PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FOXA1	2	ESR1	0	affinity chromatography technology, imaging technique	Jozwik KM (2016), Toska E (2017)	2
AHR	3	FOXA1	2	imaging technique, imaging technique	Ahmed S (2012), Ahmed S (2012)	2
ESR1	0	PIAS1	4	two hybrid	Kobayashi S (2004)	1
FOXA1	2	RCC1	2	affinity chromatography technology, affinity chromatography technology	Li X (2015), Jozwik KM (2016)	2
FOXA1	2	AR	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao N (2003), Gao N (2003), Toropainen S (2015), Grasso CS (2012), Grasso CS (2012)	5
AHR	3	ESR1	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study	Wormke M (2003), Klinge CM (2000), MacPherson L (2009), Beischlag TV (2005), Ohtake F (2007), Ohtake F (2007), Ohtake F (2007), Ohtake F (2007)	8
FOXA1	2	PIAS1	4	affinity chromatography technology, imaging technique	Toropainen S (2015), Toropainen S (2015)	2
AR	3	PIAS1	4	two hybrid, affinity chromatography technology	Kotaja N (2000), Toropainen S (2015)	2
KMT2C	28	FOXA1	2	imaging technique, affinity chromatography technology	Jozwik KM (2016), Jozwik KM (2016)	2
FOXA1	2	HDAC7	4	affinity chromatography technology, affinity chromatography technology	Malik S (2010), Malik S (2010)	2
AR	3	AHR	3	affinity chromatography technology	Sun F (2015)	1
HDAC7	4	AR	3	affinity chromatography technology	Karvonen U (2006)	1
HDAC7	4	ESR1	0	affinity chromatography technology, affinity chromatography technology	Malik S (2010), Malik S (2010)	2