PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
H2AFX	1	DHX9	3	affinity chromatography technology, pull down, affinity chromatography technology	Mischo HE (2005), Mischo HE (2005), Mischo HE (2005)	3
XPC	1	H2AFX	1	affinity chromatography technology, affinity chromatography technology	Ray A (2009), Huttlin EL (2017)	2
DHX9	3	XRCC5	5	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Q (2005), Zhang S (2004), Zhang S (2004), Zhang S (2004), Sand-Dejmek J (2011)	5
RPA1	0	XRCC5	5	affinity chromatography technology	Marechal A (2014)	1
MACROD1	0	PPP2R1A	8	affinity chromatography technology	Wu Z (2015)	1
MACROD1	0	IKBKB	1	affinity chromatography technology	Wu Z (2015)	1
XPC	1	CETN2	0	biochemical, pull down, affinity chromatography technology, biochemical, bioid, affinity chromatography technology, affinity chromatography technology	Araki M (2001), Araki M (2001), Bunick CG (2006), Havugimana PC (2012), Gupta GD (2015), Huttlin EL (2017), Lan X (2016)	7
PARP1	3	XRCC5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Ju BG (2006), Galande S (1999), Galande S (1999), Galande S (1999), Idogawa M (2007), Li B (2004), Li B (2004), Yin H (2006), Yin H (2006), Sand-Dejmek J (2011), Wu T (2013)	11
HNRNPU	12	DDX21	0	affinity chromatography technology	Hein MY (2015)	1
HNRNPU	12	YBX1	1	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
EXOC3	2	MACROD1	0	affinity chromatography technology	Huttlin EL (2017)	1
MACROD1	0	YBX1	1	affinity chromatography technology	Wu Z (2015)	1
RPA1	0	HNRNPL	3	affinity chromatography technology	Marechal A (2014)	1
DLD	1	RPA1	0	affinity chromatography technology	Malty RH (2017)	1
MACROD1	0	CSTF3	1	affinity chromatography technology	Wu Z (2015)	1
ERC1	0	IKBKG	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wu ZH (2010), Ducut Sigala JL (2004), Ducut Sigala JL (2004), Ducut Sigala JL (2004)	4
DLD	1	PPP2R1A	8	affinity chromatography technology	Malty RH (2017)	1
MACROD1	0	PARP2	0	affinity chromatography technology	Huttlin EL (2017)	1
DLD	1	MACROD1	0	affinity chromatography technology	Malty RH (2017)	1
MACROD1	0	XPC	1	affinity chromatography technology	Huttlin EL (2017)	1
PARP1	3	SUPT16H	4	enzymatic study	Huang JY (2006)	1
XRCC6	3	XPC	1	affinity chromatography technology	Huttlin EL (2017)	1
MACROD1	0	HBE1	0	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	XRCC5	5	affinity chromatography technology	Fei T (2017)	1
IKBKB	1	EIF2AK2	1	affinity chromatography technology	Bonnet MC (2000)	1
RPA1	0	XRCC6	3	affinity chromatography technology	Marechal A (2014)	1
DHX9	3	HNRNPU	12	affinity chromatography technology, biochemical, affinity chromatography technology	Chu L (2012), Kristensen AR (2012), Hein MY (2015)	3
IKBKB	1	HNRNPU	12	affinity chromatography technology, affinity chromatography technology	Tsuchiya Y (2010), Tsuchiya Y (2010)	2
XPC	1	PARP1	3	affinity chromatography technology	Huttlin EL (2017)	1
XRCC6	3	PARP2	0	affinity chromatography technology	Huttlin EL (2017)	1
SSRP1	1	SUPT16H	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Birch JL (2009), Tan BC (2006), Tan BC (2006), Pavri R (2006), Huang JY (2006), Huang JY (2006), OConnell BC (2010), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	12
HNRNPU	12	SUPT16H	4	affinity chromatography technology	Hein MY (2015)	1
HNRNPU	12	HNRNPL	3	affinity chromatography technology	Hein MY (2015)	1
MACROD1	0	RPA1	0	affinity chromatography technology	Huttlin EL (2017)	1
MACROD1	0	SUPT16H	4	affinity chromatography technology	Huttlin EL (2017)	1
H2AFX	1	SSRP1	1	affinity chromatography technology, pull down, affinity chromatography technology	Du YC (2006), Heo K (2008), Huttlin EL (2017)	3
RPA1	0	DHX9	3	affinity chromatography technology	Marechal A (2014)	1
LIG3	6	XRCC6	3	affinity chromatography technology, pull down, affinity chromatography technology	Leppard JB (2003), Leppard JB (2003), Huttlin EL (2017)	3
BAG3	4	MACROD1	0	affinity chromatography technology	Chen Y (2013)	1
XRCC6	3	SSRP1	1	affinity chromatography technology	Huttlin EL (2017)	1
BAG3	4	PARP1	3	affinity chromatography technology	Chen Y (2013)	1
PTP4A1	0	MACROD1	0	affinity chromatography technology	Li X (2016)	1
XRCC5	5	XRCC6	3	two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology	Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017)	46
MACROD1	0	ERC1	0	affinity chromatography technology	Wu Z (2015)	1
RPA1	0	PARP1	3	affinity chromatography technology	Marechal A (2014)	1
DLD	1	EIF2AK2	1	affinity chromatography technology	Malty RH (2017)	1
PTPN7	3	MACROD1	0	affinity chromatography technology	Li X (2016)	1
LIG3	6	PARP1	3	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Leppard JB (2003), Leppard JB (2003), Leppard JB (2003), Leppard JB (2003)	4
EIF2AK2	1	DHX9	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Li S (2011), Li S (2011), Sadler AJ (2009), Sadler AJ (2009), Sadler AJ (2009), Sadler AJ (2009), Sadler AJ (2009)	7
XRCC6	3	SUPT16H	4	affinity chromatography technology	Huttlin EL (2017)	1
MACROD1	0	HBA2	0	affinity chromatography technology	Huttlin EL (2017)	1
MACROD1	0	SSRP1	1	affinity chromatography technology	Huttlin EL (2017)	1
MACROD1	0	XRCC6	3	affinity chromatography technology, affinity chromatography technology	Wu Z (2015), Wu Z (2015)	2
H2AFX	1	DDX21	0	pull down	Kobayashi J (2012)	1
H2AFX	1	YBX1	1	affinity chromatography technology	Huttlin EL (2017)	1
XRCC5	5	SSRP1	1	affinity chromatography technology, imaging technique	Sand-Dejmek J (2011), Sand-Dejmek J (2011)	2
MACROD1	0	DDX21	0	affinity chromatography technology	Wu Z (2015)	1
PARP1	3	CETN2	0	affinity chromatography technology	Wu T (2013)	1
IKBKB	1	ERC1	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wu ZH (2010), Ducut Sigala JL (2004), Ducut Sigala JL (2004), Ducut Sigala JL (2004)	4
HNRNPL	3	CSTF3	1	affinity chromatography technology	Fei T (2017)	1
XPC	1	PARP2	0	affinity chromatography technology	Huttlin EL (2017)	1
MACROD1	0	CETN2	0	affinity chromatography technology	Huttlin EL (2017)	1
XRCC5	5	SUPT16H	4	affinity chromatography technology, affinity chromatography technology	Sand-Dejmek J (2011), Sand-Dejmek J (2011)	2
DLD	1	SUPT16H	4	affinity chromatography technology	Malty RH (2017)	1
H2AFX	1	SUPT16H	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Du YC (2006), Heo K (2008), Heo K (2008), Heo K (2008), Huttlin EL (2017)	5
BAG3	4	IKBKG	0	affinity chromatography technology	Ammirante M (2010)	1
MACROD1	0	DHX9	3	affinity chromatography technology	Wu Z (2015)	1
H2AFX	1	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Du YC (2006), Du YC (2006), Heo K (2008), Heo K (2008), Heo K (2008), Yang X (2010), Yang X (2010), Huttlin EL (2017)	8
RPA1	0	LIG3	6	affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Elia AE (2015)	2
DHX9	3	XRCC6	3	affinity chromatography technology	Wang Q (2005)	1
RPA1	0	HNRNPU	12	affinity chromatography technology	Marechal A (2014)	1
PTPN6	0	MACROD1	0	affinity chromatography technology	Li X (2016)	1
XPC	1	SUPT16H	4	affinity chromatography technology	Huttlin EL (2017)	1
SSRP1	1	PARP1	3	affinity chromatography technology	Huttlin EL (2017)	1
H2AFX	1	CETN2	0	affinity chromatography technology	Huttlin EL (2017)	1
PARP1	3	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Ju BG (2006), Galande S (1999), Galande S (1999), Galande S (1999), Idogawa M (2007), Li B (2004), Li B (2004), Yin H (2006), Yin H (2006), Wu T (2013), Huttlin EL (2017)	11
MACROD1	0	LIG3	6	affinity chromatography technology	Huttlin EL (2017)	1
DDX21	0	PARP1	3	biochemical	Havugimana PC (2012)	1
H2AFX	1	LIG3	6	affinity chromatography technology	Huttlin EL (2017)	1
H2AFX	1	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Mischo HE (2005), Mischo HE (2005), Heo K (2008), Heo K (2008), Heo K (2008), Lee HS (2010), Kobayashi J (2012), Huttlin EL (2017)	8
H2AFX	1	XRCC5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Heo K (2008), Heo K (2008), Sand-Dejmek J (2011)	3
SSRP1	1	XPC	1	affinity chromatography technology	Huttlin EL (2017)	1
H2AFX	1	440686	0	affinity chromatography technology	Huttlin EL (2017)	1
PARP1	3	PARP2	0	affinity chromatography technology	Schreiber V (2002)	1
MACROD1	0	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Wu Z (2015), Wu Z (2015)	2
DHX9	3	SSRP1	1	biochemical	Havugimana PC (2012)	1
BAG3	4	HNRNPU	12	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
MACROD1	0	EIF2AK2	1	affinity chromatography technology	Wu Z (2015)	1
PARP1	3	MACROD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wu Z (2015), Wu Z (2015), Wu Z (2015), Wu Z (2015), Huttlin EL (2017)	5
DDX21	0	SUPT16H	4	biochemical	Havugimana PC (2012)	1
IKBKG	0	MACROD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Wu Z (2015), Wu Z (2015), Wu Z (2015), Wu Z (2015), Wu Z (2015)	5
HNRNPL	3	MACROD1	0	affinity chromatography technology	Fei T (2017)	1
DLD	1	XRCC6	3	affinity chromatography technology	Malty RH (2017)	1
DLD	1	CSTF3	1	affinity chromatography technology	Malty RH (2017)	1
RPA1	0	XPC	1	pull down	Thoma BS (2005)	1
MACROD1	0	440686	0	affinity chromatography technology	Huttlin EL (2017)	1
IKBKB	1	IKBKG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, biochemical, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, pull down, affinity chromatography technology	Chen G (2002), Chen G (2002), Chariot A (2002), Wu RC (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010), Lee KY (2005), Rothwarf DM (1998), Ea CK (2006), Thurston TL (2009), Orel L (2010), Wu ZH (2010), Napolitano G (2009), Liu J (2009), Skaug B (2011), Li S (2011), Li S (2011), Kensche T (2012), Chiaravalli J (2011), Wu CJ (2006), Wu ZH (2006), Ahmad R (2007), Ahmad R (2007), Palkowitsch L (2008), Palkowitsch L (2008), Lo YC (2008), Mabb AM (2006), Baima ET (2010), Tegethoff S (2003), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), Lee DF (2007), Rottenberg S (2002), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Funakoshi-Tago M (2005), Ivins FJ (2009), Shibata Y (2012), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Wu ZH (2008), Mitsuhashi S (2008), Fujita H (2014), Golden MS (2013), Lee SH (2012), Cote SM (2013), Kim HJ (2014), Jackson SS (2014), Liao W (2008), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), So J (2015), Liu D (2014), Guo B (2014), Guo B (2014), Guo B (2014), Zhou L (2014), Zhou L (2014), Hein MY (2015), Bagneris C (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Rushe M (2008), Hauenstein AV (2017), Bal E (2017)	78
LIG3	6	XRCC5	5	affinity chromatography technology, pull down	Leppard JB (2003), Leppard JB (2003)	2
H2AFX	1	PARP2	0	affinity chromatography technology	Huttlin EL (2017)	1
DLD	1	XRCC5	5	affinity chromatography technology	Malty RH (2017)	1
PARP1	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, pull down	Wu Z (2015), Wu Z (2015), Wu Z (2015)	3
MACROD1	0	H2AFX	1	affinity chromatography technology	Huttlin EL (2017)	1
MACROD1	0	HNRNPU	12	affinity chromatography technology	Wu Z (2015)	1