PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
COPS5	0	NCOA1	6	two hybrid, pull down	Chauchereau A (2000), Chauchereau A (2000)	2
HNF4G	1	PRDX6	0	two hybrid	Albers M (2005)	1
HNF4G	1	PSMC5	4	two hybrid	Albers M (2005)	1
NSD1	25	HNF4G	1	two hybrid	Chan CM (2013)	1
RANBP9	5	COPS5	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Wang H (2013), Wang H (2013), Wang H (2013)	3
HNF4G	1	NCOA1	6	two hybrid, two hybrid	Chan CM (2013), Albers M (2005)	2
COPS5	0	GAPDH	0	affinity chromatography technology	Bennett EJ (2010)	1
HNF4G	1	COPS5	0	two hybrid	Albers M (2005)	1
HNF4G	1	PNRC1	0	two hybrid	Albers M (2005)	1
HNF4G	1	RANBP9	5	two hybrid	Albers M (2005)	1
HNF4G	1	GAPDH	0	two hybrid	Albers M (2005)	1
HNF4G	1	PNRC2	0	two hybrid	Albers M (2005)	1
HNF4G	1	TNNI2	2	two hybrid	Albers M (2005)	1
HLF	0	HNF4G	1	two hybrid	Ravasi T (2010)	1
HNF4G	1	NR0B2	1	two hybrid	Albers M (2005)	1
HNF4G	1	HAX1	1	two hybrid	Albers M (2005)	1
DNMT3L	2	HNF4G	1	pull down	Pacaud R (2014)	1