PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NCK1	0	SOCS7	1	two hybrid, pull down	Matuoka K (1997), Matuoka K (1997)	2
CUL5	1	SOCS7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Simo S (2013), Huttlin EL (2017)	3
SOCS7	1	STAT3	0	two hybrid, affinity chromatography technology	Martens N (2005), Martens N (2005)	2
SOCS7	1	DAB1	1	pull down, enzymatic study	Simo S (2013), Simo S (2013)	2
SOCS7	1	SORBS3	5	two hybrid	Martens N (2004)	1
SEPT6	0	SOCS7	1	affinity chromatography technology	Kremer BE (2007)	1
SOCS7	1	STAT5A	4	affinity chromatography technology	Martens N (2005)	1