PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RHOU	0	BRF1	6	pull down	Dart AE (2015)	1
TP53	0	BRF1	6	affinity chromatography technology	Chesnokov I (1996)	1
CSNK2A2	1	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Huttlin EL (2015), Wan C (2015), Gao Z (2014), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
TP53	0	ASF1A	0	affinity chromatography technology	Lunardi A (2010)	1
TCF20	18	BRF1	6	affinity chromatography technology	Hein MY (2015)	1
TBP	0	GTF3C5	4	pull down	Hsieh YJ (1999)	1
ACSL4	1	BRF1	6	affinity chromatography technology	Hein MY (2015)	1
ASF1A	0	BRF1	6	imaging technique	Pchelintsev NA (2013)	1
GTF3C3	2	GTF3C5	4	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
UBN1	3	BRF1	6	imaging technique	Pchelintsev NA (2013)	1
CSNK2A2	1	BRF1	6	affinity chromatography technology	Johnston IM (2002)	1
UBN1	3	HIRA	5	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ray-Gallet D (2011), Tang Y (2012), Tang Y (2012), Tang Y (2012), Tang Y (2012), Tang Y (2012), Lee JS (2016), Lee JS (2016), Lee JS (2016), Pchelintsev NA (2013), Pchelintsev NA (2013)	11
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
BRF1	6	GTF3C5	4	affinity chromatography technology	Hsieh YJ (1999)	1
BRF1	6	APP	1	pull down	Olah J (2011)	1
TBP	0	GTF3C3	2	pull down	Hsieh YJ (1999)	1
HIRA	5	BRF1	6	imaging technique	Pchelintsev NA (2013)	1
GTF3C3	2	POLR3E	1	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	ACSL4	1	affinity chromatography technology	Fogeron ML (2013)	1
UBC	7	VPS50	3	pull down	Zhang X (2017)	1
RBL2	5	BRF1	6	pull down, affinity chromatography technology	Sutcliffe JE (1999), Sutcliffe JE (1999)	2
RBL1	1	BRF1	6	pull down, affinity chromatography technology	Sutcliffe JE (1999), Sutcliffe JE (1999)	2
RBL2	5	RBL1	1	affinity chromatography technology	Litovchick L (2007)	1
UBN1	3	ASF1A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang Y (2012), Hein MY (2015), Huttlin EL (2017), Pchelintsev NA (2013), Pchelintsev NA (2013)	5
UBC	7	BRF1	6	pull down	Nathan JA (2013)	1
RB1	2	TP53	0	affinity chromatography technology, pull down	Delston RB (2011), Sommer MH (1994)	2
CSNK2A1	15	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study	Uhle S (2003), Fogeron ML (2013), Bhansali M (2014), Chen TC (2014), Walerych D (2004), Walerych D (2004)	6
CSNK2A1	15	APP	1	pull down	Olah J (2011)	1
UBC	7	CSNK2A2	1	affinity chromatography technology	Matsumoto M (2005)	1
PCBD2	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
BRF1	6	PCBD2	0	two hybrid	Ravasi T (2010)	1
DTNBP1	1	VPS50	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ACSL4	1	APP	1	pull down	Olah J (2011)	1
RB1	2	BRF1	6	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Johnston IM (2002), Sutcliffe JE (1999), Sutcliffe JE (1999), Chu WM (1997), Chu WM (1997)	5
UBC	7	CSNK2A1	15	affinity chromatography technology	Matsumoto M (2005)	1
TBP	0	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Seto E (1992), Cvekl A (1999), Wu Y (2001), Qadri I (2002), Qadri I (2002), Sommer MH (1994)	6
GTF3C3	2	BRF1	6	affinity chromatography technology	Hsieh YJ (1999)	1
VPS50	3	BRF1	6	affinity chromatography technology	Hein MY (2015)	1
RB1	2	TBP	0	pull down	Shao Z (1997)	1
CSNK2A1	15	BRF1	6	affinity chromatography technology	Johnston IM (2002)	1
POLR3E	1	BRF1	6	affinity chromatography technology	Hein MY (2015)	1
TBP	0	BRF1	6	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McCulloch V (2000), McCulloch V (2000), Wang Z (1995), Chen D (2002), Lim J (2006), Hein MY (2015), Woiwode A (2008), Woiwode A (2008)	8
ASF1A	0	HIRA	5	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang Y (2006), Tang Y (2006), Tang Y (2006), Zhang R (2005), Zhang R (2005), Galvani A (2008), Yang JH (2011), Zhang R (2007), Hein MY (2015), Huttlin EL (2017), Lee JS (2016), Lee JS (2016), Pchelintsev NA (2013), Pchelintsev NA (2013)	14
TP53	0	GTF3C3	2	affinity chromatography technology	Fogeron ML (2013)	1
DTNBP1	1	BRF1	6	two hybrid	Camargo LM (2007)	1