Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
HTT 3064 DASOTRALINE CHEMBL3301595 inhibitor ChemblInteractions
HTT 3064 PAROXETINE HYDROCHLORIDE CHEMBL1708 inhibitor ChemblInteractions
HTT 3064 CLOMIPRAMINE HYDROCHLORIDE CHEMBL1200710 inhibitor ChemblInteractions
HTT 3064 PAROXETINE MESYLATE CHEMBL1200609 inhibitor ChemblInteractions
HTT 3064 FLUOXETINE HYDROCHLORIDE CHEMBL1201082 inhibitor ChemblInteractions
HTT 3064 VILAZODONE HYDROCHLORIDE CHEMBL1615374 inhibitor ChemblInteractions
HTT 3064 IMIPRAMINE HYDROCHLORIDE CHEMBL1692 inhibitor ChemblInteractions
HTT 3064 DESVENLAFAXINE FUMARATE CHEMBL3039565 inhibitor ChemblInteractions
HTT 3064 METHAMPHETAMINE HYDROCHLORIDE CHEMBL1200952 inhibitor ChemblInteractions
HTT 3064 MAZINDOL CHEMBL781 inhibitor ChemblInteractions
HTT 3064 VALPROIC ACID CHEMBL109 inhibitor TTD
HTT 3064 SIBUTRAMINE HYDROCHLORIDE CHEMBL1200765 inhibitor ChemblInteractions
HTT 3064 TEDATIOXETINE CHEMBL2104986 inhibitor ChemblInteractions
HTT 3064 ESCITALOPRAM OXALATE CHEMBL1200322 inhibitor ChemblInteractions
HTT 3064 DESVENLAFAXINE SUCCINATE CHEMBL1201728 inhibitor ChemblInteractions
HTT 3064 IMIPRAMINE PAMOATE CHEMBL1200631 inhibitor ChemblInteractions
HTT 3064 NEFAZODONE HYDROCHLORIDE CHEMBL1200492 inhibitor ChemblInteractions
HTT 3064 DESVENLAFAXINE CHEMBL1118 inhibitor ChemblInteractions
HTT 3064 GSK163090 CHEMBL1631540 antagonist ChemblInteractions
HTT 3064 TRAZODONE HYDROCHLORIDE CHEMBL1200798 inhibitor ChemblInteractions
HTT 3064 VORTIOXETINE HYDROBROMIDE CHEMBL2107387 inhibitor ChemblInteractions
HTT 3064 LEVOMILNACIPRAN HYDROCHLORIDE CHEMBL2105732 inhibitor ChemblInteractions
HTT 3064 ITI-007 (CHEMBL3545044) CHEMBL3545044 inhibitor ChemblInteractions
HTT 3064 FLUVOXAMINE MALEATE CHEMBL1409 inhibitor ChemblInteractions
HTT 3064 DULOXETINE HYDROCHLORIDE CHEMBL1200328 inhibitor ChemblInteractions
HTT 3064 MILNACIPRAN HYDROCHLORIDE CHEMBL2096626 inhibitor ChemblInteractions
HTT 3064 VENLAFAXINE HYDROCHLORIDE CHEMBL1201066 inhibitor ChemblInteractions
HTT 3064 AMOXAPINE CHEMBL1113 inhibitor ChemblInteractions
HTT 3064 LIAFENSINE CHEMBL2364614 inhibitor ChemblInteractions
HTT 3064 CITALOPRAM HYDROBROMIDE CHEMBL1200781 inhibitor ChemblInteractions
HTT 3064 SERTRALINE HYDROCHLORIDE CHEMBL1709 inhibitor ChemblInteractions
HTT 3064 CHLORPHENTERMINE HYDROCHLORIDE CHEMBL1200595 ChemblInteractions
HTT 3064 PROTRIPTYLINE HYDROCHLORIDE CHEMBL1200332 inhibitor ChemblInteractions
HTT 3064 FAXELADOL CHEMBL2103829 inhibitor ChemblInteractions
HTT 3064 AMITRIPTYLINE HYDROCHLORIDE CHEMBL1200964 inhibitor ChemblInteractions
HTT 3064 NORTRIPTYLINE HYDROCHLORIDE CHEMBL1201156 inhibitor ChemblInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
HTT rs362306 A risperidone efficacy no The A allele was initially significantly more frequent in patients designated as non-responders to risperidone (i.e. <50% reduction in PANSS score compared to the cohort average). However, significance was lost following correction for multiple testing. Allele A is associated with decreased response to risperidone in people with Schizophrenia as compared to allele G. 28696411 1450928129
HTT rs362272 G methylphenidate efficacy no The authors carried out a GWAS in a Spanish cohort of pediatric patients, than performed a meta-analysis using data from the Spanish cohort and data from a Brazilian adult patient cohort. This variant was not significant in the meta-analysis after Bonferroni correction had been applied, and was nominally significant (i.e did not reach genome-wide significance) in the initial GWAS in the Spanish cohort. Response was measured on the Clinical Global Impression-Improvement scale (CGI-I). A CGI-I score of two points or less after eight weeks of treatment was considered a good response. Allele G is associated with increased response to methylphenidate in people with Attention Deficit Disorder with Hyperactivity. 29382897 1449166325
HTT rs362267 T risperidone efficacy no The T allele was initially significantly more frequent in patients designated as non-responders to risperidone (i.e. <50% reduction in PANSS score compared to the cohort average). However, significance was lost following correction for multiple testing. Allele T is associated with decreased response to risperidone in people with Schizophrenia as compared to allele C. 28696411 1450928121