PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2T	0	LNX2	2	two hybrid	Markson G (2009)	1
AMFR	2	UBC	7	pull down, pull down, imaging technique, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Zhong X (2004), Yang H (2010), Ying Z (2009), Jo Y (2011), Ye Y (2003), Xu Y (2012), Liu S (2012), Liu S (2012), Xu Y (2012), Morito D (2008), Flierman D (2006), Liu W (2014), Fang S (2001)	13
BRCA1	7	EWSR1	2	affinity chromatography technology	Ertych N (2016)	1
UBE2T	0	FANCL	0	two hybrid, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, two hybrid, protein complementation assay, two hybrid, two hybrid, pull down, pull down	Machida YJ (2006), Machida YJ (2006), Hodson C (2011), Machida YJ (2006), Hodson C (2014), Hodson C (2014), Longerich S (2014), Alpi AF (2008), Li YC (2014), Hira A (2015), Hira A (2015), Hira A (2015), Lv Z (2017)	13
AMFR	2	MGRN1	4	affinity chromatography technology, affinity chromatography technology	Mukherjee R (2016), Mukherjee R (2016)	2
EWSR1	2	UBE2T	0	bioid	Elzi DJ (2014)	1
PRKN	1	UBE2T	0	pull down	Kazlauskaite A (2014)	1
UBE2T	0	PCGF2	3	two hybrid	van Wijk SJ (2009)	1
FANCD2	3	BRCA1	7	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reuter TY (2003), Vandenberg CJ (2003), Garcia-Higuera I (2001), Garcia-Higuera I (2001), Loke J (2015)	5
UBA1	1	CHEK1	2	pull down	Tan X (2015)	1
ARIH2	4	TRIM27	2	two hybrid	Woodsmith J (2012)	1
FANCD2	3	FANCL	0	unspecified method, enzymatic study, enzymatic study, enzymatic study, pull down	Hodson C (2011), Longerich S (2014), Lv Z (2017), Sato K (2014), Sato K (2014)	5
UBE2T	0	FANCD2	3	enzymatic study	Hira A (2015)	1
UBC	7	UBE2T	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
CDK2	0	UBA1	1	affinity chromatography technology	Neganova I (2011)	1
BRCA1	7	UBA1	1	affinity chromatography technology	Ertych N (2016)	1
FANCB	0	FANCL	0	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Ling C (2007), Ling C (2007), Medhurst AL (2006), Medhurst AL (2006)	4
UBE2T	0	ARIH2	4	two hybrid	Markson G (2009)	1
CHEK1	2	BRCA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference	Yarden RI (2002), Yarden RI (2002), Inoue Y (2007), Shen JP (2017)	4
UBC	7	UBA1	1	affinity chromatography technology, unspecified method, x-ray crystallography, biochemical, affinity chromatography technology, pull down	Nicassio F (2007), Zhao B (2012), Schaefer A (2014), Schaefer A (2014), Bish RA (2007), Zhang X (2017)	6
FGB	2	UBA1	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2M	0	PRKN	1	enzymatic study	Choo YS (2012)	1
ZNF277	1	UBE2T	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBA1	1	UBE2T	0	pull down, enzymatic study	Jin J (2007), Huguenin-Dezot N (2016)	2
EWSR1	2	UBE2M	0	bioid	Elzi DJ (2014)	1
UBE2T	0	PRDX2	1	biochemical	Wan C (2015)	1
CDK5R1	0	UBE2T	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GTF2E2	2	UBA6	4	affinity chromatography technology	Huttlin EL (2017)	1
FANCL	0	FAAP100	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Singh TR (2010), Ling C (2007), Ling C (2007), Ling C (2007), Huang Y (2014), Huang Y (2014), Ali AM (2012), Ali AM (2012), Ali AM (2012)	9
SNRNP27	0	UBA6	4	affinity chromatography technology	Huttlin EL (2017)	1
UBE2T	0	RNF144B	0	two hybrid	Markson G (2009)	1
UBE2T	0	BRCA1	7	pull down	Ueki T (2009)	1
CHEK1	2	UBE2T	0	enzymatic study	Lv Z (2017)	1
UBE2T	0	FAAP100	1	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	FANCD2	3	pull down, affinity chromatography technology	Rego MA (2012), Yamamoto KN (2011)	2
SLC25A32	5	UBE2T	0	affinity chromatography technology	Huttlin EL (2015)	1
CHEK1	2	FANCD2	3	enzymatic study, genetic interference	Zhi G (2009), Pichierri P (2004)	2
UBE2T	0	AMFR	2	two hybrid	van Wijk SJ (2009)	1
UBE2T	0	RACK1	2	biochemical	Wan C (2015)	1
ROCK1	6	UBE2T	0	enzymatic study	Lv Z (2017)	1
UBE2T	0	UBE2T	0	enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study	Alpi AF (2008), David Y (2010), David Y (2010), Hira A (2015), Miles JA (2015)	5
C11orf65	0	UBE2T	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SRA1	0	UBE2T	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CDK2	0	PRDX2	1	affinity chromatography technology	Neganova I (2011)	1
EWSR1	2	PRDX2	1	affinity chromatography technology, bioid	Elzi DJ (2014), Elzi DJ (2014)	2
UBE2T	0	RNF128	1	two hybrid	Markson G (2009)	1
UBE2T	0	FANCB	0	affinity chromatography technology	Huttlin EL (2017)	1
RPS6KA1	3	UBE2T	0	enzymatic study	Lv Z (2017)	1
FANCB	0	FAAP100	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Ling C (2007), Ling C (2007), Ling C (2007), Ali AM (2012)	4
GTF2E2	2	OIP5	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2M	0	UBE2T	0	biochemical	Havugimana PC (2012)	1
UBE2T	0	MARCH5	0	two hybrid	Markson G (2009)	1
OIP5	1	UBE2T	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK2	0	UBE2M	0	affinity chromatography technology	Ewing RM (2007)	1
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
RNF144B	0	UBC	7	enzymatic study	Michel MA (2017)	1
CDK2	0	CDK5R1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang J (2012), Huttlin EL (2015), Huttlin EL (2017)	3
UBE2T	0	RNF4	1	two hybrid	van Wijk SJ (2009)	1
FGB	2	UBE2T	0	affinity chromatography technology	Huttlin EL (2017)	1
GTF2E2	2	UBE2T	0	affinity chromatography technology	Huttlin EL (2017)	1
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
UBA6	4	UBE2T	0	pull down	Jin J (2007)	1
ARIH2	4	UBC	7	enzymatic study	Marteijn JA (2009)	1
CDK2	0	UBE2T	0	enzymatic study	Lv Z (2017)	1
TRIM27	2	SORBS3	5	two hybrid	Rolland T (2014)	1
CDK2	0	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Ruffner H (1999), Ruffner H (1999), Ruffner H (1999), Wang H (1997), Chen Y (1996)	5
RDH12	0	UBE2T	0	affinity chromatography technology	Huttlin EL (2015)	1
SNRNP27	0	UBE2T	0	affinity chromatography technology	Huttlin EL (2017)	1
CDK2	0	RACK1	2	affinity chromatography technology	Neganova I (2011)	1
MBD5	14	UBA6	4	affinity chromatography technology	Huttlin EL (2015)	1
UBE2T	0	SORBS3	5	biochemical	Havugimana PC (2012)	1
BRCA1	7	RACK1	2	affinity chromatography technology, affinity chromatography technology	Woods NT (2012), Ertych N (2016)	2
UBE2T	0	MGRN1	4	two hybrid	Markson G (2009)	1
PRKCG	3	UBE2T	0	enzymatic study	Lv Z (2017)	1
PRKN	1	MARCH5	0	affinity chromatography technology	Sarraf SA (2013)	1
UBC	7	TRIM27	2	affinity chromatography technology	Matsumoto M (2005)	1
UBA6	4	UBC	7	pull down, enzymatic study, unspecified method, affinity chromatography technology	Gavin JM (2012), Gavin JM (2012), Zhao B (2012), Bish RA (2007)	4
RNF4	1	UBC	7	enzymatic study, enzymatic study	Groocock LM (2014), Branigan E (2015)	2
MBD5	14	UBE2T	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2T	0	TRIM27	2	two hybrid	Markson G (2009)	1