PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CREBBP	29	MYB	3	x-ray crystallography, pull down, genetic interference, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, x-ray crystallography, pull down	Zor T (2002), Zor T (2002), Bessa M (2001), Kurahashi T (2005), Kurahashi T (2005), Sano Y (2001), Sano Y (2001), Nomura T (2004), Yang F (2006), Giri R (2013)	10
HLF	0	MYB	3	two hybrid	Ravasi T (2010)	1
HLF	0	TLK1	5	affinity chromatography technology	Huttlin EL (2017)	1
HLF	0	CREBBP	29	two hybrid, pull down	Gradin K (2002), Gradin K (2002)	2
HLF	0	HNF4G	1	two hybrid	Ravasi T (2010)	1
DBP	1	HLF	0	two hybrid	Wang J (2011)	1