PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZNF638	8	EFEMP2	0	two hybrid	Rual JF (2005)	1
FAM107A	0	PLSCR1	0	two hybrid	Mu P (2017)	1
HOXA1	4	RBPMS	0	two hybrid	Rolland T (2014)	1
BAG6	2	EFEMP2	0	two hybrid	Rual JF (2005)	1
RERE	9	EFEMP2	0	two hybrid	Lim J (2006)	1
TP53	0	EFEMP2	0	two hybrid, affinity chromatography technology	Gallagher WM (1999), Gallagher WM (1999)	2
ATXN1	2	RBPMS	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
PLSCR1	0	EFEMP2	0	two hybrid	Rual JF (2005)	1
GFI1B	1	EFEMP2	0	two hybrid	Lim J (2006)	1
ZNF263	2	EFEMP2	0	two hybrid	Rual JF (2005)	1
NEDD4L	3	EFEMP2	0	enzymatic study	Persaud A (2009)	1
EFEMP2	0	401508	0	two hybrid	Rolland T (2014)	1
ATXN1	2	RHOXF2	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
EFEMP2	0	SGTB	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ATN1	2	EFEMP2	0	two hybrid	Lim J (2006)	1
EFEMP2	0	PIDD1	5	two hybrid	Rual JF (2005)	1
HOXA1	4	PLSCR1	0	two hybrid	Rual JF (2005)	1
RBPMS	0	EFEMP2	0	two hybrid	Rolland T (2014)	1
EFEMP2	0	CATSPER1	2	two hybrid	Rual JF (2005)	1
TCAF1	1	ZNF263	2	two hybrid	Rolland T (2014)	1
RBPMS	0	FAM124B	2	two hybrid	Rolland T (2014)	1
STK16	1	EFEMP2	0	two hybrid	Rolland T (2014)	1
CREB5	4	RBPMS	0	two hybrid	Rolland T (2014)	1
RERE	9	ATN1	2	pull down, pull down, two hybrid, two hybrid	Yanagisawa H (2000), Yanagisawa H (2000), Lim J (2006), Lim J (2006)	4
IL16	2	EFEMP2	0	two hybrid	Rual JF (2005)	1
RIBC2	1	EFEMP2	0	two hybrid	Rual JF (2005)	1
CCDC33	3	RHOXF2	0	two hybrid	Xin X (2009)	1
RBPMS	0	RHOXF2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
EFEMP2	0	LINGO1	3	two hybrid	Rual JF (2005)	1
CCNK	1	EFEMP2	0	two hybrid	Rual JF (2005)	1
EFEMP2	0	LCE2D	0	two hybrid	Rolland T (2014)	1
SGTB	2	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
PLSCR1	0	CCDC33	3	two hybrid	Rual JF (2005)	1
ATN1	2	RBPMS	0	two hybrid	Lim J (2006)	1
PLSCR1	0	PLSCR4	0	two hybrid	Rual JF (2005)	1
PTGER3	2	EFEMP2	0	two hybrid	Rolland T (2014)	1
HHEX	1	EFEMP2	0	two hybrid	Rual JF (2005)	1
DGCR6	0	MEOX2	2	two hybrid	Corominas R (2014)	1
PLSCR1	0	ZNF638	8	two hybrid	Rual JF (2005)	1
ATN1	2	BAG6	2	two hybrid	Lim J (2006)	1
EFEMP2	0	ZNF426	2	two hybrid	Rual JF (2005)	1
PLSCR1	0	LCE3C	0	two hybrid	Rolland T (2014)	1
EFEMP2	0	RHPN1	2	two hybrid	Rual JF (2005)	1
HOXA1	4	CCDC33	3	two hybrid	Rolland T (2014)	1
UBQLN4	2	CCDC33	3	two hybrid	Lim J (2006)	1
CCND3	1	EFEMP2	0	two hybrid	Rual JF (2005)	1
DGCR6	0	EFEMP2	0	two hybrid	Corominas R (2014)	1
CACNA1A	21	EFEMP2	0	two hybrid	Kahle JJ (2011)	1
ATN1	2	RHOXF2	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
UBQLN1	1	BAG6	2	affinity chromatography technology, affinity chromatography technology	Kurlawala Z (2017), Kurlawala Z (2017)	2
AQP1	1	EFEMP2	0	two hybrid	Rual JF (2005)	1
COL8A1	3	EFEMP2	0	two hybrid	Rual JF (2005)	1
UBQLN4	2	BAG6	2	two hybrid, affinity chromatography technology	Lim J (2006), Suzuki R (2016)	2
APEX2	2	EFEMP2	0	two hybrid	Rual JF (2005)	1
CREB5	4	EFEMP2	0	two hybrid	Rolland T (2014)	1
EFEMP2	0	FAM124B	2	two hybrid	Rual JF (2005)	1
ATXN1	2	CCNK	1	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
EFEMP2	0	PLSCR4	0	two hybrid	Rual JF (2005)	1
GLRX3	1	LCE2D	0	two hybrid	Rolland T (2014)	1
MEOX2	2	PTGER3	2	two hybrid	Rolland T (2014)	1
PLSCR1	0	LCE2D	0	two hybrid	Rolland T (2014)	1
EFEMP2	0	C5orf24	0	two hybrid	Rolland T (2014)	1
RERE	9	PLSCR1	0	two hybrid	Lim J (2006)	1
TCAF1	1	EFEMP2	0	two hybrid	Rual JF (2005)	1
UBQLN4	2	COL8A1	3	two hybrid	Lim J (2006)	1
MEOX2	2	EFEMP2	0	two hybrid	Rolland T (2014)	1
NOS3	7	EFEMP2	0	two hybrid	Soler-Lopez M (2011)	1
HDAC4	10	EFEMP2	0	two hybrid	Rolland T (2014)	1
PLSCR1	0	CATSPER1	2	two hybrid	Rolland T (2014)	1
SGTA	1	BAG6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, pull down	Winnefeld M (2006), Xu Y (2012), Xu Y (2012), Xu Y (2012), Leznicki P (2013), Taipale M (2014), Taipale M (2014), Rolland T (2014), Darby JF (2014), Darby JF (2014), Darby JF (2014), Liu Y (2014), Krysztofinska EM (2016), Krysztofinska EM (2016)	14
UBQLN4	2	EFEMP2	0	two hybrid	Lim J (2006)	1
PLSCR1	0	STK16	1	two hybrid	Rolland T (2014)	1
ATN1	2	PLSCR1	0	two hybrid	Lim J (2006)	1
HOXA1	4	EFEMP2	0	two hybrid	Rual JF (2005)	1
ATXN7	0	EFEMP2	0	two hybrid	Kahle JJ (2011)	1
EFEMP2	0	RHOXF2	0	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
GLRX3	1	EFEMP2	0	two hybrid	Rual JF (2005)	1
HDAC4	10	ATXN1	2	affinity chromatography technology	Bolger TA (2007)	1
PTGER3	2	CCDC33	3	two hybrid	Rolland T (2014)	1
SGTA	1	EFEMP2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
DGCR6	0	CCDC33	3	two hybrid	Corominas R (2014)	1
EFEMP2	0	LCE3C	0	two hybrid	Rolland T (2014)	1
CCNK	1	RBPMS	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MEOX2	2	STK16	1	two hybrid	Rolland T (2014)	1
EFEMP2	0	CCDC33	3	two hybrid	Rolland T (2014)	1
ATXN1	2	UBQLN4	2	two hybrid, two hybrid	Davidson JD (2000), Lim J (2006)	2
PLSCR1	0	GLRX3	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ZNF638	8	HDAC4	10	affinity chromatography technology	Boldt K (2016)	1
UBQLN1	1	EFEMP2	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Lim J (2006), Rolland T (2014)	3
ATXN1	2	EFEMP2	0	two hybrid	Lim J (2006)	1
NEDD4L	3	APEX2	2	pull down	Persaud A (2009)	1
COL8A1	3	CREB5	4	two hybrid	Rolland T (2014)	1
GLRX3	1	ZNF426	2	two hybrid	Rolland T (2014)	1
EFEMP2	0	NUFIP2	1	two hybrid	Rolland T (2014)	1
STK16	1	CCDC33	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
FAM107A	0	EFEMP2	0	two hybrid	Rual JF (2005)	1
MEOX2	2	401508	0	two hybrid	Rolland T (2014)	1
UBQLN4	2	UBQLN1	1	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Lim J (2006), Havugimana PC (2012), Lee DY (2013), Lee DY (2013)	4
CCNK	1	RHOXF2	0	two hybrid	Rual JF (2005)	1