Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
GRM7 2917 L-GLUTAMATE CHEMBL575060 DrugBank 17360958
GRM7 2917 DEXFOSFOSERINE CHEMBL284377 agonist GuideToPharmacologyInteractions
GRM7 2917 CHEMBL284193 CHEMBL284193 antagonist GuideToPharmacologyInteractions
GRM7 2917 CHEMBL432038 CHEMBL432038 antagonist GuideToPharmacologyInteractions
GRM7 2917 CHEMBL1488784 CHEMBL1488784 antagonist GuideToPharmacologyInteractions
GRM7 2917 CHEMBL86508 CHEMBL86508 antagonist GuideToPharmacologyInteractions
GRM7 2917 CHEMBL41013 CHEMBL41013 antagonist GuideToPharmacologyInteractions
GRM7 2917 CHEMBL299683 CHEMBL299683 antagonist GuideToPharmacologyInteractions
GRM7 2917 CHEMBL33567 CHEMBL33567 agonist GuideToPharmacologyInteractions
GRM7 2917 CHEMBL3114673 CHEMBL3114673 agonist GuideToPharmacologyInteractions
GRM7 2917 CHEMBL34453 CHEMBL34453 agonist GuideToPharmacologyInteractions
GRM7 2917 CHEMBL277475 CHEMBL277475 agonist GuideToPharmacologyInteractions
GRM7 2917 CHEMBL1613220 CHEMBL1613220 allosteric modulator GuideToPharmacologyInteractions
GRM7 2917 CHEMBL1609272 CHEMBL1609272 antagonist GuideToPharmacologyInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
GRM7 rs3792452 T methylphenidate efficacy no Clinical Global Impression-Severity (CGI-S) scale and the Children’s Global Assessment Scale (CGAS). Allele T is not associated with response to methylphenidate in children with Attention Deficit Disorder with Hyperactivity as compared to allele C. 28871191 1450376598
GRM7 rs3792452 CT methylphenidate efficacy not stated signifi- cant association between the G/A genotype and a good response at the completion of the 8 week treatment period based on ADHD-RS scores (72.2% vs. 55.4%, OR = 4.38, p = 0.011) after controlling for baseline ADHD-RS score, age, sex, IQ, and final dose of MPH. Comparing posttreatment changes in ADHD-RS scores treating the scores as a continuous variable, no significant differences were found between subjects with the G/A genotype and those with the G/G genotype (-13.92 – 11.91 vs. - 11.23 – 11.28, t = 1.27, d = 0.23, p = 0.205. Genotype CT is associated with increased response to methylphenidate in children with Attention Deficit Disorder with Hyperactivity as compared to genotype CC. 24815731 1450376953
GRM7 rs2069062 CC risperidone efficacy yes Psychotic-naive or minimal antipsychotic exposure. Improvement measured with Brief Psychiatric Rating Scale. Genotype CC is associated with increased response to risperidone in people with as compared to genotypes CG + GG. 26905411 1447949447