PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HIPK2	0	CXCL1	0	affinity chromatography technology, pull down	Sung KS (2005), Sung KS (2005)	2
SRSF1	0	CXCL1	0	affinity chromatography technology	Sun D (2011)	1
CXCL1	0	ACKR1	4	pull down	Kashiwazaki M (2003)	1
XRCC3	1	CXCL1	0	two hybrid	Arroyo R (2015)	1
ESR1	0	SRSF1	0	affinity chromatography technology	Tarallo R (2011)	1
CXCL1	0	CXCL1	0	x-ray crystallography	Fairbrother WJ (1993)	1
PTEN	24	ESR1	0	pull down	Lin HK (2004)	1
ESR1	0	CXCL1	0	two hybrid	Arroyo R (2015)	1
HRAS	2	CXCL1	0	two hybrid	Arroyo R (2015)	1
PTEN	24	CXCL1	0	two hybrid	Arroyo R (2015)	1