PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ATF3	0	ATF2	1	two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Ravasi T (2010), Reinke AW (2013), Reinke AW (2013)	3
DNMT3L	2	DDIT3	1	pull down	Pacaud R (2014)	1
HIST2H2AC	1	HIST2H2BE	1	pull down	Long L (2014)	1
DNMT3L	2	AES	2	pull down	Pacaud R (2014)	1
CREB1	1	NFIL3	1	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
FOSL2	2	JUN	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pognonec P (1997), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017)	6
JUN	0	SMAD4	9	affinity chromatography technology	Li X (2015)	1
RELA	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Zhong H (2002), Zhong H (2002), Zhong H (2002), Zhong H (2002), Ashburner BP (2001), Ashburner BP (2001), OShea JM (2010), OShea JM (2010), Liu Y (2006), Cao W (2006), Hu J (2004), Hu J (2004), Sun JM (2007), Deckmann K (2012)	15
DNMT3B	3	CREB1	1	affinity chromatography technology	Hervouet E (2009)	1
ATF4	2	JUN	0	pull down, two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe, imaging technique	Hai T (1991), Bandyopadhyay S (2010), Reinke AW (2013), Reinke AW (2013), Chen TC (2014)	5
GSK3B	1	NFKB1	2	enzymatic study	Demarchi F (2001)	1
AES	2	SMAD3	1	two hybrid	Rolland T (2014)	1
RELA	1	TP53	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Huang WC (2007), Huang WC (2007), Ivanov AA (2017)	3
DNMT3L	2	PAX6	3	pull down, imaging technique, affinity chromatography technology	Pacaud R (2014), Pacaud R (2014), Pacaud R (2014)	3
NR3C1	2	JUN	0	pull down	Lerner L (2003)	1
ETS1	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee S (2008), Lee S (2008), Kim E (2003), Zhu M (2014)	4
DNMT3L	2	EGR4	0	pull down	Pacaud R (2014)	1
NR1H2	2	YY1	7	two hybrid	Wang J (2011)	1
3227	0	SMAD3	1	two hybrid	Ravasi T (2010)	1
GSK3B	1	RELA	1	affinity chromatography technology	Neumann M (2011)	1
CREB1	1	TP53	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Giebler HA (2000), Giebler HA (2000), Giebler HA (2000), Okoshi R (2011), Borger DR (2006), Chen TC (2014)	6
HDAC1	4	ESR1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Kawai H (2003), Kawai H (2003), Varshochi R (2005), Varshochi R (2005), Kurtev V (2004), Liu XF (2004), Itoh Y (2007), Tarallo R (2011), Yoshimaru T (2013)	9
DNMT3L	2	GMEB1	4	pull down	Pacaud R (2014)	1
DNMT3L	2	NR3C1	2	pull down	Pacaud R (2014)	1
ATF2	1	CREB1	1	biochemical	Wan C (2015)	1
DNMT3L	2	NFIL3	1	pull down	Pacaud R (2014)	1
DNMT3L	2	HIST2H2BE	1	pull down	Ooi SK (2007)	1
DDIT3	1	JUNB	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
SMAD4	9	YY1	7	imaging technique, pull down, affinity chromatography technology	Kurisaki K (2003), Kurisaki K (2003), Kurisaki K (2003)	3
E2F4	0	ASH2L	2	affinity chromatography technology	Tyagi S (2007)	1
DNMT3L	2	MAFK	0	pull down	Pacaud R (2014)	1
DNMT3L	2	E2F3	0	pull down	Pacaud R (2014)	1
DNMT3L	2	NR6A1	3	pull down	Pacaud R (2014)	1
ATF2	1	SMAD4	9	two hybrid, pull down, affinity chromatography technology	Sano Y (1999), Sano Y (1999), Sano Y (1999)	3
DNMT3L	2	NR1H2	2	pull down	Pacaud R (2014)	1
MEF2A	1	HDAC1	4	affinity chromatography technology	Aude-Garcia C (2010)	1
DNMT3L	2	ESR2	1	pull down	Pacaud R (2014)	1
GSK3B	1	JUN	0	enzymatic study, imaging technique	Chen BK (2007), Chen TC (2014)	2
DNMT3L	2	ATF2	1	pull down	Pacaud R (2014)	1
JUNB	0	ATF2	1	affinity chromatography technology	Huttlin EL (2017)	1
E2F4	0	SMAD3	1	affinity chromatography technology, pull down	Chen CR (2002), Chen CR (2002)	2
RELA	1	DNMT3B	3	imaging technique	Pacaud R (2014)	1
ATF2	1	FOS	0	pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hai T (1991), Reinke AW (2013), Reinke AW (2013), Miyamoto-Sato E (2010), Rolland T (2014), Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	8
NR1I2	5	RXRA	1	two hybrid, two hybrid, pull down	Albers M (2005), Rana R (2013), Doricakova A (2013)	3
JUNB	0	JUN	0	affinity chromatography technology	Huttlin EL (2017)	1
MAX	0	JUN	0	affinity chromatography technology	Boldt K (2016)	1
EGR1	1	JUNB	0	affinity chromatography technology	Hein MY (2015)	1
RELA	1	JUN	0	two hybrid, genetic interference	Yang X (1999), Yang X (1999)	2
DNMT3L	2	HAND2	1	pull down	Pacaud R (2014)	1
CREB1	1	DR1	1	biochemical	Havugimana PC (2012)	1
MECP2	36	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kimura H (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006)	4
DNMT3L	2	GTF3C5	4	pull down	Pacaud R (2014)	1
GATA1	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Watamoto K (2003), Watamoto K (2003)	2
SMAD1	0	PAX6	3	affinity chromatography technology	Grocott T (2007)	1
DNMT3L	2	ATF4	2	pull down	Pacaud R (2014)	1
JUNB	0	YY1	7	affinity chromatography technology	Wang CC (2007)	1
MAX	0	MECP2	36	affinity chromatography technology	Li X (2015)	1
RELA	1	SMAD4	9	two hybrid	Wang J (2011)	1
TP53	0	GTF2I	1	affinity chromatography technology	Horikawa I (2014)	1
NFKB1	2	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Palvimo JJ (1996), Dhar SK (2006), Williams SA (2006), Williams SA (2006), Hassa PO (2005), Hassa PO (2005), Sasaki CY (2005), Jeon YJ (2010), Urban MB (1991), Beauchef G (2012), Ryo A (2003), Burstein E (2005), Beinke S (2002), Sharif-Askari E (2010), Mifflin RC (2002), Nie M (2003), Nehra R (2010), Wang J (2011), Mellits KH (1993), Gallois C (1998), Milanovic M (2013), Milanovic M (2013), Kwon JH (2003), Cimen I (2011), Saha RN (2007), Wi SM (2014), Wi SM (2014), Hochrainer K (2012), Longoni N (2013), Li X (2015)	31
JUN	0	FOSB	0	affinity chromatography technology, protein complementation assay	Li X (2015), Edison N (2017)	2
SMAD4	9	MAX	0	pull down	Grinberg AV (2003)	1
TP53	0	YY1	7	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Groenroos E (2004), Groenroos E (2004), Sui G (2004), Sui G (2004), Sui G (2004), Wu S (2007), Wan M (2012), Kotlyar M (2015)	8
DNMT3L	2	NR1I3	2	pull down	Pacaud R (2014)	1
SMAD3	1	NR3C1	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li G (2003), Li G (2003), Song CZ (1999), Song CZ (1999)	4
NFIL3	1	ATF1	0	affinity chromatography technology	Huttlin EL (2017)	1
NR2E1	0	HDAC1	4	affinity chromatography technology	Yokoyama A (2008)	1
DNMT3L	2	ID1	0	pull down	Pacaud R (2014)	1
ATF2	1	SMAD3	1	two hybrid, pull down, affinity chromatography technology	Sano Y (1999), Sano Y (1999), Sano Y (1999)	3
DNMT3L	2	HOXA5	0	pull down	Pacaud R (2014)	1
DNMT3L	2	E2F5	0	pull down	Pacaud R (2014)	1
DNMT3L	2	ESR1	0	pull down	Pacaud R (2014)	1
DNMT3L	2	NFKB1	2	pull down	Pacaud R (2014)	1
YY1	7	CREB1	1	pull down, two hybrid	Zhou Q (1995), Zhou Q (1995)	2
SMAD3	1	JUN	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Verrecchia F (2000), Liberati NT (1999), Liberati NT (2001), Lee SY (2011)	7
GSK3B	1	ATF3	0	affinity chromatography technology	Lee SH (2010)	1
DNMT3L	2	ESRRG	2	imaging technique, pull down, affinity chromatography technology	Pacaud R (2014), Pacaud R (2014), Pacaud R (2014)	3
FOSL2	2	JUNB	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mathas S (2009), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
DNMT3L	2	JUN	0	pull down	Pacaud R (2014)	1
DNMT3L	2	HAND1	0	pull down	Pacaud R (2014)	1
SMAD3	1	JUNB	0	two hybrid, pull down	Liberati NT (1999), Liberati NT (1999)	2
MAFK	0	RELA	1	affinity chromatography technology	Liu GH (2008)	1
DNMT3L	2	SMAD1	0	pull down	Pacaud R (2014)	1
RELA	1	AES	2	two hybrid, pull down, affinity chromatography technology, pull down	Tetsuka T (2000), Tetsuka T (2000), Tetsuka T (2000), Buss H (2004)	4
NR3C1	2	CREB1	1	pull down, affinity chromatography technology	Imai E (1993), Guo C (2010)	2
NUDT21	0	DNMT3L	2	two hybrid	Vinayagam A (2011)	1
MAX	0	YY1	7	affinity chromatography technology, affinity chromatography technology	de Nigris F (2007), de Nigris F (2007)	2
TP53	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Lu D (2013), Ali A (2013)	4
TP53	0	ASH2L	2	affinity chromatography technology, pull down	Tang Z (2013), Tang Z (2013)	2
FOSL1	0	JUN	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Pognonec P (1997), Pognonec P (1997), Kumar NV (2001), Kumar NV (2001), Reinke AW (2013), Reinke AW (2013)	6
DDIT3	1	ATF3	0	affinity chromatography technology, pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Chen BP (1996), Chen BP (1996), Reinke AW (2013), Reinke AW (2013)	4
ATF3	0	FOS	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DNMT3L	2	CREM	1	pull down	Pacaud R (2014)	1
ATF3	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kang Y (2003), Kang Y (2003), Yin X (2010), Yin X (2010)	4
CREM	1	HDAC1	4	affinity chromatography technology, pull down, pull down	Tenbrock K (2006), Tenbrock K (2006), Tenbrock K (2006)	3
SMAD3	1	FOS	0	two hybrid, pull down, affinity chromatography technology	Zhang Y (1998), Zhang Y (1998), Lee SY (2011)	3
RELA	1	RXRA	1	pull down, imaging technique, pull down	Na SY (1999), Chen TC (2014), Gu X (2006)	3
DNMT3L	2	NR1I2	5	pull down	Pacaud R (2014)	1
ETS1	4	SMAD3	1	imaging technique	Chen TC (2014)	1
DNMT3L	2	MEF2A	1	pull down	Pacaud R (2014)	1
SMAD3	1	HDAC1	4	two hybrid, pull down	Liberati NT (2001), Akiyoshi S (1999)	2
FOS	0	ESR1	0	affinity chromatography technology	Baron S (2007)	1
RELA	1	SMAD3	1	two hybrid	Wang J (2011)	1
CREB1	1	ATF1	0	affinity chromatography technology	Li X (2015)	1
JUNB	0	FOSL1	0	two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Rual JF (2005), Reinke AW (2013), Reinke AW (2013)	3
SMAD4	9	JUNB	0	pull down, two hybrid	Liberati NT (1999), Colland F (2004)	2
DNMT3L	2	FOSL2	2	pull down	Pacaud R (2014)	1
DNMT3L	2	HIST2H2AC	1	pull down	Ooi SK (2007)	1
DDIT3	1	ATF2	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
DNMT3L	2	JUNB	0	pull down	Pacaud R (2014)	1
DNMT3L	2	LDB1	2	pull down	Pacaud R (2014)	1
DDIT3	1	HOXA5	0	two hybrid	Ravasi T (2010)	1
DNMT3L	2	BLZF1	0	pull down	Pacaud R (2014)	1
FOS	0	JUNB	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Rolland T (2014), Huttlin EL (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017)	7
DNMT3A	17	HDAC1	4	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Fuks F (2001), Fuks F (2001), Fuks F (2001), Hervouet E (2009)	4
DNMT3L	2	TP53	0	pull down	Pacaud R (2014)	1
JUN	0	ETS1	4	pull down, pull down	Logan SK (1996), Miyamoto-Sato E (2010)	2
GSK3B	1	SMAD1	0	enzymatic study, imaging technique	Fuentealba LC (2007), Chen TC (2014)	2
SMAD1	0	SMAD4	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Hanai J (1999), Lopez-Rovira T (2002), Kato Y (2002), Wang L (2011), Li L (2004), Hata A (1998), Barrios-Rodiles M (2005), Wu RY (1997), Wu RY (1997), Colland F (2004), Qiu T (2007), Yan X (2016), Zhou F (2017)	14
ESR2	1	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, biochemical	Ogawa S (1998), Ogawa S (1998), Ogawa S (1998), Poelzl G (2000), Rossi V (2009), Monroe DG (2003), Nassa G (2011)	7
LDB1	2	LHX2	0	two hybrid	Ravasi T (2010)	1
HDAC1	4	E2F3	0	affinity chromatography technology	Chen L (2012)	1
ESR2	1	MED7	1	pull down	Kang YK (2002)	1
DNMT3B	3	HDAC1	4	biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Geiman TM (2004), Suzuki M (2006), Geiman TM (2004), Geiman TM (2004), Cai Y (2014)	5
ATF3	0	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
MECP2	36	HIST2H2BE	1	x-ray crystallography	Yang C (2011)	1
DNMT3A	17	DNMT3B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ling Y (2004), Lehnertz B (2003), Kim GD (2002), Kim GD (2002), Kashiwagi K (2011), Kashiwagi K (2011), Huttlin EL (2017)	7
DNMT3L	2	100188776	0	pull down	Pacaud R (2014)	1
DNMT3L	2	KLF12	5	pull down	Pacaud R (2014)	1
MEF2D	5	HDAC1	4	affinity chromatography technology	Aude-Garcia C (2010)	1
DDIT3	1	FOS	0	pull down, affinity chromatography technology, fluorescent resonance energy transfe	Ubeda M (1999), Ubeda M (1999), Reinke AW (2013)	3
SMAD3	1	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid	Brown KA (2008), Wu RY (1997), Wu RY (1997)	3
DNMT3L	2	FOS	0	pull down	Pacaud R (2014)	1
DNMT3L	2	CREB1	1	pull down	Pacaud R (2014)	1
PAX6	3	LHX2	0	pull down	Mikkola I (2001)	1
ATF3	0	RELA	1	pull down, affinity chromatography technology	Hua B (2006), Hua B (2006)	2
DNMT3L	2	GTF2H2	0	pull down	Pacaud R (2014)	1
SMAD4	9	NFKB1	2	affinity chromatography technology	Li X (2015)	1
TP53	0	MAFK	0	affinity chromatography technology	Dohi Y (2008)	1
FOSL1	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Hoffmann E (2005), Hoffmann E (2005)	2
SMAD3	1	MAX	0	pull down, imaging technique	Grinberg AV (2003), Chen TC (2014)	2
HDAC1	4	GTF2I	1	affinity chromatography technology	Wen YD (2003)	1
TP53	0	EGR1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Liu J (2001), Liu J (2001), Kim HA (2011), Yu J (2004)	4
ATF4	2	FOS	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, imaging technique	Reinke AW (2013), Reinke AW (2013), Chen TC (2014)	3
DDIT3	1	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
NFKB1	2	CDX2	4	affinity chromatography technology	Mutoh H (2007)	1
NR3C1	2	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sengupta S (2000), Sengupta S (2001), Sengupta S (2001), Sengupta S (2001)	4
LDB1	2	ESR1	0	pull down	Johnsen SA (2009)	1
CREB1	1	MECP2	36	affinity chromatography technology	Li X (2015)	1
GSK3B	1	CREB1	1	enzymatic study	Li B (2003)	1
MAFK	0	HDAC1	4	affinity chromatography technology	Liu GH (2008)	1
HDAC1	4	YY1	7	pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Yang WM (1997), He Y (2007), He G (2002), Sun JM (2007)	4
FOS	0	JUN	0	pull down, two hybrid, pull down, x-ray crystallography, two hybrid, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, pull down, imaging technique, pull down, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, biochemical, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ito T (2001), Pognonec P (1997), Pognonec P (1997), Glover JN (1995), Yang X (1999), Nomura N (1993), Finkel T (1993), Finkel T (1993), Venugopal R (1998), Kumar NV (2001), Dumin E (2006), Bandyopadhyay S (2010), Asim M (2010), Asim M (2010), Srivastav RK (2011), Bossis G (2005), Bossis G (2005), Gupta K (2000), Bachmann M (2004), Reinke AW (2013), Miyagi M (2005), Subbaramaiah K (2007), Jang M (2012), Yamaguchi K (2005), Varjosalo M (2013), Miyamoto-Sato E (2010), Miyamoto-Sato E (2010), Varjosalo M (2013), Tang HY (2006), Marden NY (2005), Adler J (2010), Adler J (2010), Adler J (2010), Billiet L (2008), Huttlin EL (2015), Hein MY (2015), Li X (2015), Li X (2015), Huttlin EL (2017)	39
JUN	0	HDAC1	4	affinity chromatography technology	Tenbrock K (2006)	1
NFKB1	2	YY1	7	two hybrid	Wang J (2011)	1
DNMT3L	2	DNMT3B	3	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique	Hata K (2002), Ooi SK (2007), Margot JB (2003), Suetake I (2004), Suetake I (2004), Suetake I (2004), Pacaud R (2014), Pacaud R (2014)	8
DNMT3L	2	EGR2	1	pull down	Pacaud R (2014)	1
DNMT3L	2	CDX2	4	pull down	Pacaud R (2014)	1
ATF3	0	TP53	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down	Stelzl U (2005), Yan C (2002), Yan C (2002), Yan C (2005), Yan C (2005), Yan C (2005), Wei S (2014)	7
HOXA5	0	SMAD1	0	two hybrid	Ravasi T (2010)	1
ESR1	0	MED7	1	pull down	Kang YK (2002)	1
DNMT3L	2	GTF2I	1	pull down	Pacaud R (2014)	1
JUN	0	ATF2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Newell CL (1994), Newell CL (1994), Kara CJ (1990), Hai T (1991), Fuchs SY (1999), Reinke AW (2013), Reinke AW (2013), Miyamoto-Sato E (2010), Hayakawa J (2004), Hein MY (2015), Li X (2015), Huttlin EL (2017)	12
MECP2	36	YY1	7	pull down, far western blotting, affinity chromatography technology	Forlani G (2010), Forlani G (2010), Forlani G (2010)	3
DNMT3L	2	NR2E1	0	pull down	Pacaud R (2014)	1
JUN	0	MEF2A	1	affinity chromatography technology, affinity chromatography technology	Li X (2015), Li X (2015)	2
ATF3	0	JUNB	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Huttlin EL (2017)	3
DNMT3L	2	ATF1	0	pull down	Pacaud R (2014)	1
ATF3	0	HDAC1	4	affinity chromatography technology, pull down	Li HF (2010), Darlyuk-Saadon I (2012)	2
DNMT3L	2	HIST2H3C	0	pull down	Ooi SK (2007)	1
JUN	0	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teyssier C (2001), Baron S (2007), Ruiz ML (2013), Ruiz ML (2013)	4
SMAD3	1	PAX6	3	affinity chromatography technology	Grocott T (2007)	1
NR1H2	2	RXRA	1	two hybrid, pull down, two hybrid	Seol W (1995), Seol W (1995), Albers M (2005)	3
SMAD1	0	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
DNMT3L	2	MAX	0	pull down, imaging technique, affinity chromatography technology	Pacaud R (2014), Pacaud R (2014), Pacaud R (2014)	3
NFIL3	1	DR1	1	pull down	Cowell IG (1996)	1
RELA	1	CDX2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mutoh H (2007), Kim SP (2004), Kim SP (2004)	3
DNMT3L	2	DNMT3A	17	affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Hata K (2002), Ooi SK (2007), Margot JB (2003), Chen ZX (2005), Chen ZX (2005), Suetake I (2004), Suetake I (2004), Suetake I (2004), Pacaud R (2014)	9
NR1I2	5	TP53	0	affinity chromatography technology, affinity chromatography technology	Elias A (2013), Elias A (2013)	2
NR3C1	2	NFKB1	2	pull down, affinity chromatography technology	Scheinman RI (1995), Ito K (2006)	2
DNMT3L	2	DLX4	2	pull down	Pacaud R (2014)	1
DNMT3L	2	F2RL1	1	pull down	Pacaud R (2014)	1
DNMT3L	2	3227	0	pull down	Pacaud R (2014)	1
GSK3B	1	TP53	0	affinity chromatography technology, two hybrid	Watcharasit P (2002), Vinayagam A (2011)	2
CDX2	4	GSK3B	1	affinity chromatography technology	Kumar Y (2016)	1
GSK3B	1	RXRA	1	two hybrid	Vinayagam A (2011)	1
HDAC1	4	NFKB1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, imaging technique	Zhong H (2002), Zhong H (2002), Zhong H (2002), Viatour P (2003), Williams SA (2006), Williams SA (2006), Sun JM (2007), Chen TC (2014)	8
TP53	0	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology	Liu G (2000), Duong V (2007), Saxena R (2016)	3
MEF2A	1	ATF3	0	affinity chromatography technology	Li X (2015)	1
ESR1	0	E2F6	2	affinity chromatography technology	Han SJ (2016)	1
SMAD3	1	BLZF1	0	two hybrid	Rolland T (2014)	1
DNMT3L	2	ETS1	4	pull down	Pacaud R (2014)	1
RELA	1	EGR1	1	pull down	Chapman NR (2000)	1
MECP2	36	HIST2H3C	0	x-ray crystallography	Yang C (2011)	1
ATF3	0	JUN	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Pearson AG (2003), Chen BP (1996), Hai T (1991), Filen S (2010), Reinke AW (2013), Reinke AW (2013), Hein MY (2015), Li X (2015)	8
DNMT3L	2	RELA	1	pull down, imaging technique, affinity chromatography technology, pull down	Pacaud R (2014), Pacaud R (2014), Pacaud R (2014), Pacaud R (2014)	4
HIST2H2AC	1	HIST2H4A	0	pull down, pull down	Hoffmann A (1996), Hoffmann A (1996)	2
GSK3B	1	DNMT3L	2	two hybrid	Vinayagam A (2011)	1
PHPT1	0	DNMT3L	2	two hybrid	Rual JF (2005)	1
DNMT3L	2	LHX2	0	pull down	Pacaud R (2014)	1
DDIT3	1	JUN	0	pull down, affinity chromatography technology, fluorescent resonance energy transfe	Ubeda M (1999), Ubeda M (1999), Reinke AW (2013)	3
MECP2	36	HIST2H2AC	1	x-ray crystallography	Yang C (2011)	1
CREB1	1	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Canettieri G (2003), Canettieri G (2003), Canettieri G (2003), Kim HC (2010)	4
PAX6	3	CDX2	4	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Hussain MA (1999), Hussain MA (1999), Hussain MA (1999), Hussain MA (1999)	4
ATF2	1	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
ATF4	2	FOSL1	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DMTF1	0	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down	Frazier DP (2012), Frazier DP (2012), Kendig RD (2017)	3
ESR1	0	ASH2L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mo R (2006), Mo R (2006), Shi L (2011), Shi L (2011)	4
DNMT3L	2	MECP2	36	pull down	Pacaud R (2014)	1
DNMT3L	2	MED7	1	pull down	Pacaud R (2014)	1
SMAD4	9	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
DNMT3L	2	FOSB	0	pull down	Pacaud R (2014)	1
DNMT3L	2	E2F4	0	pull down, imaging technique, affinity chromatography technology	Pacaud R (2014), Pacaud R (2014), Pacaud R (2014)	3
ETS1	4	ATF2	1	pull down	Giese K (1995)	1
NUDT21	0	HDAC1	4	affinity chromatography technology	Shimazu T (2007)	1
ETS1	4	NFKB1	2	imaging technique	Chen TC (2014)	1
ESR1	0	RELA	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Olivier S (2006), Nettles KW (2008), Nettles KW (2008), Rubio MF (2006), Rubio MF (2006)	5
DNMT3L	2	EGR1	1	pull down	Pacaud R (2014)	1
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
SMAD1	0	YY1	7	pull down	Kurisaki K (2003)	1
ESR1	0	HIST2H2AC	1	pull down	Nalvarte I (2010)	1
DNMT3L	2	ATF3	0	pull down	Pacaud R (2014)	1
DDIT3	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Alter J (2012), Ohoka N (2007)	2
SMAD3	1	MAFK	0	affinity chromatography technology	Okita Y (2013)	1
ATF4	2	DDIT3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Reinke AW (2013), DeGrado-Warren J (2008)	3
TP53	0	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Chau JF (2012), Chau JF (2012)	2
DNMT3L	2	SMAD4	9	pull down	Pacaud R (2014)	1
ATF4	2	JUNB	0	two hybrid	Wang J (2011)	1
RXRA	1	NR1I3	2	pull down, pull down, pull down, imaging technique, pull down	Baes M (1994), Goodwin B (2002), Yoshinari K (2010), Yoshinari K (2010), Molnar F (2005)	5
DDIT3	1	FOSL2	2	two hybrid	Rolland T (2014)	1
ESR1	0	NUDT21	0	pull down	Nalvarte I (2010)	1
CREB1	1	JUN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Benbrook DM (1990), Li X (2015), Li X (2015)	3
EGR1	1	FOSL2	2	affinity chromatography technology	Hein MY (2015)	1
SMAD3	1	YY1	7	pull down, affinity chromatography technology	Kurisaki K (2003), Brown KA (2008)	2
ATF2	1	ATF1	0	biochemical	Wan C (2015)	1
JUN	0	MEF2D	5	affinity chromatography technology	Li X (2015)	1
DNMT3L	2	CREBL2	2	pull down	Pacaud R (2014)	1
NR3C1	2	RELA	1	affinity chromatography technology, pull down, pull down	Ray A (1994), Nissen RM (2000), Caldenhoven E (1995)	3
DNMT3L	2	RSL24D1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NFKB1	2	RXRA	1	pull down	Na SY (1999)	1
DNMT3L	2	HNF4G	1	pull down	Pacaud R (2014)	1
HDAC1	4	E2F6	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
DNMT3L	2	ASH2L	2	pull down	Pacaud R (2014)	1
DNMT3L	2	DMTF1	0	pull down	Pacaud R (2014)	1
DNMT3L	2	HDAC1	4	pull down, pull down, pull down, pull down, affinity chromatography technology	Aapola U (2002), Aapola U (2002), Deplus R (2002), Deplus R (2002), Deplus R (2002)	5
E2F4	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ferreira R (1998), Iavarone A (1999), Chen L (2012)	3
MAX	0	E2F6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2015), Cheng J (2017), Hauri S (2016), Hauri S (2016)	4
ATF1	0	JUNB	0	biochemical	Wan C (2015)	1
RELA	1	MED7	1	pull down	Naeaer AM (1999)	1
DDIT3	1	NFIL3	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
FOSL2	2	ATF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NR3C1	2	HDAC1	4	affinity chromatography technology, affinity chromatography technology, biochemical, fluorescent resonance energy transfe, pull down	Qiu Y (2006), Jee YK (2005), Kristensen AR (2012), Qiu Y (2011), Qiu Y (2011)	5
DNMT3L	2	RXRA	1	pull down	Pacaud R (2014)	1
GSK3B	1	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology	Guo X (2008), Guo X (2008), Choi SI (2011)	3
ATF4	2	ATF2	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
MEF2A	1	MEF2D	5	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ornatsky OI (1996), Ornatsky OI (1996), Ornatsky OI (1996), Aude-Garcia C (2010), Li X (2015)	5
DNMT3L	2	YY1	7	pull down	Pacaud R (2014)	1
ATF1	0	FOSL2	2	biochemical	Havugimana PC (2012)	1
SMAD3	1	GMEB1	4	two hybrid	Colland F (2004)	1
DNMT3L	2	FOSL1	0	pull down	Pacaud R (2014)	1
DNMT3L	2	GATA1	1	pull down	Pacaud R (2014)	1
JUNB	0	FOSB	0	affinity chromatography technology	Huttlin EL (2017)	1
DNMT3L	2	DR1	1	pull down	Pacaud R (2014)	1
ATF4	2	ATF3	0	affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Wang Q (2009), Reinke AW (2013), Reinke AW (2013)	3
DNMT3L	2	MEF2D	5	pull down	Pacaud R (2014)	1
SMAD4	9	PAX6	3	affinity chromatography technology	Grocott T (2007)	1
DNMT3L	2	SMAD3	1	pull down	Pacaud R (2014)	1
ATF2	1	YY1	7	two hybrid, pull down	Ravasi T (2010), Zhou Q (1995)	2
SMAD1	0	GMEB1	4	two hybrid	Colland F (2004)	1
SMAD3	1	ESR1	0	affinity chromatography technology	Ito I (2010)	1
RELA	1	FOS	0	two hybrid, genetic interference	Yang X (1999), Yang X (1999)	2
FOS	0	FOSB	0	affinity chromatography technology	Li X (2015)	1
MEF2A	1	HAND1	0	affinity chromatography technology, pull down	Morin S (2005), Morin S (2005)	2
DNMT3L	2	HIST2H4A	0	pull down	Ooi SK (2007)	1
DNMT3L	2	E2F6	2	pull down	Pacaud R (2014)	1
CREB1	1	CREM	1	affinity chromatography technology, affinity chromatography technology	Srivastava V (2012), Li X (2015)	2
ASH2L	2	MEF2D	5	affinity chromatography technology, affinity chromatography technology	Rampalli S (2007), Rampalli S (2007)	2