PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZBTB24	1	KLF15	1	two hybrid	Rolland T (2014)	1
PRKAB2	0	KLF15	1	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
STAT3	0	PIK3R3	0	two hybrid	Grossmann A (2015)	1
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
STAT3	0	KLF15	1	two hybrid	Grossmann A (2015)	1
CRK	0	PIK3R3	0	affinity chromatography technology, two hybrid	Brehme M (2009), Grossmann A (2015)	2
APPL1	1	KLF15	1	two hybrid	Grossmann A (2015)	1
KLF15	1	EP300	36	affinity chromatography technology	Lu Y (2013)	1
ZBTB24	1	SUV39H1	0	two hybrid	Weimann M (2013)	1
KLF15	1	KAT2B	2	pull down, affinity chromatography technology	Wang B (2008), Wang B (2008)	2
KLF15	1	SNX13	3	two hybrid	Wang J (2011)	1
KLF15	1	VWA2	2	affinity chromatography technology	Huttlin EL (2017)	1
KLF15	1	TCF21	0	two hybrid	Wang J (2011)	1
KLF15	1	ADD3	4	affinity chromatography technology	Huttlin EL (2017)	1
KLF15	1	PPP2R5E	4	affinity chromatography technology	Huttlin EL (2017)	1
CRK	0	KLF15	1	two hybrid	Grossmann A (2015)	1
KLF15	1	SUV39H1	0	two hybrid	Weimann M (2013)	1
ANKS1A	3	PIK3R3	0	two hybrid	Grossmann A (2015)	1
STAT3	0	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakashima K (1999), Nakashima K (1999), Ray S (2002), Ray S (2002), Yuan ZL (2005), Yuan ZL (2005), Gupta M (2011), Wang R (2005), Gray MJ (2005), Hou T (2008), Kotla S (2015)	11
ANKS1A	3	KLF15	1	two hybrid	Grossmann A (2015)	1
PIK3R3	0	KLF15	1	two hybrid	Grossmann A (2015)	1