PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GRIA1	5	GRID2	5	affinity chromatography technology, affinity chromatography technology	Kohda K (2003), Kohda K (2003)	2
GRID2	5	PTPN4	0	two hybrid, affinity chromatography technology	Hironaka K (2000), Hironaka K (2000)	2
GRIA2	4	GRID2	5	affinity chromatography technology	Kohda K (2003)	1
GRIK2	4	GRIK5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wenthold RJ (1994), Ripellino JA (1998), Valluru L (2005)	3
GRIK2	4	GRIA1	5	affinity chromatography technology	Wenthold RJ (1994)	1
GOPC	5	GRID2	5	affinity chromatography technology, two hybrid	Yue Z (2002), Yue Z (2002)	2
GRIK2	4	GRIA2	4	affinity chromatography technology	Wenthold RJ (1994)	1
GRIA1	5	GRIA2	4	affinity chromatography technology, affinity chromatography technology	Leuschner WD (1999), Correia SS (2008)	2
GRIK2	4	GRID2	5	affinity chromatography technology, affinity chromatography technology	Kohda K (2003), Kohda K (2003)	2
GRIK5	5	GRID2	5	affinity chromatography technology	Kohda K (2003)	1
GRID2	5	GRID2IP	9	two hybrid, pull down, affinity chromatography technology	Miyagi Y (2002), Miyagi Y (2002), Miyagi Y (2002)	3