PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SP1	0	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, two hybrid, imaging technique, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Gao J (2009), Goto T (2006), Hung JJ (2006), Hung JJ (2006), Hung JJ (2006), Choi HS (2002), Walker GE (2001), Kundu TK (2000), Suzuki T (2000), Suzuki T (2000), Wang X (2008), Wang X (2008), Wang X (2008), Chen YJ (2007), Chen YJ (2007), Azahri NS (2012), Azahri NS (2012), Li J (2013), Li J (2013), Wang SA (2014)	20
TBX21	1	EP300	36	affinity chromatography technology, affinity chromatography technology	Chen GY (2006), Chen GY (2006)	2
EP300	36	UBC	7	enzymatic study, affinity chromatography technology	Delvecchio M (2013), Kirilyuk A (2012)	2
TBX21	1	UBC	7	affinity chromatography technology	Pan L (2014)	1
TBX21	1	SP1	0	affinity chromatography technology, affinity chromatography technology	Chen GY (2006), Chen GY (2006)	2
SP1	0	GATA3	2	affinity chromatography technology, pull down	Hong SJ (2008), Hong SJ (2008)	2
USP10	2	UBC	7	enzymatic study, unspecified method, pull down	Bomberger JM (2009), Ernst A (2013), Kwasna D (2018)	3
3227	0	TBX21	1	two hybrid	Ravasi T (2010)	1
CREBBP	29	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goto T (2006), Leclerc GJ (2010), Chuang JY (2012), Guo W (2014)	4
3227	0	SP1	0	two hybrid	Ravasi T (2010)	1
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
TBX21	1	USP10	2	affinity chromatography technology	Pan L (2014)	1
TBX21	1	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Chen GY (2006), Chen GY (2006)	2
TBX21	1	GATA3	2	affinity chromatography technology, affinity chromatography technology	Chen GY (2006), Chen GY (2006)	2
EXOC5	2	TBX21	1	two hybrid	Wang J (2011)	1
TBX21	1	ZNF490	1	two hybrid	Ravasi T (2010)	1