PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VHL	0	HNRNPL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lai Y (2011), Yao P (2013), Yao P (2013)	3
ESR1	0	HNRNPD	3	pull down	Nalvarte I (2010)	1
BRCA1	7	HNRNPH2	2	affinity chromatography technology	Ertych N (2016)	1
FBXW11	2	HNRNPH1	3	affinity chromatography technology	Coyaud E (2015)	1
EP300	36	YBX1	1	affinity chromatography technology	Sengupta S (2011)	1
EP300	36	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pao GM (2000), Pao GM (2000), Pao GM (2000), Pao GM (2000), Fan S (2002), Fan S (2002), Ma Y (2010), Subbaramaiah K (2011), Subbaramaiah K (2012)	9
HNRNPL	3	EP300	36	affinity chromatography technology	Fei T (2017)	1
HNRNPD	3	HNRNPH3	1	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
PTBP1	2	HNRNPL	3	two hybrid, two hybrid, two hybrid, pull down, pull down, pull down, biochemical, biochemical	Hahm B (1998), Kim JH (2000), Kim JH (2000), Kim JH (2000), Kim JH (2000), Hahm B (1998), Havugimana PC (2012), Wan C (2015)	8
HNRNPA1	1	HNRNPH1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Jeronimo C (2007), Jeronimo C (2007), Close P (2012), Havugimana PC (2012), Roy R (2014), Wan C (2015), Hein MY (2015)	7
HNRNPA1	1	HNRNPH3	1	affinity chromatography technology, biochemical, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Close P (2012), Havugimana PC (2012), Hegele A (2012), Hegele A (2012), Roy R (2014), Wan C (2015), Hein MY (2015)	7
VHL	0	HNRNPAB	4	affinity chromatography technology	Lai Y (2011)	1
HNRNPH1	3	HNRNPH2	2	affinity chromatography technology, biochemical, biochemical	Jeronimo C (2007), Havugimana PC (2012), Wan C (2015)	3
ESR1	0	HNRNPH2	2	affinity chromatography technology	Han SJ (2016)	1
HNRNPA2B1	2	YBX1	1	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
ERG	1	HNRNPA1	1	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
EP300	36	ESR1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Fajas L (2002), Fan S (2002), Fan S (2002), Fan S (2002), Kang YK (2002), Kang YK (2002), Hao L (2010), Jin W (2008), Cui Y (2006), Dutertre M (2003), Dutertre M (2003), Shiozawa T (2003), Kim SH (2010), Ma Y (2010), Ma Y (2010), Fujita T (2003), Likhite VS (2004), Band AM (2011), Loven MA (2004), Nalvarte I (2010), Yi P (2015)	21
HNRNPA1	1	HNRNPAB	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Roy R (2014), Hein MY (2015)	3
BRCA1	7	HNRNPL	3	affinity chromatography technology	Ertych N (2016)	1
HNRNPDL	1	HNRNPH1	3	biochemical	Havugimana PC (2012)	1
HNRNPDL	1	HNRNPH2	2	biochemical	Havugimana PC (2012)	1
HNRNPL	3	FBXW11	2	affinity chromatography technology	Fei T (2017)	1
ERG	1	HNRNPH1	3	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
YBX1	1	PTBP1	2	biochemical	Kristensen AR (2012)	1
BRCA1	7	LMNA	2	affinity chromatography technology	Ertych N (2016)	1
PSMA3	1	HNRNPA1	1	affinity chromatography technology	Fedorova OA (2011)	1
HNRNPA1	1	PTBP1	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical	Close P (2012), Havugimana PC (2012), Kristensen AR (2012), Roy R (2014), Wan C (2015)	5
HNRNPA2B1	2	HNRNPAB	4	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CSNK2A1	15	VHL	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Lolkema MP (2005), Lolkema MP (2005), Yang H (2007)	3
HNRNPDL	1	HNRNPL	3	biochemical	Havugimana PC (2012)	1
HNRNPH1	3	HNRNPH3	1	biochemical, two hybrid, two hybrid	Havugimana PC (2012), Hegele A (2012), Hegele A (2012)	3
LMNA	2	HNRNPA2B1	2	bioid, affinity chromatography technology	Roux KJ (2012), Depreux FF (2015)	2
ERG	1	HNRNPH3	1	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
BRCA1	7	HNRNPA1	1	affinity chromatography technology	Goina E (2008)	1
LMNA	2	CTNNB1	30	affinity chromatography technology	Choi J (2004)	1
FBXW11	2	HNRNPDL	1	affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014)	2
HNRNPD	3	HNRNPL	3	biochemical	Havugimana PC (2012)	1
HNRNPA2B1	2	CSNK2A1	15	affinity chromatography technology, enzymatic study, pull down, enzymatic study	Pancetti F (1999), Pancetti F (1999), Pancetti F (1999), Zhang M (2011)	4
HNRNPD	3	HNRNPA2B1	2	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015)	3
LMNA	2	HNRNPH1	3	affinity chromatography technology	Depreux FF (2015)	1
ERG	1	HNRNPDL	1	affinity chromatography technology, affinity chromatography technology, pull down	Brenner JC (2011), Wang S (2014), Wang S (2014)	3
HNRNPH2	2	HNRNPD	3	affinity chromatography technology	Hein MY (2015)	1
HNRNPH2	2	HNRNPH3	1	affinity chromatography technology	Hein MY (2015)	1
FBXW11	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe N (2005), Fuchs SY (1999), Gao D (2011), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Low TY (2014)	8
VHL	0	HNRNPH2	2	affinity chromatography technology	Lai Y (2011)	1
HNRNPDL	1	HNRNPD	3	biochemical	Havugimana PC (2012)	1
HNRNPDL	1	HNRNPA2B1	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
BRCA1	7	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Li H (2010), Li H (2010), Li H (2010), Ertych N (2016)	4
FBXW11	2	HNRNPH3	1	affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014)	2
HNRNPAB	4	PTBP1	2	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
SPTA1	10	LMNA	2	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
CSNK2A1	15	BRCA1	7	pull down	OBrien KA (1999)	1
BRCA1	7	HNRNPAB	4	affinity chromatography technology	Ertych N (2016)	1
HNRNPD	3	BRCA1	7	affinity chromatography technology, two hybrid, affinity chromatography technology	Shimizu Y (2012), Lehner B (2004), Ertych N (2016)	3
CTNNB1	30	ESR1	0	affinity chromatography technology	Kouzmenko AP (2004)	1
FBXW11	2	HNRNPAB	4	affinity chromatography technology	Coyaud E (2015)	1
HNRNPA2B1	2	VHL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pioli PA (2001), Lai Y (2011), Yao P (2013), Liu Y (2016), Liu Y (2016)	5
HNRNPH1	3	HNRNPA2B1	2	affinity chromatography technology, biochemical, biochemical	Jeronimo C (2007), Havugimana PC (2012), Wan C (2015)	3
HNRNPH1	3	HNRNPAB	4	biochemical	Wan C (2015)	1
ERG	1	HNRNPD	3	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
ESR1	0	HNRNPA1	1	affinity chromatography technology, pull down	Tarallo R (2011), Nalvarte I (2010)	2
ERG	1	HNRNPA2B1	2	affinity chromatography technology, affinity chromatography technology, pull down	Brenner JC (2011), Wang S (2014), Wang S (2014)	3
BRCA1	7	HNRNPDL	1	affinity chromatography technology	Ertych N (2016)	1
YBX1	1	HNRNPAB	4	biochemical	Kristensen AR (2012)	1
HNRNPH3	1	HNRNPA2B1	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
BRCA1	7	HNRNPA2B1	2	affinity chromatography technology, affinity chromatography technology	Goina E (2008), Ertych N (2016)	2
LMNA	2	HNRNPA1	1	bioid, affinity chromatography technology	Roux KJ (2012), Roy R (2014)	2
CTNNB1	30	HNRNPA2B1	2	affinity chromatography technology, affinity chromatography technology	Sato S (2005), Sato S (2005)	2
CTNNB1	30	HNRNPA1	1	affinity chromatography technology, affinity chromatography technology	Tian Q (2004), Sato S (2005)	2
BRCA1	7	HNRNPH3	1	affinity chromatography technology	Ertych N (2016)	1
BRCA1	7	PTBP1	2	affinity chromatography technology	Ertych N (2016)	1
FBXW11	2	YBX1	1	affinity chromatography technology	Low TY (2014)	1
VHL	0	HNRNPA1	1	affinity chromatography technology	Lai Y (2011)	1
CSNK2A1	15	HNRNPL	3	enzymatic study	Zhang M (2011)	1
HNRNPA1	1	HNRNPA2B1	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Jeronimo C (2007), Havugimana PC (2012), Kristensen AR (2012), Roy R (2014), Wan C (2015), Hein MY (2015)	6
HNRNPA1	1	HNRNPD	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Close P (2012), Havugimana PC (2012), Roy R (2014), Hein MY (2015)	4
HNRNPD	3	PTBP1	2	biochemical, two hybrid, two hybrid, biochemical, biochemical	Havugimana PC (2012), Hegele A (2012), Hegele A (2012), Kristensen AR (2012), Wan C (2015)	5
PSMA3	1	HNRNPA2B1	2	affinity chromatography technology, pull down	Fedorova OA (2011), Fedorova OA (2011)	2
HNRNPA1	1	HNRNPDL	1	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Jeronimo C (2007), Havugimana PC (2012), Roy R (2014), Wan C (2015), Hein MY (2015)	5
HNRNPD	3	YBX1	1	two hybrid, pull down, affinity chromatography technology	Moraes KC (2003), Moraes KC (2003), Hein MY (2015)	3
ESR1	0	HNRNPA2B1	2	affinity chromatography technology, pull down	Tarallo R (2011), Nalvarte I (2010)	2
ESR1	0	HNRNPAB	4	affinity chromatography technology	Tarallo R (2011)	1
CTNNB1	30	EP300	36	genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, genetic interference, affinity chromatography technology	Kennell JA (2003), Sun Y (2000), Sun Y (2000), Sun Y (2000), Saegusa M (2005), Daniels DL (2002), Levy L (2004), Labalette C (2004), Lee YH (2006), Zhao Y (2016)	10
VHL	0	HNRNPD	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down	Lai Y (2011), Xin H (2011), Xin H (2011), Xin H (2011), Xin H (2011), Xin H (2011)	6
LMNA	2	YBX1	1	affinity chromatography technology	Depreux FF (2015)	1
VHL	0	HNRNPH1	3	affinity chromatography technology	Lai Y (2011)	1
ZMAT3	0	HNRNPA2B1	2	affinity chromatography technology, affinity chromatography technology	Prahl M (2008), Prahl M (2008)	2
EP300	36	HNRNPA2B1	2	affinity chromatography technology, affinity chromatography technology	Xuan Y (2016), Xuan Y (2016)	2
PTBP1	2	HNRNPA2B1	2	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
ESR1	0	YBX1	1	affinity chromatography technology	Tarallo R (2011)	1
HNRNPH1	3	HNRNPD	3	affinity chromatography technology	Jeronimo C (2007)	1
PSMA3	1	PTBP1	2	affinity chromatography technology	Fedorova OA (2011)	1
LMNA	2	CSNK2A1	15	affinity chromatography technology	Depreux FF (2015)	1
VHL	0	HNRNPDL	1	affinity chromatography technology	Lai Y (2011)	1
LMNA	2	HNRNPL	3	affinity chromatography technology	Depreux FF (2015)	1
BRCA1	7	HNRNPH1	3	affinity chromatography technology	Ertych N (2016)	1
HNRNPA1	1	HNRNPH2	2	affinity chromatography technology, affinity chromatography technology, biochemical	Close P (2012), Roy R (2014), Wan C (2015)	3
FBXW11	2	HNRNPH2	2	affinity chromatography technology	Coyaud E (2015)	1
ERG	1	HNRNPAB	4	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
HNRNPA1	1	HNRNPL	3	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Havugimana PC (2012), Roy R (2014), Hein MY (2015)	5
BRCA1	7	ESR1	0	imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Zheng L (2001), Fan S (2001), Fan S (2001), Kawai H (2002), Fan S (2002), Fan S (2002), Nakuci E (2006), Wang C (2005), Wang C (2005), Dizin E (2010), Dizin E (2010), Ma Y (2010), Ma Y (2010), Fan S (2001), Ma YX (2005), Ma YX (2005), Ma YX (2005), Ma Y (2007), Ma Y (2007), Kawai H (2002), Jung YS (2014), Kawai H (2002), Kawai H (2002)	23
FBXW11	2	HNRNPD	3	affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014)	2
EP300	36	VHL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roe JS (2006), Roe JS (2011), Roe JS (2011), Ji W (2014), Chen K (2015)	5
HNRNPA2B1	2	HNRNPL	3	affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Hamilton BJ (1999), Havugimana PC (2012), Yao P (2013), Yao P (2013), Yao P (2013), Fei T (2017)	6
CSNK2A1	15	PSMA3	1	enzymatic study	Zhang M (2011)	1
HNRNPD	3	HNRNPAB	4	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
HNRNPDL	1	PTBP1	2	biochemical	Havugimana PC (2012)	1
HNRNPA2B1	2	HNRNPH2	2	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
FBXW11	2	HNRNPA2B1	2	affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014)	2
HNRNPH1	3	HNRNPL	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
HNRNPDL	1	HNRNPH3	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
BRCA1	7	YBX1	1	affinity chromatography technology, affinity chromatography technology	Woods NT (2012), Ertych N (2016)	2
SPTA1	10	HNRNPA2B1	2	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
CSNK2A1	15	HNRNPDL	1	enzymatic study	Zhang M (2011)	1
CSNK2A1	15	YBX1	1	enzymatic study	Zhang M (2011)	1
FBXW11	2	HNRNPA1	1	affinity chromatography technology	Coyaud E (2015)	1