PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FOXA1	2	ESR1	0	affinity chromatography technology, imaging technique	Jozwik KM (2016), Toska E (2017)	2
DNTTIP2	1	KAT5	1	affinity chromatography technology, affinity chromatography technology	Koiwai K (2011), Koiwai K (2011)	2
FOXA1	2	DNTTIP2	1	affinity chromatography technology	Jozwik KM (2016)	1
TRIM25	5	RPL35	1	affinity chromatography technology	Choudhury NR (2017)	1
OBSL1	9	HNRNPA1	1	affinity chromatography technology	Hanson D (2014)	1
DGCR8	4	NIFK	1	affinity chromatography technology	Huttlin EL (2017)	1
PHF8	6	DNTTIP2	1	affinity chromatography technology	Hein MY (2015)	1
NIFK	1	DNTTIP2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SIRT7	1	DNTTIP2	1	affinity chromatography technology	Tsai YC (2012)	1
IFI16	1	DNTTIP2	1	affinity chromatography technology	Diner BA (2015)	1
TRIM25	5	RXRA	1	affinity chromatography technology	Choudhury NR (2017)	1
SPP1	0	DNTTIP2	1	two hybrid	Long P (2012)	1
HNRNPA1	1	DNTTIP2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNTTIP2	1	HIST2H3A	0	pull down	Fujita K (2003)	1
FOXA1	2	RBM4	1	affinity chromatography technology	Jozwik KM (2016)	1
DNTT	1	DNTTIP2	1	pull down, two hybrid	Fujita K (2003), Fujita K (2003)	2
OBSL1	9	HIST4H4	1	affinity chromatography technology	Hanson D (2014)	1
ESR2	1	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, biochemical	Ogawa S (1998), Ogawa S (1998), Ogawa S (1998), Poelzl G (2000), Rossi V (2009), Monroe DG (2003), Nassa G (2011)	7
TRIM25	5	ESR2	1	affinity chromatography technology	Choudhury NR (2017)	1
FGF3	1	DNTTIP2	1	affinity chromatography technology	Huttlin EL (2017)	1
KAT5	1	ESR1	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Nakajima A (2007), Gaughan L (2001), Jeong KW (2011)	3
OBSL1	9	HIST2H3A	0	affinity chromatography technology	Hanson D (2014)	1
CTNNBL1	1	DNTTIP2	1	genetic interference	Horlbeck MA (2018)	1
DNTTIP2	1	ESR2	1	pull down	Bu H (2004)	1
HDAC11	0	DNTTIP2	1	affinity chromatography technology	Joshi P (2013)	1
DNTTIP2	1	HIST1H2BA	0	pull down	Fujita K (2003)	1
IFI16	1	NIFK	1	affinity chromatography technology	Diner BA (2015)	1
PPARG	0	KAT5	1	pull down, unspecified method	van Beekum O (2008), Lee G (2002)	2
ESR1	0	HNRNPA1	1	affinity chromatography technology, pull down	Tarallo R (2011), Nalvarte I (2010)	2
RBM4	1	DNTTIP2	1	affinity chromatography technology	Huttlin EL (2017)	1
ZNF2	1	DNTTIP2	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	ESR1	0	affinity chromatography technology, pull down, enzymatic study	Nakajima A (2007), Nakajima A (2007), Nakajima A (2007)	3
SIRT7	1	NIFK	1	affinity chromatography technology	Tsai YC (2012)	1
DNTTIP2	1	RXRA	1	pull down	Bu H (2004)	1
OBSL1	9	RBM4	1	affinity chromatography technology	Hanson D (2014)	1
DNTTIP2	1	HIST3H2A	0	pull down	Fujita K (2003)	1
ESR1	0	DNTTIP2	1	two hybrid, pull down, affinity chromatography technology	Bu H (2004), Bu H (2004), Bu H (2004)	3
TRIM25	5	HNRNPA1	1	affinity chromatography technology	Choudhury NR (2017)	1
OBSL1	9	NIFK	1	affinity chromatography technology	Hanson D (2014)	1
DNTTIP2	1	RPL35	1	genetic interference	Horlbeck MA (2018)	1
DNTTIP2	1	HIST4H4	1	pull down	Fujita K (2003)	1
KAT5	1	ESR2	1	two hybrid	Gaughan L (2001)	1
SPP1	0	CTNNBL1	1	two hybrid	Rual JF (2005)	1
HIST1H2BA	0	KAT5	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNTTIP2	1	PPARG	0	pull down	Bu H (2004)	1
KAT5	1	HIST4H4	1	enzymatic study	Cui H (2015)	1
TRIM25	5	PHF8	6	affinity chromatography technology	Choudhury NR (2017)	1
OBSL1	9	DNTTIP2	1	affinity chromatography technology	Hanson D (2014)	1
TRIM25	5	DNTTIP2	1	affinity chromatography technology	Choudhury NR (2017)	1
RXRA	1	PPARG	0	biochemical, pull down, x-ray crystallography, pull down, pull down, pull down, imaging technique, pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, two hybrid, x-ray crystallography, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tontonoz P (1994), Berger J (2000), Gampe RT (2000), Tontonoz P (1998), Billiet L (2008), Tachibana K (2013), Song K (2013), Mukherjee R (1997), Lee G (2002), Li S (2013), Bernardes A (2012), Bernardes A (2012), Nickkho-Amiry M (2012), Jurkowski W (2011), Gupta RA (2003), Rochel N (2011), Rochel N (2011), Malerod L (2003), Chen F (2003), Chen F (2003), Tagami T (2009), Chandra V (2008), Lu J (2008), Molnar F (2005), Jeninga EH (2007), Ray DM (2008), Ray DM (2008), DiRenzo J (1997), Li X (2015), Park S (2015)	30
CTNNBL1	1	HIST4H4	1	affinity chromatography technology	Ganesh K (2011)	1
DGCR8	4	DNTTIP2	1	affinity chromatography technology	Huttlin EL (2017)	1