PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ESR1	0	PBX1	9	imaging technique	Toska E (2017)	1
BARX1	0	HOXD9	1	two hybrid	Wang J (2011)	1
MEIS1	0	HOXD9	1	pull down	Shanmugam K (1999)	1
PBX1	9	HOXD9	1	pull down	Shanmugam K (1999)	1
MEIS1	0	PBX1	9	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Shen WF (1999), Shanmugam K (1999), Jacobs Y (1999), Argiropoulos B (2010), Argiropoulos B (2010)	5
GORAB	1	HOXD9	1	two hybrid	Wang J (2011)	1
ETV5	0	HOXD9	1	two hybrid	Wang J (2011)	1
HOXD9	1	FCMR	0	two hybrid	Ravasi T (2010)	1
HMGB1	0	HOXD9	1	pull down	Zappavigna V (1996)	1
HOXC9	0	HOXD9	1	two hybrid	Ravasi T (2010)	1
ESR1	0	HOXD9	1	affinity chromatography technology	Han SJ (2016)	1