PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RAB8A	0	EHD1	5	imaging technique	Roland JT (2007)	1
HNRNPL	3	EHD3	0	affinity chromatography technology	Fei T (2017)	1
EHD3	0	EHD1	5	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Galperin E (2002), Galperin E (2002), Galperin E (2002), Naslavsky N (2006), Naslavsky N (2006)	5
EHD3	0	RAB11FIP2	2	two hybrid, affinity chromatography technology	Naslavsky N (2006), Naslavsky N (2006)	2
STX7	2	SNAP29	1	pull down, affinity chromatography technology, biochemical, affinity chromatography technology	Steegmaier M (1998), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
HNRNPL	3	SNAP29	1	affinity chromatography technology	Fei T (2017)	1
EHD1	5	RBSN	2	two hybrid, pull down, two hybrid, affinity chromatography technology	Naslavsky N (2004), Henry GD (2010), Naslavsky N (2006), Huttlin EL (2017)	4
RAB8A	0	EHD3	0	imaging technique	Roland JT (2007)	1
INTU	1	EHD3	0	affinity chromatography technology	Boldt K (2016)	1
STX7	2	EHD3	0	biochemical	Wan C (2015)	1
EHD1	5	SNAP29	1	two hybrid, pull down	Rotem-Yehudar R (2001), Rotem-Yehudar R (2001)	2
EHD3	0	SNAP29	1	two hybrid	Rotem-Yehudar R (2001)	1
STX7	2	EHD1	5	biochemical	Wan C (2015)	1
EHD3	0	RBSN	2	two hybrid, two hybrid, affinity chromatography technology	Naslavsky N (2004), Naslavsky N (2006), Huttlin EL (2017)	3
EHD3	0	EHD3	0	two hybrid	Naslavsky N (2006)	1
HNRNPL	3	INTU	1	affinity chromatography technology	Fei T (2017)	1
EHD1	5	RAB11FIP2	2	pull down, two hybrid, affinity chromatography technology	Henry GD (2010), Naslavsky N (2006), Naslavsky N (2006)	3