PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	TP73	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Stindt MH (2015), Puca R (2011), De Laurenzi V (1998), Di Como CJ (1999)	4
MAP3K1	4	DYRK1A	36	affinity chromatography technology	Ritterhoff S (2010)	1
SMAD3	1	DYRK1A	36	affinity chromatography technology	Brown KA (2008)	1
AXIN1	1	DAXX	5	two hybrid, affinity chromatography technology, affinity chromatography technology	Li Q (2007), Li Q (2007), Li Q (2007)	3
PML	7	DAXX	5	two hybrid, two hybrid, affinity chromatography technology, imaging technique, two hybrid, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique	Ishov AM (1999), Li H (2000), Li H (2000), Li H (2000), Lehembre F (2001), Zhong S (2000), Cuchet-Lourenco D (2011), Chu Y (2011), Meinecke I (2007), Jang MS (2002), Chang CC (2011), Wethkamp N (2011), Ferguson BJ (2007), Delbarre E (2013), Delbarre E (2013), Sahin U (2014), Lin DY (2006), Lin DY (2006), Lin DY (2006), Lin DY (2006), Torii S (1999)	21
UBE2I	0	EP300	36	enzymatic study, affinity chromatography technology	Girdwood D (2003), Bian XL (2017)	2
NLK	1	MDM2	2	affinity chromatography technology	Zhang HH (2014)	1
EP300	36	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005)	22
SUMO2	0	MYB	3	pull down	Saether T (2011)	1
TP53	0	SENP1	0	affinity chromatography technology	Wu SY (2009)	1
TP53	0	ACTBL2	0	affinity chromatography technology	Horikawa I (2014)	1
MYB	3	SKI	3	pull down, affinity chromatography technology, pull down	Nomura T (2004), Nomura T (2004), Nomura T (2004)	3
HNRNPL	3	EP300	36	affinity chromatography technology	Fei T (2017)	1
DYRK1B	1	STUB1	4	affinity chromatography technology	Varjosalo M (2013)	1
TP63	0	FBXW7	2	affinity chromatography technology	Galli F (2010)	1
TP53	0	RANBP9	5	two hybrid	Chen J (2008)	1
DYRK1B	1	CREBBP	29	affinity chromatography technology	Varjosalo M (2013)	1
SUMO1	0	HIPK2	0	two hybrid, imaging technique, pull down	Lee BH (2003), de la Vega L (2011), de la Vega L (2011)	3
SUMO2	0	SENP2	3	two hybrid, pull down	Rolland T (2014), Ouyang J (2009)	2
SP100	4	SUMO2	0	two hybrid, two hybrid, pull down	Wang J (2011), Hecker CM (2006), Hecker CM (2006)	3
DCAF7	4	DYRK1B	1	affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skurat AV (2004), Ritterhoff S (2010), Ritterhoff S (2010), Miyata Y (2011), Varjosalo M (2013), Glenewinkel F (2016), Glenewinkel F (2016), Huttlin EL (2017), Hauri S (2016)	9
CREBBP	29	MYB	3	x-ray crystallography, pull down, genetic interference, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, x-ray crystallography, pull down	Zor T (2002), Zor T (2002), Bessa M (2001), Kurahashi T (2005), Kurahashi T (2005), Sano Y (2001), Sano Y (2001), Nomura T (2004), Yang F (2006), Giri R (2013)	10
EP300	36	PARP1	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Messner S (2009), Hassa PO (2005), Hassa PO (2005), Hassa PO (2005), Hassa PO (2008), Hassa PO (2008), Hassa PO (2003), Hassa PO (2003), Hassa PO (2003), Kim BK (2014), Kim BK (2014)	11
SUMO1	0	TP73	2	two hybrid	Minty A (2000)	1
CREBBP	29	DAXX	5	two hybrid, affinity chromatography technology	Kuo HY (2005), Kuo HY (2005)	2
DAXX	5	SUMO1	0	two hybrid, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, two hybrid, x-ray crystallography, two hybrid	Lin DY (2002), Ryu SW (2000), Ryu SW (2000), Ryu SW (2000), Escobar-Cabrera E (2011), Escobar-Cabrera E (2011), Naik MT (2011), Chang CC (2011), Chang CC (2011), Chen A (2006), Chen A (2006), Saul VV (2014), Ullmann R (2012), Lin DY (2006), Lin DY (2006), Ullmann R (2012), Ullmann R (2012), Lin DY (2006), Naik MT (2011), Li C (2017)	20
SMAD3	1	DCAF7	4	affinity chromatography technology	Brown KA (2008)	1
HIPK2	0	MECP2	36	affinity chromatography technology, affinity chromatography technology, enzymatic study	Bracaglia G (2009), Bracaglia G (2009), Bracaglia G (2009)	3
TRIM25	5	AXIN1	1	affinity chromatography technology	Choudhury NR (2017)	1
SENP2	3	SUMO3	0	enzymatic study, two hybrid, enzymatic study, enzymatic study	Zhang H (2002), Rolland T (2014), Zhang H (2002), Zhao Y (2015)	4
SMAD3	1	BTRC	1	affinity chromatography technology	Wan M (2004)	1
TP53INP1	0	HIPK2	0	pull down, pull down, affinity chromatography technology	Tomasini R (2003), Tomasini R (2003), Tomasini R (2003)	3
PML	7	CREBBP	29	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsuzaki K (2003), Matsuzaki K (2003), Matsuzaki K (2003), Doucas V (1999), Doucas V (1999), Zhong S (1999), Chen Y (2015)	7
TP63	0	DAXX	5	two hybrid, affinity chromatography technology, two hybrid, pull down	Kim EJ (2003), Kim EJ (2003), Gostissa M (2004), Gostissa M (2004)	4
MECP2	36	SKI	3	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Kokura K (2001), Kokura K (2001), Kokura K (2001), Kokura K (2001)	4
MAP3K1	4	MBP	0	enzymatic study	Ninomiya-Tsuji J (2003)	1
DAXX	5	TP53	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, unspecified method	Tang J (2006), Kim EJ (2003), Kim EJ (2003), Kim EJ (2003), Ohiro Y (2003), Ohiro Y (2003), Ohiro Y (2003), Ohiro Y (2003), Wethkamp N (2011), Zhao LY (2004), Zhao LY (2004), Zhao LY (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Zhao LY (2004), Zhao LY (2004), Zhang H (2013), Zhang H (2013), Chen TC (2014), Li Z (2017)	23
UBE2I	0	SKI	3	pull down, affinity chromatography technology	Ding B (2012), Ding B (2012)	2
CUL1	7	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Cenciarelli C (1999), Sowa ME (2009), Megumi Y (2005), Davis M (2002), Kawakami T (2001), Read MA (2000), Suzuki H (1999), Kumar KG (2007), Schweitzer K (2007), Chua YS (2011), Winston JT (1999), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Latres E (1999), Yoshida Y (2007), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), Chung FZ (2014), Chen ZW (2015), Kim TY (2014), Read MA (2000), Coyaud E (2015), Low TY (2014), Coyaud E (2015), He N (2005), Huttlin EL (2017), Kuang P (2016), Reitsma JM (2017), Reitsma JM (2017)	34
PARP1	3	UBE2I	0	two hybrid, affinity chromatography technology, pull down, enzymatic study, enzymatic study, pull down, enzymatic study	Masson M (1997), Masson M (1997), Masson M (1997), Zilio N (2013), Matafora V (2009), Zilio N (2013), Gocke CB (2005)	7
RANBP9	5	TP73	2	pull down, affinity chromatography technology	Kramer S (2005), Kramer S (2005)	2
STUB1	4	MAP3K7	2	affinity chromatography technology	Wang S (2013)	1
CREBBP	29	TP73	2	pull down, pull down	Zeng X (2000), Lemasson I (2001)	2
TP73	2	CUL1	7	affinity chromatography technology	Peschiaroli A (2009)	1
HNRNPL	3	MBP	0	affinity chromatography technology	Fei T (2017)	1
HIPK2	0	CXCL1	0	affinity chromatography technology, pull down	Sung KS (2005), Sung KS (2005)	2
CREBBP	29	NLK	1	affinity chromatography technology, enzymatic study	Kurahashi T (2005), Yasuda J (2004)	2
STUB1	4	ABL1	9	enzymatic study, affinity chromatography technology	Tsukahara F (2010), Huang H (2017)	2
PAX6	3	EP300	36	pull down, affinity chromatography technology, affinity chromatography technology	Hussain MA (1999), Hussain MA (1999), Hussain MA (1999)	3
CUL1	7	FBXO3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Shima Y (2008), Reitsma JM (2017)	3
HIPK2	0	FBXO3	0	affinity chromatography technology	Shima Y (2008)	1
TRIM25	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
SUMO2	0	UBE2I	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2006), Knipscheer P (2007), Boutell C (2011), Hecker CM (2006), Hecker CM (2006), Zilio N (2013), Tatham MH (2001), Knipscheer P (2007), Ullmann R (2012), Matic I (2008), Xu Y (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	14
UBE2I	0	CHMP4B	2	two hybrid, two hybrid	Rual JF (2005), Tsang HT (2006)	2
HIPK2	0	SP100	4	affinity chromatography technology	Moeller A (2003)	1
CBX4	1	PARP1	3	affinity chromatography technology	Vandamme J (2011)	1
TP53	0	HNRNPL	3	affinity chromatography technology	Horikawa I (2014)	1
SMAD1	0	STUB1	4	affinity chromatography technology, x-ray crystallography, enzymatic study, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Wang L (2011), Wang L (2011), Wang L (2011), Li L (2004), Li L (2004), Li L (2004), Li L (2004), Shimamoto S (2013), Shimamoto S (2013)	9
SMAD1	0	PAX6	3	affinity chromatography technology	Grocott T (2007)	1
HIPK2	0	TRADD	0	affinity chromatography technology	Li X (2000)	1
CHMP4B	2	HIPK2	0	two hybrid	Tsang HT (2006)	1
MDM4	0	EP300	36	pull down	Kadakia M (2002)	1
CREBBP	29	MYBL1	0	affinity chromatography technology, pull down	Kurahashi T (2005), Facchinetti V (1997)	2
DYRK1B	1	SKI	3	affinity chromatography technology	Varjosalo M (2013)	1
SMAD3	1	RUNX1	0	affinity chromatography technology, affinity chromatography technology	Hanai J (1999), Nitta E (2005)	2
MDM2	2	SUMO1	0	enzymatic study	Xirodimas DP (2002)	1
NLK	1	MYB	3	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study	Kurahashi T (2005), Kurahashi T (2005), Kurahashi T (2005), Kanei-Ishii C (2004), Kanei-Ishii C (2004)	5
DAXX	5	SUMO3	0	pull down	Chang CC (2011)	1
SMAD1	0	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Harada J (2003), Takeda M (2004), Mizuide M (2003)	4
EP300	36	TP63	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Liao JM (2013), Liao JM (2013), MacPartlin M (2005), MacPartlin M (2005), MacPartlin M (2005), MacPartlin M (2005), MacPartlin M (2005), Restelli M (2015), Restelli M (2015)	9
STUB1	4	PARP1	3	affinity chromatography technology, affinity chromatography technology	Choi JR (2016), Choi JR (2016)	2
DCAF7	4	DYRK1A	36	biochemical, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skurat AV (2004), Skurat AV (2004), Ritterhoff S (2010), Ritterhoff S (2010), Miyata Y (2011), Miyata Y (2011), Miyata Y (2011), Miyata Y (2011), Miyata Y (2011), Varjosalo M (2013), Miyata Y (2014), Miyata Y (2014), Glenewinkel F (2016), Glenewinkel F (2016), Glenewinkel F (2016), Huttlin EL (2017), Boldt K (2016), Hauri S (2016)	18
SP100	4	SUMO1	0	two hybrid, two hybrid, pull down, two hybrid	Rual JF (2005), Hecker CM (2006), Hecker CM (2006), Rolland T (2014)	4
CREBBP	29	MDM2	2	affinity chromatography technology, enzymatic study, affinity chromatography technology	Inoue Y (2011), Wang X (2004), Sanchez M (2012)	3
MDM4	0	HIPK2	0	affinity chromatography technology	Mancini F (2016)	1
PML	7	MYB	3	affinity chromatography technology, pull down	Dahle O (2004), Dahle O (2004)	2
MDM4	0	MDM2	2	pull down, two hybrid, enzymatic study, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, two hybrid, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, two hybrid, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Kadakia M (2002), Tanimura S (1999), Badciong JC (2002), Tanimura S (1999), Tanimura S (1999), Linke K (2008), Okamoto K (2005), Pan Y (2003), Kashuba E (2011), Kashuba E (2011), Ohtsubo C (2009), Singh RK (2007), Zhu Y (2009), Zhu Y (2009), Allende-Vega N (2010), Okamoto K (2009), Okamoto K (2009), Li X (2011), Nie J (2010), Nie J (2010), Li M (2011), Li M (2011), Singh RK (2007), de Graaf P (2003), Wade M (2012), Uldrijan S (2007), Wade M (2012), Stad R (2000), Dolezelova P (2012), Kulikov R (2005), Kawai H (2007), Kawai H (2007), Miller KR (2010), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Li C (2002), Wu S (2012), Ranaweera RS (2013), Woodsmith J (2012), Wang J (2011), Egorova O (2014), Chang YS (2013), Malbert-Colas L (2014), Yasuhara T (2014), Yasuhara T (2014), Iyappan S (2010), Stad R (2001), Marcar L (2015), Ling X (2014), Leslie PL (2015), Jacob AG (2014), Jacob AG (2014), Tournillon AS (2015), Tournillon AS (2015), Tournillon AS (2015), Zhang H (2015), Chen L (2015), Pellegrino M (2015), Pellegrino M (2015), Pellegrino M (2015), Medina-Medina I (2016), Medina-Medina I (2016), Moscetti I (2016), Liu T (2017), Liu T (2017), Liu T (2017), Huttlin EL (2017), Wu W (2015), Ivanov AA (2017), Mancini F (2016), Mancini F (2016)	74
CUL1	7	HNRNPL	3	affinity chromatography technology	Bennett EJ (2010)	1
HIPK2	0	EP300	36	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Aikawa Y (2006), Aikawa Y (2006), Aikawa Y (2006), Aikawa Y (2006)	4
MAP3K7	2	SMAD3	1	imaging technique	Chen TC (2014)	1
MYB	3	EP300	36	pull down, imaging technique, affinity chromatography technology, enzymatic study, pull down	Nicot C (2001), Jin W (2011), Sandberg ML (2005), Tomita A (2000), Uttarkar S (2015)	5
PML	7	CUL1	7	affinity chromatography technology	Shima Y (2008)	1
UBE2I	0	CREBBP	29	affinity chromatography technology, pull down, enzymatic study, two hybrid	Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Liu ST (2012)	4
BTRC	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down	Inuzuka H (2010), Inuzuka H (2010), Inuzuka H (2010)	3
PML	7	TP63	0	affinity chromatography technology, pull down	Bernassola F (2005), Bernassola F (2005)	2
TP53	0	STUB1	4	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Stankiewicz M (2010), Tripathi V (2007), Tripathi V (2007), Esser C (2005), Lim JH (2011), Wang J (2011), Burch L (2004), Landre V (2013), Horikawa I (2014), Horikawa I (2014), Horikawa I (2014), Fraser JA (2015), Narayan V (2015), Yue X (2016), Parrales A (2016), Parrales A (2016)	17
TP53	0	SMAD2	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Tateossian H (2009), Lu D (2013), Chen TC (2014)	5
MYBL2	2	CREBBP	29	genetic interference, affinity chromatography technology, affinity chromatography technology	Bessa M (2001), Bessa M (2001), Kurahashi T (2005)	3
UBE2I	0	PML	7	enzymatic study, pull down, enzymatic study, two hybrid, two hybrid, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Knipscheer P (2008), Kim YE (2005), Satow R (2012), Duprez E (1999), Wang J (2011), Tatham MH (2003), Duprez E (1999), Gocke CB (2005), Lin DY (2006), Jo S (2016), Schilling EM (2017)	11
MAP3K7	2	HIPK2	0	enzymatic study	Kanei-Ishii C (2004)	1
TP63	0	ZBTB4	6	affinity chromatography technology	Amoresano A (2010)	1
MDM2	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, unspecified method, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, biochemical, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, protein complementation assay, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, imaging technique, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, pull down, unspecified method, fluorescent resonance energy transfe, two hybrid, pull down	Li M (2003), Latonen L (2001), Zhang Y (2003), Zhang Y (2003), Kurki S (2003), Kurki S (2003), Freeman DJ (2003), Ito A (2002), Ito A (2002), Grossman SR (1998), Fang S (2000), Liu G (2000), Zhang Y (1998), Zhang Y (1998), Chen J (1993), Thut CJ (1997), Leung KM (2002), Wawrzynow B (2009), Ochocka AM (2009), Chen D (2009), Hedstroem E (2009), Brenkman AB (2008), Qiu W (2008), Qiu W (2008), Zhang Z (2008), Muller P (2008), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Tang Y (2008), Tang Y (2008), Lu X (2007), Lukashchuk N (2007), Lukashchuk N (2007), Lee JH (2007), Carter S (2007), Sasaki M (2007), Brooks CL (2007), Li L (2007), Becker K (2007), Zhao BX (2006), Zhao BX (2006), Abida WM (2007), Yang WH (2006), Ma J (2006), Wallace M (2006), Shimizu H (2006), Andrews P (2006), Yang J (2009), Zhu Z (2009), Wang C (2005), Higashitsuji H (2005), Higashitsuji H (2005), Yan C (2005), Vega FM (2004), Dai MS (2004), Dai MS (2004), Groenroos E (2004), Ohkubo S (2006), Sui G (2004), Di Stefano V (2004), Brignone C (2004), Katayama H (2004), Linares LK (2003), OKeefe K (2003), Wang W (2003), Blattner C (2002), Matt T (2004), Matt T (2004), Eyckerman S (2005), Shimizu H (2002), Shimizu H (2002), Migliorini D (2002), Gu J (2001), Sengupta S (2001), Chernov MV (2001), Cross B (2011), Cross B (2011), Cross B (2011), Buschmann T (2001), Nakamura S (2000), Rodriguez MS (2000), Rodriguez MS (2000), Geyer RK (2000), Zaika A (1999), Maki CG (1999), Chen L (2010), Chen L (2010), Lin RK (2010), Fuchs SY (1998), Xirodimas DP (2001), Fuchs SY (1998), Inoue T (2001), Wu L (2011), Du W (2009), Li DQ (2009), Illuzzi JL (2011), Oliver TG (2011), Kim MM (2007), Marchenko ND (2007), Vaseva AV (2009), Vaseva AV (2009), Lai KP (2010), Naderi EH (2011), Zdzalik M (2010), Singh RK (2007), Meng L (2011), Moore L (2007), Kim S (2010), Inoue Y (2011), Fraser JA (2010), Worrall EG (2009), Wu H (2011), Wang KS (2011), Wang KS (2011), Wang KS (2011), Izumi T (2010), Huang YF (2009), Tang J (2006), Tang J (2006), Fu X (2010), Fu X (2010), Shloush J (2011), Yadavilli S (2009), Stevenson LF (2007), Suzuki T (2010), Cheng Q (2009), Kulikov R (2010), Kulikov R (2010), Li L (2010), Li L (2010), Cheng Q (2011), Li D (2011), Nie J (2010), Demma M (2010), Sun XX (2011), Jung CR (2010), Jung CR (2010), Jung CR (2010), Jung CR (2010), Nishida T (2011), Li M (2011), Li M (2011), Amson R (2011), Amson R (2011), Bhatt P (2011), David Y (2011), Zhang Y (2010), Liu J (2010), Liu J (2010), Song MS (2008), Cummins JM (2004), Kim CK (2010), Kim CK (2010), Yan C (2010), Wang X (2011), Phillips A (2010), Phillips A (2010), Kang HN (2011), Kang HN (2011), Wang X (2004), Sionov RV (2001), Wei S (2012), Camus S (2012), Ding B (2012), Yang Z (2012), Yang Z (2012), Tripathi V (2007), Tripathi V (2007), Dai C (2011), Chen S (2012), Honda R (1997), Kinyamu HK (2003), Zhan C (2012), Zhan C (2012), Lee CW (2010), Zhou X (2012), Bouska A (2008), Wade M (2012), Ferreon JC (2009), Domenici F (2011), Uldrijan S (2007), Uldrijan S (2007), Stad R (2000), Stad R (2000), Banks D (2006), Banks D (2006), Bernal F (2010), Bernal F (2010), Jain AK (2012), Kane SA (2000), Tan Z (2000), Yang Z (2012), Wawrzynow B (2007), Wawrzynow B (2007), Wawrzynow B (2007), Hiramatsu K (2006), Bao-Lei T (2006), Kulikov R (2005), Yang Y (2005), Lindstroem MS (2007), Bech-Otschir D (2001), Li Y (2012), Gillotin S (2010), Burch L (2004), Liu WL (2001), OHagan HM (2004), OHagan HM (2004), Funari G (2009), Candeias MM (2008), Brew CT (2006), Wang J (2011), Calabro V (2002), Burch L (2004), Iyappan S (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Kurki S (2004), Tian LF (2006), Wang J (2006), Bae S (2012), Bae S (2012), Frazier DP (2012), Frazier DP (2012), Lew QJ (2012), Lew QJ (2012), Huart AS (2012), Li Z (2004), Balint E (1999), Balint E (1999), Funston G (2012), Dou X (2012), Sadagopan S (2012), Sadagopan S (2012), Dixit D (2012), Roxburgh P (2012), Xu L (2012), Drago-Ferrante R (2008), Li H (2009), Negorev D (2001), Wang X (2012), Wang X (2012), Wang X (2012), Boettger A (1997), Jung H (2008), Oliner JD (1992), Seemann S (2005), Kawai H (2007), Schuster K (2007), Dawson R (2003), DArcy P (2009), Schon O (2004), Schon O (2004), Hogan C (2008), Lottin-Divoux S (2005), Latini P (2011), Latini P (2011), Latini P (2011), McCoy MA (2003), Kussie PH (1996), Shieh SY (1997), Shieh SY (1997), Naski N (2009), Naski N (2009), Schon O (2002), Tamborini E (2001), Wade M (2006), Wade M (2006), Lohrum MA (2003), Garcia JF (2002), Garcia JF (2002), Kallen J (2009), Kulikov R (2006), Kulikov R (2006), Czarna A (2009), Czarna A (2009), Hu B (2007), Chi SW (2005), Yu GW (2006), Yu GW (2006), Saji S (2001), Chen L (1997), Zhang H (1998), Issaeva N (2004), Wade M (2008), Wade M (2008), Chen HF (2007), Chen HF (2007), Li HH (2004), Wang J (2011), Gu L (2009), Gu L (2009), Meng L (2008), Meng L (2008), Okamoto K (2006), Malaguarnera R (2008), Zhou M (2003), Zhou M (2003), Di Conza G (2012), Xirodimas DP (2004), Auger KR (2005), Li J (2011), Li J (2011), Li J (2011), Lee SJ (2007), Chau JF (2012), Lu X (2005), Mazars A (2010), Mazars A (2010), Mazars A (2010), Olson DC (1993), Picksley SM (1994), Issaeva N (2004), Issaeva N (2004), Zhang J (2012), Wen W (2013), Wen W (2013), Bursac S (2012), Yang Y (2013), Yang Y (2013), Landre V (2013), Pettersson S (2012), Thin TH (2007), Thin TH (2007), Piccinin S (2012), Shan B (2012), Caratozzolo MF (2012), Lui K (2013), Kobet E (2000), Lim KH (2010), Ranaweera RS (2013), Cui D (2013), Ebina M (2013), He Y (2013), He Y (2013), Siepe D (2009), Suh HW (2013), Zhan YA (2013), Wang J (2011), Hjerpe R (2010), Murray MF (2007), Jin L (2013), Jin L (2013), Zhang R (2013), Yan S (2013), Sun XX (2011), Heyne K (2014), Heyne K (2014), Bista M (2013), Jin J (2014), Mikawa T (2014), Qi M (2014), Cheng Q (2014), Zhang HH (2014), Perry ME (2000), Nishizaki M (2004), Sanchez-Aguilera A (2006), Chen YC (2013), Bertamino A (2013), Ding G (2013), Kubo N (2013), Kubo N (2013), Hsueh KW (2013), Kofod-Olsen E (2014), Fogeron ML (2013), Chang YS (2013), Gotoh T (2014), Gotoh T (2014), Oi N (2014), Corcoran CA (2009), Corcoran CA (2009), Ayroldi E (2014), Wu G (2014), Rajendra R (2004), Zhang J (2014), Lee MG (2014), Lee MG (2014), Freedman DA (1997), Freedman DA (1997), Saxena A (2006), Shi D (2009), Lohrum MA (2001), Lohrum MA (2001), Grossman SR (2003), Yan S (2013), Xirodimas DP (2004), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Saville MK (2004), Rodriguez MS (1999), Lui K (2013), Wu PY (2003), Pavithra L (2009), He Y (2013), Tan BX (2014), Huttlin EL (2015), Marcar L (2015), Borcherds W (2014), Borcherds W (2014), Li YC (2014), Ayroldi E (2014), Ling X (2014), Batuello CN (2015), Zhu N (2006), Mo XL (2015), Chen TC (2014), Stindt MH (2015), Caratozzolo MF (2014), Li X (2015), Saxena R (2016), Reed SM (2014), Du C (2016), Du C (2016), Du C (2016), Fraser JA (2015), Fraser JA (2015), Wu B (2015), Qin JJ (2015), Raza S (2015), Raza S (2015), Yamauchi T (2014), Yamauchi T (2014), Yamauchi T (2014), Shi Y (2010), Ahn HJ (2015), Lim KH (2015), Kang JH (2016), Chen J (2015), Liu X (2016), Yang P (2016), Yang P (2016), Liu D (2016), Liu D (2016), Liu D (2016), Datta D (2015), Reddy BA (2014), He X (2016), Shostak K (2014), Liu LJ (2016), Liu LJ (2016), Stegh AH (2010), Liu XH (2005), Medina-Medina I (2016), Medina-Medina I (2016), Kayama K (2017), Singh AK (2016), Liu WT (2016), Yue X (2016), Soares J (2015), Mukhopadhyay R (2016), Mukhopadhyay R (2016), Zhou X (2016), Zhou X (2016), Xie X (2016), Leao M (2015), Luo H (2016), Luo H (2016), Xie N (2016), Maeda R (2017), Maeda R (2017), Maeda R (2017), Sheng W (2017), Sheng W (2017), Liu M (2010), Huttlin EL (2017), Chauhan KM (2016), Goetz C (1999), Zhang J (2017), Unger T (1999), Liu Z (2004), Wu W (2015), Tan G (2017), Nomura K (2017), Lu W (2017), Lu W (2017), Hjerrild M (2001), Landre V (2017), Landre V (2017), Landre V (2017), Landre V (2017), Shangary S (2008), Shangary S (2008), Du WW (2017), Du WW (2017), Bista M (2013), Bista M (2013), Jin M (2017), LaRusch GA (2007), LaRusch GA (2007), Kurokawa M (2013), Ivanov AA (2017), Wong JH (2017), Wong JH (2017)	496
RUNX1	0	PML	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kraemer OH (2008), Nguyen LA (2005), Nguyen LA (2005), Nguyen LA (2005), Nguyen LA (2005)	5
TP53	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Lu D (2013), Ali A (2013)	4
DYRK1B	1	EP300	36	affinity chromatography technology	Varjosalo M (2013)	1
TRIM25	5	STUB1	4	affinity chromatography technology	Choudhury NR (2017)	1
SMAD2	5	DCAF7	4	affinity chromatography technology	Brown KA (2008)	1
HIPK2	0	MYBL2	2	affinity chromatography technology	Kurahashi T (2005)	1
MYB	3	SP100	4	two hybrid	Ravasi T (2010)	1
SUMO1	0	TP53	0	two hybrid	Minty A (2000)	1
HIPK2	0	DAXX	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hofmann TG (2003), Hofmann TG (2003), McDonough H (2009), Kumar N (2013)	4
ABL1	9	TP73	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yuan ZM (1999), Yuan ZM (1999), Agami R (1999), Tompkins JD (2009), Satija YK (2016)	5
PML	7	FBXO3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shima Y (2008), Shima Y (2008), Shima Y (2008)	3
TRIM25	5	DCAF7	4	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	SKI	3	affinity chromatography technology	Choudhury NR (2017)	1
HIPK2	0	AATF	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	De Nicola F (2014), De Nicola F (2014), De Nicola F (2014)	3
SIAH1	2	UBE2I	0	two hybrid, two hybrid	Depaux A (2007), Hu G (1997)	2
UBE2I	0	MAP3K1	4	two hybrid, pull down, affinity chromatography technology	Saltzman A (1998), Saltzman A (1998), Kubota Y (2011)	3
AATF	0	SMAD3	1	two hybrid	Wang J (2011)	1
MAP3K1	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Islam MR (2010), Islam MR (2010), Chipps E (2015), Chipps E (2015), Chipps E (2015)	5
STUB1	4	RUNX1	0	affinity chromatography technology, pull down, affinity chromatography technology	Shang Y (2009), Shang Y (2009), Shang Y (2009)	3
FBXW7	2	TRIM25	5	two hybrid	Arroyo R (2015)	1
UBE2I	0	MDM2	2	pull down, affinity chromatography technology, enzymatic study, unspecified method	Buschmann T (2001), Buschmann T (2001), Buschmann T (2001), Buschmann T (2001)	4
HIPK2	0	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Di Stefano V (2005), Di Stefano V (2005), Rinaldo C (2007), Rinaldo C (2007), He Y (2013)	5
PML	7	SUMO1	0	two hybrid, imaging technique, fluorescent resonance energy transfe, two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, x-ray crystallography, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down	Lin DY (2002), Cuchet-Lourenco D (2011), Percherancier Y (2009), Cuchet-Lourenco D (2012), Stehmeier P (2009), Duprez E (1999), Shen TH (2006), Shen TH (2006), Saether T (2007), Cappadocia L (2015), Cappadocia L (2015), Cappadocia L (2015), Li C (2017), Li C (2017)	14
PML	7	SP100	4	imaging technique, imaging technique, imaging technique, imaging technique, two hybrid, imaging technique	Cuchet-Lourenco D (2011), Cuchet-Lourenco D (2011), Cuchet D (2011), Negorev D (2001), Sternsdorf T (1997), Sahin U (2014)	6
NLK	1	MAP3K7	2	affinity chromatography technology, imaging technique	Li M (2010), Chen TC (2014)	2
NLK	1	SKI	3	affinity chromatography technology	Varjosalo M (2013)	1
TP63	0	HIPK2	0	two hybrid	Kim EJ (2002)	1
SMAD2	5	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Luo K (1999), Tabata T (2009), Prunier C (2003), Prunier C (2003), Akiyoshi S (1999), Akiyoshi S (1999), Takeda M (2004), Inoue Y (2011), Ferrand N (2010), Chen W (2007), Brown KA (2008), He J (2003), Rashidian J (2015), Zhou F (2017)	15
HIPK2	0	SIAH2	0	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Calzado MA (2009), Calzado MA (2009), Calzado MA (2009), Calzado MA (2009), Lee MG (2014)	5
DAXX	5	CHMP4B	2	affinity chromatography technology	Hein MY (2015)	1
HNRNPL	3	HIPK2	0	affinity chromatography technology	Fei T (2017)	1
RGMA	2	HIPK2	0	affinity chromatography technology	Hein MY (2015)	1
PML	7	SIAH2	0	affinity chromatography technology, affinity chromatography technology, pull down	Fanelli M (2004), Fanelli M (2004), Fanelli M (2004)	3
MECP2	36	HIST2H2BE	1	x-ray crystallography	Yang C (2011)	1
DYRK1A	36	LZTS2	4	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	5
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
CUL1	7	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inuzuka H (2010), Inuzuka H (2010), He Y (2014)	3
HIPK2	0	HSPA1A	0	affinity chromatography technology	Choi JR (2016)	1
UBE2I	0	TP73	2	two hybrid	Minty A (2000)	1
PARP1	3	HSPA1A	0	affinity chromatography technology	Choi JR (2016)	1
DAXX	5	SUMO2	0	x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, two hybrid	Escobar-Cabrera E (2011), Escobar-Cabrera E (2011), Chen A (2006), Chen A (2006), Ullmann R (2012), Ullmann R (2012), Lin DY (2006), Ouyang J (2009), Li C (2017)	9
SKI	3	RANBP9	5	affinity chromatography technology	Rashidian J (2015)	1
SMAD3	1	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid	Brown KA (2008), Wu RY (1997), Wu RY (1997)	3
SKI	3	DCAF7	4	affinity chromatography technology	Rashidian J (2015)	1
TRIM25	5	MDM2	2	affinity chromatography technology	Choudhury NR (2017)	1
SMAD2	5	STUB1	4	pull down	Li L (2004)	1
TRIM25	5	HSPA1A	0	affinity chromatography technology, affinity chromatography technology	Pauli EK (2014), Choudhury NR (2017)	2
HIPK2	0	ACTBL2	0	affinity chromatography technology	Huttlin EL (2017)	1
ZBTB4	6	HIPK2	0	two hybrid, pull down, affinity chromatography technology, imaging technique, enzymatic study	Yamada D (2009), Yamada D (2009), Yamada D (2009), Yamada D (2009), Yamada D (2009)	5
PML	7	SKI	3	affinity chromatography technology, pull down	Khan MM (2001), Khan MM (2001)	2
EP300	36	BTRC	1	affinity chromatography technology, affinity chromatography technology	Kimbrel EA (2009), Kimbrel EA (2009)	2
TRIM25	5	SMAD3	1	affinity chromatography technology	Choudhury NR (2017)	1
MAP3K1	4	DCAF7	4	affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Bouwmeester T (2004), Ritterhoff S (2010), Ritterhoff S (2010), Miyata Y (2014)	4
SUMO3	0	SP100	4	pull down	Hecker CM (2006)	1
XAF1	1	HIPK2	0	genetic interference, affinity chromatography technology	Lee MG (2014), Lee MG (2014)	2
HNRNPL	3	TP53INP1	0	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	SKI	3	affinity chromatography technology	Fei T (2017)	1
TP53	0	HIPK2	0	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Hofmann TG (2002), Hofmann TG (2002), Hofmann TG (2002), Hofmann TG (2002), Kim EJ (2002), Sung KS (2005), Li Q (2011), Di Stefano V (2005), Rinaldo C (2007), Rinaldo C (2007), Lee MG (2014), Mancini F (2016)	12
DAXX	5	HIST2H2BE	1	affinity chromatography technology	Tang M (2015)	1
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
MAP3K1	4	AXIN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2002), Zhang Y (2000), Zhang Y (2000), Sue Ng S (2010), Sue Ng S (2010), Loke J (2014)	6
SENP1	0	PML	7	enzymatic study	Galisson F (2011)	1
HNRNPL	3	NLK	1	affinity chromatography technology	Fei T (2017)	1
PARP1	3	TP53	0	affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, pull down, pull down	Gueven N (2004), Malanga M (1998), Vaziri H (1997), Vaziri H (1997), Wesierska-Gadek J (2003), Simbulan-Rosenthal CM (2003)	6
CREBBP	29	XAF1	1	pull down, affinity chromatography technology	Sun Y (2008), Sun Y (2008)	2
HIPK2	0	BTRC	1	affinity chromatography technology	Kanei-Ishii C (2008)	1
AXIN1	1	HIPK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li Q (2011), He Y (2013), He Y (2013)	3
TRIM25	5	DYRK1A	36	affinity chromatography technology	Choudhury NR (2017)	1
DYRK1A	36	CREBBP	29	affinity chromatography technology	Varjosalo M (2013)	1
SMAD3	1	CUL1	7	affinity chromatography technology	Ray D (2005)	1
ABL1	9	MBP	0	enzymatic study	Bae GU (2009)	1
SUMO3	0	HIPK2	0	pull down	de la Vega L (2011)	1
HIPK2	0	CBX4	1	affinity chromatography technology, imaging technique	de la Vega L (2011), de la Vega L (2011)	2
SMAD3	1	STUB1	4	pull down	Li L (2004)	1
SMAD3	1	HIPK2	0	pull down	Harada J (2003)	1
TP53	0	PML	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kurki S (2003), Kurki S (2003), Fogal V (2000), Fogal V (2000), Guo A (2000), Guo A (2000), Insinga A (2004), Chu Y (2011), Li Q (2011), Li Q (2011), Bernassola F (2005), Yang Q (2013), Yang Q (2013), Catalano A (2004), Chen TC (2014)	15
SENP1	0	PARP1	3	enzymatic study	Messner S (2009)	1
PML	7	SIAH1	2	affinity chromatography technology	Kraemer OH (2008)	1
SENP2	3	SUMO1	0	enzymatic study, pull down	Zhang H (2002), Hemelaar J (2004)	2
RUNX1	0	CREBBP	29	affinity chromatography technology	Nguyen LA (2005)	1
TRIM25	5	ABL1	9	affinity chromatography technology	Choudhury NR (2017)	1
UBE2I	0	SP100	4	enzymatic study, pull down, two hybrid, enzymatic study, enzymatic study, enzymatic study	Knipscheer P (2008), Knipscheer P (2008), Bandyopadhyay S (2010), Pelisch F (2010), Meulmeester E (2008), Knipscheer P (2007)	6
SKI	3	SIAH2	0	affinity chromatography technology	Zhao HL (2010)	1
TP63	0	MDM2	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zdzalik M (2010), Zdzalik M (2010), Galli F (2010), Calabro V (2002), Calabro V (2002), Stindt MH (2015)	6
HIPK2	0	FBXW7	2	affinity chromatography technology	Kanei-Ishii C (2008)	1
CREBBP	29	TP53	0	enzymatic study, pull down, genetic interference, pull down, enzymatic study, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Ito A (2002), Livengood JA (2002), Livengood JA (2002), Giebler HA (2000), Tang Y (2008), Jenkins LM (2009), Shi D (2009), Zhao Y (2006), Saifudeen Z (2005), Scolnick DM (1997), Scolnick DM (1997), Gu W (1997), Gu W (1997), Matsuda S (2004), Pasqualucci L (2011), Lee SK (1999), Dai C (2011), Lee CW (2010), Ferreon JC (2009), Ruas JL (2010), Ruas JL (2010), Huang WC (2007), Huang WC (2007), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Col E (2002), Jansma AL (2014), Jansma AL (2014), Krois AS (2016), Hasegawa K (2008), Huang X (2013), Huang X (2013), Piskacek M (2016)	35
SIAH2	0	XAF1	1	affinity chromatography technology, genetic interference, two hybrid, affinity chromatography technology	Lee MG (2014), Lee MG (2014), Lee MG (2014), Lee MG (2014)	4
SIAH1	2	RUNX1	0	affinity chromatography technology, affinity chromatography technology	Kraemer OH (2008), Kraemer OH (2008)	2
SUMO1	0	MYB	3	pull down	Saether T (2011)	1
NKX2-1	4	HIPK2	0	two hybrid	Missero C (2001)	1
TRIM25	5	HIPK2	0	affinity chromatography technology	Choudhury NR (2017)	1
MYB	3	FBXW7	2	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kanei-Ishii C (2008), Kanei-Ishii C (2008), Kitagawa K (2010), Kitagawa K (2010)	4
SKI	3	HIPK2	0	pull down, pull down, affinity chromatography technology	Harada J (2003), Harada J (2003), Harada J (2003)	3
CREBBP	29	SUMO1	0	x-ray crystallography, pull down	Diehl C (2016), Diehl C (2016)	2
HIPK2	0	MYBL1	0	pull down	Kurahashi T (2005)	1
DYRK1B	1	RANBP9	5	pull down, affinity chromatography technology, two hybrid	Zou Y (2003), Zou Y (2003), Zou Y (2003)	3
SMAD3	1	PAX6	3	affinity chromatography technology	Grocott T (2007)	1
ABL1	9	TP53	0	pull down	Nie Y (2000)	1
HIPK2	0	DYRK1A	36	affinity chromatography technology	Ritterhoff S (2010)	1
DYRK1A	36	EP300	36	affinity chromatography technology	Varjosalo M (2013)	1
MDM4	0	TP53	0	enzymatic study, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, protein complementation assay, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, fluorescent resonance energy transfe, pull down	Badciong JC (2002), Shvarts A (1997), Shvarts A (1997), Tang Y (2008), Okamoto K (2005), Chen L (2005), Wang X (2001), Ohtsubo C (2009), Zdzalik M (2010), Singh RK (2007), Kim S (2010), Li M (2011), Li M (2011), David Y (2011), de Graaf P (2003), Wade M (2012), Wade M (2012), Wade M (2012), Stad R (2000), Stad R (2000), Bernal F (2010), Bernal F (2010), Bernal F (2010), Bernal F (2010), Miller KR (2010), Zuckerman V (2009), Kallen J (2009), Czarna A (2009), Czarna A (2009), Popowicz GM (2008), Hu B (2007), Sharp DA (1999), Li C (2002), Di Conza G (2012), Mancini F (2009), Mancini F (2009), Wu S (2012), Shan B (2012), Wu S (2012), Wu S (2012), Ranaweera RS (2013), Bista M (2013), Bista M (2013), Wang CL (2014), Wang CL (2014), Rallapalli R (1999), Chang YS (2013), Chang YS (2013), Tan BX (2014), Huttlin EL (2015), Sanchez MC (2010), Sanchez MC (2010), Li YC (2014), Li X (2015), Chen X (2015), Chen L (2015), Chen L (2015), Chen L (2015), Wei X (2016), Wei X (2016), Xie X (2016), Huttlin EL (2017), Borcherds W (2017), Shangary S (2008), Ivanov AA (2017), Mancini F (2016)	66
HIPK2	0	PML	7	affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study	de la Vega L (2011), Renner F (2010), Sung KS (2011), Sung KS (2011), Gresko E (2009), Gresko E (2009), Gresko E (2009)	7
HIST2H2BE	1	EP300	36	pull down, enzymatic study, enzymatic study, enzymatic study	Kutney SN (2004), Cereseto A (2005), Loven MA (2004), Thomas MC (2005)	4
CBX4	1	DCAF7	4	affinity chromatography technology	Hauri S (2016)	1
TP63	0	UBE2I	0	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Huang YP (2004), Huang YP (2004), Huang YP (2004), Ghioni P (2005)	4
MYBL2	2	PARP1	3	affinity chromatography technology, pull down	Cervellera MN (2000), Cervellera MN (2000)	2
SMAD2	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Xi Q (2008), Chan EC (2010), He W (2006), Chen W (2007), Colland F (2004), Cui Q (2005)	6
CREBBP	29	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kang JS (2005), Alliston T (2005), Xi Q (2008), Cui Q (2005), Cui Q (2005), Chen W (2007), Nishihara A (1999), Tomita M (2004), Oussaief L (2009), Oussaief L (2009), Cui Q (2005)	11
EP300	36	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Wotton D (1999), Pessah M (2001), Furumatsu T (2005), Wang J (2011), Suganuma T (2002)	5
HIPK2	0	PARP1	3	affinity chromatography technology, pull down, affinity chromatography technology	Choi JR (2016), Choi JR (2016), Choi JR (2016)	3
PAX6	3	SUMO1	0	pull down	Yan Q (2010)	1
SENP1	0	HIPK2	0	enzymatic study	Kim YH (2005)	1
TP63	0	BTRC	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Gallegos JR (2008), Gallegos JR (2008), Gallegos JR (2008), Gallegos JR (2008)	4
MDM4	0	TP73	2	affinity chromatography technology, pull down, affinity chromatography technology	Wang X (2001), Zdzalik M (2010), Huttlin EL (2017)	3
AATF	0	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	De Nicola F (2007), De Nicola F (2007), De Nicola F (2014)	3
BTRC	1	AXIN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Kitagawa M (1999), Kitagawa M (1999), Li VS (2012), Coyaud E (2015), Coyaud E (2015), Novellasdemunt L (2017)	6
PML	7	MDM2	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bernardi R (2004), Bernardi R (2004), Zhu H (2003), Zhu H (2003), Kurki S (2003), Kurki S (2003), Wei X (2003), Wei X (2003), Wu Q (2009), Chu Y (2011), Yang Q (2013), Yang Q (2013), Bursac S (2012)	13
SMAD2	5	RUNX1	0	affinity chromatography technology	Hanai J (1999)	1
MDM2	2	TP73	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Balint E (1999), Zeng X (1999), Zeng X (1999), Chen L (2010), Zdzalik M (2010), Kim JW (2008), Balint E (1999), Balint E (1999), Wang J (2011), Ongkeko WM (1999), Ongkeko WM (1999), Ongkeko WM (1999), Ongkeko WM (1999), Wu H (2015), Stindt MH (2015), Zhou X (2015), Zhou X (2015)	17
SUMO1	0	TP63	0	affinity chromatography technology	Huang YP (2004)	1
RUNX1	0	HIPK2	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Aikawa Y (2006), Aikawa Y (2006), Aikawa Y (2006)	3
PARP1	3	ABL1	9	affinity chromatography technology	Wu T (2013)	1
BTRC	1	DYRK1A	36	affinity chromatography technology	Liu Q (2016)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
AXIN1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, pull down	Li Q (2011), Li Q (2011), He Y (2013), He Y (2013), He Y (2013), He Y (2013)	6
HIPK2	0	MKNK1	0	two hybrid	Wang J (2011)	1
CREBBP	29	HIST2H2BE	1	enzymatic study	Gatta R (2011)	1
NLK	1	MYBL1	0	pull down, affinity chromatography technology, enzymatic study	Kurahashi T (2005), Kurahashi T (2005), Kurahashi T (2005)	3
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
UBE2I	0	HIPK2	0	two hybrid, two hybrid, two hybrid, pull down, two hybrid, enzymatic study	Lee BH (2003), Bandyopadhyay S (2010), Sung KS (2005), Sung KS (2005), Hofmann TG (2005), Sung KS (2005)	6
SUMO3	0	PML	7	imaging technique	Cuchet-Lourenco D (2011)	1
RANBP9	5	UBE2I	0	affinity chromatography technology	Chang LK (2008)	1
CUL1	7	HSPA1A	0	affinity chromatography technology	Bennett EJ (2010)	1
FBXW7	2	CUL1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu G (2001), Tron AE (2012), Busino L (2012), Busino L (2012), Busino L (2012), Matsumoto A (2011), Bennett EJ (2010), Strohmaier H (2001), Davis MA (2013), JunGang Z (2012), Busino L (2003), Pierce NW (2013), Chung FZ (2014), Yumimoto K (2012), Low TY (2014), Kourtis N (2015), Gorelik M (2016), Gorelik M (2016), Huttlin EL (2017), Reiterer V (2017), Reiterer V (2017), Ye M (2017), Reitsma JM (2017)	23
HSPA1A	0	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaur J (1996), Fogeron ML (2013), Horikawa I (2014), Matsumoto H (1994), Matsumoto H (1994)	5
AXIN1	1	SKI	3	affinity chromatography technology	Koinuma D (2011)	1
DAXX	5	PARP1	3	affinity chromatography technology	Hein MY (2015)	1
SKI	3	ACTBL2	0	affinity chromatography technology	Rashidian J (2015)	1
PAX6	3	HIPK2	0	affinity chromatography technology, enzymatic study	Kim EA (2006), Kim EA (2006)	2
TP53	0	NLK	1	affinity chromatography technology, pull down, pull down, genetic interference, affinity chromatography technology	Zhang HH (2014), Zhang HH (2014), Zhang HH (2014), Zhang HH (2014), Zhang HH (2014)	5
NKX2-1	4	CREBBP	29	two hybrid, pull down, enzymatic study	Naltner A (2000), Yi M (2002), Yang L (2004)	3
BTRC	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Xia Y (2009), Verma S (2011)	2
TP73	2	EP300	36	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Strano S (2005), Uramoto H (2004), Zeng X (2000), Zeng X (2000), Zeng X (2000), Zeng X (2000), Zeng X (2000), Mantovani F (2004), Burge S (2009), Burge S (2009), Costanzo A (2002), Hoffmann A (2008), Kramer D (2015)	13
NLK	1	CUL1	7	affinity chromatography technology	Kanei-Ishii C (2008)	1
EP300	36	FBXO3	0	affinity chromatography technology, affinity chromatography technology	Shima Y (2008), Wang SA (2014)	2
TRIM25	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
CREBBP	29	PARP1	3	enzymatic study, imaging technique	Hassa PO (2005), Chen H (2014)	2
EP300	36	MYBL2	2	affinity chromatography technology, enzymatic study	Johnson LR (2002), Johnson LR (2002)	2
SMAD3	1	RANBP9	5	two hybrid	Colland F (2004)	1
CUL1	7	HIST2H2BE	1	affinity chromatography technology	Bennett EJ (2010)	1
TP73	2	DAXX	5	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Kim EJ (2003), Kim EJ (2003), Kim EJ (2003), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004)	6
TP63	0	MDM4	0	pull down, pull down	Zdzalik M (2010), Zdzalik M (2010)	2
UBE2I	0	DAXX	5	two hybrid, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, two hybrid	Ryu SW (2000), Knipscheer P (2008), Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Chang CC (2011), Lin DY (2006), Lin DY (2006)	8
HIPK2	0	MYB	3	pull down, two hybrid, affinity chromatography technology	Kurahashi T (2005), Kanei-Ishii C (2004), Kanei-Ishii C (2004)	3
DAXX	5	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Ivanchuk SM (2008), Ivanchuk SM (2008), Tang J (2006), Tang J (2006), Tang J (2006), Song MS (2008), Zhao LY (2004), Tang J (2013), Tang J (2013), Zhao LY (2004), Zhang H (2013), Zhang H (2013), Li Z (2017)	13
HNRNPL	3	MDM4	0	affinity chromatography technology	Fei T (2017)	1
HIPK2	0	SENP2	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Hofmann TG (2005), Hofmann TG (2005), Hofmann TG (2005)	3
TRIM25	5	BTRC	1	affinity chromatography technology	Choudhury NR (2017)	1
SMAD3	1	PML	7	affinity chromatography technology	Lin HK (2004)	1
HIPK2	0	RANBP9	5	two hybrid, affinity chromatography technology	Wang Y (2002), Wang Y (2002)	2
MDM2	2	HIST2H2BE	1	pull down, affinity chromatography technology, enzymatic study	Minsky N (2004), Minsky N (2004), Minsky N (2004)	3
PML	7	SMAD2	5	affinity chromatography technology	Lin HK (2004)	1
SMAD3	1	TP63	0	affinity chromatography technology	Lu D (2013)	1
CREBBP	29	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Pearson KL (1999), Sun Y (2001)	2
TP53INP1	0	TP53	0	pull down, pull down, affinity chromatography technology, pull down	Tomasini R (2003), Tomasini R (2003), Tomasini R (2003), Okamura S (2001)	4
TP53	0	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Chau JF (2012), Chau JF (2012)	2
DCAF7	4	HIPK2	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, imaging technique, imaging technique, affinity chromatography technology	Ritterhoff S (2010), Ritterhoff S (2010), Ritterhoff S (2010), Ritterhoff S (2010), Ritterhoff S (2010), Ritterhoff S (2010), Glenewinkel F (2016)	7
HIPK2	0	SIAH1	2	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Calzado MA (2009), Calzado MA (2009), Calzado MA (2009), Calzado MA (2009), Calzado MA (2009), Winter M (2008), Winter M (2008), Winter M (2008), Kim SY (2009), Kim SY (2009), Kim SY (2009), Kim SY (2009), Kurokawa K (2013)	13
BTRC	1	AATF	0	affinity chromatography technology, bioid	Coyaud E (2015), Coyaud E (2015)	2
NLK	1	MYBL2	2	affinity chromatography technology	Kurahashi T (2005)	1
CHMP4B	2	MECP2	36	affinity chromatography technology	Hein MY (2015)	1
STUB1	4	HSPA1A	0	pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Imai Y (2002), Havugimana PC (2012), Jinwal UK (2012), Yang SW (2013), Choi JR (2016), Schoenbuehler B (2016)	8
HIST2H2BE	1	HIPK2	0	imaging technique, pull down, affinity chromatography technology, enzymatic study	Rinaldo C (2012), Rinaldo C (2012), Rinaldo C (2012), Rinaldo C (2012)	4
EP300	36	SMAD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pearson KL (1999), Nakashima K (1999), Nakashima K (1999), Jeon EJ (2006), Jun JH (2010), Weng Q (2012)	6
HIPK2	0	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Hofmann TG (2002), Hofmann TG (2002)	2
SMAD1	0	RUNX1	0	affinity chromatography technology	Hanai J (1999)	1
MKNK1	0	CREBBP	29	two hybrid	Bandyopadhyay S (2010)	1
SIAH1	2	SIAH2	0	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Depaux A (2006), Depaux A (2006), Depaux A (2006), Huttlin EL (2017)	5
SUMO2	0	HIPK2	0	pull down	de la Vega L (2011)	1
MAP3K1	4	DYRK1B	1	affinity chromatography technology	Ritterhoff S (2010)	1
TP73	2	PAX6	3	affinity chromatography technology	Lunardi A (2010)	1
CUL1	7	ACTBL2	0	affinity chromatography technology	Bennett EJ (2010)	1
MYB	3	PARP1	3	affinity chromatography technology	Shi L (2008)	1
TP53	0	TP63	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McDade SS (2011), Lu D (2013), Chae YS (2012), Chae YS (2012), Stindt MH (2015), Wei S (2014)	6
SENP1	0	SUMO2	0	fluorescent resonance energy transfe, pull down, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Shen L (2006), Shen L (2006), Shen LN (2006), Shen LN (2006), Shen LN (2006), Mukhopadhyay D (2006), Schulz S (2012)	7
ABL1	9	MDM4	0	affinity chromatography technology, affinity chromatography technology	Zuckerman V (2009), Zuckerman V (2009)	2
HIPK2	0	DYRK1B	1	affinity chromatography technology	Ritterhoff S (2010)	1
SMAD2	5	HIPK2	0	pull down	Harada J (2003)	1
TP53	0	CHMP4B	2	affinity chromatography technology	Horikawa I (2014)	1
TP63	0	HNRNPL	3	affinity chromatography technology	Amoresano A (2010)	1
SENP1	0	SUMO3	0	enzymatic study, enzymatic study, pull down, enzymatic study	Shen LN (2006), Gong L (2006), Schulz S (2012), Schulz S (2012)	4
MYB	3	UBE2I	0	two hybrid, enzymatic study	Bies J (2002), Kanei-Ishii C (2012)	2
MDM4	0	SMAD3	1	pull down	Kadakia M (2002)	1
HIPK2	0	340571	0	affinity chromatography technology, affinity chromatography technology	Calzado MA (2009), Calzado MA (2009)	2
SMAD2	5	RANBP9	5	two hybrid	Colland F (2004)	1
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
HNRNPL	3	SENP1	0	affinity chromatography technology	Fei T (2017)	1
SENP2	3	DAXX	5	enzymatic study	Lin DY (2006)	1
HIPK2	0	CUL1	7	affinity chromatography technology	Kanei-Ishii C (2008)	1
HNRNPL	3	LZTS2	4	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	CREBBP	29	affinity chromatography technology	Fei T (2017)	1
LZTS2	4	HIPK2	0	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K1	4	HIPK2	0	affinity chromatography technology, imaging technique	Ritterhoff S (2010), Ritterhoff S (2010)	2
TRIM25	5	WSB1	2	affinity chromatography technology	Choudhury NR (2017)	1
PML	7	AXIN1	1	affinity chromatography technology, affinity chromatography technology, pull down	Li Q (2011), Li Q (2011), Li Q (2011)	3
NLK	1	HIPK2	0	two hybrid, pull down	Kanei-Ishii C (2004), Kanei-Ishii C (2004)	2
SUMO2	0	HSPA1A	0	pull down	Ouyang J (2009)	1
HIPK2	0	ABL1	9	affinity chromatography technology, pull down, enzymatic study	Reuven N (2015), Reuven N (2015), Reuven N (2015)	3
SMAD3	1	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Ueki N (2003), Ueki N (2003), Tabata T (2009), Prunier C (2003), Liberati NT (2001), Akiyoshi S (1999), Akiyoshi S (1999), Takeda M (2004), Mizuide M (2003), Wu K (2003), Chen W (2007), Band AM (2009), Qin BY (2002), He J (2003), He J (2003), Jinnin M (2007), Jinnin M (2007), Rashidian J (2015)	19
HIPK2	0	HIPK2	0	pull down, enzymatic study, enzymatic study	Aikawa Y (2006), Rinaldo C (2012), Rinaldo C (2007)	3
FBXW7	2	TP53	0	affinity chromatography technology	Huttlin EL (2017)	1
DAXX	5	STUB1	4	affinity chromatography technology, pull down	McDonough H (2009), McDonough H (2009)	2
HIPK2	0	WSB1	2	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Choi DW (2008), Choi DW (2008), Choi DW (2008), Choi DW (2008), Choi DW (2008)	5
TP53	0	DCAF7	4	affinity chromatography technology	Fogeron ML (2013)	1
TRIM25	5	PML	7	affinity chromatography technology	Choudhury NR (2017)	1
HIPK2	0	MBP	0	enzymatic study	Hofmann TG (2000)	1
SIAH2	0	UBE2I	0	two hybrid, two hybrid, two hybrid	Depaux A (2007), Hu G (1997), Wang J (2011)	3
EP300	36	SUMO2	0	pull down, enzymatic study	Ullmann R (2012), Ullmann R (2012)	2
RUNX1	0	EP300	36	affinity chromatography technology, enzymatic study	Aikawa Y (2006), Yamaguchi Y (2004)	2
SENP1	0	SP100	4	enzymatic study	Schulz S (2012)	1
SENP1	0	SUMO1	0	x-ray crystallography, fluorescent resonance energy transfe, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study	Shen L (2006), Shen L (2006), Shen L (2006), Shen LN (2006), Mukhopadhyay D (2006), Gong L (2006), Schulz S (2012), Schulz S (2012)	8
TP53	0	XAF1	1	affinity chromatography technology, genetic interference, affinity chromatography technology, pull down	Lee MG (2014), Lee MG (2014), Lee MG (2014), Lee MG (2014)	4
SUMO2	0	PML	7	imaging technique, two hybrid, pull down	Cuchet-Lourenco D (2011), Li C (2017), Li C (2017)	3
HIPK2	0	STUB1	4	affinity chromatography technology, affinity chromatography technology	Choi JR (2016), Choi JR (2016)	2
DYRK1B	1	LZTS2	4	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2017)	4
EP300	36	MDM2	2	pull down, affinity chromatography technology, biochemical, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study	Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Matt T (2004), Wang X (2004), Gillotin S (2010), Kobet E (2000), Nihira NT (2017)	9
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
SKI	3	TP53	0	affinity chromatography technology	Inoue Y (2011)	1
UBE2I	0	SUMO3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Li T (2006), Boutell C (2011), Hecker CM (2006), Tatham MH (2001), Wan C (2015), Huttlin EL (2017)	7
ABL1	9	MDM2	2	affinity chromatography technology, pull down, enzymatic study, unspecified method, enzymatic study	Goldberg Z (2002), Goldberg Z (2002), Goldberg Z (2002), Batuello CN (2015), Batuello CN (2015)	5
SMAD2	5	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe	Brown KA (2008), Wu RY (1997), Wu RY (1997), Ivanov AA (2017)	4
TP63	0	TP73	2	affinity chromatography technology	Huttlin EL (2017)	1
SMAD1	0	HIPK2	0	pull down, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Harada J (2003), Harada J (2003)	3
TP73	2	HIPK2	0	two hybrid	Kim EJ (2002)	1
TRIM25	5	MKNK1	0	affinity chromatography technology	Choudhury NR (2017)	1