PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CHEK2	2	APP	1	pull down	Olah J (2011)	1
APC	5	HOXC6	0	two hybrid	Arroyo R (2015)	1
BCAR3	5	APP	1	pull down	Olah J (2011)	1
HMGB1	0	HOXC6	0	pull down	Zappavigna V (1996)	1
BCAR3	5	HOXC6	0	two hybrid	Arroyo R (2015)	1
TGFB1	2	APP	1	imaging technique	Chen TC (2014)	1
FGFR2	6	HOXC6	0	two hybrid	Arroyo R (2015)	1
IGF1R	5	APP	1	pull down	Olah J (2011)	1
CHEK2	2	HOXC6	0	two hybrid	Arroyo R (2015)	1
TGFB1	2	HOXC6	0	two hybrid	Arroyo R (2015)	1
FGFR2	6	APP	1	pull down	Olah J (2011)	1
IGF1R	5	HOXC6	0	two hybrid	Arroyo R (2015)	1
HOXC6	0	APP	1	pull down	Olah J (2011)	1
PTPRJ	5	HOXC6	0	two hybrid	Arroyo R (2015)	1