PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CHMP4A	1	EGFR	5	affinity chromatography technology	Ali N (2013)	1
CHMP4A	1	CHMP4A	1	two hybrid	Tsang HT (2006)	1
CHMP4A	1	CDK13	18	two hybrid	Tsang HT (2006)	1
CHMP4A	1	RBBP7	1	biochemical	Kristensen AR (2012)	1
PPIA	0	CHMP4A	1	affinity chromatography technology	Strack B (2003)	1
EGFR	5	VPS4B	3	affinity chromatography technology	Tong J (2014)	1
CHMP4A	1	ADSS	1	biochemical	Kristensen AR (2012)	1
VAX2	0	CHMP3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHMP4A	1	TTC19	0	two hybrid	Tsang HT (2006)	1
CHMP4A	1	TALDO1	2	biochemical	Kristensen AR (2012)	1
CHMP4A	1	EFHD2	2	biochemical	Kristensen AR (2012)	1
CHMP4A	1	SYT17	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Tsang HT (2006), Rolland T (2014)	3
PDCD6IP	3	CHMP4B	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ichioka F (2007), Ichioka F (2007), von Schwedler UK (2003), Zhou X (2010), Sette P (2013), Hein MY (2015), Dores MR (2015)	7
IDH1	0	ADSS	1	biochemical	Kristensen AR (2012)	1
COX15	3	CHMP4A	1	affinity chromatography technology	Malty RH (2017)	1
EIF6	2	CHMP4A	1	biochemical	Wan C (2015)	1
CHMP4A	1	CHRAC1	0	biochemical	Kristensen AR (2012)	1
DCK	0	RBBP7	1	biochemical	Kristensen AR (2012)	1
EGFR	5	RANBP1	0	affinity chromatography technology	Foerster S (2013)	1
DCK	0	EFHD2	2	biochemical	Kristensen AR (2012)	1
CHMP4A	1	VPS4B	3	biochemical	Havugimana PC (2012)	1
VPS4B	3	PDCD6IP	3	two hybrid, biochemical	von Schwedler UK (2003), Havugimana PC (2012)	2
CHMP4A	1	HSPE1	0	biochemical	Kristensen AR (2012)	1
EFHD2	2	IDH1	0	biochemical	Kristensen AR (2012)	1
CHMP4A	1	RCN1	0	biochemical	Kristensen AR (2012)	1
TFG	3	CHMP4B	2	affinity chromatography technology	Hein MY (2015)	1
HSPE1	0	PPIA	0	biochemical	Wan C (2015)	1
CHMP4C	1	CC2D1A	1	two hybrid	Tsang HT (2006)	1
CHMP4A	1	RANBP1	0	biochemical	Kristensen AR (2012)	1
VPS4A	4	CHMP3	0	affinity chromatography technology	Kuang Z (2011)	1
TFG	3	CHMP5	0	affinity chromatography technology	Hein MY (2015)	1
TFG	3	CHMP3	0	affinity chromatography technology	Hein MY (2015)	1
RANBP1	0	IDH1	0	biochemical	Kristensen AR (2012)	1
DCK	0	TALDO1	2	biochemical	Kristensen AR (2012)	1
ARL6IP6	2	CHMP4A	1	affinity chromatography technology	Huttlin EL (2017)	1
CHRAC1	0	ADSS	1	biochemical	Kristensen AR (2012)	1
PDCD6IP	3	CHMP4A	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid	Rauch S (2011), von Schwedler UK (2003), Strack B (2003), Strack B (2003), Carlton JG (2008)	5
CHMP3	0	CHMP4B	2	two hybrid, two hybrid, biochemical, affinity chromatography technology	Tsang HT (2006), Tsang HT (2006), Wan C (2015), Hein MY (2015)	4
CHMP4A	1	VPS4A	4	two hybrid, two hybrid, two hybrid	von Schwedler UK (2003), Strack B (2003), Tsang HT (2006)	3
CHMP4A	1	CHMP3	0	two hybrid	von Schwedler UK (2003)	1
COX15	3	PPIA	0	affinity chromatography technology	Malty RH (2017)	1
CHMP4C	1	PDCD6IP	3	two hybrid, two hybrid	von Schwedler UK (2003), Wang J (2011)	2
STAMBP	2	GAK	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TFG	3	CHMP4A	1	affinity chromatography technology	Hein MY (2015)	1
CHMP5	0	STAMBP	2	two hybrid	Wang J (2011)	1
DCK	0	HSPE1	0	biochemical	Kristensen AR (2012)	1
F2R	1	PDCD6IP	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Dores MR (2012), Dores MR (2012), Dores MR (2012), Dores MR (2015)	4
STAMBP	2	CHMP4A	1	two hybrid, two hybrid	Row PE (2007), Tsang HT (2006)	2
ADSS	1	RBBP7	1	biochemical	Kristensen AR (2012)	1
VAX2	0	CHMP4A	1	affinity chromatography technology	Huttlin EL (2017)	1
ADSS	1	TALDO1	2	biochemical	Kristensen AR (2012)	1
VPS4B	3	CHMP5	0	two hybrid	Rolland T (2014)	1
CHMP4B	2	CHMP4A	1	two hybrid	Tsang HT (2006)	1
TALDO1	2	HSPE1	0	biochemical	Kristensen AR (2012)	1
TFG	3	PDCD6IP	3	affinity chromatography technology	Hein MY (2015)	1
STAMBP	2	CHMP4B	2	two hybrid, two hybrid, two hybrid	Row PE (2007), Tsang HT (2006), Tsang HT (2006)	3
EGFR	5	CDK13	18	affinity chromatography technology	Yao Z (2017)	1
NFYA	2	CHMP4A	1	affinity chromatography technology	Huttlin EL (2017)	1
DCK	0	IDH1	0	biochemical	Kristensen AR (2012)	1
COX15	3	CHMP4B	2	affinity chromatography technology	Malty RH (2017)	1
CHMP4A	1	IDH1	0	biochemical	Kristensen AR (2012)	1
CHMP5	0	CHMP4B	2	two hybrid, biochemical, affinity chromatography technology	Tsang HT (2006), Wan C (2015), Hein MY (2015)	3
CHRAC1	0	TALDO1	2	biochemical	Kristensen AR (2012)	1
EGFR	5	SYT17	0	affinity chromatography technology	Yao Z (2017)	1
CHMP4C	1	CHMP4A	1	two hybrid	von Schwedler UK (2003)	1
IDH1	0	RCN1	0	biochemical	Kristensen AR (2012)	1
IDH1	0	RBBP7	1	biochemical	Kristensen AR (2012)	1
CHMP4A	1	CC2D1A	1	two hybrid	Tsang HT (2006)	1
CHMP4C	1	CHMP4B	2	two hybrid, two hybrid	von Schwedler UK (2003), Tsang HT (2006)	2
EFHD2	2	RCN1	0	biochemical	Kristensen AR (2012)	1
EIF6	2	CHMP4B	2	biochemical	Wan C (2015)	1
IDH1	0	HSPE1	0	biochemical	Kristensen AR (2012)	1
CHMP4B	2	CC2D1A	1	affinity chromatography technology	Hein MY (2015)	1
CHMP5	0	CHMP3	0	affinity chromatography technology	Huttlin EL (2017)	1
VPS4A	4	CHMP5	0	affinity chromatography technology	Kuang Z (2011)	1
VPS4A	4	CHMP4B	2	two hybrid, two hybrid	Tsang HT (2006), Tsang HT (2006)	2
IDH1	0	TALDO1	2	biochemical	Kristensen AR (2012)	1
STAMBP	2	CHMP4C	1	pull down	Row PE (2007)	1
SMARCB1	1	CHMP4A	1	biochemical	Wan C (2015)	1
F2R	1	CHMP4A	1	affinity chromatography technology	Dores MR (2012)	1
STAMBP	2	CHMP3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, imaging technique, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Sowa ME (2009), Kyuuma M (2006), Kyuuma M (2006), Kyuuma M (2006), Agromayor M (2006), Agromayor M (2006), Row PE (2007), Row PE (2007), Ma YM (2007), Ma YM (2007), McCullough J (2006), Zamborlini A (2006), Tsang HT (2006), Tsang HT (2006), Tsang HT (2006), Tsang HT (2006), Rolland T (2014), Huttlin EL (2015), Lata S (2008), Huttlin EL (2017)	20
CHMP5	0	CHMP4A	1	two hybrid, biochemical	Tsang HT (2006), Wan C (2015)	2
CDCA3	0	CHMP4A	1	affinity chromatography technology	Huttlin EL (2017)	1
ADSS	1	HSPE1	0	biochemical	Kristensen AR (2012)	1
CHMP4C	1	VPS4A	4	two hybrid	von Schwedler UK (2003)	1
DCK	0	ADSS	1	biochemical	Kristensen AR (2012)	1
EGFR	5	PDCD6IP	3	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Schmidt MH (2004), Schmidt MH (2003), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
DCK	0	RANBP1	0	biochemical	Kristensen AR (2012)	1
DCK	0	CHRAC1	0	biochemical	Kristensen AR (2012)	1
RCN1	0	HSPE1	0	biochemical	Wan C (2015)	1
HSPE1	0	RBBP7	1	biochemical	Kristensen AR (2012)	1
CHRAC1	0	RBBP7	1	biochemical	Kristensen AR (2012)	1
GAK	5	CHMP4A	1	affinity chromatography technology	Hein MY (2015)	1
DCK	0	CHMP4A	1	biochemical	Kristensen AR (2012)	1
VPS4A	4	VPS4B	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2