PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FBXW7	2	GRM3	0	genetic interference	Bailey ML (2015)	1
GRM3	0	PICK1	2	two hybrid, pull down	Hirbec H (2002), Hirbec H (2002)	2
GRM3	0	PPM1A	1	two hybrid, affinity chromatography technology	Flajolet M (2003), Flajolet M (2003)	2
GRM3	0	GRIP1	1	two hybrid, pull down	Hirbec H (2002), Hirbec H (2002)	2
GRM3	0	SDCBP	0	pull down	Hirbec H (2002)	1