PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LIN7A	1	GUCY1A2	2	affinity chromatography technology	Hauri S (2013)	1
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
LIN7A	1	GUCY1B3	0	affinity chromatography technology	Hauri S (2013)	1
SCRIB	8	GUCY1A2	2	affinity chromatography technology	Ivarsson Y (2014)	1
GUCY1A2	2	DLG1	2	affinity chromatography technology	Russwurm M (2001)	1
GUCY1A2	2	DLG4	11	affinity chromatography technology	Russwurm M (2001)	1
GUCY1A2	2	GUCY1B3	0	affinity chromatography technology, affinity chromatography technology	Russwurm M (2001), Huttlin EL (2017)	2
GUCY1A2	2	STUB1	4	affinity chromatography technology, enzymatic study	Xia T (2007), Xia T (2007)	2
GUCY1A2	2	HSP90AA1	7	affinity chromatography technology	Xia T (2007)	1
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
STUB1	4	HSPA4	3	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Dai Q (2005), Tateishi Y (2004), Tateishi Y (2004), Ko HS (2009), Qian SB (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Wang L (2011), Wang L (2011), Graf C (2010), Kundrat L (2010), Matsumoto K (2011), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Luo W (2010), Soss SE (2011), Zhou P (2003), Kalia LV (2011), Gao Y (2010), Gao Y (2010), Grelle G (2006), Rao SN (2010), Tetzlaff JE (2008), Kim SA (2005), Dai Q (2003), Zhang X (2011), Zhang X (2011), Muller P (2012), Jang KW (2011), Schuelke JP (2010), Jinwal UK (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Mao RF (2013), Lee JS (2013), Lee JS (2013)	42
SNTA1	1	GUCY1A2	2	unspecified method	Boisguerin P (2004)	1
GUCY1B3	0	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology	Venema RC (2003), Venema RC (2003), Venema RC (2003)	3
GUCY1A2	2	HSPA4	3	affinity chromatography technology	Xia T (2007)	1
DLG3	1	DLG4	11	two hybrid, pull down	Masuko N (1999), Masuko N (1999)	2
DLG1	2	LIN7A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Hauri S (2013)	3
STUB1	4	GUCY1B3	0	affinity chromatography technology	Meurer S (2009)	1
DLG4	11	LIN7A	1	pull down	Jo K (1999)	1
ERBIN	5	GUCY1A2	2	unspecified method	Boisguerin P (2004)	1
DLG3	1	DLG1	2	affinity chromatography technology	Hein MY (2015)	1
DLG2	4	DLG4	11	affinity chromatography technology	Hsueh YP (1997)	1
GUCY1A2	2	DLG3	1	affinity chromatography technology	Russwurm M (2001)	1
HSP90AA1	7	SCRIB	8	affinity chromatography technology	Gano JJ (2010)	1
GUCY1A2	2	DLG2	4	affinity chromatography technology	Russwurm M (2001)	1