN (2014), Budhidarmo R (2014), Mace PD (2010), Varfolomeev E (2007), Bertrand MJ (2008), Wauer T (2015)	18
OTUB1	0	UBE2L3	1	affinity chromatography technology	Scholz CC (2016)	1
RABGEF1	1	TRAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
TRAF1	0	RIPK2	0	affinity chromatography technology	Thome M (1998)	1
GSK3B	1	XIAP	0	affinity chromatography technology	Sun M (2009)	1
CASP10	1	CASP9	6	enzymatic study	Srinivasula SM (1996)	1
CD27	1	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Yamamoto H (1998), Akiba H (1998)	2
TRIM25	5	EGLN3	0	affinity chromatography technology	Choudhury NR (2017)	1
LYG2	3	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	UBE2S	2	biochemical, affinity chromatography technology	Havugimana PC (2012), Choudhury NR (2017)	2
XIAP	0	UBC	7	x-ray crystallography, pull down, pull down, pull down	Tse MK (2011), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Nakatani Y (2012)	4
TRIM25	5	UBE2V1	0	pull down	Sanchez JG (2016)	1
HTRA2	1	DIABLO	2	far western blotting, affinity chromatography technology	Hegde R (2002), Hegde R (2002)	2
BIRC2	1	GCC1	1	two hybrid	Rolland T (2014)	1
CBLC	1	RAF1	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRAF1	0	UBC	7	affinity chromatography technology	Greenfeld H (2015)	1
EGFR	5	DHX9	3	affinity chromatography technology	Liccardi G (2014)	1
CD40	3	TRAF3	1	pull down, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsukamoto N (1999), Hu HM (1994), Hu HM (1994), Hu HM (1994), Ni CZ (2000), Roy N (1997), Qiao G (2007), Mosialos G (1995), Davies CC (2005), Pullen SS (1998), Werneburg BG (2001), Peters AL (2010), Li C (2003), Boucher LM (1997), Graham JP (2009), Sato T (1995), Sato T (1995), Sato T (1995), Deregibus MC (2003), Hostager BS (1999), Basaki Y (2002), Cheng G (1995), Miliara S (2013), Elmetwali T (2014), Hostager BS (2010), Hostager BS (2010), Yao X (2016)	27
TRAF1	0	ABHD17A	1	two hybrid	Yu H (2011)	1
RHOA	0	TNFRSF1A	3	biochemical	Gajate C (2005)	1
TRAF1	0	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
CASP7	1	CASP2	1	enzymatic study	Paroni G (2001)	1
TNFAIP3	3	UBE2D1	0	pull down, pull down	Wertz IE (2004), Lee JH (2017)	2
CDC42	3	TRAF2	1	affinity chromatography technology, pull down	Marivin A (2013), Marivin A (2013)	2
MAP3K14	1	TANK	1	affinity chromatography technology	Kanno Y (2010)	1
PRDX3	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BIRC3	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
BIRC5	1	CASP7	1	pull down, enzymatic study, pull down	Tamm I (1998), Shin S (2001), Shin S (2001)	3
MAGEA11	1	PRDX3	3	two hybrid	Rual JF (2005)	1
UBE2D2	0	RAF1	3	enzymatic study	Demand J (2001)	1
UBE2L3	1	CBLC	1	two hybrid	Markson G (2009)	1
UBC	7	SH3KBP1	1	pull down, x-ray crystallography, pull down, x-ray crystallography, pull down, x-ray crystallography	Bezsonova I (2008), Korzhnev DM (2009), Ortega Roldan JL (2013), Ortega Roldan JL (2013), Stamenova SD (2007), Bezsonova I (2008)	6
UBE2D2	0	RNF181	0	two hybrid, pull down	van Wijk SJ (2009), Pedersen SM (2015)	2
MAGEA11	1	WDYHV1	0	two hybrid	Rolland T (2014)	1
PCSK9	3	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Xu W (2012), Xu W (2012)	2
UBE2L3	1	USP9X	15	biochemical	Havugimana PC (2012)	1
UBE2D2	0	NFKBIA	0	enzymatic study	Gonen H (1999)	1
TRIM25	5	PGAM5	4	affinity chromatography technology	Choudhury NR (2017)	1
OTUB1	0	CSE1L	1	affinity chromatography technology	Scholz CC (2016)	1
BIRC3	1	IKBKG	0	pull down, affinity chromatography technology	Gyrd-Hansen M (2008), Goncharov T (2013)	2
RABGEF1	1	UBE2D1	0	pull down	Kalesnikoff J (2007)	1
TAS2R7	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BIRC2	1	HTRA2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hegde R (2003), Hegde R (2003), Verhagen AM (2002), Suzuki Y (2001), Huttlin EL (2017)	5
CLEC11A	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D2	0	USP9X	15	biochemical	Havugimana PC (2012)	1
RAF1	3	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, enzymatic study, imaging technique	Dogan T (2008), Tian S (2006), Tian S (2006), Tian S (2006), Tian S (2006), Tian S (2006), Chen TC (2014)	7
UBC	7	DNASE2B	2	pull down	Nathan JA (2013)	1
EGLN3	0	USP15	4	affinity chromatography technology	Rodriguez J (2016)	1
XIAP	0	CASP9	6	two hybrid, far western blotting, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Rual JF (2005), Davoodi J (2004), Deveraux QL (1998), Deveraux QL (1998), Richter BW (2001), Morizane Y (2005), Fu J (2003), Fu J (2003), Hao Y (2004), Varfolomeev E (2007), Vucic D (2002), Qiu XB (2005), Srinivasula SM (2001), Cheung HH (2006), Kulathila R (2009), Shiozaki EN (2003), Davoodi J (2007), Checinska A (2007), Huang Y (2003), Sun M (2009), Martin SA (2005), Lee JS (2012), Rolland T (2014), McDonald ER (2004), Chen TC (2014)	25
MAVS	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Yu H (2011), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	7
TUFT1	1	RABGEF1	1	affinity chromatography technology	Boldt K (2016)	1
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
TOLLIP	3	DZIP3	6	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
XAF1	1	TRAF2	1	affinity chromatography technology	Lin B (2016)	1
TRIM25	5	TOMM20	0	affinity chromatography technology	Choudhury NR (2017)	1
TLR3	2	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang M (2011), Jiang Z (2003), Jiang Z (2003), Cusson-Hermance N (2005), Zinngrebe J (2016)	5
OTUB1	0	UBE2D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sun XX (2011), Herhaus L (2013), Li Y (2014), Scholz CC (2016)	4
UBE2D2	0	XIAP	0	two hybrid, two hybrid, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Markson G (2009), Dynek JN (2010), Nakatani Y (2012), Nakatani Y (2012), Markson G (2009), Fang S (2001), Hu S (2003), Buetow L (2015), Foglizzo M (2016), Edison N (2017)	10
UBE2D1	0	USP9X	15	biochemical, biochemical	Havugimana PC (2012), You J (2001)	2
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
BIRC2	1	RAF1	3	pull down	Dogan T (2008)	1
BIRC3	1	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
IKBKG	0	RHOA	0	pull down	Kim HJ (2014)	1
BIRC2	1	CCNYL1	0	affinity chromatography technology	Huttlin EL (2017)	1
USP7	14	TRAF1	0	pull down	Zapata JM (2001)	1
BIRC2	1	UBE2B	3	two hybrid	Dynek JN (2010)	1
ULK1	8	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mukhopadhyay S (2016), Mukhopadhyay S (2016)	2
EGFR	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Puliyappadamba VT (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
UBC	7	FBXO7	1	affinity chromatography technology	Matsumoto M (2005)	1
DIABLO	2	BIRC7	0	affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma L (2006), Ma L (2006), Vucic D (2002), Shiozaki EN (2003), Ma L (2006), Dou H (2012), Huttlin EL (2015), Liu GH (2015), Huttlin EL (2017)	9
TRAF6	0	UBE2V1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Lamothe B (2007), Kanayama A (2004), Shi CS (2010), Xia ZP (2009), Yang WL (2009), Murata H (2013), Ning S (2008), Sun L (2004), Lin Y (2014)	10
TRAF6	0	UBE2L3	1	pull down, pull down	Geetha T (2005), Babu JR (2005)	2
CD40LG	0	TRAF1	0	affinity chromatography technology	Salzmann S (2013)	1
MAP3K14	1	CASP3	0	imaging technique	Chen TC (2014)	1
UBE2L3	1	UBXN7	3	biochemical	Havugimana PC (2012)	1
TRIM25	5	ULK1	8	affinity chromatography technology	Choudhury NR (2017)	1
EGFR	5	ILF2	3	affinity chromatography technology	Liccardi G (2014)	1
NOD2	1	IKBKG	0	affinity chromatography technology	Damgaard RB (2012)	1
EGFR	5	TSG101	1	affinity chromatography technology	Yao Z (2017)	1
IKBKG	0	TNFAIP3	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhang SQ (2000), Zhang SQ (2000), Skaug B (2011), Skaug B (2011), Klinkenberg M (2001), Verhelst K (2012), Verhelst K (2012), Wang J (2011), Zilberman-Rudenko J (2016)	9
LYG2	3	TRAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
CD40	3	RIPK2	0	affinity chromatography technology	McCarthy JV (1998)	1
MAVS	1	RIPK2	0	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TNFRSF1A	3	RABGEF1	1	affinity chromatography technology	Huttlin EL (2017)	1
CASP10	1	CASP7	1	enzymatic study	Srinivasula SM (1996)	1
BIRC3	1	UBE2Q2	4	two hybrid	Dynek JN (2010)	1
TRIM25	5	USP7	14	affinity chromatography technology	Choudhury NR (2017)	1
TRAF1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Greenfeld H (2015)	2
TRAF6	0	UBE2N	1	genetic interference, pull down, two hybrid, biochemical, two hybrid, x-ray crystallography, two hybrid, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, two hybrid	Deng L (2000), Deng L (2000), Markson G (2009), Yin Q (2009), Dynek JN (2010), Yin Q (2009), Yin Q (2009), Petroski MD (2007), Mercier P (2007), Lamothe B (2008), Kanayama A (2004), Murata H (2013), Ning S (2008), Markson G (2009), Lin Y (2014), Chen J (2015), Zhang J (2016), Boldt K (2016), Rezaeian AH (2017), Xing J (2016), Schimmack G (2017), Schimmack G (2017)	22
NOD2	1	XIAP	0	affinity chromatography technology, pull down	Damgaard RB (2012), Krieg A (2009)	2
TRAF1	0	DCAF7	4	affinity chromatography technology	Greenfeld H (2015)	1
IKBKG	0	HSP90B1	3	affinity chromatography technology	Liu D (2014)	1
LTBR	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BIRC3	1	PACS2	9	enzymatic study, affinity chromatography technology, pull down	Guicciardi ME (2014), Guicciardi ME (2014), Guicciardi ME (2014)	3
CD40	3	USP15	4	affinity chromatography technology	Ewing RM (2007)	1
RIPK3	2	RIPK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu PW (1999), Yu PW (1999), Li S (2011), Lee EW (2012), Petersen SL (2015), Moquin DM (2013), Moriwaki K (2016)	7
RIPK2	0	UBC	7	affinity chromatography technology	Park S (2013)	1
UBE2N	1	UBE2V1	0	biochemical, pull down, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deng L (2000), Deng L (2000), Zhang M (2005), Andersen PL (2005), Andersen PL (2005), Scheper J (2010), Scheper J (2010), Scheper J (2010), Wooff J (2004), Plans V (2006), Huen MS (2008), Huen MS (2008), Havugimana PC (2012), Bohgaki M (2008), Petroski MD (2007), Sawasaki T (2008), Wan C (2015), Chen J (2015), Boldt K (2016), Zhang Y (2018)	20
TRIM25	5	GSPT1	3	affinity chromatography technology	Choudhury NR (2017)	1
CASP8	1	CASP3	0	enzymatic study, enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996), Chandra D (2004)	3
USP19	1	CSE1L	1	affinity chromatography technology	Sowa ME (2009)	1
UBE2W	0	XIAP	0	two hybrid, two hybrid	Markson G (2009), Dynek JN (2010)	2
ILF3	5	ILF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reichman TW (2002), Shi L (2007), Shamanna RA (2011), Havugimana PC (2012), Karmakar S (2010), Karmakar S (2010), Karmakar S (2010), Huttlin EL (2015), Huttlin EL (2017), Zhu X (2016), Zhu X (2016)	11
UBXN1	0	UBR5	13	affinity chromatography technology	Alexandru G (2008)	1
TRIM25	5	USP19	1	affinity chromatography technology	Choudhury NR (2017)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
USP15	4	UBC	7	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Hetfeld BK (2005), Bremm A (2010), Komander D (2009), Loch CM (2012), Herhaus L (2014), Wauer T (2015), Das T (2017), Zhang X (2017), Kwasna D (2018)	9
GCC1	1	IKBKG	0	two hybrid	Wang J (2011)	1
CASP10	1	CASP3	0	enzymatic study	Srinivasula SM (1996)	1
ILF2	3	JUP	7	biochemical	Havugimana PC (2012)	1
RIPK3	2	TNFRSF1A	3	affinity chromatography technology	Yu PW (1999)	1
NOD2	1	RIPK1	2	affinity chromatography technology	Damgaard RB (2012)	1
CASP10	1	TNFRSF1A	3	biochemical, affinity chromatography technology	Gajate C (2005), Vincenz C (1997)	2
IKBKE	2	CYLD	2	affinity chromatography technology, affinity chromatography technology	Friedman CS (2008), Zhou AY (2013)	2
BIRC2	1	RIPK4	0	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
TSG101	1	SH3KBP1	1	biochemical	Wan C (2015)	1
NFKBIA	0	BCL10	0	affinity chromatography technology, affinity chromatography technology	Carvalho G (2010), Carvalho G (2010)	2
USP19	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Mei Y (2011), Mei Y (2011), Mei Y (2011)	3
CBLC	1	UBE2D1	0	pull down	Kim M (2004)	1
IKBKG	0	TANK	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Chariot A (2002), Chariot A (2002), Chariot A (2002), Zhang W (2010), Zhang W (2010), Zhao T (2007), Wang J (2011), Wang W (2015), Huttlin EL (2017)	9
AIMP2	0	TANK	1	two hybrid	Wang J (2011)	1
UBA1	1	UBE2S	2	enzymatic study, pull down, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Wauer T (2015), Huguenin-Dezot N (2016)	4
OTUB1	0	UBE2W	0	affinity chromatography technology	Scholz CC (2016)	1
EGLN3	0	PGAM5	4	affinity chromatography technology	Rodriguez J (2016)	1
OTUB1	0	AIMP2	0	affinity chromatography technology	Scholz CC (2016)	1
UBXN1	0	VPS4B	3	biochemical	Havugimana PC (2012)	1
HTRA2	1	VPS4B	3	unspecified method	Vande Walle L (2007)	1
CASP8	1	CASP2	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
TRAF2	1	HTRA2	1	affinity chromatography technology	Behrends C (2010)	1
XIAP	0	UBE2L6	0	affinity chromatography technology	Hu S (2003)	1
TLR3	2	IKBKG	0	affinity chromatography technology	Zinngrebe J (2016)	1
TRIM32	2	UBE2D2	0	affinity chromatography technology, pull down, pull down	Napolitano LM (2011), Streich FC (2013), Mokhonova EI (2015)	3
USP15	4	OTUB1	0	enzymatic study	Loch CM (2012)	1
BIRC2	1	PGAM5	4	enzymatic study, pull down, affinity chromatography technology	Zhuang M (2013), Zhuang M (2013), Zhuang M (2013)	3
UBA1	1	UBE2D1	0	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Kang D (2002), Wauer T (2015), Huguenin-Dezot N (2016)	5
EGLN3	0	OTUB1	0	affinity chromatography technology	Rodriguez J (2016)	1
WDYHV1	0	TRAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
BIRC3	1	RNF31	3	affinity chromatography technology	Goncharov T (2013)	1
UBE2V1	0	TRIM32	2	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	4
BIRC2	1	NMB	0	two hybrid	Rolland T (2014)	1
TMEM9B	0	TRAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1A	3	TRAF6	0	affinity chromatography technology	Chang YL (2014)	1
BIRC2	1	WDR1	3	affinity chromatography technology	Goncharov T (2013)	1
XIAP	0	BCL10	0	affinity chromatography technology	Hu S (2006)	1
EGFR	5	CSE1L	1	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Yao Z (2017)	2
UBE2L6	0	TRIM25	5	affinity chromatography technology	Urano T (2002)	1
CASP8	1	RIPK3	2	affinity chromatography technology	Lee EW (2012)	1
UBE2V1	0	DZIP3	6	two hybrid	Markson G (2009)	1
CD40	3	TRAF6	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Tsukamoto N (1999), Roy N (1997), Davies CC (2005), Pullen SS (1998), Peters AL (2010), Ye H (2002), Deregibus MC (2003), Basaki Y (2002), Zhang W (2010), Zhang W (2010), He B (2010), Hostager BS (2010), Hostager BS (2010), Verstak B (2014)	14
CD40	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Werneburg BG (2001), Peters AL (2010), Hostager BS (2010), Hostager BS (2010)	4
BIRC2	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Hinz M (2010), Hinz M (2010), Shibata Y (2012), Goncharov T (2013), Fu J (2013)	6
BIRC2	1	CBLC	1	two hybrid	Woodsmith J (2012)	1
BIRC2	1	ABHD17A	1	two hybrid	Yu H (2011)	1
TRAF3	1	BIRC3	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Mao AP (2010), de Jong SJ (2013), Goncharov T (2013)	3
BIRC2	1	BIRC5	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dohi T (2004), Samuel T (2005), Samuel T (2005), Jung SA (2015), Jung SA (2015), Jung SA (2015)	6
TSG101	1	UBC	7	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down	Schlundt A (2009), Sundquist WI (2004), Bishop N (2002), Bishop N (2002), Pornillos O (2002), Kharitidi D (2015), Zhang X (2017)	7
ADAMTS4	1	TRAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
GPR107	0	TRAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2S	2	UBC	7	enzymatic study, pull down, x-ray crystallography, enzymatic study, enzymatic study	Bremm A (2010), Wickliffe KE (2011), Wickliffe KE (2011), Kelly A (2014), Michel MA (2017)	5
BIRC3	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Hu S (2003), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Hu S (2006), Guicciardi ME (2014)	6
TNFRSF1A	3	TRAF1	0	affinity chromatography technology, pull down, affinity chromatography technology	Hsu H (1996), Mosialos G (1995), Wicovsky A (2009)	3
CASP8	1	TRAF1	0	affinity chromatography technology, enzymatic study	Micheau O (2003), Leo E (2001)	2
TRAF2	1	UBE2D1	0	pull down	Alvarez SE (2010)	1
BIRC3	1	TRIM32	2	affinity chromatography technology	Ryu YS (2011)	1
PRDX3	3	TNFRSF1A	3	two hybrid	Wang J (2011)	1
CDC42	3	XIAP	0	affinity chromatography technology, pull down, enzymatic study, pull down	Murali A (2017), Murali A (2017), Murali A (2017), Murali A (2017)	4
TRIM25	5	USP9X	15	affinity chromatography technology	Choudhury NR (2017)	1
TLR3	2	RNF31	3	affinity chromatography technology	Zinngrebe J (2016)	1
UBC	7	ILF3	5	pull down	Zhang X (2017)	1
CBLC	1	UBE2D3	1	pull down	Kim M (2004)	1
CDC42	3	CASP3	0	imaging technique	Chen TC (2014)	1
BIRC2	1	UBE2N	1	two hybrid	Schimmack G (2017)	1
TRAF2	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Huttlin EL (2017)	2
MAP3K2	1	MAP3K3	3	pull down, affinity chromatography technology	Takeda AN (2014), Hein MY (2015)	2
FBXO7	1	UBE2D3	1	pull down, pull down	Vingill S (2016), Teixeira FR (2016)	2
BCL10	0	RNF31	3	affinity chromatography technology, affinity chromatography technology	Yang YK (2016), Yang YK (2016)	2
CYLD	2	DNAJB2	0	affinity chromatography technology	Elliott PR (2016)	1
GSK3B	1	BIRC3	1	affinity chromatography technology	Sun M (2009)	1
UBC	7	UBXN7	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Kelsall IR (2013), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
XIAP	0	RIPK1	2	pull down	Bertrand MJ (2011)	1
BIRC7	0	XAF1	1	affinity chromatography technology	Arora V (2007)	1
TRIM25	5	LTBR	0	affinity chromatography technology	Choudhury NR (2017)	1
LTBR	0	TRAF2	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marsters SA (1997), Sanjo H (2010), Sanjo H (2010), Li C (2003), Liu HP (2011), Huttlin EL (2015), Huttlin EL (2017)	7
CLEC11A	0	TRAF2	1	affinity chromatography technology	Huttlin EL (2015)	1
RIPK1	2	XAF1	1	affinity chromatography technology	Lin B (2016)	1
XIAP	0	DIABLO	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down	Hunter AM (2003), Davoodi J (2004), Song Z (2003), Verhagen AM (2000), Verhagen AM (2000), Verhagen AM (2000), Verhagen AM (2000), Verhagen AM (2002), Samuel T (2006), McNeish IA (2005), Yoon K (2004), Fu J (2003), Fu J (2003), Fu J (2003), Fu J (2003), Hu S (2003), Hao Y (2004), Sekine K (2005), Csomos RA (2009), Bartke T (2004), Burke SP (2010), Burke SP (2010), Vucic D (2002), Qiu XB (2005), Qiu XB (2005), Scott FL (2005), Srinivasula SM (2001), Martins LM (2002), Kulathila R (2009), Huang Y (2001), Chai J (2001), Liu Z (2001), Liu Z (2001), Gao Z (2007), Davoodi J (2007), Hegde R (2002), Krieg A (2009), Huang Y (2003), Huang Y (2003), Arnt CR (2002), Damgaard RB (2013), Lee S (2014), Hao Y (2004), Hao Y (2004), Masoumi KC (2012), Guvenc H (2013), Buetow L (2015), Wo L (2016), Huttlin EL (2017), Wu G (2001), Wu G (2001), Hou Y (2017)	52
MAVS	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Wang P (2013), Wang P (2013), Shi Z (2015), Shi Z (2015), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	11
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
BCL10	0	USP9X	15	affinity chromatography technology	Park Y (2013)	1
TRIM25	5	IGF2BP1	2	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
TRAF2	1	UBE2V1	0	pull down	Deng L (2000)	1
RIPK1	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Li H (2006), Ea CK (2006), Dynek JN (2010), Skaug B (2011), Wagner S (2008), Wu CJ (2006), Legarda-Addison D (2009), Yang Y (2011), Bohgaki M (2008), Lucas PC (2001), Biton S (2011), Zhu G (2007), Zhu G (2007), Keusekotten K (2013), Jeon J (2014), Wu CJ (2006), Vincendeau M (2016), Baratchian M (2016), Zilberman-Rudenko J (2016), Medunjanin S (2016), Bal E (2017), Bal E (2017)	23
EGFR	5	ILF3	5	affinity chromatography technology	Liccardi G (2014)	1
RABGEF1	1	RNF31	3	affinity chromatography technology	Huttlin EL (2017)	1
TUFT1	1	DZIP3	6	affinity chromatography technology	Boldt K (2016)	1
UBE2J1	1	BIRC2	1	two hybrid, pull down, affinity chromatography technology	van Wijk SJ (2009), Wu CJ (2005), Elangovan M (2017)	3
BIRC2	1	FBXO7	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Chang YF (2006), Kuiken HJ (2012), Teixeira FR (2016)	3
TANK	1	TRAF3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology	Bouwmeester T (2004), Rothe M (1996), Gatot JS (2007), Li S (2011), Li C (2003), Li C (2002), Li C (2002), Ng MH (2011)	8
TRIM25	5	ADRM1	4	affinity chromatography technology	Choudhury NR (2017)	1
UBE2D2	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
TRAF2	1	UBE2N	1	genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Deng L (2000), Liu J (2011), Liu J (2011), Liu J (2011), Alvarez SE (2010), Sasai M (2010), Zhou AY (2013), Shen RR (2012)	9
RIPK4	0	IKBKG	0	affinity chromatography technology	Rodriguez J (2016)	1
XIAP	0	TRIM32	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ryu YS (2011), Ryu YS (2011), Ryu YS (2011)	3
BIRC2	1	MAP3K3	3	enzymatic study	Takeda AN (2014)	1
BIRC2	1	GSPT1	3	affinity chromatography technology, pull down	Hegde R (2003), Hegde R (2003)	2
EGLN3	0	CSE1L	1	affinity chromatography technology	Rodriguez J (2016)	1
UBE2D2	0	DZIP3	6	two hybrid, pull down	Markson G (2009), Zhou W (2008)	2
ADRM1	4	UBE2N	1	affinity chromatography technology	Boldt K (2016)	1
USP7	14	WDR1	3	affinity chromatography technology	Hein MY (2015)	1
E2F1	0	GSK3B	1	affinity chromatography technology	Zhou F (2008)	1
UBE2N	1	TRIM25	5	two hybrid, pull down, x-ray crystallography, affinity chromatography technology	Markson G (2009), Sanchez JG (2016), Sanchez JG (2016), Choudhury NR (2017)	4
XIAP	0	CASP3	0	affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Suzuki Y (2001), Suzuki Y (2001), Silke J (2002), Riedl SJ (2001), Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Nakhaei P (2012), Qiu XB (2005), Nomura T (2003), Paulsen M (2008), Scott FL (2005), Mufti AR (2006), Rajalingam K (2006), Dudich E (2006), Chai J (2001), Checinska A (2007), Sun M (2009), Takahashi R (1998), Conde C (2012), Walsh JG (2008), Lee JS (2012), Lin YF (2013), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Hou Y (2017)	30
RIPK1	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim JW (2000), Duan H (1997), Hsu H (1996), Blankenship JW (2009), Newton K (2008), Varfolomeev E (2008), Fearns C (2006), Vince JE (2009), Dynek JN (2010), Kim S (2010), Cheung HH (2009), Tenev T (2011), Mahul-Mellier AL (2011), Won M (2010), Glowacka WK (2012), Fan YH (2011), Cusson-Hermance N (2005), ODonnell MA (2012), Zheng L (2006), Vince JE (2007), Mitsuhashi S (2008), Kim TW (2013), Wertz IE (2004), Liao W (2008), Wang YB (2015), Chang YL (2014), Zilberman-Rudenko J (2016), Zemirli N (2014), Moquin DM (2013), Nakazawa S (2016), Jeong M (2017), Huttlin EL (2017), Elliott PR (2016)	33
CASP3	0	CASP9	6	enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Qiu XB (2005), Denault JB (2007), Srinivasula SM (2001), Walsh JG (2008), Chen TC (2014)	5
OTUB1	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, unspecified method, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Wang T (2009), Bremm A (2010), Juang YC (2012), Ernst A (2013), Ernst A (2013), Nakasone MA (2013), Wiener R (2013), Edelmann MJ (2009), Bish RA (2007), Mevissen TE (2013), Juang YC (2012), Herhaus L (2013), Ernst A (2013), Herhaus L (2015), Herhaus L (2015), Herhaus L (2015), Wauer T (2015), Michel MA (2015), Kristariyanto YA (2015), Scholz CC (2016), Scholz CC (2016), Altun M (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	26
CYLD	2	DHX9	3	affinity chromatography technology	Elliott PR (2016)	1
RIPK2	0	TNFRSF1A	3	affinity chromatography technology	McCarthy JV (1998)	1
BIRC7	0	UBE2D1	0	two hybrid	Dynek JN (2010)	1
MAP3K2	1	XIAP	0	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, pull down, enzymatic study	Winsauer G (2008), Winsauer G (2008), Takeda AN (2014), Takeda AN (2014), Takeda AN (2014), Takeda AN (2014)	6
UBC	7	C19orf44	1	affinity chromatography technology	Matsumoto M (2005)	1
CYLD	2	ILF2	3	affinity chromatography technology	Elliott PR (2016)	1
UBE2L3	1	UBXN1	0	biochemical	Havugimana PC (2012)	1
TNFRSF1A	3	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Blankenship JW (2009), Vince JE (2009)	2
MRE11	3	BIRC2	1	affinity chromatography technology	Nicholson J (2017)	1
BIRC2	1	EXOSC5	0	two hybrid	Rolland T (2014)	1
BIRC2	1	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hegde R (2003), Verhagen AM (2000), Samuel T (2006), Samuel T (2006), Yang QH (2004), Hu S (2003), Hu S (2003), Csomos RA (2009), Burke SP (2010), Kulathila R (2009), Kulathila R (2009), Arnt CR (2002), Budhidarmo R (2014), Lee S (2014), Wo L (2016), Huttlin EL (2017)	16
USP19	1	BIRC2	1	affinity chromatography technology	Mei Y (2011)	1
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
BIRC7	0	UBE2D2	0	two hybrid, pull down, x-ray crystallography, pull down	Dynek JN (2010), Dou H (2012), Dou H (2012), Ma L (2006)	4
BIRC2	1	UBXN1	0	affinity chromatography technology, affinity chromatography technology	Wang YB (2015), Wang YB (2015)	2
UBE2V1	0	XIAP	0	two hybrid	Markson G (2009)	1
MAP3K14	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varfolomeev E (2007), Kanno Y (2010), Lee S (2014), Lee S (2014)	4
DNAJB2	0	UBC	7	affinity chromatography technology, pull down, two hybrid	Westhoff B (2005), Fenner BJ (2009), Westhoff B (2005)	3
RAC1	7	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
CD40LG	0	BIRC2	1	affinity chromatography technology	Salzmann S (2013)	1
EGLN3	0	NFKBIA	0	affinity chromatography technology	Rodriguez J (2016)	1
UBXN1	0	UBXN7	3	affinity chromatography technology	Raman M (2015)	1
RNF31	3	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Draber P (2015), Nakazawa S (2016), Elliott PR (2016)	3
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
CASP8	1	UBC	7	pull down	Bellail AC (2012)	1
UBXN1	0	JUP	7	affinity chromatography technology	Raman M (2015)	1
RIPK2	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	McCarthy JV (1998), Thome M (1998), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	8
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
BIRC2	1	UBE2V1	0	pull down	Bertrand MJ (2008)	1
BIRC7	0	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Oberoi-Khanuja TK (2012), Oberoi-Khanuja TK (2012), Huttlin EL (2015), Huttlin EL (2017)	4
GSK3B	1	IGF2BP1	2	affinity chromatography technology	Ewing RM (2007)	1
UBR5	13	GSK3B	1	affinity chromatography technology, pull down	Hay-Koren A (2011), Hay-Koren A (2011)	2
CD40LG	0	TRAF2	1	affinity chromatography technology	Salzmann S (2013)	1
BIRC2	1	DZIP3	6	two hybrid	Woodsmith J (2012)	1
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
RABGEF1	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Penengo L (2006), Yao Z (2017)	2
BIRC2	1	GNAZ	1	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	UBR4	15	affinity chromatography technology	Tong J (2014)	1
BIRC3	1	UBA1	1	affinity chromatography technology	Goncharov T (2013)	1
TRAF2	1	IKBKG	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Poyet JL (2000), Shen RR (2012), Shen RR (2012), Bal E (2017), Bal E (2017)	6
TRAF6	0	TRIM25	5	two hybrid	Woodsmith J (2012)	1
OTUB1	0	TRAF6	0	affinity chromatography technology, enzymatic study	Li S (2010), Bremm A (2010)	2
USP19	1	UBC	7	enzymatic study, pull down, pull down	Lee JG (2014), Zhang X (2017), Kwasna D (2018)	3
CYLD	2	BIRC2	1	affinity chromatography technology	Elliott PR (2016)	1
BIRC3	1	OTUB1	0	affinity chromatography technology	Goncharov T (2013)	1
DHX9	3	MRE11	3	biochemical	Kristensen AR (2012)	1
FSD1	3	BIRC2	1	affinity chromatography technology	Huttlin EL (2015)	1
BIRC2	1	TRIM32	2	affinity chromatography technology	Ryu YS (2011)	1
USP7	14	TRAF3	1	pull down	Zapata JM (2001)	1
UBXN1	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Wang YB (2015)	2
ILF2	3	MRE11	3	biochemical, affinity chromatography technology	Kristensen AR (2012), Karmakar S (2010)	2
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
UBE2D1	0	WDR1	3	biochemical	Havugimana PC (2012)	1
RABGEF1	1	UBE2D3	1	pull down	Xu L (2010)	1
GSPT1	3	XIAP	0	affinity chromatography technology, pull down	Hegde R (2003), Hashimoto Y (2015)	2
TOLLIP	3	XIAP	0	affinity chromatography technology	Li S (2011)	1
TNFRSF12A	0	BIRC2	1	affinity chromatography technology	Ikner A (2011)	1
EGLN3	0	TSG101	1	affinity chromatography technology	Rodriguez J (2016)	1
DNAJB2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
OTUB1	0	RHOA	0	enzymatic study	Edelmann MJ (2010)	1
TNFSF12	0	OTUB1	0	affinity chromatography technology	Goncharov T (2013)	1
DCAF12	0	XIAP	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2W	0	DZIP3	6	two hybrid	Markson G (2009)	1
CASP7	1	TNFRSF1A	3	enzymatic study	Ethell DW (2001)	1
XIAP	0	WDYHV1	0	two hybrid	Rual JF (2005)	1
DZIP3	6	RABGEF1	1	affinity chromatography technology	Boldt K (2016)	1
NFKBIA	0	OTUB1	0	affinity chromatography technology	Huttlin EL (2015)	1
CASP8	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Micheau O (2003), Knox PG (2011), Mahul-Mellier AL (2011), Gonzalvez F (2012), Gonzalvez F (2012), Xu L (2017), Xu L (2017)	7
BIRC2	1	ADRM1	4	affinity chromatography technology	Blankenship JW (2009)	1
IKBKG	0	USP7	14	affinity chromatography technology, affinity chromatography technology	Daubeuf S (2009), Li T (2014)	2
UBE2B	3	USP9X	15	biochemical	Havugimana PC (2012)	1
NOD2	1	CYLD	2	affinity chromatography technology	Draber P (2015)	1
TRIM32	2	UBE2N	1	two hybrid, affinity chromatography technology, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Saccone V (2008), Saccone V (2008), van Wijk SJ (2009), Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Boldt K (2016)	8
USP7	14	USP19	1	affinity chromatography technology	Sowa ME (2009)	1
BIRC2	1	UBE2D3	1	affinity chromatography technology, two hybrid, pull down	Hu S (2003), Dynek JN (2010), Hu S (2003)	3
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
UBE2D3	1	TRAF6	0	two hybrid, enzymatic study, pull down, pull down, pull down	Markson G (2009), Petroski MD (2007), Xia ZP (2009), Markson G (2009), Wauer T (2015)	5
UBR4	15	USP9X	15	biochemical	Havugimana PC (2012)	1
OTUB1	0	UBE2S	2	enzymatic study	Bremm A (2010)	1
BIRC3	1	BCL10	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Yoneda T (2000), Hu S (2006), Yui D (2001), Hu S (2006), Hu S (2006), Hu S (2006), Hu S (2006)	7
IKBKG	0	MAP3K14	1	affinity chromatography technology, affinity chromatography technology	Li Y (1999), Huttlin EL (2017)	2
LTBR	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GLMN	2	BIRC3	1	affinity chromatography technology, pull down	Suzuki S (2017), Suzuki S (2017)	2
TRAF1	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Hsu H (1996), Wicovsky A (2009), Rolland T (2014)	3
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
MAGEA11	1	E2F1	0	affinity chromatography technology	Su S (2013)	1
TOMM20	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mukhopadhyay S (2016), Mukhopadhyay S (2016)	2
NFKBIA	0	MAP3K14	1	pull down	Cohen L (1998)	1
TRAF2	1	CD40	3	x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McWhirter SM (1999), Tsukamoto N (1999), Malinin NL (1997), Knox PG (2011), Davies CC (2005), Pullen SS (1998), Werneburg BG (2001), Peters AL (2010), Boucher LM (1997), Graham JP (2009), Deregibus MC (2003), Yacoub D (2010), Hostager BS (1999), Basaki Y (2002), Zhang W (2010), Zhang W (2010), He B (2010), Rolland T (2014), Hostager BS (2010), Hostager BS (2010), Yao X (2016)	21
IKBKG	0	EGLN3	0	affinity chromatography technology, affinity chromatography technology, pull down	Fu J (2013), Fu J (2013), Fu J (2013)	3
TNF	0	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Tokunaga F (2012), Verhelst K (2012), Keusekotten K (2013), Fu J (2013), Schaeffer V (2014), Draber P (2015)	7
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
BIRC7	0	CASP3	0	pull down, affinity chromatography technology	Kasof GM (2001), Liu GH (2013)	2
RNF31	3	TRAF6	0	enzymatic study	Kliza K (2017)	1
MAP3K14	1	TRAF3	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Luftig MA (2001), Sanjo H (2010), Sanjo H (2010), Song HY (1997), Hu WH (2004), Liao G (2004), Liao G (2004), Choudhary S (2013), Lee S (2014), Huttlin EL (2017)	10
CASP9	6	BIRC7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Kasof GM (2001), Vucic D (2002), Vucic D (2000), Rolland T (2014)	4
BIRC2	1	UBR5	13	affinity chromatography technology	Goncharov T (2013)	1
UBR5	13	UBE2D2	0	pull down, pull down, pull down, enzymatic study, pull down	Maddika S (2009), Honda Y (2002), Cojocaru M (2011), Matta-Camacho E (2012), Zhang W (2016)	5
USP19	1	XIAP	0	affinity chromatography technology, affinity chromatography technology	Mei Y (2011), Mei Y (2011)	2
BIRC3	1	WDR82	3	affinity chromatography technology	Goncharov T (2013)	1
UBE2W	0	BIRC2	1	two hybrid	van Wijk SJ (2009)	1
TRAF3	1	RIPK1	2	affinity chromatography technology	Hsu H (1996)	1
BIRC3	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3
CDC42	3	PRDX3	3	affinity chromatography technology	Hein MY (2015)	1
UBE2D3	1	XIAP	0	two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Hu S (2003), Dynek JN (2010), Bartke T (2004), Bornstein B (2011), Damgaard RB (2013), Markson G (2009)	7
TNF	0	RAC1	7	genetic interference	Ahmad M (2002)	1
LRRN2	2	XIAP	0	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K3	3	TRAF6	0	affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Nakamura K (2010), Nakamura K (2010), Nakamura K (2010), Yamazaki K (2009), Yamazaki K (2009), Huang Q (2004), Chen TC (2014)	7
UBC	7	ZFAND6	0	pull down, affinity chromatography technology, pull down, pull down	Fenner BJ (2009), Fenner BJ (2009), Nathan JA (2013), Zhang X (2017)	4
MAP3K14	1	NFKB2	3	affinity chromatography technology, affinity chromatography technology	Xiao G (2001), Qing G (2007)	2
RNF31	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Niu J (2011), Fujita H (2014), Tokunaga F (2011), Tokunaga F (2011), Xia ZP (2009), Fu J (2013), Emmerich CH (2013), Chen Y (2015), Bal E (2017)	11
TRAF1	0	TRAF6	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Wang J (2011), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	4
BIRC2	1	OTUB1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Goncharov T (2013), Goncharov T (2013), Goncharov T (2013)	3
CASP3	0	TRAF3	1	enzymatic study, enzymatic study	Lee ZH (2001), Leo E (2001)	2
CASP2	1	CASP9	6	genetic interference	Guo Y (2002)	1
TRIM25	5	C19orf44	1	affinity chromatography technology	Choudhury NR (2017)	1
EGLN3	0	GSK3B	1	affinity chromatography technology	Rodriguez J (2016)	1
IKBKE	2	XIAP	0	enzymatic study	Nakhaei P (2012)	1
TRIM25	5	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Pauli EK (2014), Pauli EK (2014), Pauli EK (2014), Pauli EK (2014)	4
EGLN3	0	RAF1	3	affinity chromatography technology	Rodriguez J (2016)	1
BIRC2	1	TNFAIP3	3	affinity chromatography technology	Yamaguchi N (2013)	1
CASP8	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Oshima S (2009), Saitoh Y (2016)	2
TRIM25	5	ILF2	3	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
TSG101	1	DZIP3	6	two hybrid	Markson G (2009)	1
CASP2	1	XIAP	0	genetic interference	Guo Y (2002)	1
NFKB2	3	IKBKG	0	affinity chromatography technology	Bouwmeester T (2004)	1
RIPK1	2	TNFAIP3	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Shembade N (2009), Wertz IE (2004), Wertz IE (2004), Wertz IE (2004), Shembade N (2008), Bellail AC (2012)	6
GSK3B	1	IKBKG	0	imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), Medunjanin S (2016), Medunjanin S (2016), Medunjanin S (2016)	4
TNF	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Fritsch J (2014)	2
BIRC2	1	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
BIRC2	1	UBR4	15	affinity chromatography technology	Goncharov T (2013)	1
BIRC3	1	USP9X	15	affinity chromatography technology	Goncharov T (2013)	1