PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
STAT3	0	PIAS3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Wang LH (2001), Okumura F (2010), Yamamoto T (2003), Yamamoto T (2003), Tsuruma R (2008), Liu B (1998), Wang J (2011)	7
DNMT3B	3	SUZ12	0	affinity chromatography technology	OHagan HM (2011)	1
MTA1	3	CHD3	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Yan C (2003), Khaleque MA (2008), Xue Y (1998), Wan C (2015)	4
DNMT1	5	DNMT3A	17	affinity chromatography technology, pull down, affinity chromatography technology	Kim GD (2002), Kim GD (2002), Rigbolt KT (2011)	3
HIC1	1	MTA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Van Rechem C (2010), Dehennaut V (2013), Dehennaut V (2013)	3
CTBP1	2	MECOM	4	affinity chromatography technology, genetic interference, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Chakraborty S (2001), Chakraborty S (2001), Chakraborty S (2001), Izutsu K (2001), Izutsu K (2001), Huttlin EL (2015), Huttlin EL (2017)	7
HIC1	1	STAT3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lin YM (2013), Lin YM (2013), Lin YM (2013), Lin YM (2013), Hu B (2016), Hu B (2016)	6
HIC1	1	EED	1	affinity chromatography technology	Boulay G (2012)	1
PHF1	1	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Cai L (2013), Hauri S (2016)	2
HIC1	1	HDAC4	10	affinity chromatography technology	Stankovic-Valentin N (2007)	1
DNMT3B	3	RBBP4	3	affinity chromatography technology	Cai Y (2014)	1
HIC1	1	MBD3	4	affinity chromatography technology	Van Rechem C (2010)	1
CTBP1	2	PIAS2	2	two hybrid	Corominas R (2014)	1
HIC1	1	RBBP4	3	affinity chromatography technology	Van Rechem C (2010)	1
PIAS2	2	HIC1	1	enzymatic study, imaging technique	Stankovic-Valentin N (2007), Sun L (2013)	2
DNMT3B	3	MTA1	3	affinity chromatography technology	Cai Y (2014)	1
HIC1	1	EZH2	4	affinity chromatography technology	Boulay G (2012)	1
UBE2I	0	MECOM	4	enzymatic study	Singh S (2013)	1
DNMT3B	3	SIRT1	3	affinity chromatography technology	OHagan HM (2011)	1
DNMT1	5	DNMT3B	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology	Lehnertz B (2003), Kim GD (2002), Kim GD (2002), Geiman TM (2004), Woloszynska-Read A (2007), OHagan HM (2011), Rigbolt KT (2011)	7
STAT3	0	DNMT1	5	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Zhang Q (2005), Zhang Q (2005), Zhang Q (2005), Xing WJ (2015)	4
HIC1	1	PHF19	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Boulay G (2012), Boulay G (2012), Boulay G (2012)	3
CTBP1	2	UBE2I	0	affinity chromatography technology	Kuppuswamy M (2008)	1
TRIM25	5	CTBP1	2	affinity chromatography technology	Choudhury NR (2017)	1
SP1	0	DNMT1	5	affinity chromatography technology, affinity chromatography technology	Esteve PO (2007), Esteve PO (2007)	2
CHD3	19	RBBP4	3	affinity chromatography technology, biochemical, affinity chromatography technology	Xue Y (1998), Havugimana PC (2012), Hauri S (2016)	3
DNMT1	5	MBD3	4	affinity chromatography technology	Cui S (2011)	1
SP1	0	RBBP4	3	affinity chromatography technology	Zhang Y (2002)	1
HDAC4	10	MECOM	4	affinity chromatography technology	Chakraborty S (2001)	1
SIRT1	3	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao X (2005), Dehennaut V (2013), Dehennaut V (2013)	3
SIRT1	3	DNMT1	5	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Peng L (2011), Peng L (2011), Peng L (2011), OHagan HM (2011), OHagan HM (2011)	5
PIAS2	2	PIAS1	4	imaging technique	Chen TC (2014)	1
SENP3	1	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang M (2016), Wang M (2016), Wang M (2016)	3
DNMT3B	3	HIC1	1	affinity chromatography technology, affinity chromatography technology	Zeng S (2016), Zeng S (2016)	2
PHF1	1	EZH2	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	OConnell S (2001), Hong Z (2008), Sarma K (2008), Cao Q (2014), Cai L (2013), Cai L (2013), Hein MY (2015), Hauri S (2016), Hauri S (2016)	9
SUZ12	0	PHF19	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Ballare C (2012), Ballare C (2012), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
CTBP1	2	HIC2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	ARID1A	16	affinity chromatography technology	Choudhury NR (2017)	1
CTBP1	2	DNMT1	5	imaging technique	Kiskinis E (2007)	1
UBE2I	0	PIAS3	2	two hybrid, two hybrid	Bandyopadhyay S (2010), Wang J (2011)	2
CTBP2	7	CTBP1	2	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sewalt RG (1999), Wang J (2011), Corominas R (2014), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
SIRT1	3	SUZ12	0	affinity chromatography technology, affinity chromatography technology	Kuzmichev A (2005), OHagan HM (2011)	2
TRIM25	5	STAT3	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	SENP3	1	affinity chromatography technology	Choudhury NR (2017)	1
PHF1	1	EED	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sarma K (2008), Cai L (2013), Hein MY (2015), Hauri S (2016), Hauri S (2016)	5
SP1	0	HIC1	1	imaging technique	Sun L (2013)	1
EZH2	4	DNMT3B	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vire E (2006), Vire E (2006), Vire E (2006), OHagan HM (2011), Gong C (2015)	5
EED	1	ARID1A	16	affinity chromatography technology	Cao Q (2014)	1
CTBP2	7	UBE2I	0	two hybrid	Wang J (2011)	1
TRIM25	5	MTA1	3	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Zang HL (2017)	2
DNMT3A	17	DNMT3B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ling Y (2004), Lehnertz B (2003), Kim GD (2002), Kim GD (2002), Kashiwagi K (2011), Kashiwagi K (2011), Huttlin EL (2017)	7
SUZ12	0	DNMT1	5	affinity chromatography technology	Xu B (2011)	1
EED	1	RBBP4	3	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2004), Cao R (2004), Hein MY (2015), Hauri S (2016), Hauri S (2016)	5
HIC1	1	TCF7L2	12	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Valenta T (2006), Valenta T (2006), Valenta T (2006), Valenta T (2006)	4
HIC1	1	SIRT1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stankovic-Valentin N (2007), Dehennaut V (2012), Dehennaut V (2012), Chen WY (2005), Dehennaut V (2013)	5
PIAS4	5	HIC1	1	imaging technique	Sun L (2013)	1
HIC1	1	HIC2	3	two hybrid, imaging technique	Deltour S (2001), Deltour S (2001)	2
SP1	0	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mottet D (2009), Mottet D (2009), Wilson AJ (2008)	3
MECOM	4	MBD3	4	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Spensberger D (2008), Spensberger D (2008), Spensberger D (2008), Spensberger D (2008)	4
PIAS4	5	MECOM	4	affinity chromatography technology, affinity chromatography technology	Singh S (2013), Singh S (2013)	2
DNMT3B	3	UBE2I	0	two hybrid, pull down	Kang ES (2001), Kang ES (2001)	2
DNMT1	5	MTA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Cui S (2011), Cui S (2011), Cai Y (2014), Cai Y (2014), Wan C (2015)	5
SP1	0	STAT3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin S (2006), Zhang Y (2007), Zhang Y (2007), Proietti CJ (2011)	4
PHF19	3	SENP3	1	affinity chromatography technology	Huttlin EL (2017)	1
SUZ12	0	TRIM25	5	affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Choudhury NR (2017)	2
EZH2	4	DNMT1	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vire E (2006), Vire E (2006), Vire E (2006), Xu B (2011), OHagan HM (2011)	5
UBE2I	0	SUZ12	0	pull down, affinity chromatography technology	Riising EM (2008), Riising EM (2008)	2
PIAS1	4	HIC1	1	enzymatic study	Stankovic-Valentin N (2007)	1
CTBP1	2	TCF7L2	12	pull down, affinity chromatography technology	Valenta T (2003), Loregger A (2015)	2
MBD3	4	MTA1	3	pull down, affinity chromatography technology, biochemical	Yildirim O (2011), Cui S (2011), Wan C (2015)	3
EZH2	4	TRIM25	5	affinity chromatography technology	Cao Q (2014)	1
EED	1	SUZ12	0	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2004), Cao R (2004), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Sarma K (2008), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Hein MY (2015), Chan YS (2013), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	22
EZH2	4	DNMT3A	17	pull down, affinity chromatography technology, affinity chromatography technology	Vire E (2006), Vire E (2006), Vire E (2006)	3
EZH2	4	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su IH (2005), Aoto T (2008), Hansen KH (2008), Li G (2010), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Pasini D (2008), Sarma K (2008), Xu B (2011), Xu B (2011), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Lee ST (2011), Havugimana PC (2012), Sahasrabuddhe AA (2014), Wang L (2013), Wu L (2013), Pasini D (2010), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Bhatnagar S (2014), Bhatnagar S (2014), Zhao R (2015), Wienken M (2016), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Mahara S (2016), Hauri S (2016), Hauri S (2016)	40
PHF19	3	PHF1	1	affinity chromatography technology	Hauri S (2016)	1
PIAS2	2	PIAS4	5	two hybrid	Wang J (2011)	1
TRIM25	5	DNMT3A	17	affinity chromatography technology	Choudhury NR (2017)	1
CTBP1	2	CHD3	19	two hybrid	Vinayagam A (2011)	1
HDAC4	10	CTBP1	2	pull down	Zhang CL (2001)	1
EED	1	MTA1	3	affinity chromatography technology	Cao Q (2014)	1
DNMT3A	17	PIAS1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Ling Y (2004), Ling Y (2004), Ling Y (2004), Ling Y (2004), Liu B (2010), Liu B (2010)	6
MTA1	3	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology	Yao YL (2003), Roche AE (2008), Cui S (2011), Cui S (2011), Rolland T (2014), Huttlin EL (2015), Alqarni SS (2014), Alqarni SS (2014), Alqarni SS (2014), Wan C (2015), Huttlin EL (2017), Millard CJ (2016), Millard CJ (2016), Millard CJ (2016), Hauri S (2016)	15
PIAS1	4	DNMT3B	3	affinity chromatography technology, imaging technique	Liu B (2010), Liu B (2010)	2
UBE2I	0	HDAC4	10	enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Knipscheer P (2008), Zhao X (2005), Zhao X (2005), Dehennaut V (2013), Tatham MH (2001), Knipscheer P (2007)	6
PIAS3	2	HIC1	1	imaging technique	Sun L (2013)	1
HIC1	1	CTBP2	7	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Van Rechem C (2009), Van Rechem C (2009), Van Rechem C (2010), Stankovic-Valentin N (2006), Stankovic-Valentin N (2006)	5
EZH2	4	RBBP4	3	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li G (2010), Kaneko S (2010), Kaneko S (2010), Cao Q (2014), Hein MY (2015), Hauri S (2016), Hauri S (2016)	7
EED	1	DNMT1	5	affinity chromatography technology, imaging technique, affinity chromatography technology	Vire E (2006), Vire E (2006), OHagan HM (2011)	3
MTA1	3	UBE2I	0	affinity chromatography technology, pull down	Cong L (2011), Cong L (2011)	2
HIC1	1	MECOM	4	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Pradhan AK (2014), Pradhan AK (2014), Pradhan AK (2014)	3
PHF19	3	EZH2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Boulay G (2011), Cao Q (2014), Ballare C (2012), Ballare C (2012), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
DNMT1	5	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Cui S (2011), Cui S (2011)	2
SENP3	1	HIC1	1	enzymatic study	Stankovic-Valentin N (2007)	1
EZH2	4	SIRT1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Kuzmichev A (2005), Kuzmichev A (2005), OHagan HM (2011), Wan J (2015), Wan J (2015), Wan J (2015)	6
HIC1	1	PHF1	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Boulay G (2012), Boulay G (2012), Boulay G (2012)	3
MTA1	3	SIRT1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EED	1	DNMT3A	17	affinity chromatography technology, imaging technique	Vire E (2006), Vire E (2006)	2
PIAS4	5	UBE2I	0	two hybrid, pull down, pull down, pull down	Wang J (2011), Yamamoto H (2003), Yin Y (2012), Ryu H (2010)	4
DNMT3A	17	HIC1	1	affinity chromatography technology, affinity chromatography technology	Zeng S (2016), Zeng S (2016)	2
EZH2	4	EED	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, pull down, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Lohuizen M (1998), van Lohuizen M (1998), van Lohuizen M (1998), van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Pasini D (2004), Cao R (2004), Su IH (2005), Hansen KH (2008), Margueron R (2008), Margueron R (2008), Shen X (2008), Shen X (2008), Hernandez-Munoz I (2005), Sarma K (2008), Sarma K (2008), Han Z (2007), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Satijn DP (2001), Satijn DP (2001), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Wang L (2013), Wu L (2013), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Hein MY (2015), Chan YS (2013), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	49
HIC1	1	SUZ12	0	affinity chromatography technology	Boulay G (2012)	1
DNMT1	5	HIC1	1	affinity chromatography technology, affinity chromatography technology	Zeng S (2016), Zeng S (2016)	2
TRIM25	5	CHD3	19	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	CTBP2	7	affinity chromatography technology	Choudhury NR (2017)	1
SIRT1	3	EED	1	affinity chromatography technology	OHagan HM (2011)	1
SUZ12	0	RBBP4	3	pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2004), Cao R (2004), Havugimana PC (2012), Pasini D (2010), Cao Q (2014), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	8
UBE2I	0	PIAS2	2	two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down	Rual JF (2005), Lee BH (2003), Bandyopadhyay S (2010), Schmidt D (2002), Wang J (2011), Rolland T (2014), Saul VV (2014), van den Akker E (2005), Schmidt D (2002)	9
HIC1	1	HIC1	1	two hybrid	Deltour S (1999)	1
PHF19	3	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballare C (2012), Hauri S (2016), Hauri S (2016)	3
HIC1	1	CTBP1	2	two hybrid, affinity chromatography technology	Van Rechem C (2009), Stankovic-Valentin N (2006)	2
DNMT3A	17	PIAS2	2	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Ling Y (2004), Ling Y (2004), Ling Y (2004), Ling Y (2004)	4
CTBP1	2	SP1	0	affinity chromatography technology, affinity chromatography technology	Glasspool RM (2005), Glasspool RM (2005)	2
EED	1	DNMT3B	3	affinity chromatography technology, imaging technique, affinity chromatography technology	Vire E (2006), Vire E (2006), OHagan HM (2011)	3
CHD3	19	PIAS4	5	two hybrid	Goehler H (2004)	1
TRIM25	5	HIC1	1	affinity chromatography technology	Choudhury NR (2017)	1
HIC1	1	ARID1A	16	two hybrid, affinity chromatography technology	Van Rechem C (2009), Van Rechem C (2009)	2
SIRT1	3	STAT3	0	affinity chromatography technology	Lin Z (2012)	1
PHF19	3	EED	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Boulay G (2011), Ballare C (2012), Ballare C (2012), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
SIRT1	3	CHD3	19	affinity chromatography technology	Kim JE (2008)	1
CHD3	19	MBD3	4	biochemical	Havugimana PC (2012)	1
TCF7L2	12	UBE2I	0	two hybrid, affinity chromatography technology	Wang J (2011), Hsieh YL (2013)	2
PHF1	1	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hong Z (2008), Sarma K (2008), Cao Q (2014), Cai L (2013), Cai L (2013), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	8
UBE2I	0	HIC1	1	enzymatic study, affinity chromatography technology	Stankovic-Valentin N (2007), Dehennaut V (2013)	2
UBE2I	0	CHD3	19	two hybrid	Lee BH (2003)	1
SUZ12	0	MTA1	3	affinity chromatography technology	Cao Q (2014)	1
HDAC4	10	RBBP4	3	affinity chromatography technology	Grozinger CM (1999)	1
SIRT1	3	MECOM	4	affinity chromatography technology, affinity chromatography technology	Pradhan AK (2011), Pradhan AK (2011)	2
HIC1	1	CHD3	19	affinity chromatography technology	Van Rechem C (2010)	1
MBD3	4	RBBP4	3	pull down, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang Y (1999), Cui S (2011), Havugimana PC (2012), Hauri S (2016)	4
UBE2I	0	PIAS1	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Lee BH (2003), Sapetschnig A (2002), Kahyo T (2001), Bandyopadhyay S (2010), Driscoll JJ (2010), Kahyo T (2001), Yin Y (2012), Gocke CB (2005), van den Akker E (2005), Ogawa H (2009), Schmidt D (2002), Gibbs-Seymour I (2015)	12
DNMT3A	17	UBE2I	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Ling Y (2004), Ling Y (2004), Ling Y (2004), Ling Y (2004)	4
TRIM25	5	RBBP4	3	affinity chromatography technology	Choudhury NR (2017)	1
SIRT1	3	UBE2I	0	enzymatic study	Hsieh YL (2013)	1